scholarly journals Uses of Natural Honey in Cancer: An Updated Review

2021 ◽  
Author(s):  
Tahereh Eteraf-Oskouei ◽  
Moslem Najafi
Keyword(s):  
Wound Healing ◽  
Anticancer Agents ◽  
Beneficial Effects ◽  
Relative Safety ◽  
Wide Range ◽  
Prevention And Treatment ◽  
Therapeutic Properties ◽  
Anti Fungal ◽  
Natural Honey

Cancer was predicted as the leading cause of death and the most important obstacle to the increased life expectancy in the 21st century worldwide. The WHO estimated number of new cases of cancers in 2020 about 19 million, and this number is estimated to be more than 295,300,000 people up to 2040 (more than 55% increase during next 20 years). Standard treatments for cancer include surgery, radiotherapy, and chemotherapy. However, all of these methods have dangerous side effects, so researchers are more interested in finding more novel and less risky therapies. In recent years, there has been a great deal of interest in the development of anticancer agents obtained from foods or natural products. The relative safety of natural and food-derived compounds makes them attractive alternatives to conventional cancer treatment drugs. As a result, the majority of people are adviced to use complementary and alternative medicine to treat and prevent cancer. In recent years, honey, as a natural product, has attracted many researchers' attention as an alternative to conventional anticancer drugs. Natural honey has long been used as a medicine and nutrient and its beneficial effects on various diseases in animal and human models have been studied. It was found that it has a wide range of therapeutic properties, including antioxidant, antibacterial, antiviral, anti-fungal, anti-diabetic, anti-inflammatory, anti-hypertensive, antiarrhythmic, wound healing, and liver protection benefits. This article aimed to review the role of natural honey in the prevention and treatment of a number of important cancers and their subsequent complications.

scholarly journals Importance of IL-10 Modulation by Probiotic Microorganisms in Gastrointestinal Inflammatory Diseases

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Alejandra de Moreno de LeBlanc ◽  
Silvina del Carmen ◽  
Meritxell Zurita-Turk ◽  
Clarissa Santos Rocha ◽  
Maarten van de Guchte ◽  
...  
Keyword(s):  
Immune Response ◽  
Inflammatory Cytokine ◽  
Inflammatory Diseases ◽  
Critical Role ◽  
Genetically Engineered ◽  
Wide Range ◽  
Prevention And Treatment ◽  
Therapeutic Properties ◽  
Anti Inflammatory Cytokine

Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that are naturally present in many foods and possess a wide range of therapeutic properties. The aim of this paper is to present an overview of the current expanding knowledge of one of the mechanisms by which LAB and other probiotic microorganisms participate in the prevention and treatment of gastrointestinal inflammatory disease through their immune-modulating properties. A special emphasis will be placed on the critical role of the anti-inflammatory cytokine IL-10, and a brief overview of the uses of genetically engineered LAB that produce this important immune response mediator will also be discussed. Thus, this paper will demonstrate the critical role that IL-10 plays in gastrointestinal inflammatory diseases and how probiotics could be used in their treatment.

scholarly journals The Curative Role of Bitumen in Traditional Persian Medicine

2018 ◽  
Vol 16 (2) ◽  
pp. 283-292
Author(s):  
Mahdi Shahriari ◽  
Majid Nimrouzi
Keyword(s):  
Wound Healing ◽  
Clinical Trials ◽  
Bone Pain ◽  
Therapeutic Effects ◽  
Beneficial Effects ◽  
Wide Range ◽  
Persian Medicine ◽  
Traditional Persian Medicine ◽  
Effective Remedy

Aim: Bitumen is a natural substance effusing from rocks’ notches in some highland areas; it has been known as an effective remedy for treating some illnesses. Considering pain relieving properties of bitumen in traditional Persian medicine (TPM) sources, this study aims to review the viewpoints of TPM sages regarding bitumen in the context of traditional Persian medicine. It also provides applicable information for interested researchers to conduct well-designed clinical trials and evaluate therapeutic effects of bitumen claimed in TPM sources. Material and method: Various databases including Embase, SID, IRANDOC, IranMedex, Scopus and PubMed were searched with keywords “bitumen” and “Shilajit”. Furthermore, main traditional Persian medicine sources including Avicenna’s “Canon of medicine”, “Continens Liber” by Razes, “The storehouse of medicaments” by Aghili, “Gift for the faithful” by Momen Tonekaboni and “Measure for medicine” written by Muhammad Akbar Shah Arzani were reviewed with Persian keywords “Moomiaii” and “Mumnaei” Results: According to TPM sources, bitumen was used by Iranian’s physicians to treat a wide range of diseases. It was known especially as an effective remedy to improve gastrointestinal digestive problems. Conclusion: Bitumen is cited in traditional Persian medicine sources as an effective remedy for treatment of a wide range of diseases, especially GI disorders and bone pain. Recent studies showed the beneficial effects of bitumen in treatment of wound healing, however using it in medical practice for other health dilemma should be confirmed by conducting well-designed clinical studies in the future.

scholarly journals Potential Application of Probiotics in the Prevention and Treatment of Inflammatory Bowel Diseases

Ulcers ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Silvina del Carmen ◽  
Alejandra de Moreno de LeBlanc ◽  
Anderson Miyoshi ◽  
Clarissa Santos Rocha ◽  
Vasco Azevedo ◽  
...  
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Antioxidant Properties ◽  
Genetically Engineered ◽  
Treatment Protocols ◽  
Host Immune Responses ◽  
Beneficial Effects ◽  
Wide Range ◽  
Prevention And Treatment ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that are naturally present in many foods and possess a wide range of therapeutic properties. The aim of this paper is to present an overview of the current expanding knowledge of the mechanisms by which LAB and other probiotic microorganisms participate in the prevention and treatment of inflammatory bowel diseases. These include changes in the gut microbiota, stimulation of the host immune responses, and reduction of the oxidative stress due to their antioxidant properties. A brief overview of the uses of genetically engineered LAB that produce either antioxidant enzymes (such as catalase and superoxide dismutase) or anti-inflammatory cytokines (such as IL-10) will also be discussed. This paper will show that probiotics should be considered in treatment protocols of IBD since they provide many beneficial effects and can enhance the effectiveness of traditional used medicines.

Understanding the Potential Role and Delivery Approaches of Nitric Oxide in the Chronic Wound Healing Management

2020 ◽  
Vol 26 ◽  
Author(s):  
Mimansa Kandhwal ◽  
Tapan Behl ◽  
Arun Kumar ◽  
Sandeep Arora
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Chronic Wound ◽  
Lower Limbs ◽  
Diabetic Patients ◽  
Pharmacological Mechanism ◽  
Novel Treatments ◽  
Beneficial Effects ◽  
Chronic Ulcers

: Nitric oxide (NO) is a promising pharmaceutical component that has vasodilator, antibacterial and wound healing activity. Chronic ulcers are non-healing disorders that are generally associated with distortion of lower limbs. Among the severe consequence’s derivative of these diseases, are the problems of chronic wound progression. NO which is categorized as smallest gaseous neurotransmitter has beneficial effects in different phases of chronic inflammation. Defensive mechanism of NO is found useful in several severe conditions such as gestational healing, gastrointestinal healing and diabetic healing. The current review presents up to date collection of literature about role of NO in chronic ulcers due to the prevalence of diabetes, DPN, and diabetic foot ulcers, and because of the lack of available effective treatments to directly address the pathology contributing to these conditions, novel treatments are being sought. This review also collects the information about deficiency of NO synthase in diabetic patients leads to a lack of vascularization of the peripheral nerves, which causes diabetic neuropathy; and this could be treated with vasodilators such as nitric oxide. Apart from pharmacological mechanism of NO, the article also reviewed and analyzed to elucidate the potential of a transdermal delivery of NO for the treatment of chronic ulcers.

Analysis of the teaching of genetics for junior students of Sechenov university

2020 ◽  
pp. 90-92
Author(s):  
С.М. Кузин ◽  
Н.В. Чебышев ◽  
Д.В. Богомолов ◽  
И.А. Беречикидзе ◽  
Т.В. Сахарова ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Regenerative Medicine ◽  
Functional Genomics ◽  
Modern Medicine ◽  
Professional Activities ◽  
Wide Range ◽  
Prevention And Treatment ◽  
The Subject ◽  
Junior Students

Развитие генетики оказывает все большее влияние на современную медицину. На основе достижений в области структурной, функциональной геномики и эпигенетики сформировались новые наиболее перспективные направления - таргетная терапия, персонализированная и регенеративная медицина. Появились принципиально новые возможности для диагностики, прогнозирования, профилактики и лечения широкого спектра заболеваний. Все возрастающая роль генетики предъявляет принципиально иные требования к ее преподаванию в медицинских ВУЗах с использованием новых педагогических методик. Простого увеличения количества часов в рамках предмета «Биология» уже недостаточно для подготовки специалистов, чья профессиональная деятельность напрямую связана с генетикой: онкологов, вирусологов, иммунологов и многих других. The development of genetics has an increasing influence on modern medicine. Based on the achievements in the field of structural, functional genomics and epigenetics, new most promising directions have been formed - targeted therapy, personalized and regenerative medicine. There are fundamentally new opportunities for the diagnosis, prediction, prevention and treatment of a wide range of diseases. The increasing role of genetics imposes fundamentally different requirements for its teaching in medical Schools using new pedagogical methods. Simply increasing the number of academic hours in the subject “Biology” is no longer enough to train specialists whose professional activities are directly related to genetics: oncologists, virologists, immunologists, and many others.

scholarly journals The role of interleukin-17 in tumor development and progression

2019 ◽  
Vol 217 (1) ◽  
Author(s):  
Junjie Zhao ◽  
Xing Chen ◽  
Tomasz Herjan ◽  
Xiaoxia Li
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Inflammatory Response ◽  
Proinflammatory Cytokine ◽  
Cancer Biology ◽  
Tissue Repair ◽  
Tumor Development ◽  
Interleukin 17 ◽  
Wide Range

IL-17, a potent proinflammatory cytokine, has been shown to intimately contribute to the formation, growth, and metastasis of a wide range of malignancies. Recent studies implicate IL-17 as a link among inflammation, wound healing, and cancer. While IL-17–mediated production of inflammatory mediators mobilizes immune-suppressive and angiogenic myeloid cells, emerging studies reveal that IL-17 can directly act on tissue stem cells to promote tissue repair and tumorigenesis. Here, we review the pleotropic impacts of IL-17 on cancer biology, focusing how IL-17–mediated inflammatory response and mitogenic signaling are exploited to equip its cancer-promoting function and discussing the implications in therapies.

scholarly journals The role of benzydamine in prevention and treatment of chemoradiotherapy-induced mucositis

2021 ◽  
Author(s):  
Ourania Nicolatou-Galitis ◽  
Paolo Bossi ◽  
Ester Orlandi ◽  
René-Jean Bensadoun
Keyword(s):  
Cancer Patients ◽  
Oral Mucositis ◽  
Common Side Effect ◽  
Beneficial Effects ◽  
Tnf Α ◽  
Prevention And Treatment ◽  
Neutrophil Degranulation ◽  
Radiation Induced ◽  
Oral Oncology

Abstract Purpose To discuss the role of benzydamine in the prevention and treatment of radiation-induced oral mucositis (OM) in head and neck (H&N) cancer patients. This document represents an expert opinion paper on indications and key-role aspects in OM pathogenesis, prevention and treatment. Oral mucositis OM represents a common side effect of chemotherapy (CHT) and radiotherapy (RT). It consists in a painful erythema involving the oral cavity mucosa, which may progress to ulceration. Five biologically dynamic phases are considered crucial in mucositis: “initiation, signalling, amplification, ulceration and healing”. Oral environment and microbiota are fundamental in mucositis development being involved in susceptibility to infections and in ulceration consequences. Different agents against mucositis have been studied and the use of benzydamine is strongly supported in literature. The Multinational Association of Supportive Care in Cancer and International Society for Oral Oncology (MASCC/ISOO) guidelines recommend its use for the prevention of OM in H&N patients undergoing RT and RT/CHT. Benzydamine Benzydamine is a local anti-inflammatory drug with analgesic properties. It can decrease TNF-α, IL-1β and prostaglandin synthesis, also inhibiting leukocyte-endothelial interactions, neutrophil degranulation, vasodilation and vascular permeability. Literature agrees on the beneficial effects of benzydamine in preventing and reducing oral mucositis severity in H&N cancer patients undergoing RT/CHT. Conclusions Mucositis represents a major concern in H&N cancer patients and a clinical and economical issue. A multimodal and multidisciplinary approach is needed for its management. International guidelines recommend benzydamine for OM prevention and treatment in H&N cancer patients, but further “real world” trials should be designed.

scholarly journals Effects of Probiotics on Human Health and Disease: A Review

2021 ◽  
Vol 48 (1) ◽  
pp. 95-100
Author(s):  
A. Amiri ◽  
F. Firoozeh ◽  
M. Zibaei ◽  
A. Khaledi
Keyword(s):  
Human Health ◽  
Digestive System ◽  
Intestinal Microflora ◽  
Normal Flora ◽  
Beneficial Effects ◽  
Prevention And Treatment ◽  
Health And Disease ◽  
The Subject ◽  
Underlying Mechanisms

Abstract Alteration of the gut microbiome in order to achieve a balance in the normal flora of the intestine could be very beneficial in maintaining the health of the human. Probiotics are living microbial supplements that are added to the diet and have beneficial effects on the host by improving the balance of the intestinal microflora. The purpose of this study is to review previous studies on the effects of probiotics on human health and various diseases. The Farsi and English electronic databases such as, SID, Iranmedex, Magiran, Google Scholar, PubMed and ISI Web of Knowledge were searched and the published articles that have studied the effects of probiotics on the prevention and treatment of various diseases were included in the study. The review of published articles related to the subject showed that consumption of probiotics, prebiotics and proper diet have the significant effects on the health of the digestive system and has reduced and improved symptoms of different disorders and diseases. Further research is needed to better understand the underlying mechanisms of probiotic function and confirm the role of the probiotics in preventing and treating various types of cancers and other diseases.

Diarylheptanoids: Potent Anticancer Agents

2021 ◽  
Vol 08 ◽  
Author(s):  
Rabia Hameed
Keyword(s):  
T Cell Activation ◽  
Anticancer Agents ◽  
Cell Activation ◽  
Dependent Manner ◽  
Current Review ◽  
Tnf Α ◽  
Wide Range ◽  
The Family ◽  
Dose Dependent

Abstract: Diarylheptanoids are widely distributed among species belonging to the family Betulaceae. Being highly polar in nature, they can either be isolated from plants by using sophisticated chromatographic techniques or can be synthesized in the laboratory. They are found to exhibit a wide range of activities, from very simple analgesics to anticancer agents. Recently, they have gained considerable attention due to inhibitory activity against NF-κB activation, NO and TNF-α production, reduction in NO and COX-2 levels in a dose-dependent manner, and suppression of T-cell activation. The current review article highlights the role of diarylheptanoids as potent anticancer agents in a variety of cancers.

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