scholarly journals Mathematical Analysis of the Effect of Control on the Dynamics of Diabetes Mellitus and Its Complications

2021 ◽  
pp. 375-395
Author(s):  
Patrick Olabanji Aye
Keyword(s):  
Diabetes Mellitus ◽  
Homotopy Perturbation Method ◽  
The Body ◽  
Control Measures ◽  
Effective Management ◽  
Homotopy Perturbation ◽  
Model Dynamics ◽  
Total Lack ◽  
Model Equations ◽  
Abstinence From Alcohol

Diabetes is a disorder in which the body becomes unable to control the amount of sugar in the blood. The pancreas (beta-cells) is not functioning normally, resulting in a partial or total lack of insulin which is the key to the mechanism converting sugar to energy. In this study, mathematical model for the dynamics of diabetes mellitus and its complications incorporating control is developed and analyzed. Positive lifestyle, which includes abstinence from alcohol, smoking and glutoning, and effective management of diabetes condition are incorporated as controls. The analytical solution of the model equations is obtained using Homotopy Perturbation Method. Numerical simulation of the model solution was done using Maple 18 Mathematical software. The parameters are varied and their effects on the model dynamics are presented graphically. The results showed that the two control measures can effectively be used to reduce the evolution of incidence of diabetes and occurrence of complications of diabetes thereby reducing the rate of morbidity and mortality due to diabetes complications.

Glucose Calibration Modeling in Blood with Spline Regression Approaching to Non-Invasive Tools

2018 ◽  
pp. 144-149
Author(s):  
Ria Hayatun Nur ◽  
Indahwati A ◽  
Erfiani A
Keyword(s):  
Diabetes Mellitus ◽  
Linear Regression ◽  
Good Health ◽  
Cubic Spline ◽  
The Body ◽  
Spline Regression ◽  
Linear Quadratic ◽  
Important Thing ◽  
Non Invasive

In this globalization era, health is the most important thing to be able to run various activities. Without good health, this will hinder many activities. Diabetes mellitus is one of the diseases caused by unhealty lifestyle.There are many treatments that can be done to prevent the occurrence of diabetes. The treatments are giving the insulin and also checking the glucose rate to the patients.Checking the glucose rate needs the tools which is safety to the body. This research want to develop non invasive tool which is safety and do not injure the patient. The purpose of this research is also finding the best model which derived from Linear, Quadratic, and Cubic Spline Regression. Some respondents were taking to get the glucose measuring by invasive and non invasive tools. It could be seen clearly that Spline Linear Regression was the best model than Quadratic and Cubic Spline Regression. It had 70% and 33.939 for R2 and RMSEP respectively.

Serum Ferritin Status of Patients with Type 2 DM Attending OPD of BIRDEM General Hospital

2020 ◽  
Vol 11 (1) ◽  
pp. 7-10
Author(s):  
Khadiza Begum ◽  
Fahmida Islam ◽  
Farjana Aktar ◽  
Murshida Aziz ◽  
Tohfa E Ayub Tahiya
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Serum Ferritin ◽  
Study Groups ◽  
Acute Phase Reactant ◽  
The Body ◽  
Iron Stores ◽  
Normal Healthy Individual ◽  
Diabetes Patients

Background: In recent times much is talked about of serum ferritin, an acute phase reactant a marker of iron stores in the body and its association with diabetes mellitus. Studies implicate that increased body iron stores and subclinical hemochromatosis has been associated with the development of glucose intolerance, type 2 diabetes and its micro as well as macrovascular complications. Material & Methods: This study was carried out to examine and to observe for any relationship between serum ferritin with Type 2 diabetes mellitus. Our study populations were included 163. Among them 81 type 2 diabetes patients as a case (M=49,F=32, mean 44.68 age in years)and 82 normal healthy individual as a control ( M=35, F=47 , mean 34.71 in years). Results: Majority were healthy outpatients who had come for regular checkup and were matched with controls. Serum ferritin and FBS were estimated and other investigations. Results showed that although Serum ferritin was in the normal range value it was increased in type 2 diabetes patients than in controls and was statistically significant, we did get a positive correlation with duration of diabetes. It can be concluded that there were positive associations between serum ferritin and FBG, age, sex among study groups. Conclusion: In conclusion our study shows that there is significant correlation between increased serum ferritin in diabetes compared to individuals with normal blood sugars in this part and hyper ferritinemia may be one of the causes for development of insulin resistance before overt diabetes. Anwer Khan Modern Medical College Journal Vol. 11, No. 1: Jan 2020, P 7-10

On Spectral-Homotopy Perturbation Method Solution of Nonlinear Differential Equations in Bounded Domains

2013 ◽  
Vol 1 (1) ◽  
pp. 25-37
Author(s):  
Ahmed A. Khidir
Keyword(s):  
Perturbation Method ◽  
Homotopy Perturbation Method ◽  
Nonlinear Boundary ◽  
Nonlinear Differential Equations ◽  
Iteration Algorithm ◽  
Test Problems ◽  
Nonlinear Boundary Value Problems ◽  
Homotopy Perturbation ◽  
Spectral Technique ◽  
Homotopy Analysis

In this study, a combination of the hybrid Chebyshev spectral technique and the homotopy perturbation method is used to construct an iteration algorithm for solving nonlinear boundary value problems. Test problems are solved in order to demonstrate the efficiency, accuracy and reliability of the new technique and comparisons are made between the obtained results and exact solutions. The results demonstrate that the new spectral homotopy perturbation method is more efficient and converges faster than the standard homotopy analysis method. The methodology presented in the work is useful for solving the BVPs consisting of more than one differential equation in bounded domains. 

Ghrelin and Obesity-An Update

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Gandhi M. ◽  
Swaminathan S.
Keyword(s):  
Diabetes Mellitus ◽  
Cardiac Output ◽  
Energy Balance ◽  
Vascular Resistance ◽  
The Body ◽  
Ghrelin Receptor ◽  
Type2 Diabetes ◽  
Type2 Diabetes Mellitus ◽  
Natural Hormones

Ghrelin as human natural hormones is involved in fundamental regulatory process of eating and energy balance. It is a stomach derived hormone that acts as at the ghrelin receptor in multiple tissues throughout to the body. Its properties includes increasing appetite, decreasing systemic inflammation, decreasing vascular resistance ,increasing cardiac output, increasing glucose and IGF-1 levels, Hence it may play a significant role in Diabetes mellitus. Many studies have linked ghrelin to obesity and this paper is an attempt to bring out recent findings on the role of ghrelin in Diabetes Mellitus, particularly type2 Diabetes mellitus.

Pengaruh Senam Diabetes Mellitus terhadap Persentase Lemak Tubuh Penderita DM Tipe II di Puskesmas Godean I

2017 ◽  
Vol 19 (1) ◽  
pp. 51-55
Author(s):  
Dyda Fahmi Fadhilah ◽  
Nurul Huda Syamsiatun ◽  
Idi Setiyobroto
Keyword(s):  
Diabetes Mellitus ◽  
Local Government ◽  
Body Fat ◽  
Fat Body ◽  
Disease Risk ◽  
Psychological Intervention ◽  
The Body ◽  
Type Ii ◽  
Paired Sample ◽  
Government Clinic

Background : The number of DM victims in the world increased year by year. According to Health Elementary Research in 2013  the highest number was in DIY, it was 2,6%. Then, according to Godean I Local Government Clinic data, DM was the second rank of Non-Communicable Disease (NCD) after hypertension. The increasing of DM victims number was connected by the overweight case that was influenced by unhealthy diet and lack ofphysic activities so it caused accumulation of fat tissues. In the next time it can cause complication for the victims. There are three pillars of DM management namely, diet, psychological intervention, and exercises. The first that should be done is exercises. One of them is physic exercises namely DM gymnastic. Its functions are to control blood sugar, lose weight and body fat so cardiovascular disease risk factor can be prevented and fixed. In this research the DM gymnastic was done three times in a week for six weeks in duration time of 30-60 minutes. Objective : Purpose of the research to know the influence of DM gymnastic to the change of fat body percentage of DM type II victims in Godean I Local Government Clinic. Method : Research method this research used quasi-experiment method, the research plan used pre-post design. The population was all of DM type II victims in Godean I Local Government Clinic with the subject number were 24 people. The data analysis used statistic test Paired Sample t Test with the credibility 95%. Result : Result of the research the statistic test Paired Sample t Ttest showed that there were not differences before and after DM gymnastic treatment for six weeks. According to the average of fat body percentage after DM gymnastic treatment was higher than before (32,52% > 32,86%). Conclusion : There was no influence of DM gymnastic to the body fat percentage of DM type II victims in GodeanI Local Government Clinic p = 0,59 or p = >0,05.   Keywords: Gymnastic, Diabetes Mellitus, Fat Body Percentage

Novel Approaches for Oral Delivery of Insulin and Current Status of Oral Insulin Products

2010 ◽  
Vol 3 (3) ◽  
pp. 1057-1064 ◽  
Author(s):  
Kinesh V P ◽  
Neelam D P ◽  
Punit B ◽  
Bhavesh S.B ◽  
Pragna K. S
Keyword(s):  
Diabetes Mellitus ◽  
Oral Delivery ◽  
Proteolytic Enzymes ◽  
Oral Route ◽  
The Body ◽  
Current Status ◽  
Intestinal Lumen ◽  
Insulin Administration ◽  
Novel Approaches ◽  
Dose Dependent

Diabetes mellitus is a serious pathologic condition that is responsible for major healthcare problems worldwide and costing billions of dollars annually. Insulin replacement therapy has been used in the clinical management of diabetes mellitus for more than 84 years. The present mode of insulin administration is by the subcutaneous route through which insulin is presented to the body in a non-physiological manner having many challenges. Hence novel approaches for insulin delivery are being explored. Challenges to oral route of insulin administration are: rapid enzymatic degradation in the stomach, inactivation and digestion by proteolytic enzymes in the intestinal lumen and poor permeability across intestinal epithelium because of its high molecular weight and lack of lipophilicity. Liposomes, microemulsions, nanocubicles, and so forth have been prepared for the oral delivery of insulin. Chitosan-coated microparticles protected insulin from the gastric environment of the body and released intestinal pH. Limitations to the delivery of insulin have not resulted in fruitful results to date and there is still a need to prepare newer delivery systems, which can produce dose-dependent and reproducible effects, in addition to increased bioavailability.

Current Status of Knowledge and Awareness of Diabetes Mellitus in Saudi Arabia

2020 ◽  
Vol 16 ◽  
Author(s):  
Asirvatham Alwin Robert ◽  
Ahmad Dakeel Al Awad ◽  
Mohamed Abdulaziz Al Dawish
Keyword(s):  
Diabetes Mellitus ◽  
Saudi Arabia ◽  
Disease Risk ◽  
Current Knowledge ◽  
Adult Population ◽  
Management Training ◽  
Control Measures ◽  
Current Status ◽  
Treatment Modalities ◽  
The Government

Abstract: Diabetes mellitus (DM) is a chronic disease, and the complications may be life-threatening; however, with proper treatment and control measures, it can be very well-managed. Self-management training and education of diabetes are critical in diabetes care and management. It is essential that patients with diabetes must have a comprehensive understanding of the nature of the disease, risk factors, complications, and possible treatment modalities to attenuate the complications. Over the last few years, DM in Saudi Arabia has been rapidly growing at an alarming rate. It has affected around one-fifth of the adult population, and by 2030, the numbers are predicted to rise further and exceed more than double the present number. An estimated tenfold increase has been reported over the past three decades in Saudi Arabia. However, there has not been much research focusing on understanding the knowledge and awareness of DM in Saudi Arabia as compared to developed nations. This review aims to present an overview of the current knowledge and awareness level of DM among the population of Saudi Arabia through an extensive review of the currently available literature. The review findings could be of immense assistance to the government, healthcare systems, educational institutions, and researchers to develop evidence-based programs, policies, and guidelines towards increasing the knowledge and awareness about diabetes and its management, so that early detection and management can be ensured to control the escalating burden of diabetes, in Saudi Arabia.

Novel Swellable/Expandable Gastroretentive Floating Films of Gliclazide Folded in Capsule Shell for the Effective Management of Diabetes Mellitus: Formulation Development, Optimization and In vitro Evaluation

2020 ◽  
Vol 15 ◽  
Author(s):  
Diksha Sharma ◽  
Deepak Sharma
Keyword(s):  
Diabetes Mellitus ◽  
Drug Absorption ◽  
Gastric Fluid ◽  
Stability Study ◽  
Gastric Retention ◽  
Effective Management ◽  
In Vitro Evaluation ◽  
Capsule Shell ◽  
Study Results

Background: Gliclazide (GLZ) belongs to the second-generation of sulphonylureas, is a drug of choice for the management of type II DM. It belongs to BCS Class II. The major site of drug absorption for GLZ is the stomach; it displayed variation in the drug absorption rate and bioavailability due to the shorter gastric retention time. Floating mechanism performance gets affected when the gastric fluid level not sufficiently higher, which ultimately obstructs the floating behavior, which is the major limitation of reported formulations. This limitation can get over by folded the film into the capsule shell that dissolved in gastric fluid and film swell/expands to dimensions higher than pylorus sphincter (12mm), thus prevents its evacuation. Objective: To explore the floating mechanism in the designing of films along with a tendency to expand by swelling and unfolding by utilizing a mixture of hydrophilic and hydrophobic polymer to achieve the controlled drug delivery and prolonged gastric retention of drug. Methods: The gastroretentive floating films were formulated by the solvent casting technique using 32 full factorial design and subjected to in vitro evaluation parameters, drug-excipient compatibility, X-ray diffraction and accelerated stability study. Results: The pre-formulation study established the purity and identification of drug. FTIR study confirmed no drug excipient interaction. F3, F6, and F9 were optimized based on in vitro floating characteristics, swelling/expanding ability, and unfolding time study. All developed formulations were unfolded within 14-22 min after capsule disintegration. The F3 was selected as final formulation as its ability to control the release of drug for 24 hrs followed by Zero-order kinetics having super case 2 transport. XRD confirmed the amorphousness of drug within formulation. The stability study results revealed that formulation was quite stable at extreme storage condition. Conclusion: The developed novel formulation has a good potential for the effective management and treatment of Diabetes Mellitus.

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