Linking Lipid Metabolism with Cell Transformation and Tumor Progression

2020 ◽  
Vol 5 (4) ◽  
pp. 153-161
Author(s):  
Meng Si Zuo ◽  
◽  
Jia Yu Yang ◽  
Pei Yun Wang ◽  
Hai Ou Yang ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Lipid Metabolism ◽  
Inflammatory Cell ◽  
Cell Transformation ◽  
Essential Fatty Acids ◽  
Tumor Development ◽  
The Body ◽  
Tumor Transformation ◽  
Major Nutrients ◽  
Abnormal Lipid Metabolism

Carbohydrates, lipids, and proteins are the three major nutrients required by the human body. The lipids, comprising triglycerides, phospholipids, and sterols, provide energy and essential fatty acids for the body, and are required for the growth and maintenance of human cells and tissues. A variety of lipid molecules and their intermediates are involved in cell signaling and inflammation, and have been reported to promote tumor transformation and progression. Fatty acid biosynthetic enzymes are also involved in the lipid metabolism of tumors. Dyslipidemia is closely related to many solid tumors, and may both play a role in both tumorigenesis and be a consequence of tumor development. Therefore, abnormal lipid metabolism is strongly associated with tumor transformation and progression. This review discusses the signaling pathways, related genes, enzymes, and inflammatory cell factors involved in tumor lipid metabolism, as well as the roles of dyslipidemia in tumor transformation and progression. We believe the information provided will serve as valuable reference highlighting molecules that can be targeted to improve the treatment of tumors.

USE OF ESSENTIAL FATTY ACIDS AND THEIR ROLE IN THE HUMAN ORGANISM DEVELOPMENT

2018 ◽  
Vol 28 (4) ◽  
pp. 1219-1225
Author(s):  
Filip Jovanovski ◽  
Toni Mitrovski ◽  
Viktorija Bezhovska
Keyword(s):  
Fatty Acids ◽  
Unsaturated Fatty Acids ◽  
Essential Fatty Acids ◽  
Normal Growth ◽  
The Body ◽  
Human Nutrition ◽  
Human Organism ◽  
Working Ability ◽  
The World ◽  
Growth Development

Food is not just a pleasure in life, it is also an important factor for our health. Human nutrition is a mixture of nutrients, which are the only source of energy needed for survival. Energy-poor diet endangers many life functions, and above all the working ability. In the world, the meaning of the diet is very serious, and hence the demands for a –rational, healthy and safe diet are growing. Human nutrition contains saturated and unsaturated fatty acids. Essential fatty acids (EFAs) must be ingested in everyday diet because the body does not produce it. They are very important for human health. They are present in each cell of the human body and are an important factor for the normal growth, development and functioning of cells, muscles, nerves and organs. They are also used in the production of certain hormones - such as prostaglandins, which are crucial for the performance of certain important processes. The deficit from EFAs is due to a number of health problems, including more serious diseases.

scholarly journals Autophagy in Viral Development and Progression of Cancer

2021 ◽  
Vol 11 ◽  
Author(s):  
Alejandra Suares ◽  
María Victoria Medina ◽  
Omar Coso
Keyword(s):  
Cell Fate ◽  
Cell Transformation ◽  
Tumor Development ◽  
Lysosomal Hydrolases ◽  
Subsequent Degradation ◽  
Cellular Context ◽  
Tumor Transformation ◽  
Proliferation And Metastasis ◽  
Viral Development ◽  
Catabolic Process

Autophagy is a complex degradative process by which eukaryotic cells capture cytoplasmic components for subsequent degradation through lysosomal hydrolases. Although this catabolic process can be triggered by a great variety of stimuli, action in cells varies according to cellular context. Autophagy has been previously linked to disease development modulation, including cancer. Autophagy helps suppress cancer cell advancement in tumor transformation early stages, while promoting proliferation and metastasis in advanced settings. Oncoviruses are a particular type of virus that directly contribute to cell transformation and tumor development. Extensive molecular studies have revealed complex ways in which autophagy can suppress or improve oncovirus fitness while still regulating viral replication and determining host cell fate. This review includes recent advances in autophagic cellular function and emphasizes its antagonistic role in cancer cells.

scholarly journals Batch spawning facilitates transfer of an essential nutrient from diet to eggs in a marine fish

2013 ◽  
Vol 9 (5) ◽  
pp. 20130593 ◽  
Author(s):  
Lee A. Fuiman ◽  
Cynthia K. Faulk
Keyword(s):  
Fatty Acids ◽  
Essential Fatty Acids ◽  
Maternal Diet ◽  
Short Interval ◽  
Rate Of Change ◽  
The Body ◽  
Sciaenops Ocellatus ◽  
Diet Shift ◽  
Spawning Site ◽  
Batch Spawning

Fatty acid composition of eggs affects development, growth and ecological performance of fish embryos and larvae, with potential consequences for recruitment success. Essential fatty acids in eggs derive from the maternal diet, and the time between ingestion and deposition in eggs is ecologically important but unknown. We examined the dynamics of diet–egg transfer of arachidonic acid (ARA) in the batch-spawning fish, red drum ( Sciaenops ocellatus ), by measuring ARA concentrations in eggs after a single diet shift and during a period of irregular variations in diet. ARA concentrations in eggs changed within 2–16 days of a diet shift. The rate of change was proportional to the magnitude of the shift, with no evidence of equilibration. These results are not consistent with eggs being assembled entirely from accumulated body stores. The immediate source of ARA in eggs appears to be the recent diet. We propose that batch spawning produces rapid diet–egg transfer of ARA because it removes large amounts of fatty acids from the body and prevents equilibration. The immediacy of the diet–egg connection suggests that spawning migration combined with short-interval batch spawning may have evolved to take advantage of nutrients critical for offspring survival that are available at the spawning site.

Lipid role in the immune system

2021 ◽  
Vol 32 (10) ◽  
pp. 6-10
Author(s):  
Rebecca Guenard ◽  
Keyword(s):  
Fatty Acids ◽  
Immune System ◽  
Essential Fatty Acids ◽  
The Body ◽  
New Members ◽  
Inflammatory Pathways ◽  
Anti Inflammatory

The essential fatty acids react with enzymes to produce a group of compounds known as specialized pro-resolving mediators, or SPMs. Researchers continually discover new members of the four groups of precursors that comprise the SPM family, called lipoxins, resolvins, protectins, and maresins. These stereospecific molecules shut down inflammation and restore the body to homeostasis, a mechanism researchers are targeting for treatment as an alternative to anti-inflammatory pathways.

ESSENTIAL FATTY ACIDS, LIPID METABOLISM AND ATHEROSCLEROSIS

The Lancet ◽  
1958 ◽  
Vol 271 (7023) ◽  
pp. 742-743 ◽  
Author(s):  
Ancel Keys ◽  
JosephT. Anderson ◽  
Francisco Grande
Keyword(s):  
Fatty Acids ◽  
Lipid Metabolism ◽  
Essential Fatty Acids

The Use of Crude Fish Oil (CFO) in Vannamei Shrimp (Litopenaeus vannamei) Feed on EPA and DHA Contents

2020 ◽  
Vol 9 (3) ◽  
pp. 232
Author(s):  
Januar Hadi Prasetyo ◽  
Agustono Agustono ◽  
Widya Paramitha Lokapirnasari
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Essential Fatty Acids ◽  
Penaeid Shrimp ◽  
The Body ◽  
Omega 3 ◽  
Alpha Linolenic Acid ◽  
Epa And Dha ◽  
Randomized Design ◽  
Omega 6

Omega-3 fatty acids (Alpha-linolenic acid) and omega-6 fatty acids (Linoleic acid) are a group of essential fatty acids. Essential fatty acids are fatty acids that cannot be synthesized by the body so that must be supplied from the diet. One of the sources of essential fatty acids is derived from fish oil. This study aims to determine the effect of Crude Fish Oil (CFO) in the feed to EPA and DHA content in penaeid shrimp meat. The research method used was a completely randomized design. The treatments used are the varying content of Crude Fish Oil (CFO), which are P0 (0%), P1 (2%), P2 (4%), P3 (6%), and P4 (8%). The results of the study showed significant differences (p <0.05) on the content of EPA and DHA in penaeid shrimp meat. The highest content of EPA and DHA found in P4 treatment (8%) and the lowest at P0 treatment (0%). The use of CFO in penaeid shrimp feed need further study related to the growth of shrimps and prawns reproductive cycle to increase the productivity of penaeid shrimp. CFO on feed should be used at a dose of 6%.

Insights into digestion and absorption of major nutrients in humans

2010 ◽  
Vol 34 (2) ◽  
pp. 44-53 ◽  
Author(s):  
Barbara E. Goodman
Keyword(s):  
Fatty Acids ◽  
Blood Stream ◽  
The Body ◽  
The Other ◽  
Transepithelial Transport ◽  
Specific Task ◽  
Gi Tract ◽  
Current Article ◽  
Major Nutrients ◽  
Living Organisms

Nutrient digestion and absorption is necessary for the survival of living organisms and has evolved into the complex and specific task of the gastrointestinal (GI) system. While most people simply assume that their GI tract will work properly to use nutrients, provide energy, and release wastes, few nonscientists know the details about how various nutrients are digested and how the breakdown products traverse the cells lining the small intestine to reach the blood stream and to be used by the other cells of the body. There have been several recent discoveries of new transporters that likely contribute to the absorption of oligopeptides and fatty acids. In addition, details are being clarified about how transporters work and in what forms nutrients can be absorbed. The enzymes that digest basic carbohydrates, proteins, and fats have been identified in various segments of the GI tract, and details are becoming clearer about what types of bonds they hydrolyze. Usually, detailed information about the digestion of basic nutrients is presented and learned in biochemistry courses and detailed information about absorption via transepithelial transport of the breakdown products of digestion is studied in physiology courses. The goal of this Staying Current article is to combine the details of the biochemistry of digestion with the updated information about the physiology of nutrient absorption into one source for teachers of physiology. Insights are included about some of the diseases and conditions that can bring about malabsorption of food in the GI tract and their consequences.

scholarly journals Effect of Enriched Feed by Different n-6 Fatty Acids Levels at 0% of n-3 on Danio rerio Reproductive Performance

2007 ◽  
Vol 5 (1) ◽  
pp. 51
Author(s):  
N.B.P Utomo ◽  
A. Rosmawati ◽  
I. Mokoginta
Keyword(s):  
Fatty Acids ◽  
Fish Species ◽  
Danio Rerio ◽  
Reproductive Performance ◽  
Essential Fatty Acids ◽  
Fertilization Rate ◽  
The Body ◽  
Two Factors ◽  
The Stability ◽  
Somatic Index

<p>Lipid and fatty acids are two factors determining reproductive performance of fish and survival rate of hatched larvae. Lipid has important role as energy source and to maintain the stability of membrane permeability.  The requirement of fatty acids differs among fish species.  Freshwater fishes need more n-6 than n-3 fatty acids, or appropriate combination of them.  In several fish species, feeding HUFA increase their fecundity, fertilization rate and eggs quality.  In this study, zebra fish, <em>Danio rerio</em> were fed with diet containing 0% n-3 essential fatty acids and different n-6 level; 0, 1 and 2%.  The result showed that there were no significant differences in gonado somatic index and several reproductive performances observed.  However, 1% of n-6 fatty acids supplementation produced a higher protein and lipid content in the body by 16.85% and 55.10%, respectively.</p> <p>Keywords: fatty acid, n-3, n-6, <em>Danio rerio</em>, reproductive performance</p> <p> </p> <p>ABSTRAK</p> <p>Lemak dan asam lemak merupakan faktor yang sangat mempengaruhi performa reproduksi dan kelangsungan hidup larva yang menetas. Lemak berperan penting sebagai sumber energi dan menjaga kestabilan permeabilitas membran. Kebutuhan asam lemak berbeda untuk setiap jenis ikan.  Ikan air tawar biasanya lebih banyak membutuhkan asam lemak <em>n</em>-6 daripada asam lemak <em>n</em>-3 atau campuran asam lemak <em>n</em>-6 dan <em>n</em>-3. Pada beberapa ikan , pemberian HUFA melalui pakan induk dapat meningkatkan fekunditas, derajat pembuahan dan kualitas telur.  Pada penelitian ini ikan zebra diberi pakan mengandung asam lemak esensial dengan kadar <em>n</em>-3 tetap (0%) dan <em>n</em>-6 berbeda yaitu 0, 1 dan 2%. Hasil penelitian menunjukkan bahwa tidak ada perbedaan nyata terhadap nilai Gonado Somatik Indeks serta beberapa parameter penampilan reproduksi lainnya pada ikan zebra, <em>Danio rerio</em>. Namun kadar asam lemak <em>n</em>-3 sebesar 0% dan <em>n</em>-6 sebesar 1% menghasilkan kadar protein dan kadar lemak tubuh tertinggi yang masing-masing mencapai 16,85% dan 55,10%</p> <p>Kata kunci: asam lemak,  <em>n</em>-3, <em>n</em>-6, <em>Danio rerio</em>, performa reproduksi</p>

scholarly journals Compuestos bioactivos, actividad antioxidante y perfil de ácidos grasos en aceite de semilla de Mezquite (Prosopis spp)

2020 ◽  
Vol 70 (1) ◽  
pp. 50-59
Author(s):  
Dora Valencia ◽  
Edgar Omar Rueda Puente ◽  
Mario Alberto Leyva Peralta ◽  
Sergio Rogelio Mazón-López ◽  
Jesús Ortega-García
Keyword(s):  
Fatty Acids ◽  
Antioxidant Activity ◽  
Sonoran Desert ◽  
Essential Fatty Acids ◽  
Saturated Fatty Acids ◽  
Ethanolic Extract ◽  
The Body ◽  
Total Phenolic ◽  
Antioxidant Power ◽  
Activity Method

La medicina tradicional y estudios realizados a diferentes especies del género Prosopis, del desierto sonorense, indican que es una fuente para la cualificación de compuestos bioactivos, con poder antioxidante y ácidos grasos (linoleico y linolénico) de la semilla. La actividad biológica, es atribuible a alcaloides, flavonoides, terpenos y compuestos fenólicos, para lo cual, se realizó el perfil fitoquímico en los extractos acuoso, etanólico, hexanico y clorofórmico (mediante técnicas colorimétricas), actividad antioxidante (método: 1,1-difenil-2-picrilhidrazil (DPPH)), fenoles totales (utilizando el reactivo de Folin-Ciocalteau) y perfil de ácidos grasos (cromatografía de gases) de la semilla de Prosopis spp. La extracción del aceite se realizó mediante Soxhlet. Se encontraron saponinas en todos los extractos, mientras que, en el etanólico, hexanico y clorofórmico, terpenos y esteroles. En el extracto etanólico se encontraron quinonas y en el acuoso aminoácidos libres. El valor más alto de la actividad antioxidante de EC50 fue de 3.272,41 ± 5,97, para el extracto etanólico, indicando su potencial como antioxidante. El contenido de fenoles totales, fue hexano> etanol > cloroformo> acuoso (81,95; 119,83; 125,18 y 127,57 mg equivalentes de ácido gálico/g de extracto seco). Los ácidos grasos en mayor proporción fueron los insaturados con 71,41 % (ácido linoleico: 42,68 %; oleico: 28.73 %) y ácidos grasos saturados: ácido palmítico (13.42 %) y estérico (4,73 %). Se concluye que este tipo de extractos presentan metabolitos importantes para la dieta, presentan actividad antioxidante y ácidos grasos esenciales para el organismo. Traditional medicine and studies with different species of the Prosopis genus, from the Sonoran Desert, is a source for the qualification of bioactive compounds, with antioxidant power and fatty acids (linoleic and linolenic) of the seed. The biological activity is attributable to alkaloids, flavonoids, terpenes and phenolic compounds, for which, the phytochemical profile was performed in the aqueous, ethanolic, hexane and chloroform extracts (using colorimetric techniques), antioxidant activity (method: 1,1-diphenyl-2-picrilhidrazil (DPPH)), total phenols (using the Folin-Ciocalteau reagent) and fatty acid profile (gas chromatography). The oil was extracted using Soxhlet. Saponins were found in all extracts, while, in ethanolic, hexanic and chloroform, terpenes and sterols. In the ethanolic extract quinones were found and in the aqueous free amino acids. The highest value of the antioxidant activity of EC50 was 3,272.41 ± 5.97, for the ethanolic extract, indicating its potential as an antioxidant. The total phenolic content was hexane> ethanol> chloroform> aqueous (81.95, 119.83, 125.18 and 127.57 mg equivalent of gallic acid / g of dry extract). The fatty acids in greater proportion were unsaturated with 71.41 % (linoleic acid: 42.68 %; oleic: 28.73 %) and saturated fatty acids: palmitic acid (13.42 %) and stearic (4.73 %). It is concluded that this type of extracts have important metabolites for the diet, have antioxidant activity and essential fatty acids for the body

Evaluation of the composition of essential fatty acids in the tissues of rainbow trout (Oncorhynchus mykiss) grown in closed water supply units

2021 ◽  
Vol 325 (4) ◽  
pp. 495-501
Author(s):  
E.A. Zykina ◽  
M.V. Gurin
Keyword(s):  
Fatty Acids ◽  
Rainbow Trout ◽  
Water Supply ◽  
Oncorhynchus Mykiss ◽  
Fish Oil ◽  
Essential Fatty Acids ◽  
The Body ◽  
Biologically Active ◽  
Rainbow Trout Oncorhynchus Mykiss ◽  
Aquaculture Products

Recently, the task of artificial cultivation of especially valuable fish species in aquaculture has become more and more urgent. The value of salmon fish, and in particular rainbow trout Oncorhynchus mykiss (Walbaum, 1792) available for breeding, is largely determined by the high content of biologically active essential and polyunsaturated fatty acids of the group ω-6 and ω-3, necessary for vital activity and not synthesized by the human body. Since the natural stocks of many popular fatty fish have decreased, farmed fish can help meet consumer demand for this product. Based on this, the assessment of the content of the main ω-6 and ω-3 fatty acids in the fat of rainbow trout grown in closed-loop water supply installations (USV) was made. The fat was extracted from the fish by thermal method with further distillation by supercritical fluid extraction on the SFT-150 unit. The ratio of fatty acids in the fish oil sample was determined using the Chromatek-Kristall-5000 M hardware and software complex. The results obtained were compared with the standard for salmon fish oil “Aquaculture products” and “Wild fish”. It is established that trout cultivated in the UZV in the Penza region, in terms of the content of the main essential fatty acids, is not inferior to the quality indicators of the standard in terms of the requirements for salmon fish of “Aquaculture products”. In fish, all essential fatty acids are present in sufficient quantities, the ratio of ω-6 to ω-3 is 2.6:1, which indicates a high nutritional value of the product and allows it to be used in human food to provide the body with essential fatty acids, as well as a raw material for obtaining therapeutic and preventive products.

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