scholarly journals Plasmonic Metasurfaces for Medical Diagnosis Applications: A Review

Sensors ◽  
2021 ◽  
Vol 22 (1) ◽  
pp. 133
Author(s):  
Zhenbiao Wang ◽  
Junjie Chen ◽  
Sayed Ali Khan ◽  
Fajun Li ◽  
Jiaqing Shen ◽  
...  

Plasmonic metasurfaces have been widely used in biosensing to improve the interaction between light and biomolecules through the effects of near-field confinement. When paired with biofunctionalization, plasmonic metasurface sensing is considered as a viable strategy for improving biomarker detection technologies. In this review, we enumerate the fundamental mechanism of plasmonic metasurfaces sensing and present their detection in human tumors and COVID-19. The advantages of rapid sampling, streamlined processes, high sensitivity, and easy accessibility are highlighted compared with traditional detection techniques. This review is looking forward to assisting scientists in advancing research and developing a new generation of multifunctional biosensors.

2013 ◽  
Vol 3 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Tore Straume ◽  
David Loftus ◽  
Jing Li ◽  
Matthew Coleman ◽  
Cristina Davis ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yazhou Wang ◽  
Yuyang Feng ◽  
Abubakar I. Adamu ◽  
Manoj K. Dasa ◽  
J. E. Antonio-Lopez ◽  
...  

AbstractDevelopment of novel mid-infrared (MIR) lasers could ultimately boost emerging detection technologies towards innovative spectroscopic and imaging solutions. Photoacoustic (PA) modality has been heralded for years as one of the most powerful detection tools enabling high signal-to-noise ratio analysis. Here, we demonstrate a novel, compact and sensitive MIR-PA system for carbon dioxide (CO2) monitoring at its strongest absorption band by combining a gas-filled fiber laser and PA technology. Specifically, the PA signals were excited by a custom-made hydrogen (H2) based MIR Raman fiber laser source with a pulse energy of ⁓ 18 μJ, quantum efficiency of ⁓ 80% and peak power of ⁓ 3.9 kW. A CO2 detection limit of 605 ppbv was attained from the Allan deviation. This work constitutes an alternative method for advanced high-sensitivity gas detection.


2004 ◽  
Vol 50 (8) ◽  
pp. 1301-1314 ◽  
Author(s):  
Shawn D Carrigan ◽  
George Scott ◽  
Maryam Tabrizian

Abstract Sepsis in the United States has an estimated annual healthcare cost of $16.7 billion and leads to 120 000 deaths. Insufficient development in both medical diagnosis and treatment of sepsis has led to continued growth in reported cases of sepsis over the past two decades with little improvement in mortality statistics. Efforts over the last decade to improve diagnosis have unsuccessfully sought to identify a “magic bullet” proteic biomarker that provides high sensitivity and specificity for infectious inflammation. More recently, genetic methods have made tracking regulation of the genes responsible for these biomarkers possible, giving current research new direction in the search to understand how host immune response combats infection. Despite the breadth of research, inadequate treatment as a result of delayed diagnosis continues to affect approximately one fourth of septic patients. In this report we review past and present diagnostic methods for sepsis and their respective limitations, and discuss the requirements for more timely diagnosis as the next step in curtailing sepsis-related mortality. We also present a proposal toward revision of the current diagnostic paradigm to include real-time immune monitoring.


Drones ◽  
2021 ◽  
Vol 5 (4) ◽  
pp. 117
Author(s):  
Derek Hollenbeck ◽  
Demitrius Zulevic ◽  
Yangquan Chen

Detecting and quantifying methane emissions is gaining an increasingly vital role in mitigating emissions for the oil and gas industry through early detection and repair and will aide our understanding of how emissions in natural ecosystems are playing a role in the global carbon cycle and its impact on the climate. Traditional methods of measuring and quantifying emissions utilize chamber methods, bagging individual equipment, or require the release of a tracer gas. Advanced leak detection techniques have been developed over the past few years, utilizing technologies, such as optical gas imaging, mobile surveyors equipped with sensitive cavity ring down spectroscopy (CRDS), and manned aircraft and satellite approaches. More recently, sUAS-based approaches have been developed to provide, in some ways, cheaper alternatives that also offer sensing advantages to traditional methods, including not being constrained to roadways and being able to access class G airspace (0–400 ft) where manned aviation cannot travel. This work looks at reviewing methods of quantifying methane emissions that can be, or are, carried out using small unmanned aircraft systems (sUAS) as well as traditional methods to provide a clear comparison for future practitioners. This includes the current limitations, capabilities, assumptions, and survey details. The suggested technique for LDAQ depends on the desired accuracy and is a function of the survey time and survey distance. Based on the complexity and precision, the most promising sUAS methods are the near-field Gaussian plume inversion (NGI) and the vertical flux plane (VFP), which have comparable accuracy to those found in conventional state-of-the-art methods.


Author(s):  
HIND BAKLI ◽  
Mohamed MOUALHI ◽  
Mourad Makhlouf

Abstract High sensitivity electrical properties measurement of composite materials using an interferometric near-field microwave technique is proposed in this paper. A one-port calibration model is developed to relate the measured transmission coefficient to the local properties of the material. To represent the probe-composite sample interaction, an electrical model based on lumped elements is developed. As a demonstration, complex permittivity and conductivity of composite materials prepared with polyvinyl chloride (PVC) and different concentration of graphene are experimentally determined at 2.45 GHz. The obtained results show that the proposed technique is sensitive for the detection of small contrast of permittivity and conductivity in composite material. When graphene concentration increases from 1 to 30%, the conductivity increases from 0.0061 s/m to 0.056 s/m.


2019 ◽  
Vol 100 (12) ◽  
pp. 2433-2450 ◽  
Author(s):  
Jerome M. Schmidt ◽  
Piotr J. Flatau ◽  
Paul R. Harasti ◽  
Robert. D. Yates ◽  
David J. Delene ◽  
...  

Abstract Descriptions of the experimental design and research highlights obtained from a series of four multiagency field projects held near Cape Canaveral, Florida, are presented. The experiments featured a 3 MW, dual-polarization, C-band Doppler radar that serves in a dual capacity as both a precipitation and cloud radar. This duality stems from a combination of the radar’s high sensitivity and extremely small-resolution volumes produced by the narrow 0.22° beamwidth and the 0.543 m along-range resolution. Experimental highlights focus on the radar’s real-time aircraft tracking capability as well as the finescale reflectivity and eddy structure of a thin nonprecipitating stratus layer. Examples of precipitating storm systems focus on the analysis of the distinctive and nearly linear radar reflectivity signatures (referred to as “streaks”) that are caused as individual hydrometeors traverse the narrow radar beam. Each streak leaves a unique radar reflectivity signature that is analyzed with regard to estimating the underlying particle properties such as size, fall speed, and oscillation characteristics. The observed along-streak reflectivity oscillations are complex and discussed in terms of diameter-dependent drop dynamics (oscillation frequency and viscous damping time scales) as well as radar-dependent factors governing the near-field Fresnel radiation pattern and inferred drop–drop interference.


2019 ◽  
Vol 18 (12) ◽  
pp. 2552-2556 ◽  
Author(s):  
Zheng Min ◽  
Zhaowen Yan ◽  
Wei Liu ◽  
Jianwei Wang ◽  
Donglin Su ◽  
...  

Micromachines ◽  
2019 ◽  
Vol 10 (8) ◽  
pp. 516 ◽  
Author(s):  
Veasna Soum ◽  
Sooyong Park ◽  
Albertus Ivan Brilian ◽  
Oh-Sun Kwon ◽  
Kwanwoo Shin

Recent advanced paper-based microfluidic devices provide an alternative technology for the detection of biomarkers by using affordable and portable devices for point-of-care testing (POCT). Programmable paper-based microfluidic devices enable a wide range of biomarker detection with high sensitivity and automation for single- and multi-step assays because they provide better control for manipulating fluid samples. In this review, we examine the advances in programmable microfluidics, i.e., paper-based continuous-flow microfluidic (p-CMF) devices and paper-based digital microfluidic (p-DMF) devices, for biomarker detection. First, we discuss the methods used to fabricate these two types of paper-based microfluidic devices and the strategies for programming fluid delivery and for droplet manipulation. Next, we discuss the use of these programmable paper-based devices for the single- and multi-step detection of biomarkers. Finally, we present the current limitations of paper-based microfluidics for biomarker detection and the outlook for their development.


2020 ◽  
Vol 6 (24) ◽  
pp. eaba8792 ◽  
Author(s):  
Rui Zhang ◽  
Wei Xiao ◽  
Yudong Ding ◽  
Yulong Feng ◽  
Xiang Peng ◽  
...  

Understanding the relationship between brain activity and specific mental function is important for medical diagnosis of brain symptoms, such as epilepsy. Magnetoencephalography (MEG), which uses an array of high-sensitivity magnetometers to record magnetic field signals generated from neural currents occurring naturally in the brain, is a noninvasive method for locating the brain activities. The MEG is normally performed in a magnetically shielded room. Here, we introduce an unshielded MEG system based on optically pumped atomic magnetometers. We build an atomic magnetic gradiometer, together with feedback methods, to reduce the environment magnetic field noise. We successfully observe the alpha rhythm signals related to closed eyes and clear auditory evoked field signals in unshielded Earth’s field. Combined with improvements in the miniaturization of the atomic magnetometer, our method is promising to realize a practical wearable and movable unshielded MEG system and bring new insights into medical diagnosis of brain symptoms.


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