scholarly journals Respiratory Safety Evaluation in Mice and Inhibition of Adenoviral Amplification in Human Bronchial Endothelial Cells Using a Novel Type of Chlorine Dioxide Gas Reactor

Toxics ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 38
Author(s):  
Hae-Sung Yang ◽  
Kyeong-Min Kim ◽  
Napissara Boonpraman ◽  
Sun-Mi Yoon ◽  
Jeong-Eun Seo ◽  
...  
Keyword(s):  
Chlorine Dioxide ◽  
Viral Infections ◽  
Recombinant Adenovirus ◽  
Safety Evaluation ◽  
Control Group ◽  
Inhalation Toxicity ◽  
Bronchial Epithelial ◽  
Chlorine Dioxide Gas ◽  
New Type ◽  
Inhibitory Power

Since the onset of the COVID-19 pandemic, there has been a growing demand for effective and safe disinfectants. A novel use of chlorine dioxide (ClO2) gas, which can satisfy such demand, has been reported. However, its efficacy and safety remain unclear. For the safe use of this gas, the stable release of specific concentrations is a must. A new type of ClO2 generator called Dr.CLOTM has recently been introduced. This study aimed to investigate: (1) the effects of Dr.CLOTM on inhibiting adenoviral amplification on human bronchial epithelial (HBE) cells; and (2) the acute inhalation safety of using Dr.CLOTM in animal models. After infecting HBE cells with a recombinant adenovirus, the inhibitory power of Dr.CLOTM on the virus was expressed as IFU/mL in comparison with the control group. The safety of ClO2 gas was indirectly predicted using mice by measuring single-dose inhalation toxicity in specially designed chambers. Dr.CLOTM was found to evaporate in a very constant concentration range at 0–0.011 ppm/m3 for 42 days. In addition, 36–100% of adenoviral amplification was suppressed by Dr.CLOTM, depending on the conditions. The LC50 of ClO2 gas to mice was approximately 68 ppm for males and 141 ppm for females. Histopathological evaluation showed that the lungs of female mice were more resistant to the toxicity from higher ClO2 gas concentrations than those of male mice. Taken together, these results indicate that Dr.CLOTM can be used to provide a safe indoor environment due to its technology that maintains the stable concentration and release of ClO2 gas, which could suppress viral amplification and may prevent viral infections.

scholarly journals Six-month low level chlorine dioxide gas inhalation toxicity study with two-week recovery period in rats

2012 ◽  
Vol 7 (1) ◽  
pp. 2 ◽  
Author(s):  
Akinori Akamatsu ◽  
Cheolsung Lee ◽  
Hirofumi Morino ◽  
Takanori Miura ◽  
Norio Ogata ◽  
...  
Keyword(s):  
Chlorine Dioxide ◽  
Recovery Period ◽  
Toxicity Study ◽  
Inhalation Toxicity ◽  
Low Level ◽  
Chlorine Dioxide Gas ◽  
Gas Inhalation

scholarly journals Inactivation of Salmonella on Eggshells by Chlorine Dioxide Gas

2016 ◽  
Vol 36 (1) ◽  
pp. 100-108 ◽  
Author(s):  
Hyobi Kim ◽  
Bora Yum ◽  
Sung-Sik Yoon ◽  
Kyoung-Ju Song ◽  
Jong-Rak Kim ◽  
...  
Keyword(s):  
Chlorine Dioxide ◽  
Chlorine Dioxide Gas

Reduction of adsorbable organically bound halogens (AOX) formation at near-neutral pH chlorine dioxide bleaching of softwood kraft pulp

Holzforschung ◽  
2020 ◽  
Vol 74 (6) ◽  
pp. 597-604
Author(s):  
Sara Starrsjö ◽  
Olena Sevastyanova ◽  
Peter Sandström ◽  
Juha Fiskari ◽  
Maria Boman ◽  
...  
Keyword(s):  
Chlorine Dioxide ◽  
High Selectivity ◽  
Bicarbonate Buffer ◽  
Neutral Ph ◽  
Elemental Chlorine ◽  
Pulp Viscosity ◽  
Softwood Kraft Pulp ◽  
New Type ◽  
Adsorbable Organically Bound Halogens

AbstractRecently, a new type of bleaching sequence, Elemental Chlorine Free (ECF) light with one D stage, has been developed. It combines the efficiency and high selectivity of chlorine dioxide (ClO2) bleaching with more environmental friendly oxygen based bleaching chemicals. This work examines the effect of pH on the formation of adsorbable organically bound halogens (AOX) in an intermediate D stage – a single ClO2 stage at the middle of an ECF light bleaching sequence. Carbon dioxide (CO2) is used to generate a bicarbonate buffer in situ, stabilizing the pH during the bleaching. Near-neutral pH is hypothesized to decrease the formation of strongly chlorinating species, so that the AOX formation is reduced. The results indicate that a near-neutral pH D stage can reduce the AOX content in the effluents with up to 30%. The ISO brightness was unchanged to a lower ClO2 consumption. The pulp viscosity was slightly higher after near-neutral pH D stage, but to its disadvantage a lesser delignification and removal of HexA was obtained. The degradation of HexA correlated well with the AOX, affirming earlier theories that HexA has a major impact on the AOX formation. The higher amounts of residual HexA and lignin resulted in more thermal yellowing of the pulps bleached with a near-neutral pH D stage.

scholarly journals Anti-Influenza with Green Tea Catechins: A Systematic Review and Meta-Analysis

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 4014
Author(s):  
Anchalee Rawangkan ◽  
Kirati Kengkla ◽  
Sukrit Kanchanasurakit ◽  
Acharaporn Duangjai ◽  
Surasak Saokaew
Keyword(s):  
Systematic Review ◽  
Green Tea ◽  
Viral Infections ◽  
Influenza Infection ◽  
Meta Analysis ◽  
Influenza Virus Infection ◽  
Control Group ◽  
Tea Consumption ◽  
Tea Catechins ◽  
Green Tea Catechins

Influenza is one of the most serious respiratory viral infections worldwide. Although several studies have reported that green tea catechins (GTCs) might prevent influenza virus infection, this remains controversial. We performed a systematic review and meta-analysis of eight studies with 5,048 participants that examined the effect of GTC administration on influenza prevention. In a random-effects meta-analysis of five RCTs, 884 participants treated with GTCs showed statistically significant effects on the prevention of influenza infection compared to the control group (risk ratio (RR) 0.67, 95%CIs 0.51–0.89, P = 0.005) without evidence of heterogeneity (I2= 0%, P = 0.629). Similarly, in three cohort studies with 2,223 participants treated with GTCs, there were also statistically significant effects (RR 0.52, 95%CIs 0.35–0.77, P = 0.001) with very low evidence of heterogeneity (I2 = 3%, P = 0.358). Additionally, the overall effect in the subgroup analysis of gargling and orally ingested items (taking capsules and drinking) showed a pooled RR of 0.62 (95% CIs 0.49–0.77, P = 0.003) without heterogeneity (I2= 0%, P = 0.554). There were no obvious publication biases (Egger’s test (P = 0.138) and Begg’s test (P = 0.103)). Our analysis suggests that green tea consumption is effective in the prophylaxis of influenza infections. To confirm the findings before implementation, longitudinal clinical trials with specific doses of green tea consumption are warranted.

Effect of Chlorine Dioxide Gas Treatment on Surface Sterilization of Grape

2011 ◽  
Vol 236-238 ◽  
pp. 2939-2944 ◽  
Author(s):  
Ri Ya Jin ◽  
Shuang Qi Hu ◽  
Zhi Chao Chi
Keyword(s):  
Chlorine Dioxide ◽  
Treatment Time ◽  
Reducing Sugar ◽  
Gas Treatment ◽  
Surface Sterilization ◽  
Log Reduction ◽  
Chlorine Dioxide Gas ◽  
Spoilage Bacteria ◽  
Effect Of Chlorine

Experiments were conducted to investigate the effect of concentration and duration of chlorine dioxide gas treatment on Surface sterilization of grape at 25°C. The results showed that the values of inactivate bacterial log reduction ofBotrytis cinerea,Penicilliumandalternariaincreased with the increasing of ClO2gas concentrations and treatment time. When the concentrations and treatment time was about 10 mg/m3and 30 minutes, respectively, more than 4 log reduction was obtained for the three spoilage bacteria on grape surface. Furthermore, the effect of chlorine dioxide gas treatment on quality of grape was investigated. It was found that the contents of vitamin C (Vc) and reducing sugar (RS) in grape also increased compared with grape without ClO2gas treatment.

Indicators of the kinin blood system in severe forms of acute respiratory viral infections in children

1982 ◽  
Vol 63 (2) ◽  
pp. 51-52
Author(s):  
V. A. Anokhin ◽  
A. D. Tsaregorodtsev
Keyword(s):  
Viral Infection ◽  
Viral Infections ◽  
Severe Form ◽  
Blood System ◽  
Control Group ◽  
Healthy Children ◽  
Respiratory Viral Infection ◽  
Respiratory Viral Infections ◽  
Acute Respiratory Viral Infection ◽  
Apparently Healthy

The aim of this work was to study the parameters of the components of the kinin blood system in children with severe forms of acute respiratory viral infections (ARVI) with neurotoxicosis syndrome. 55 children with ARVI (aged from 1 to 6 months - 14, from 6 months to 1 year - 18, from 1 to 3 years - 11, from 3 to 7 years - 12). 38 patients were admitted in the first three days of illness, 12 - on 4-5 days and 5 - at a later date. 30 children had a severe form of acute respiratory viral infection and 25 - moderate. Adenovirus infection was diagnosed in 14 patients, influenza - in 16, parainfluenza - in 7, MS-viral infection in 5, mixed viral infection - in 13. The control group consisted of 10 apparently healthy children.

scholarly journals Hydrogen peroxide and chlorine dioxide against parasite Ichthyophthirius multifiliis (Protozoa, Ciliophora) in jundiá fingerlings

2017 ◽  
Vol 47 (12) ◽  
Author(s):  
Natalia da Costa Marchiori ◽  
Fabiano Muller Silva ◽  
Maurício Laterça Martins ◽  
Hilton Amaral Junior ◽  
Bruno Corrêa da Silva
Keyword(s):  
Hydrogen Peroxide ◽  
Chlorine Dioxide ◽  
Fish Farming ◽  
Control Group ◽  
Chemical Agent ◽  
Ichthyophthirius Multifiliis ◽  
Larval Phase ◽  
Group Data ◽  
Active Chemical ◽  
Continuous Bath

ABSTRACT: Ichthyophthiriasis is a worldwide fish disease with great financial impact on freshwater fish farming due to its associated high mortality rates. Current study assesses the parasiticidal capacity of hydrogen peroxide (H2O2) and chlorine dioxide (ClO2) against the causative agent, Ichthyophthirius multifiliis, in jundiá. Median lethal concentration (LC50, 96h) of each chemical agent was established, as well as the minimum inhibitory concentration of hydrogen peroxide for the parasite´s infectious larval phase (theront). Products were tested asynchronously in parasitized fingerlings for short and long baths at the following concentrations and exposure times: 1. Hydrogen peroxide: (T1) continuous bath - 30ppm and (T2) 50ppm; (T3) short bath - 150ppm, during 1h and (T4) 250ppm during 1h; control group (without any chemical agent). 2. Chlorine dioxide: (T1) continuous bath - 4ppm and (T2) 20ppm; (T3) short bath - 200ppm, during 1min; (T4) short bath - 400ppm, during 1min and control group. Data analysis demonstrated a concentration of 82.54ppm of the commercial product (or 24.76ppm of the active chemical agent) as LC50, 96h of H2O2 and 38.4ppm product (or 2.68ppm of the active chemical agent) for ClO2. Hydrogen peroxide concentration causing 100% mortality rate of theronts in 1h was 25ppm (product, or 7.5ppm of the active chemical agent). At the end of the fourth day of curative experiment, 98% of the animals died by ichthyophthiriasis. No treatment was effective against the parasite.

A study on the safety evaluation of buphrenorphine administered through an autoinjector compared with manual injection using haematological and biochemical variables in rats

2016 ◽  
Vol 36 (9) ◽  
pp. 901-909 ◽  
Author(s):  
D Sheela ◽  
R Vijayaraghavan ◽  
S Senthilkumar
Keyword(s):  
Body Weight ◽  
Research Work ◽  
Safety Evaluation ◽  
Weight Ratio ◽  
The Body ◽  
Control Group ◽  
Body Weight Ratio ◽  
Significant Difference ◽  
Manual Group ◽  
Significant Change

Buprenorphine drug cartridge was made for autoinjector device for use in emergency and critical situations to reduce the morbidity and mortality. Water-filled cartridges were prepared and buprenorphine was injected aseptically in the cartridge, to make 0.05 and 0.10 mg/mL. Rats were injected intraperitoneally, buprenorphine (0.3 and 0.6 mg/kg), repeatedly with the autoinjector and compared with manual injection (7 days and 14 days) using various haematological and biochemical parameters. No significant change was observed in the body weight, organ to body weight ratio and haematological variables in any of the experimental groups compared with the control group. Except serum urea and aspartate aminotransferase, no significant change was observed in glucose, cholesterol, triglycerides, bilirubin, protein, albumin, creatinine, uric acid, alanine aminotransferase, gamma glutamyltransferase and alkaline phosphatase. The autoinjectors deliver the drugs with spray effect and force for faster absorption. In the present study, the autoinjector meant for intramuscular injection was injected intraperitoneally in rats, and the drug was delivered with force on the vital organs. No significant difference was observed in the autoinjector group compared to the manual group showing tolerability and safety of the buphrenorphine autoinjector. This study shows that buprenorphine autoinjector can be considered for further research work.

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