THE EFFICIENCY OF USING NITROGEN-CONTAINING COMPOUNDS IN THE BODY OF YOUNG CATTLE WHEN ADDING N-CARBOMILGLUTAMATE INTO THE DIET

2021 ◽  
pp. 37-40
Author(s):  
А.С. КУЗНЕЦОВ ◽  
Е.Л. ХАРИТОНОВ ◽  
К.С. ОСТРЕНКО ◽  
А.Н. ОВЧАРОВА
Keyword(s):  
Blood Plasma ◽  
Body Weight Gain ◽  
The Body ◽  
Dairy Calves ◽  
Feed Additive ◽  
Control Group ◽  
Resistance To Stress ◽  
Young Cattle ◽  
Nitrogen Containing Compounds ◽  
Experimental Group

Изучен метаболизм азотсодержащих соединений в организме телят-молочников и бычков на откорме при включении в рационы кормовой добавки N-карбомилглутамат (NCG). Введение в основной рацион NCG приводит к снижению уровня свободного аммиака в плазме крови телят-молочников в 2 раза относительно контрольной группы. У молодняка на откорме в опытных группах концентрация аммиака в плазме крови была меньше на 20,9% в 1 группе и на 54,2% во II группе. При этом в опытной группе телят-молочников зафиксировано повышение прироста массы тела на 5,01% по сравнению с контролем. Введение кормовой добавки NCG способствовало переводу токсичного аммиака из плазмы крови, вследствие активизации орнитинового цикла в клетках печени и стенке рубца с образованием избытка карбомоилфосфата и синтеза эндогенного аргинина. Экзогенный аргинин из корма может быть заменен на NCG в рационе у жвачных животных. Добавление NCG в корм или ЗЦМ позволит улучшить утилизацию аммиака, повысить эффективность использования белка рациона, устойчивость к стрессам и будет являться фактором повышения продуктивности молодняка крупного рогатого скота. The influence of the metabolism of nitrogen-containing compounds in the body of dairy calves and calves on fattening was studied when the feed additive N-carbomylglutamate (NCG) was included in the diets. The introduction of the NCG feed supplement into the main diet leads to a decrease in the level of free ammonia in the blood plasma of dairy calves by 2 times compared to the control group. In fattened calves in the experimental groups, the concentration of ammonia in the blood plasma was less by 20.9% in group 1 and by 54.2% in group II. At the same time, in the experimental group of dairy calves, an increase in body weight gain was recorded by 5.01% compared to the control. The introduction of the feed additive NSP contributed to the transfer of toxic ammonia from the blood plasma, due to the activation of the ornithine cycle in the liver cells and the scar wall with the formation of an excess of carbomoylphosphate and the synthesis of endogenous arginine. Exogenous arginine from feed can be replaced with NCG in the diet of ruminants. The addition of NCG to feed or ZCM will improve the utilization of ammonia, increase the efficiency of the use of protein in the diet, resistance to stress, and will be a factor in increasing the productivity of young cattle.

scholarly journals The Influence of Highly Dispersed Metal Forms on Calcium and Phosphorus Metabolism in Polygastric Animals

2022 ◽  
Author(s):  
Makaeva Ayna Maratovna ◽  
Sizova Elena Anatolevna ◽  
Atlanderova Ksenya Nikolaevna
Keyword(s):  
Feed Additives ◽  
The Body ◽  
Feed Additive ◽  
Utilization Rate ◽  
Control Group ◽  
Ruminal Fluid ◽  
Group I ◽  
Calcium And Phosphorus ◽  
Group Ii ◽  
Experimental Group

Determining which forms of mineral feed additives can increase farm animal productivity is a key area of research. This study assessed the mineral composition of ruminal fluid and the effectiveness of calcium and phosphorus used by animals after the introduction of finely dispersed particles (FDP) of SiO2 (group I) and FeCo (group II) with a hydrodynamic radius of 109.6 ± 16.6 and 265 ± 25 nm, respectively. The deposition and use of calcium and phosphorus in the body of the experimental animals exceeded the control values. In group I, 30.8% more calcium was deposited (p ≥ 0.05), and in group II, the value was 30.3% (p ≥ 0.01). In the experimental groups, the calcium utilization rate was 27.3% higher in group I (p ≥ 0.05), and 28.2% higher in group II (p ≥ 0.01) compared to in the control. Phosphorus deposition was 34% higher (p ≤ 0.01) in experimental group I and 6% higher in experimental group II, compared with the control. Group I had a high utilization rate of phosphorus from the feed (with a 29% difference compared to the control). Comparison of the experimental groups revealed that the introduction of SiO2 FDP promoted an increase in the concentration of silicon, phosphorus, and calcium in the ruminal fluid. The introduction of FeCo FDP was accompanied by a decrease in the concentration of iron and cobalt in the ruminal fluid. Thus, the use of feed additive in finely dispersed form in the diet of animals was accompanied by an increase in the use of calcium and phosphorus by the animal’s body, which is advisable when intensifying milk and meat productivity. The obtained results require further research. Keywords: finely dispersed forms of microelements, ruminants, calcium and phosphorus exchange, feeding

scholarly journals Rabbit Dietary Supplementation with Echinacea purpurea L.: The Quality Profile of Rabbit Meat

2020 ◽  
Vol 50 (2) ◽  
pp. 185-193
Author(s):  
Roman Voroshilin ◽  
Marina Kurbanova ◽  
Sergey Rassolov ◽  
Elena Ul'rih
Keyword(s):  
Technological Development ◽  
Saturated Fatty Acids ◽  
Echinacea Purpurea ◽  
The Body ◽  
Feed Additive ◽  
Control Group ◽  
Meat Production ◽  
Rabbit Meat ◽  
Positive Effect ◽  
Experimental Group

Introduction. Rabbit meat is an excellent source of dietetic food. High-quality and safe meat production is a priority of the scientific and technological development of the Russian Federation. The research objective was to determine the optimal dose of Echinacea purpurea L. extract in the rabbit diet and study its effect on the physicochemical and morphological quality parameters of rabbit meat. Study objects and methods. At 70 days of age, the experimental animals started to receive various doses of a phytobiotic feed additive based on the Echinacea purpurea extract. The experiment lasted 30 days. Results and discussion. The daily dose of 1.0 g and 1.5 g per animal proved to stimulate the redox processes in the rabbit metabolism. The body weight of the test animals significantly increased compared with the control group. The test slaughter revealed a high level of meat productivity. The animals in experimental groups II and III showed the best slaughter indicators. Each animal received 1.5 g of the extract per day. The morphological composition of chilled carcass indicated that the additive had a positive effect on the mass indicators. According to the physical and chemical analysis, the contents of water, protein, and ash in the experimental group was the same as in the control group. The ratio of unsaturated and saturated fatty acids in the control group was 1.34:1, while in the experimental group III is was 1.39:1. This optimal proportion proved a high biological value of rabbit meat, which makes it a dietary product. The phytobiotic additive proved commercial as the test animals demonstrated an intensive weight gain compared with the control group. Experimental groups II and III showed the best slaughter indicators. Conclusion. 1.5 g of the extract of Echinacea purpurea had a positive effect on the composition and physicochemical parameters of rabbit meat, as well as meat production.

Influence of feed additive Vitartil on the productive traits and biochemical parameters of steers’ blood

2021 ◽  
pp. 25-32
Author(s):  
S. S. Mirgalimova ◽  
A. O. Trufanova ◽  
R. R. Fatkullin
Keyword(s):  
Physiological State ◽  
Relative Number ◽  
Blood Parameters ◽  
The Body ◽  
Biologically Active ◽  
Feed Additive ◽  
Control Group ◽  
Vital Functions ◽  
Productive Traits ◽  
Experimental Group

The physiological state of animals is to a certain extent characterized by hematological indicators, since blood occupies a special place in the body. By transferring nutrients and biologically active substances, the blood performs the general regulation of vital functions of the body. The use of Vitartil as a feed additive in the diets of animals leads to an increase in glycolytic processes and a decrease in the body’s need for oxygen delivery, which contributes to the growth of the animal body. The purpose of the research was to study the changes in blood parameters taking into account the age of Hereford steers against the background of the use of Vitartil feed additive to the main diet and its effect on the productive traits of animals. In order to carry out the experiment two groups of steers-analogs of Hereford breed have been formed at the age of 6 months per 10 heads in each. The difference between the groups was that the steers of the experimental group have been received the feed additive Vitartil in addition to the main diet. The greater yield of the meat part was in the steers of the experimental group in comparison with the herdmates of the control group. This indicator in the experimental group was 78,9 %, while in the control group it was lower by 1,6 %. The animals of the experimental group were superior to their herdmates in terms of meat weight by 1,4 kg or by 8,8 %. The relative number of bones was lower in the experimental group and amounted to 18,4 %, and in the control group 19,2 %. The meat content index was high in the steer have been received the biologically active additive Vitartil and was 4,3, and in the control group 4,0. It has been found that the use of Vitartil feed additive to the main diet of Hereford steers increases the blood content of hemoglobin and glucose, which has a certain effect on the morphological and chemical composition of meat, as well as increases its energy value.

scholarly journals The effect of sodium selenite and feed additive “Metisevit plus” on the protein-synthesizing function and functional state of the liver of rats under prolonged cadmium and lead loading

2020 ◽  
Vol 22 (100) ◽  
pp. 54-59
Author(s):  
S. О. Slobodian ◽  
B. V. Gutyj ◽  
D. F. Gufriy ◽  
P. S. Hnativ ◽  
S. D. Murska
Keyword(s):  
Liver Function ◽  
Functional State ◽  
Total Protein ◽  
Sodium Selenite ◽  
The Body ◽  
Feed Additive ◽  
Control Group ◽  
Physiological Values ◽  
Cadmium And Lead ◽  
Experimental Group

In the conditions of modern technogenic pollution of the environment, environmental problems, improving the quality of livestock products and their food safety is an important and urgent issue today. Pollution of the environment with heavy metals due to man-made activities of the population has led to a number of problems of agricultural production. The aim of the study was to investigate the effect of sodium selenite and feed additive “Metisevit plus” on the protein-synthesizing function and functional state of the liver of rats in lead-cadmium intoxication. It was found that the level of total protein in the blood of rats exposed to cadmium and lead was reduced. These changes were due to a decrease in albumin levels and an increase in globulin levels. Thus, hypoproteinemia resulting from cadmium and lead poisoning may indicate impaired hepatic protein synthesis. Transamination enzymes play a major role in the relationship between protein and carbohydrate metabolism, which is important for switching the oxidation of energy substrates from glucose to amino acid energy nutrition, which is extremely important under the influence of various environmental factors. The most active transaminases are aspartate aminotransferase and alanine aminotransferase. In the study of the activity of aminotransferases in the serum of rats treated with lead acetate and cadmium chloride, an increase in the activity of enzymes in all periods of the study. The highest activity of aminotransferases was on days 21 and 28 of the experiment in the control group of rats, which carried out the combined load of cadmium and lead. Thus, the load of the body of animals with cadmium and lead contributes to the violation of the functional state and protein-synthesizing function of the liver of animals of the experimental groups. With the introduction of sodium selenite into the body of rats, the activity of ALT and AST in the serum of the first experimental group was slightly reduced compared with the control group. However, the activity of these enzymes did not reach physiological values. When setting the feed additive “Metisevit plus” throughout the experiment, it was found that the activity of aminotransferases in the serum of rats of the second experimental group ranged within physiological values. This is due to the hepatoprotective effect of the components of the feed additive “Metisevit Plus”. In the study of protein-synthesizing function of rat liver in experimental lead-cadmium toxicosis, it was found that after application to rats of the first experimental group of sodium selenite on days 14, 21 and 28, the level of total protein in serum gradually increased, but did not reach physiological values. Using the feed supplement “Metisevit plus” rats of the second experimental group, found a slightly higher level of total protein in their blood, which on the 28th day of the experiment reached physiological values and, accordingly, amounted to 66.8 ± 1.99 g/l. It should be noted that when administering the feed additive “Metisevit plus” protein-synthesizing liver function and liver function of rats of the second experimental group were restored faster than when administering sodium selenite to the first experimental group.

scholarly journals Features of protein metabolism in the body of broiler chickens when using the feed additive Peak-Antistress in the diet

2020 ◽  
pp. 103-110
Author(s):  
A. V. Mitfakhutdinov ◽  
E. R. Saifulmuliukov
Keyword(s):  
Broiler Chickens ◽  
Protein Composition ◽  
Feed Additives ◽  
The Body ◽  
Feed Additive ◽  
Control Group ◽  
Protein Accumulation ◽  
White Meat ◽  
Scientific Publications ◽  
Experimental Group

Scientific publications describe the positive effect of feed additives and pharmacological complexes on metabolic processes in the body of broiler chickens, in particular, on the protein composition of the blood, meat productivity and protein accumulation in meat. The Peak-Antistress feed additive developed at the Department of Morphology, Physiology and Pharmacology of the South Ural State Agrarian University allows to reduce the technological load on the poultry body by stimulating the general metabolism and complex antioxidant action. Experiments on the use of the feed additive Peak-Antistress were carried out on broiler chickens of the final hybrid of the Arbor Acres cross in an industrial-type poultry farm with floor technology. The poultry was divided into three groups of 6,000 chickens each and kept in one workshop in separate sections. The control group received the main diet, the 1st experimental group received the main diet and feed additive at a dose of 1269 g / t of feed 5 days before slaughter, the 2nd experimental group received the main diet and feed additive at a dose of 1693 g / t of feed 5 days before slaughter. Slaughter of broiler chickens was carried out according to the technological instructions of the enterprise on the 38th day. Against the background of the use of the feed additive in the experimental groups of broiler chickens, stimulation of protein metabolism was observed, as evidenced by an increase in total protein in the blood by 7.9–20.1%, an increase in the level of protein in white meat by 0.1–0.3%, and a tendency to an increase in amino acids in white meat protein by 0.2–12.3%.

scholarly journals «Energosil» in the diets of replacement gilts

2019 ◽  
Vol 20 (2) ◽  
pp. 153-162
Author(s):  
A. A. Suvorov ◽  
в Sh. Gayirbegov ◽  
A. S. Fedin ◽  
A. M. Guryanov
Keyword(s):  
Body Weight ◽  
Live Weight ◽  
Feed Additives ◽  
The Body ◽  
Feed Additive ◽  
Control Group ◽  
Practical Training ◽  
Optimal Dosage ◽  
Growth Energy ◽  
Experimental Group

The article gives scientific substantiation of using silicon-containing new feed additive “Energosil” for replacement gilts. The studies were conducted in pig-breeding complex of the Center for Practical Training of Agricultural Specialists in Mordovia Republic. There were three experimental groups of replacement gilts (10 animals each). The effect of various dosages of Energosil (5.0, 7.5, and 10 mg per kg of body weight) on digestibility, nutrient utilization, and animal growth energy was studied. The most optimal dosage of a new feed additive in their rations was revealed, which constituted 5 mg / kg of the animal live weight. It was established that the animals from the first experimental group, who received silicon-containing feed additives of this amount digested the nutrients of the diet better than their counterparts from the other groups. Compared to the control group, the digestibility of dry matter increased by 3.62% (p<0.05), organic matter by 3.29% (p<0.01), crude protein by 4.09% (p<0.001), fat by 4.30% (p<0.01), cellulose by 3.79% (p<0.01) and nitrogen-free extractives by 2.03% (p>0.05).Replacement gilts of the first experimental group, who were given Energosil in the amount of 5 mg / kg body weight in addition to the basic ration, retained nitrogen in their bodies by 17.1%, calcium by 55.9% and phosphorus by 69.7% more than their counterparts from the control group. It contributed to an increase in body weight of gilts from the first group compared to control counterparts by 10.8%. Increased dosages of Energosil (7.5 and 10 mg / kg body weight) also had a better effect on the growth energy of gilts compared with the control group. The feed additive in the amount of 7.5 mg kg of animal  live weight contributed to an increase in animal weight compared with control counterparts by 6.21 kg or 4.8% (p<0.05), with a third experimental group by 4.4 kg or by 3.4% (p<0.05). When given Energosil in the dosage of 10 mg/kg, the body weight of gilts from the third experimental group was higher by 1.81 kg or 1.4% (p> 0.05) compared with the control counterparts.

ACTION OF NEW FEEDING ADDITIVE TO MEAT PRODUCTIVITY AND QUALITY OF BULL-CALVES MEAT

1970 ◽  
pp. 57-60
Author(s):  
I. F. Gorlov ◽  
М. I. Slozhenkina ◽  
А. V. Randelin ◽  
V. V. Randelina ◽  
О. А. Sutorma ◽  
...  
Keyword(s):  
Protein Quality ◽  
Feed Additives ◽  
The Body ◽  
Feed Additive ◽  
Bull Calves ◽  
Young Cattle ◽  
Meat Productivity ◽  
Positive Effect ◽  
Experimental Group

As a result of the researchers found a positive effect of new feed additive on the growth rate, the qualitative indicators of meat fattening. It was found that the effect of feed additives on the productivity increased with increasing doses of feed additives from 100 to 300 g per head. Thus, at the age of 18 months, the bulls of the first experimental group surpassed the control analogues by 3.86, the second – by 5.53 and the third – by 6.42% and the average daily increase by 7.50, 11.63 and 12.45%, respectively. On the basis of the control of the slaughter was revealed that the weight of the paired carcasses in calves from the experimental group was higher than that of peers, not consuming the Supplement, of 5.82-of 9.91%, and their output is up 0.09 to 0.86 percent. At the output of the pulp of the bulls of the experimental groups exceeded the control analogues by 0.72-1.05%. The meat index of their carcasses was, respectively, higher by 0.25-0.36. In average the sample of the flesh of the carcasses of young animals who consumed the study Supplement contained more protein compared with the control 0,28-0,57% fat, respectively 0,68-1,19%. The influence of feed additive and on the content of amino acids in meat was revealed. Thus, essential amino acid tryptophan in the longest muscle of the back of the bulls of the experimental groups was higher by 1.58 – 2.87% and protein quality index-higher by 0.37-0.63. The flesh of the carcasses of calves of the experimental groups had higher technological properties. The moisture-retaining ability of their longest back muscle was higher than that of analogues of the control, by 2,05-2,22%, the fading – lower by 2,04-2,41%. In the body of young cattle, consuming feed additive, protein was postponed more than in control, by 8,67-14,85% and fat – respectively by 11,96-21,44%. The conversion rate of protein they were higher by 0.78-0.86%, energy - respectively 0.67-1.06%. The level of profitability of beef production in the experimental groups was higher than in control at 4, 18-of 1.29%.

THE ECONOMIC EFFICIENCY OF OPHTHALMECTIN IN THE TREATMENT OF CALVES

2019 ◽  
pp. 97-101
Author(s):  
Bespalova ◽  
Grigorieva ◽  
Vozgor’kova
Keyword(s):  
Economic Efficiency ◽  
Body Weight Gain ◽  
Productivity Loss ◽  
Economic Loss ◽  
Economic Losses ◽  
Control Group ◽  
White Breed ◽  
Treatment Measures ◽  
Young Cattle ◽  
Experimental Group

Thelaziosis is a widespread, seasonal, enzootic disease caused by Thelazia nematodes. Despite the absence of lethality, the disease leads to significant economic losses in cattle farming. The economic loss from thelaziosis in young cattle depends on the number of days of illness, the productivity loss degree (body weight gain) and treatment expense. The aim of the research was to study the economic efficiency of new complex drug Ophthalmectin, which has antiparasitic and antimicrobial effects, under the treatment of young cattle affected by thelaziosis. The experiments were carried out on spontaneously infected calves of red-and-white breed on the basis of "Agrosvet" CJSC of Kashirskiy district of Voronezh region (6-months old) and in "Kolos Agro" OJSC of Eletskiy district of Lipetsk region (4-months old). The animals of the experimental group were injected with Ophthalmectin into the cavity of the conjunctival bag of the affected eye, and the control group was given an ointment Mizophen. The efficacy of drugs was determined by the method of "Control test", weights gains were tracked in both groups, costs of treatment measures were calculated depending on the applied drug and recovery timeline. It was established that the average daily weights gain for healthy animals in the farms under study was on average 0.9 kg, and for patients – 0.6 kg. The animals in the experimental group recovered on average 4 days earlier compared to the control. Considering that the cost of the studied drug is significantly lower than the base one, the use of ophthalmectin is economically advantageous in the treatment of calves with thelaziosis. The economic efficiency per ruble is 1.66 rubles.

The effectiveness of feeding complex mineral and vitamin feed additive «Nadezhda» to lactating cows

2021 ◽  
pp. 30-37
Author(s):  
A. R. Farkhutdinova ◽  
M. T. Sabitov ◽  
M. G. Malikova
Keyword(s):  
The Body ◽  
Metabolic Energy ◽  
Feed Consumption ◽  
Feed Additive ◽  
Control Group ◽  
Black And White ◽  
Lactating Cows ◽  
White Breed ◽  
Quality Of Milk ◽  
Experimental Group

The feasibility of using the complex mineral and vitamin feed additive “Nadezhda” in the rations of lactating first-calf heifers of Black-and-White breed has been examined in the article. It has been established that feed contain a low content of elements such as calcium, phosphorus, magnesium, sulfur, manganese, copper, zinc and cobalt. The ratio of nutrients and minerals, the degree of their availability for assimilation by the body does not provide their need. The use of the complex mineral and vitamin feed additive contributed to an increase in the milk productivity of first-calf heifers and the quality of milk, feed consumption per unit of production. All tested recipes of the complex mineral and vitamin feed additive, which have different versions of macro-, microelements and vitamins in their composition had a positive effect on the metabolic processes in the body of animals. For the production of 1 kg of milk in the experimental groups of cows less metabolic energy was spent by 5,09 (P < 0,05) and 8,06 % (P < 0,05), respectively, raw protein by 5,19 and 8,19 % (P < 0,05), digestible protein by 5,12 (P < 0,05) and 8,15 % (P < 0,05) compared with the animals of the control group. At the same time from the cows of the 1st experimental group have been received more milk by 151,6 kg in the amount of 2489 rubles, from the 2nd experimental group by 250,6 kg of milk in the amount of 4248,0 rubles. The prime cost of production of 1 kg of milk in cows of the 1st experimental group in comparison with the animals of the control group decreased by 0,72 rubles, and the 2nd experimental group by 1,21 rubles. The level of profitability of milk production in cows have been fed with additive recipe No. 1, in comparison with the animals of the control group increased by 3,71 abs.%, recipe No. 2 by 9,91 abs.%.

scholarly journals Intestinal histostructure and immune protection activity of age -1+ carp after consumption of a prebiotic feed additive

2021 ◽  
Vol 4 (2) ◽  
pp. 31-37
Author(s):  
O. P. Dobrianska ◽  
M. I. Zhyla ◽  
O. I. Vishchur ◽  
O. V. Deren ◽  
M. Z. Koryliak
Keyword(s):  
The Body ◽  
Natural Resistance ◽  
Feed Additive ◽  
Phagocytic Index ◽  
Control Group ◽  
Average Weight ◽  
Histological Structure ◽  
Nonspecific Resistance ◽  
Positive Effects ◽  
Experimental Group

Currently, it is important in aquaculture to study and use products and additives, which have positive effects on the digestibility of nutrients by helping to normalize the intestinal microflora, thereby modulating fish immune response. The aim of the study was to assess the effect of a prebiotic based on mannan oligosaccharides produced from the outer walls of Saccharomyces cerevisiae cells on the histological structure, morphometric state of the intestine and activity of cellular and humoral components of nonspecific resistance of age -2+ carp. The experiment was conducted in four analogous ponds, which were stocked with age-1 scaly carp with an average weight of 55–58 g with a stocking density of 1000 fish/ha. Carp had been fed balanced compound feed for 60 days. Experimental groups of fish were fed with a prebiotic as a feed additive in the amount of: 0.025 % – Experiment 1, 0.05 % – Experiment 2 and 0.075 % – Experiment 3. Use of the studied prebiotic did not damage the intestinal histological structure of carp of the experimental groups. The villi height and intestinal crypt depth of carp in Experiment 1 (P < 0.05) and Experiment 2 (P < 0.01) were larger compared to the control group. Experiment 3 showed destructive changes in intestinal mucosa. The results of histological examination indicated the effectiveness of the use of the studied prebiotic in the amount of 0.025 and 0.05 % in the diet of age -1+ carp due to the absence of pathological changes and active morphofunctional state of the intestine, which, in turn, had a positive effect on feed absorption and metabolic processes in fish body. Analysis of the indicators of cellular and humoral links of natural resistance showed that in carp of the second and third experimental groups lysozyme activity of serum was 5 and 11 % (P < 0.001) higher than in the control group. Similar changes, though found in a greater extent, were recorded in the study of bactericidal activity of blood serum, especially in individuals of the second and third experimental groups (by 6.8 (P < 0.01) and 15.2 %). While with carps of the third experimental group, which used a prebiotic drug in the amount of 0.075 %, the content of CEC was 20.5 % higher than in the control group, which indicates an additional antigenic load on the body and is an unfavorable diagnostic factor. At the same time, with the fish of the second experimental group, which received, respectively, 0.05 % of the supplement of the drug “Actigen” to the main diet, probably higher phagocytic activity of blood neutrophils was recorded. A direct dependence of the growth of the phagocytic index and the phagocytic number of neutrophils on the dose of the studied prebiotic was detected. Immunological studies indicated a dose-dependent effect of the prebiotic on the activity of cellular and humoral components of non-specific resistance of carp. Given this, for the effective functioning of innate protective mechanisms, for the increase of the body's immune potential and productivity, it is most appropriate to apply to the diet of carp prebiotic supplement “Actigen” in the amount of 0.025 and 0.05 %.

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