scholarly journals PRESEPSIN IS A NOVEL HIGHLY EFFECTIVE SEPSIS MARKER(REVIEW)

2020 ◽  
Vol 44 (1) ◽  
pp. 84-87
Author(s):  
S. D. Shapoval ◽  
I. L. Savon ◽  
L. V. Vasylevska ◽  
M. M. Sofilkanych
Keyword(s):  
Adverse Effects ◽  
Systemic Infection ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Highly Effective ◽  
Sepsis Marker

Abstract In this review the most effective markers of septic process like Procalcitonin, C-reactive protein, and cytokines compared to the new marker – Presepsin (PSP) are analyzed. At sepsis initiation, PSP increases 30 to 60 minutes after the onset of systemic infection. PSP levels at admission to the hospital predict the risk of adverse and adverse effects that other markers used for the diagnosis of sepsis do not have.

C-Reactive Protein in Neonatal Sepsis

2008 ◽  
Vol 27 (2) ◽  
pp. 117-120 ◽  
Author(s):  
Michelle Hawk
Keyword(s):  
Blood Culture ◽  
Neonatal Sepsis ◽  
Complete Blood Count ◽  
Length Of Hospital Stay ◽  
Acute Phase Reactant ◽  
Definitive Diagnosis ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
High Negative Predictive Value ◽  
Sepsis Marker

SEPSIS IS ONE OF THE MOST COMMON diagnostic challenges in the NICU. Currently a definitive diagnosis can be made only with the gold-standard blood culture, which is generally not available for 48 hours.1,2 Difficulty obtaining a large enough sample to detect a positive blood culture, as well as increased use of antenatal antibiotics, has complicated the ability to make a definitive diagnosis of sepsis.3 If left untreated, sepsis can increase morbidity and mortality. Therefore, many infants are treated empirically with broad-spectrum antibiotics.4,5 Two kinds of tests would be most helpful in the diagnosis of neonatal sepsis: one that quickly confirms the diagnosis and one that conclusively rules it out. In fact, a diagnostic sepsis marker with a high negative predictive value (the value representing patients without sepsis who are correctly diagnosed) might reduce the short- and long-term adverse effects of antibiotics, health care costs, and length of hospital stay.6 Despite extensive investigation no single test meets the criteria that would make it an ideal marker for the early diagnosis of sepsis in the newborn.5,7,8 Generally, screening includes a complete blood count with differential and may be accompanied by other adjunctive tests such as a C-reactive protein (CRP).9–11 This column examines CRP, an acute phase reactant (APR), as a diagnostic marker for neonatal sepsis.

scholarly journals C-reactive protein and cytokines in the diagnosis of neonatal sepsis

2006 ◽  
Vol 59 (11-12) ◽  
pp. 545-549 ◽  
Author(s):  
Borisav Jankovic ◽  
Dobrila Veljkovic ◽  
Srdjan Pasic ◽  
Zorica Rakonjac ◽  
Dragana Jevtic ◽  
...  
Keyword(s):  
Acute Phase ◽  
Neonatal Sepsis ◽  
Current Knowledge ◽  
Systemic Infection ◽  
Serum Levels ◽  
C Reactive Protein ◽  
Correct Treatment ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Serum Crp

Introduction. Accurate evaluation and correct treatment of neonates for possible sepsis still represent the most challenging clinical tasks. Early diagnosis of neonatal sepsis is largely based on the measurement of serum concentrations of different mediators of systemic inflammation, as well as, on a group of proteins named acute phase reactants. Among acute phase reactants, C-reactive protein (CRP) has been the most extensively used and investigated so far. Synthesis and biological role of CRP. This article reviews current knowledge on the synthesis, structure and biologic roles of CRP. Also, we present our original results in regard to the kinetics of serum CRP concentration during the first 24 hours of systemic infection, as well as different patterns of CRP dynamics associated with the initial choice of antibiotics, complications and the final outcome of systemic infection. Interleukins and procalcitonin in diagnosis of sepsis. Because CRP is specific, but somewhat late marker of neonatal sepsis, possible diagnostic use of other indicators of inflammation, i.e. interleukins 6 and 8, and procalcitonin during neonatal sepsis is also considered. The theoretical advantage of these early indicators is discussed in comparative analysis of the time of their activation after initial infectious stimuli. Conclusion. In conclusion, we point to the diagnostic accuracy of serial measurements of serum CRP levels. As an alternative, simultaneous measurement of CRP and serum levels using a faster marker, such as procalcitonin, is recommended.

scholarly journals Porphyromonas gingivalis in dental plaque and serum C-reactive protein levels in pregnancy

2010 ◽  
Vol 4 (06) ◽  
pp. 362-366 ◽  
Author(s):  
Nada M. Souccar ◽  
Marita Chakhtoura ◽  
Joseph G. Ghafari ◽  
Alexander Michael Abdelnoor
Keyword(s):  
Pregnant Women ◽  
Porphyromonas Gingivalis ◽  
Preterm Labour ◽  
Systemic Infection ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Vaginal Swabs ◽  
Serum Crp ◽  
In Pregnancy

Background: The periodontopathogen Porphyromonas gingivalis (Pg) has been reported as a risk factor for preterm labour. Its pathogenesis and role in pregnancy have not been investigated in Lebanon. Elevated C-reactive protein (CRP) levels in pregnant women with periodontitis also appear to mediate preterm labour. Methodology: The study included 20 pregnant women with periodontitis and 20 with normal periodontium. PCR was done for Pg detection in oral plaque and vaginal samples. Serum CRP levels were determined by ELISA. Results: Pg was detected in the oral plaque of 13 of 20 pregnant subjects with clinical periodontitis (patients) and 2 of 20 controls with a healthy periodontium. Vaginal swabs were all Pg-negative, ruling out systemic infection. Serum CRP levels were elevated in 12 of 20 patients and 8 of 20 controls. None of the participants experienced preterm labour. Conclusions: This is the first report that implicates Pg in Lebanese periodontitis patients. Preliminary results do not indicate a relationship among Pg, periodontitis, CRP levels and preterm labour.

New strategies in sepsis diagnosis

2012 ◽  
Vol 19 (3) ◽  
pp. 160-162
Author(s):  
Linas Pieteris ◽  
Giedrė Bakšytė ◽  
Tadas Česnaitis ◽  
Astra Vitkauskienė ◽  
Andrius Macas
Keyword(s):  
Early Diagnosis ◽  
Successful Treatment ◽  
C Reactive Protein ◽  
Sepsis Diagnosis ◽  
Reactive Protein ◽  
Diagnosis And Prognosis ◽  
Sepsis Marker ◽  
New Strategies

Successful treatment of sepsis begins from early diagnosis and prognosis. In last decades the number of sepsis cases is growing, so establishing early diagnosis of sepsis as well as effectiveness of treatment are very significant. That is why development of new diagnostic sepsis markers is important. In this review we evaluated a new sepsis marker Presepsin (sCD14) and compared it to other markers: Procalcitonin (PCT), C-reactive protein (CRP) and Interleukine-6 (IL-6).

Evaluation of a turbidimetric C-reactive protein assay to monitor early-onset neonatal sepsis in South Kivu (Democratic Republic of the Congo)

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Guy Mulinganya ◽  
Serge Balolebwami ◽  
Serge Zigabe ◽  
Jules Mongane ◽  
Isia Nianci ◽  
...  
Keyword(s):  
Birth Weight ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Systemic Infection ◽  
Sub Saharan Africa ◽  
C Reactive Protein ◽  
Protein Assay ◽  
Reactive Protein ◽  
Sub Saharan ◽  
Serum Crp

AbstractObjectivesNeonatal sepsis, a condition defined as bacteremia within the first month of life accompanied by signs of systemic infection, is the most preventable cause of infant mortality in sub-Saharan Africa. Despite the development of new infection markers, C-reactive protein (CRP) is the most extensively studied acute phase reactant so far and the preferred index in many neonatal intensive care units (NICUs). The aim of the present study was to evaluate an affordable, non-commercial turbidimetric CRP assay for monitoring early-onset neonatal sepsis (EOS).MethodsA total of 148 neonates admitted at the NICU of the Hôpital Provincial Général de Référence de Bukavu to diagnose and to monitor EOS were enrolled in the study. CRP was assayed using a functional turbidimetric assay based on the interaction of CRP with phosphocholine containing particles (Intralipid®).ResultsIn total, 62/148 (41.9%) cases were identified as blood culture-proven EOS. Different serum CRP slopes were observed among the different birth weight categories. Moreover, the serum (CRP 48 h–CRP 12 h) difference and the birth weight predicted the outcome of these septic newborns.ConclusionsOur turbidimetric CRP assay is a potential novel tool that can be used in the management of EOS in sub-Saharan Africa. The simplicity of the assay and the extremely low price make the CRP method very well suited for developing countries.

scholarly journals 2-Day versus C-reactive protein guided antibiotherapy with levofloxacin in acute COPD exacerbation: A randomized controlled trial

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251716
Author(s):  
Msolli Mohamed Amine ◽  
Messous Selma ◽  
Sekma Adel ◽  
Bel haj ali Khaoula ◽  
Khalil Mohamed Hassene ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Interquartile Range ◽  
Secondary Outcome ◽  
Controlled Study ◽  
Cure Rate ◽  
C Reactive Protein ◽  
Icu Admission ◽  
Reactive Protein ◽  
Randomized Controlled ◽  
One Year

Introduction Duration of antibiotic treatment in acute exacerbation of COPD (AECOPD) is most commonly based on expert opinion. Biomarker guided strategy is increasingly recommended to limit unnecessary antibiotic use. We performed a randomized controlled study to evaluate the efficacy of 2-day versus C-reactive protein (CRP)-guided treatment with levofloxacin in patients with AECOPD. Methods Patients with AECOPD were randomized to receive oral levofloxacin daily for 7 days unless the serum CRP level decreased by at least 50% from the baseline value or levofloxacin for two days; thereafter, oral placebo tablet was prescribed according to the CRP. The primary outcome measure was cure rate, and secondary outcome included need for additional antibiotics, intensive care unit (ICU) admission, exacerbation rates and exacerbation free interval (EFI) within one-year follow-up. Results In intention to treat (ITT) analysis, cure rate was 76.1% (n = 118) and 79.3% (n = 123) respectively in 2-day and CRP-guided groups. In per protocol (PP) analysis, cure rate was 73% (n = 92) and 70.4% (n = 88) respectively in 2-day and CRP-guided groups. The difference between the two groups was not significant. The need for additional antibiotics and ICU admission rates were not significantly different between the two groups. One-year exacerbation rate was 27% (n = 42) in 2-day group versus 30.3% (n = 47) in CRP-guided group (p = 0.53); the EFI was 125 days (interquartile range, 100–151) versus 100 days (interquartile range, 78–123) in 2-day and CRP-guided groups respectively (p = 0.45). No difference in adverse effects was detected. Conclusion Levofloxacin once daily for 2 days had similar efficacy compared to CRP-guided in AECOPD. This short course treatment decreased antibiotic consumption which would improve patient compliance and reduce adverse effects.

scholarly journals C-reactive protein as a marker of infection in children with severe acute malnutrition in Khartoum state, Sudan

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Abdelmoneim E.M. Kheir ◽  
Balla G. Gebreel
Keyword(s):  
Severe Acute Malnutrition ◽  
Systemic Infection ◽  
Acute Phase Reactant ◽  
Study Data ◽  
Acute Malnutrition ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Presenting Symptoms ◽  
Severe Infections

Severe acute malnutrition and acute systemic infection are often synergistic in children and lead to considerable mortality. The main aim of this research was to determine whether children with severe acute malnutrition can mount an acute phase reactant response measured by C-reactive protein. This was a descriptive, cross-sectional, hospital-based study that was carried out in the five main children hospitals in Khartoum state, from November 1st, 2012 to March 1st, 2013. 132 children with severe acute malnutrition were included in the study. Data collection included history, examination and C-reactive protein measurement. The data were analyzed using Statistical Package for Social Sciences (SPSS) for descriptive and inferential statistics. The main results revealed that 93(70.5%) children between 12-23 months of age and most of them had marasmus. Diarrhoea was the commonest presenting symptoms in 86.4%, followed by fever and vomiting. Most of the children (82.6%) had positive C-reactive protein with variable levels. In conclusion malnourished children are able to synthesize C-reactive protein in response to an infectious process and the magnitude of this response is increased in those with severe infections.

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