scholarly journals Polycystic Ovarian Syndrome (PCOS), A Distress of Female Reproductive Health

2021 ◽  
Vol 8 (S1-Feb) ◽  
pp. 46-53
Author(s):  
Anuja Bhalerao ◽  
Ivan Aranha
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Environmental Pollutants ◽  
Clinical Manifestations ◽  
Reproductive Age ◽  
Sleep Cycle ◽  
Metabolic Disturbances ◽  
Hormonal Imbalance ◽  
Increased Risk ◽  
Xenobiotic Compounds ◽  
Ovarian Syndrome

Women of reproductive age are suffering from severe hormonal imbalance due to polycystic ovarian syndrome (PCOS).Clinical manifestations of PCOS are diverse including hyperandrogenism, anovulation, infertility and increased risk of metabolic diseases besides psychosocial dysfunction.Additionally, PCOS leads to various other disturbances such as glucose tolerance, cardiovascular disease, dyslipidemia, obesity and metabolic disturbances. Environmental pollutants and Xenobiotic compounds cause changes in gut microbiota, which further affects metabolism causing metabolic disturbances may lead to PCOS.Various metabolic anomalies resulting from interaction with xenobiotic compounds and environmental pollutants contribute for hormonal imbalance. It is an interlinked vicious circle affected by epigenetic and environmental parameters.Epigenetic approach and molecular analysis of genes involved in PCOS is essential for specific treatment.Biochemical markers like assessment of hormones(hyperandrogenism)and ultrasound (in patients above twenty years of age)used as diagnostic parameters for detection of PCOS. Adaptinga healthy lifestyle and minimal exposure to xenobiotic compounds and resetting the disturbed sleep cycle will benefit the patient. Study of molecular markers will help in treating the PCOS in a better manner. This review focuses on important parameters of pathophysiology, which will help in understanding andcreating awarenesson PCOS.

scholarly journals An Ayurvedic Approach in Management of Poly Cystic Ovarian Syndrome

2020 ◽  
Vol 11 (4) ◽  
pp. 644-649
Author(s):  
Saroj Kumari ◽  
Sarvesh Kumar Singh ◽  
Kshipra Rajoria ◽  
Avadhesh Kumar
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Dietary Habits ◽  
Reproductive Age ◽  
Herbal Drugs ◽  
Polycystic Ovaries ◽  
Female Population ◽  
Hormonal Imbalance ◽  
Hormonal Dysfunction ◽  
Cardinal Feature ◽  
Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is a probably fastest growing endocrinological disorder in females of reproductive age. In PCOS, follicular growth is influenced by hormonal imbalance during the ovarian cycle, leads to affected follicles remain in the ovary. The prevalence of PCOS is estimated 6-10% globally and 3.7% - 22.5% in Indian female population, which is relatively high. It is characterised by hyperandrogenism, anovulation and polycystic ovaries which clinically manifests in the terms of amenorrhea or oligomenorrhea, hirsutism, acne, infertility etc. In present scenario, incidence of this disease increasing exponentially due to sedentary lifestyle and faulty dietary habits. This particular disease is not described word to word in Ayurveda. Associated features of PCOS are closely resembling with Bandhya Yonivyapada, Artavavahasrotasa-Vidhha Lakshana, Nastartava and Ksheenaartava described by Acharya Sushruta and Pushpghani Jatharini and Vikuta Jatharini mentioned by Acharya Kashyap. Maximum congruence of PCOS can be established with Bandhya Yonivyapada. The purpose of this study is to understand Nastartava which is the cardinal feature of Bandhya. Word Artava has been used exclusively in Samhita in context of menstrual blood, ovum and ovarian hormones. Therefore Amenorrhea, anovulation, hormonal dysfunction is considered exposed manifestations of Nastartava. Possible line of treatment is stipulated with Nidanaparivarjan, herbal drugs and Panchakarma procedures. Keywords- Ayurveda, Artava, Nastartava, PCOS, Herbal drugs, Panchakarma

scholarly journals Pregnancy Complications in Women with PCOS

2019 ◽  
Vol 3 (5) ◽  
Keyword(s):  
Pregnancy Loss ◽  
Polycystic Ovarian Syndrome ◽  
First Trimester ◽  
Reproductive Age ◽  
Multiple Pregnancies ◽  
Proper Understanding ◽  
Life Styles ◽  
Reproductive Age Women ◽  
Increased Risk ◽  
Ovarian Syndrome

The Polycystic ovarian syndrome affects 6-15 % of reproductive age women worldwide. And recently the changing life styles and rising obesity worldwide have contributed to a rise in the incidence of PCOS. Though there are many issues with PCOS post conception. PCOS women are at increased risk of early pregnancy loss which is approx. three fold as compared to the women without PCOS. After successfully crossing the first trimester, they are at risk of developing pre- eclampsia, GDM, preterm birth and birth of small for gestational age infant. Also higher incidence of multiple pregnancies is there and the risks associated with them. All these leading to higher rate of c -section delivery. So, proper understanding of these risks, informing and counseling the patients regarding them facilitate closer maternal and fetal surveillance and help improving the outcome of pregnancy.

Studying Cytotoxic T-lymphocyte- Associated Antigen-4 (CTLA-4) gene Polymorphism in a Sample of Iraqi Women with Polycystic Ovarian Syndrome

2019 ◽  
pp. 1-6
Keyword(s):  
Gene Polymorphism ◽  
Polycystic Ovarian Syndrome ◽  
Cytotoxic T Lymphocyte ◽  
Reproductive Age ◽  
Amplification Refractory Mutation System ◽  
Low Grade ◽  
Metabolic Disturbances ◽  
Mutation System ◽  
Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) considers as the most common disorder among women during reproductive age. Its common features involve hyperandrogenism, chronic anovulation, and weight gain. Till now, the pathogenesis of PCOS stay unknown, and there is evidence considered PCOS as a low-grade inflammatory disease. Polycystic ovarian syndrome is associated with a variety of endocrine and metabolic disturbances. The present study was designed to detect the role of (CTLA-4) gene polymorphism (rs733618) with PCOS. A total of 60 PCOS patients and 30 healthy women, matching in average age and body mass index (BMI), were enrolled in this study. Patients with PCOS were attend to AL - Nahrain University High Institute for Infertility Assisted Reproductive Technology, in Baghdad between Septembers to December/2018. Blood samples were aspirated from both groups to detection (CTLA-4) gene polymorphism (rs733618) by tetra-primer amplification-refractory mutation system based on real time polymerase chain reaction (ARMS-qPCR). The obtained results revealed normal genotyping for both groups. The result of current study confirms that there is no role of (CTLA-4) gene polymorphism (rs 733618) in PCOS.

scholarly journals An attempt to understand the concept of PCOS w. s. r. to artavavaha sroto dusti

2018 ◽  
Vol 6 (04) ◽  
Author(s):  
Dharmaraj Nagorao Lone ◽  
Chitra Gawande ◽  
Pratibha Kulkarni ◽  
Nagorao Dattarao Lone
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovarian Syndrome ◽  
Modern Medicine ◽  
The Body ◽  
Reproductive Age ◽  
Fallopian Tubes ◽  
Women Of Reproductive Age ◽  
Androgen Excess ◽  
Hormonal Imbalance ◽  
Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is the most common endocrine ovarian disorder affecting 5 to 10% women of reproductive age. It is also known as stein- laventhal syndrome or hyper androgenic Anovulation. The main primary character of PCOS is irregular menstrual cycle which leads to improper ovulation. Exact pathogenesis of PCOS is not understood clearly, it may be discussed under following headings: Abnormality of Hypothalamic-pituitary compartment (Hormonal imbalance), androgen excess, anovulation, obesity and insulin resistance etc. Srotas are the circulatory channels through which Dosha’s, Dhatu’s and Mala’s moves from one part to another part of the body. Each srotas has srotomoola, srotomarga and srotomukha. The moolasthana of artavavaha srotas are garbhashaya(uterus) and artavavahi dhamani’s(uterine & ovarian arteries). Artavavaha srotas may be categorized into Shonita artavavaha srotas which carries menstrual blood through blood vessels and capillaries of the uterus & Beejartavavaha srotas which carries ovum through fallopian tubes. Abnormality of Artavavaha srotas causes Vandhyatva, Maithuna Asahishnuta and Artavanasha. Vandhyatva caused due to abnormality in chaturvidha garbhottpadaka(rutu, kshetra, ambu and beeja) samagri. Maithuna Asahishnuta related to vatala, paripluta, vipluta and shandi yoniyapada, while Artavanasha related to Vandhya, Arajaska and shushka yonivyapada. All these symptoms like Vandhyatva, Maithuna Asahishnuta and Artavanasha are correlated with common symptoms of PCOS which include Infertility, Dyspareunia & Amenorrhoea respectively. As there is no curative treatment available in modern medicine, understanding of PCOS with reference to Artavavaha sroto dusti may be a ray of hope to treat PCOS with Ayurvedic remedies. KEY WORDS: Artava, Srotas, PCOS, Vandhyatva, Yonivyapada.

scholarly journals “Polycystic Ovarian Syndrome Benefitted by Yoga.”

2020 ◽  
Vol 8 (04) ◽  
Author(s):  
Gayatri Patil
Keyword(s):  
Weight Reduction ◽  
Polycystic Ovarian Syndrome ◽  
Therapeutic Potential ◽  
Reproductive Age ◽  
Lifestyle Modifications ◽  
Hormonal Imbalance ◽  
Dietary Regime ◽  
Ovarian Syndrome

Now a days PCOS is one of the commonest problems of reproductive age caused by hormonal imbalance. Aims and Objects: To Study PCOS. To assess the effectiveness of Yoga in management of PCOS. To highlight the key messages. Conclusion : Weight reduction is main preventive and therapeutic potential to combat with this. It can be achieved by incorporating lifestyle modifications. Ayurveda dietary regime the wholesome food (Pathya Ahar) and Yoga interventions mentioned in Ayurveda literature are main key  

scholarly journals Prevalence and symptomatology of polycystic ovarian syndrome in Indian women: is there a rising incidence?

2017 ◽  
Vol 6 (11) ◽  
pp. 4971 ◽  
Author(s):  
Anjali Choudhary ◽  
Shweta Jain ◽  
Priyanka Chaudhari
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Age Group ◽  
Metabolic Disturbances ◽  
Cross Sectional ◽  
Irregular Menses ◽  
Study Population ◽  
Ovarian Syndrome ◽  
Reproductive Age Group

Background: Polycystic ovarian syndrome [PCOS] is a complex ill understood hormonal disorder resulting in myriads of symptoms like irregular menses, hyperandrogenism, metabolic disturbances and infertility. It occurs in about 8-11% of reproductive age group women. Recently changing lifestyles and rising obesity worldwide have contributed to rise in the incidence of PCOS. Objective of the present is to study the prevalence and symptomatology of PCOS in Indian women.Methods: 170 women in reproductive age group, with irregular menstrual cycles attending OPD, voluntarily participated in a cross sectional study. All were subjected to detailed history, examination and investigated with a battery of lab tests to confirm PCOS. Out of 170 women investigated 70 women with features of PCOS were included in the study (diagnosed as PCOS by NIH criteria).Results: The overall prevalence of PCOS in the study population was, 41%. It was 16% in married women and 24 % in unmarried girls. Common menstrual irregularity was-oligomenorrhea (40%), Menorrhagia (12.8%) amenorrhea (11%). Common symptoms were hirsutism, acne, infertility and alopecia.Conclusions: PCOS is rising in young women and to some extent the changing lifestyle in urban women may be linked to it. There in a world-wide increase in the incidence of obesity, diabetes mellitus and metabolic syndrome, PCOS and its accompanying insulin resistance is contributing to it. Treating PCOS and its complications is adding to health care burden.

scholarly journals Prevalence of polycystic ovarian syndrome among selected group of Sudanese housewives with infertility disorders

2019 ◽  
Vol 2 (01) ◽  
Author(s):  
Mohammed A.Gafoor A.Gadir ◽  
Mohammed Omer Mohammed Hussein ◽  
Mosab Nouraldein Mohammed Hamad
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Clinical Symptoms ◽  
Polycystic Ovary ◽  
Pancreatic Beta Cell ◽  
Reproductive Age ◽  
Ovary Syndrome ◽  
Cell Dysfunction ◽  
Increased Risk ◽  
Ovarian Syndrome

Polycystic ovary syndrome (PCOS), also recognized as the Stein-Leventhal syndrome, is one of the most widespread endocrinopathies between women of reproductive age. Hyperinsulinemia in mixture with pancreatic beta cell dysfunction consequences in an increased risk of numerous illnesses, counting type 2 diabetes, hypertension, dyslipidemia, endothelial dysfunction, atherosclerosis and cardiovascular diseases. Insulin also stimulates the theca cells of the ovary to create excessive testosterone, which is accountable for the clinical symptoms of hyperandrogenism

scholarly journals Effect of Knowledge Intervention on Polycystic Ovarian Syndrome among the Students of PJTSAU

2020 ◽  
pp. 75-83
Author(s):  
K. Santhi Sirisha ◽  
R. Geetha Reddy ◽  
T. V. Hymavathi
Keyword(s):  
Polycystic Ovarian Syndrome ◽  
Clinical Manifestations ◽  
Total Sample ◽  
Educational Programme ◽  
Reproductive Age ◽  
Knowledge Level ◽  
Intervention Programme ◽  
Post Test ◽  
Community Science ◽  
Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is one of the most common reproductive endocrinological disorders with a broad spectrum of clinical manifestations affecting about 6-8% women of reproductive age. Many adolescent girls and women lack knowledge of Polycystic ovarian syndrome. The present study was designed so as to evaluate the knowledge of sixty undergraduate girl students from College of Community Science, Saifabad, Hyderabad, PJTSAU before and after the intervention programme on Polycystic ovarian syndrome. Knowledge assessment schedule developed by Kalpana, [1] was used with modifications as a data collection tool. High levels of knowledge was observed to be on basic terminology and definitions (31.6%),  pathophysiology of the disease (16.6%), complications of Polycystic ovarian syndrome (21.6%),  and management of Polycystic ovarian syndrome (26.6%) before the educational programme. An educational programme was provided as intervention to improve the students’ knowledge level regarding Polycystic ovarian syndrome. Then, a post test was conducted to measure the effectiveness of the intervention. The knowledge level of 83.3%, 68.3%, 75% and 83.3% of the total sample was found to be high on basic terminology and definitions, pathophysiology, complications and management of Polycystic ovarian syndrome respectively. Mean scores of the post-test were significantly higher compared to their values at pre-test (p<0.001). Thus the results prove that the knowledge intervention in the form of educational programme is effective in enhancing the knowledge of the students.

scholarly journals Diagonostic parameters of polycystic ovarian syndrome in outpatient setting

2021 ◽  
Vol 53 (1-2) ◽  
pp. 17-22
Author(s):  
Zannatul Ferdous Jesmin ◽  
Eti Saha ◽  
Farjana Yasmin ◽  
Anjuman Ara ◽  
SM Khaliduzmnan
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Syndrome ◽  
Polycystic Ovarian Syndrome ◽  
Clinical Manifestations ◽  
Reproductive Age ◽  
Clinical Feature ◽  
Cross Sectional ◽  
Total Study Population ◽  
Cystic Ovary ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is one of the most common endocrinopathy in reproductive age women. PCOS has complex etiopathology, diverse clinical presentation and diagnostic criteria. Objective: Objective of this study was to find out the determinant clinical feature and investigations for improving diagnostic accuracy and assessment of PCOS, thereby evolving opportunity for proper treatment. Methods: This prospective cross sectional observational study was conducted in Islami Bank hospital, Khulna, from January 2017 to February 2020. Women seeking gynecological consultation in outdoor with at least one complaint of oligomenorrhoea, hirsutism, weight gain or infertility were enrolled for study. Subjects were selected on the basis of inclusion and exclusion criteria. A structured proforma, based on relevant history, laboratory work up, risk factors and co morbidities were prepared before-hand. Diagnosis of PCOS was based on Rotterdam criteria, 2003. The clinical manifestations of PCOS, frequency of different sub phenotypes and associated morbidities were measured as outcome. Results: Total study population was 202. Age of subjects were in between 13- 37 years. Thirty seven (18%) were adolescent, one hundred forty (65.7%) patients were overweight and obese. Majority of cases were married. Complaint of infertility was present in 125 (61.9%) cases. Oligomenorrhoea, hirsutism, poly cystic ovary was present in 145 (71.8%), 137 (67%), and 130 (64.4%) patients respectively. LH/FSH ratio >2 in 45 (22.3%) cases, Serum free testosterone >0.79 ngm/ml were associated with hirsutism. PCOS with clinical sub phenotypes A, B, C, and D were 38(18.9%), 72 (35.6%), 27 (13.4%) and 65 (32.2%) cases respectively. Case morbidities were Hypertension 75 (37.1%), Diabetes mellitus 18 (8.9%) and Metabolic syndrome 44 (20.1%). Link with Hypothyroidism Hyperprolactinemia were identified in 47 (19%) cases. Conclusion: Oligo-anovulatory woman with hyperandrogenism with or without poly cystic ovary were diagnosed as a largest group of PCOS-A and B sub phenotypes. Infertility, hypothyroidism, hypertension, diabetes mellitus, metabolic syndrome and endometerial hyperplasia were common. Bang Med J Khulna 2020: 53 : 17-22

scholarly journals Usefulness of Anti-Müllerian Hormone in Polycystic Ovarian Syndrome in Infertile Women

2019 ◽  
Vol 14 (1) ◽  
pp. 40-43
Author(s):  
Hima Rijal
Keyword(s):  
Menstrual Cycle ◽  
Polycystic Ovarian Syndrome ◽  
Transvaginal Ultrasound ◽  
Clinical Manifestations ◽  
Serum Marker ◽  
Mean Value ◽  
Reproductive Age ◽  
University Teaching ◽  
Polycystic Ovaries ◽  
Ovarian Syndrome

Aims: To correlate the AMH level with various clinical and biochemical parameters in patients presenting to infertility clinic with diagnosis of PCOS. Methods: This is a hospital based prospective study carried out in the Department of Obstetrics and Gynecology, Tribhuvan University Teaching Hospital from January 2018 to December 2018. Women of reproductive age (21– 35 years) who presented to infertility clinic were recruited for study after taking informed consent. PCOS patients were selected by the Rotterdam criteria. Data regarding menstrual history, clinical manifestations of hyperandrogenism, transvaginal ultrasound (TVS) assessments for ovarian follicles, and the levels of AMH, LH, FSH, testosterone and Estradiol were collected. Blood sampling for hormone measurement (LH, FSH, Testosterone, Estradiol) was performed in the second day of menstrual cycle. Serum AMH was measured in any day of menstrual cycle. TVS was performed for morphology of ovaries during follicular phase. Results: There were 54 patients with PCOS based on Rotterdem criteria. The mean age was 26.6±3.7 year (range=20-35). Among the study population 42 patients (78%) had primary infertility.  High AMH with bilateral polycystic ovaries was in 32(59.2%), bilateral PCO with normal AMH was in 13(24%), unilateral polycystic ovaries with high AMH was in 2(3.7%). AMH mean value was 9.8±4.1 ng/ml (range=2.8-19.8), high in 40 women (74%) and normal in 14 women (26%). Conclusions: Serum AMH can be a useful serum marker of PCOS and it correlates with the clinical and biochemical abnormalities in women with PCOS. Keywords:  anti mullarian hormone, infertility, hyperandrogenism, polycystic ovarian syndrome

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