Application of the 2014 NICE cholesterol guidelines in the English population: a cross-sectional analysis

BackgroundThe 2014 guidelines on cardiovascular risk assessment and lipid modification from the National Institute for Health and Care Excellence (NICE) recommend statin therapy for adults with prevalent cardiovascular disease (CVD), and for adults with a 10-year CVD risk of ≥10%, estimated using the QRISK2 algorithm.AimTo determine risk factor levels required to exceed the risk threshold for statin therapy, and to estimate the number of adults in England who would require statin therapy under the guidelines.Design and settingCross-sectional study using a sample representative of the English population aged 30–84 years.MethodTo estimate 10-year CVD risk different combinations of risk factor levels were entered into the QRISK2 algorithm. The NICE guidelines were applied to the sample using data from the Health Survey for England 2011.ResultsEven with optimal risk factor levels, males of different ethnicities would exceed the 10% risk threshold between the ages of 60 and 70 years, and females would exceed the threshold between 65 and 75 years. Under the NICE guidelines, 11.8 million males and females (37% of the adults aged 30–84 years) would require statin therapy, most of them (9.8 million) for primary prevention. When analysed by age, 95% of males and 66% of females without CVD in ages 60–74 years, including all males and females in ages 75–84 years, would require statin therapy.ConclusionUnder the 2014 NICE guidelines, 11.8 million (37%) adults in England aged 30–84 years, including almost all males >60 years and all females >75 years, require statin therapy.

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Prevalence of Cardiovascular Risk Factors among Tile and Ceramic Workers in Yazd, Iran

ISRN Preventive Medicine ◽

10.5402/2013/921860 ◽

2013 ◽

Vol 2013 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Amir Houshang Mehrparvar ◽

Seyyed Jalil Mirmohammadi ◽

Mehrdad Mostaghaci ◽

Maryam Bahaloo ◽

Mohammad Heydari ◽

...

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Cross Sectional Study ◽

International Standards ◽

Cvd Risk ◽

Cross Sectional ◽

High Prevalence ◽

Low Hdl ◽

Simple Sampling ◽

Ceramic Workers

Introduction. Cardiovascular disorders (CVDs) are among the most important diseases in the world and determination of their risk factors is essential for primary and secondary prevention. This study aimed to evaluate these risk factors in workers of tile and ceramic industry, a main industry in Yazd. Materials and Methods. In a cross-sectional study, 1075 tile and ceramic workers were selected by simple sampling method. BMI, blood pressure, FBS, and lipid profile were measured and compared to international standards. Results. 731 individuals (68%) had at least one risk factor, and 52%, 12%, 3%, and 0.7% had one, two, three, and four risk factors, respectively. The most common risk factor was abnormal BMI (49.6%); low HDL (48.4%) and high TG (14.1%) were in the second and third orders. Conclusion. This study showed a relatively high prevalence for CVD risk factors among tile and ceramic workers. Low HDL, high TG, and overweight were the most frequent risk factors in this population.

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Low Self-Rated Health as A Risk Factor for Depression in South Korea: A Survey of Young Males and Females

Healthcare ◽

10.3390/healthcare9040452 ◽

2021 ◽

Vol 9 (4) ◽

pp. 452

Author(s):

Yunyoung Kim ◽

Eunsu Jang

Keyword(s):

Risk Factor ◽

South Korea ◽

Economic Status ◽

Cross Sectional Study ◽

General Information ◽

Cross Sectional ◽

Young Males ◽

Self Rated Health ◽

Significant Difference ◽

Males And Females

This is a cross-sectional study aimed to examine whether low self-rated health (SRH) is a risk factor for depression among young males and females. Data from the SRH, quality of life (QoL) and depression questionnaires as well as general information, were collected from 512 males and females aged 20–29 years in South Korea. Chi-square test was used to analyze the distribution of depression between the high and low SRH groups. Logistic regression was used to analyze the relationship between SRH and depression after adjusting for covariates. There were 32.6% males and 30.1% females who were at risk for depression. A significant difference in the distribution of depression between the low and high SRH groups in both males and females was found. The low SRH group had a higher prevalence of depression than the high SRH group in both males and females in the crude analysis. However, when the BMI, economic status, and mental component score were adjusted, the OR of the low SRH group was still significant in males. Low SRH may be a risk factor for depression especially in males. Further studies to improve SRH by developing preventive measures against depression status while considering gender characteristics are needed.

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Self-Reported Modifiable Risk Factors of Cardiovascular Disease among Seafarers: A Cross-Sectional Study of Prevalence and Clustering

Journal of Personalized Medicine ◽

10.3390/jpm11060512 ◽

2021 ◽

Vol 11 (6) ◽

pp. 512

Author(s):

Getu Gamo Sagaro ◽

Gopi Battineni ◽

Marzio Di Canio ◽

Francesco Amenta

Keyword(s):

Risk Factors ◽

Risk Factor ◽

Cross Sectional Study ◽

Categorical Variables ◽

Modifiable Risk Factors ◽

Sectional Study ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Cross Sectional ◽

Job Duration

Background: Cardiovascular diseases (CVD) are the major cause of work-related mortality from diseases onboard ships in seafarers. CVD burden derives mainly from modifiable risk factors. To reduce the risk factors and the burden of CVD onboard ships in seafarers, it is important to understand the up-to-date prevalence of modifiable risk factors. The primary purpose of this study was to assess the prevalence and clustering of self-reported modifiable CVD risk factors among seafarers. We have also explored the association between socio-demographic and occupational characteristics and reported modifiable CVD risk factor clustering. Materials and methods: A cross-sectional study was conducted among seafarers from November to December 2020 on board ships. In total, 8125 seafarers aged 18 to 70 were selected from 400 ships. Data were collected using a standardized and anonymous self-reported questionnaire. The prevalence value for categorical variables and mean differences for continuous variables were compared using chi-square and independent sample t-tests. Multinomial logistic regression models were performed to identify independent predictors for modifiable CVD risk factor clustering. Results: Out of a total of 8125 seafarers aged ≥18 years on selected vessels, 4648 seafarers volunteered to participate in the survey, with a response rate of 57.2%. Out of 4318 participants included in analysis, 44.7% and 55.3% were officers and non-officers, respectively. The prevalence of reported hypertension, diabetes, current smoking and overweight or obesity were 20.8%, 8.5%, 32.5%, and 44.7%, respectively. Overall, 40%, 20.9%, 6% and 1.3% of the study participants respectively had one, two, three and four modifiable CVD risk factors. Older age (51+ years) (odds ratio (OR): 3.92, 95% confidence interval (CI): 2.44–6.29), being non-officers (OR: 1.36, 95% CI: 1.09–1.70), job duration (10–20 years) (OR: 2.73, 95% CI: 2.09–3.57), job duration (21+ years) (OR: 2.60, 95% CI: 1.79–3.78), working 57–70 h per week (OR: 2.03, 95% CI: 1.65–2.49) and working 71+ h per week (OR: 3.08, 95% CI: 2.42–3.92) were independent predictors for at least two self-reported modifiable CVD risk factor clustering. Conclusion: The results of our study demonstrate that more than four in six (68.5%) seafarers aged between 19 and 70 years have at least one of the modifiable CVD risk factors. Therefore, CVD prevention and modifiable risk factors reduction strategies targeting high-risk groups should be designed and implemented on board ships.

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Abstract P015: Serum Thrombospondin-2 Of Cardiovascular Risk Factor Is Strongly Associated With Liver Fibrosis In A General Population

Circulation ◽

10.1161/circ.143.suppl_1.p015 ◽

2021 ◽

Vol 143 (Suppl_1) ◽

Author(s):

Nagisa Morikawa ◽

Hisashi Adachi ◽

Mika Enomoto ◽

Ako Fukami ◽

Akiko Sakaue ◽

...

Keyword(s):

Risk Factor ◽

Liver Fibrosis ◽

General Population ◽

Cross Sectional Study ◽

High Serum ◽

Cvd Risk ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Log Odds ◽

Restricted Cubic Splines

Background: Non-alcoholic fatty liver disease is increasing in decades and has been recently reported to be associated with cardiovascular disease (CVD). However, the underlying pathophysiology has not been elucidated. Thrombospondin(TSP)-2 is a cardio-protective extracellular matrix, while some clinical studies showed that high serum TSP-2 is a good predictor for adverse events in patients with heart failure. We previously found that in healthy people, serum TSP-2 was associated with insulin resistance, N-terminal pro-brain natriuretic peptide and atrial fibrillation, which suggested a potential CVD risk factor. Therefore, serum thrombospondin-2 can affect on the association between liver fibrosis and CVD. Hypotheses: Serum TSP-2 levels were associated with liver fibrosis in a general population. Methods: We performed a cross-sectional study with a health-check up in 224 participants (mean age: 69.0±7.8 years, men: 42.0%) in Uku, Japan in 2019. Serum TSP was measured by ELISA. Liver fibrosis was defined by the Fibrosis-4 (FIB-4) index ≥2.67, where FIB-4 was calculated as {(ageхaspartate aminotransferase)/(plateletх(alanine aminotransferase) 0.5 )}/10. Continuous serum TSP-2 was modeled using restricted cubic splines with 3 knots (5 th , 50 th , 95th) to allow a nonlinear association with the log odds ratio of liver fibrosis. Results: Mean FIB-4 was 1.92±0.89 and 14.3% of total had liver fibrosis. Age and sex adjusted log odds ratios (ORs) for liver fibrosis was associated with serum TSP-2 non-linearly and the risk accelerate when serum TSP-2 ≥29.5ng/mL(Figure 1). ORs(95% CI) for 29.5 and 31.0 of serum TSP-2 compared to 23.0(median) were 1.57(1.11-2.21) and 1.86(1.25-2.78), respectively. Conclusion: Serum TSP-2, which is a CVD biomarker, was strongly associated with liver fibrosis in the pathological range in a general population. This finding provides a new insight into the pathology in the link between liver fibrosis and CVD.

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Health Status of Senior Citizens: A Cross-sectional study

Indian Journal of Health and Wellbeing ◽

10.15614/ijhw.v11i01.14 ◽

2020 ◽

Vol 11 (01) ◽

Author(s):

Priyanka Beniwal ◽

Chandrakala Singh

Keyword(s):

Health Status ◽

Senior Citizens ◽

Total Sample ◽

Cross Sectional Study ◽

Age Group ◽

Poor Health Status ◽

Cross Sectional ◽

Males And Females ◽

The Individual ◽

Average Health

Aging is a series of processes that begin with life and continue throughout the lifecycle. It represents the closing period in the lifespan, a time when the individual looks back on life, lives on past accomplishments and begins to finish off his life course. It represents the accumulation of changes in person over time. The study aims to investigate the health status of senior citizens. The present study was carried out in Hisar and Sirsa district of Haryana state. A total of 400 elderly equally representing both males and females of age group 65-70 years were selected randomly for the study. Modified inventory developed by Khan and Lal (2011) was used to assess health status of senior citizens. The results of the study elucidated that health status of senior citizens depicted that 54.25 per cent of the total respondents had average health status followed by good (25.25%) and poor health status (20.50%). The most common health problems reported by the senior citizens were joint pains, back pains, blood pressure, and chest pain etc. Gender wise comparison of total sample further pointed out that females were poor in their health against males.

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Eyelid Dermatitis and Contact Sensitization to Nickel: Results from an Italian Multi-Centric Observational Study

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530318666180731114418 ◽

2019 ◽

Vol 19 (1) ◽

pp. 38-45 ◽

Cited By ~ 2

Author(s):

Alessandro Borghi ◽

Monica Corazza ◽

Elisa Maietti ◽

Cataldo Patruno ◽

Maddalena Napolitano ◽

...

Keyword(s):

Risk Factor ◽

Cross Sectional Study ◽

Sectional Study ◽

Contact Sensitization ◽

Main Risk Factor ◽

Nickel Allergy ◽

Cross Sectional ◽

Triggering Factor ◽

Irritant Action ◽

Allergic Contact

Background: Due to the sensitizing constituents of eye cosmetics, allergic contact dermatitis is considered a frequent cause of eyelid dermatitis. An association between eyelid dermatitis and nickel contained in make-ups remains controversial. Objective: The study aimed to assess the association between nickel allergy, the use of pigmented makeup products and self-reported eyelid dermatitis. Method: This multi-centric, cross-sectional study enrolled 165 women sensitized to nickel (patients) and 103 women without intolerance to metals (controls). We recorded: demographics, atopy, use of pigmented eye cosmetics (mascara, eyeshadow, eyeliner, eyebrow pencil), and previous eyelid dermatitis. Among the patients, any co-sensitization to cosmetics or metals was recorded. Results: 87.3% of the patients and 91.3% of the controls reported their use of eye make-up; 44.9% and 52.4%, respectively, reported previous episodes of eyelid dermatitis, without significant differences. The occurrence of eyelid dermatitis was significantly associated with the use of eye make-up products, both in general and considering each product separately. Age, atopy, or co-sensitization to other metals or cosmetics did not affect the occurrence of eyelid dermatitis. Conclusion: Nickel allergy should not be considered the main risk factor for eyelid dermatitis. The use of pigmented eye make-up may be a triggering factor for eyelid dermatitis, probably due to an irritant action.

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A Questionnaire-Based Survey to Assess the Level of Knowledge and Awareness about Drug–Food Interactions among General Public in Western Saudi Arabia

Pharmacy ◽

10.3390/pharmacy9020076 ◽

2021 ◽

Vol 9 (2) ◽

pp. 76

Author(s):

Syed Faisal Zaidi ◽

Rayan Mgarry ◽

Abdullah Alsanea ◽

Sakar Khalid Almutairi ◽

Yaser Alsinnari ◽

...

Keyword(s):

Saudi Arabia ◽

Statistical Significance ◽

Cross Sectional Study ◽

Exclusion Criteria ◽

Cross Sectional ◽

Jeddah City ◽

Fundamental Information ◽

Inadequate Knowledge ◽

Level Of Knowledge ◽

Males And Females

Introduction: Various drug–food interactions exist that may hinder treatment and can sometimes be lethal. Our aim was to assess the level of public knowledge and awareness in Jeddah city, Western Saudi Arabia, about drug–food interactions, along with the effects of demographics on their knowledge. Methods: A survey questionnaire was administered in this cross-sectional study to participants spread across multiple locations in Jeddah, including in malls and public gatherings. Participants included both males and females. Sample size was calculated through Raosoft® software. Data analysis was executed using IBM Statistic SPSS and the level of statistical significance was set at p < 0.05. Results: A total of 410 people participated in the study and only 92.68% (380) of responses were enrolled in the study; 7.32% (30) were not enrolled due to the exclusion criteria. Surprisingly, only six out of eighteen questions regarding drug–food interactions in the administered questionnaire were correctly answered by 380 participants. Data indicated that the participants had a poor to intermediate level of both knowledge and awareness with respect to drug–food interactions. Furthermore, participants showed moderate to strong awareness of the effects of alcohol and tea generally, and their interaction with medication. Conclusion: Participants in our study showed inadequate knowledge of basic and fundamental information about drug–food interactions, which highlights the dire need to increase awareness.

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33. Concerning Trends of Pediatric Leprosy in Minas Gerais, Brazil and Associations with Number of Municipality Medical Facilities

Open Forum Infectious Diseases ◽

10.1093/ofid/ofaa417.032 ◽

2020 ◽

Vol 7 (Supplement_1) ◽

pp. S17-S17

Author(s):

Taylor Landay ◽

Julie A Clennon ◽

José A Ferreira ◽

Lucia A Fraga ◽

Maria Aparecida F Grossi ◽

...

Keyword(s):

Cross Sectional Study ◽

Minas Gerais ◽

Chi Square ◽

Cross Sectional ◽

Period 2 ◽

Time Period ◽

Medical Facilities ◽

Age Of Diagnosis ◽

Using Data ◽

Incident Cases

Abstract Background Leprosy in children under 15 years of age, and in particular, the presence of leprosy grade 2 disability (G2D) in children, signifies ongoing transmission and the need for improved surveillance. Our objective was to describe the epidemiology of pediatric leprosy in Minas Gerais, Brazil and to explore associations with access to medical facilities. Methods A cross-sectional study was conducted using data from the Brazilian Notifiable Diseases Surveillance System (SINAN) from 2002–2017. Incident cases were included if they resided in a municipality with both adult and pediatric cases. Municipalities were divided by the number of medical facilities per municipality: < 5, 5–17, and 18 or higher. Analyses compared pediatric cases across two time periods (2002–2009 and 2010–2017) and number of medical facilities / municipality using chi-square, t-tests, and logistic regression. Results A total of 27,725 cases were reported with 1,611 under 15 years of age. Overall incidence declined from 34.8 per 100,000 to 13.6 per 100,000 during the study period with pediatric incidence declining from 2.6 per 100,000 to 0.8 per 100,000. Time period 2 (TP2) showed an increase in the proportion of pediatric G2D (2.58% vs 1.91%, p < 0.0001) when compared to time period 1 (TP1). Mean age of diagnosis in children was younger in TP2 then in TP1 (10.06 vs 10.43, p=0.02). In 2017, the pediatric incidence in municipalities with the fewest medical facilities was 0.95 per 100,000 compared to 0.23 per 100,000 in municipalities with > 5 facilities (p=0.009). There was significantly higher odds of disability at diagnosis (grades 1 and 2) in pediatric cases residing in municipalities with < 5 medical facilities (aOR 1.88; 95% CI 1.37–2.59), adjusted for age and sex. See map (Fig 1). Figure 1. Cases of Pediatric Disability By Number of Municipality Medical Facilities from 2002–2017 (White areas without reported pediatric leprosy) Conclusion The increasing proportion of G2D in children in the second half of the study period despite declining incidence suggest occult infections among children and adults alike in Minas Gerais. Furthermore, the average age of diagnosis in children should increase, not decrease, if M. leprae transmission was truly declining. Lastly, the association between fewer municipality health facilities and increased disability suggest barriers to timely diagnosis and a critical area of focus for research into access to healthcare and leprosy risk. Disclosures All Authors: No reported disclosures

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Association between chronic low back pain and degree of stress: a nationwide cross-sectional study

Scientific Reports ◽

10.1038/s41598-021-94001-1 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Sungwoo Choi ◽

Sangun Nah ◽

Hae-Dong Jang ◽

Ji Eun Moon ◽

Sangsoo Han

Keyword(s):

Low Back Pain ◽

Back Pain ◽

Multiple Logistic Regression Analysis ◽

Cross Sectional Study ◽

Low Back ◽

Sectional Study ◽

Severe Stress ◽

Cross Sectional ◽

Korean People ◽

Using Data

AbstractLow back pain (LBP) is a very common health problem worldwide, and has a major impact on quality of life. This is a cross-sectional study using data obtained from the Korea National Health and Nutrition Examination Survey (KNHANES) to investigate the health and nutritional status of Korean people, conducted in 2013, 2014, and 2015. The total of 8,473 patients included in the analysis. A 357 (19.34%) subjects in the chronic LBP group and 1,697 (25.61%) subjects in the no chronic LBP group reported no stress (P < 0.001). The numbers of subjects reporting mild, moderate, and severe stress in the two groups were 934 (50.6%) vs. 3,785 (57.11%), 432 (23.4%) vs. 910 (13.73%), and 123 (6.66%) and 235 (3.55%), respectively (all P < 0.001). Multiple logistic regression analysis with full adjustment for other variables indicated higher OR for severe stress (OR 2.82, P < 0.001) than moderate (OR 2.54, P < 0.001) and mild (OR 1.55, P < 0.001) stress. We confirmed that there was a significant association between chronic LBP and degree of stress. Therefore, the degree of stress should be assessed in clinical treatment of chronic LBP patients.

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