scholarly journals Using least angular regression to model the antibacterial potential of metronidazole complexes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Tahir Mehmood ◽  
Mudassir Iqbal ◽  
Bushra Rafique
Keyword(s):  
Antibacterial Activity ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Mean Square ◽  
E Coli ◽  
Asymmetric Least Squares ◽  
Selection Operators ◽  
Antitumor Properties ◽  
Antibacterial Medication ◽  
Antibacterial Potential

AbstractImidazole has anti-inflammatory, antituberculotic, antimicrobial, antimycotic, antiviral, and antitumor properties in the human body, to name a few. Metronidazole [1-(2-Hydroxyethyl)-2-methyl-5-nitroimidazole] is a widely used antiprotozoan and antibacterial medication. Using fourier transform infrared spectroscopy, the current study models the antibacterial activity of already synthesised Metronidazole (MTZ) complexes ($$MTZ-Benz$$ M T Z - B e n z , $$MTZ-Benz-Cu$$ M T Z - B e n z - C u , $$MTZ-Benz-Cu-Cl_2CHCOOH$$ M T Z - B e n z - C u - C l 2 C H C O O H , $$MTZ$$ MTZ , $$MTZ-Cu$$ M T Z - C u , $$MTZ-Cu-Cl_2CHCOOH$$ M T Z - C u - C l 2 C H C O O H , $$MTZ-Benz-Ag$$ M T Z - B e n z - A g , $$MTZ-Benz-Ag-Cl_2CHCOOH$$ M T Z - B e n z - A g - C l 2 C H C O O H , $$MTZ-Ag$$ M T Z - A g and $$MTZ-Ag-Cl_2CHCOOH$$ M T Z - A g - C l 2 C H C O O H ) against E. coli, B. bronceptica, S. epidermidis, B. pumilus and S. aureus. To characterise the Metronidazole complexes for antibacterial activity against 05 microbes, the least angular regression and least absolute shrinkage selection operators were used. Asymmetric Least Squares was used to correct the spectrum baseline. Least angular regression outperforms cross-validated root mean square error in the fitted models. Using Least angular regression, influential wavelengths that explain the variation in antibacterial activity of Metronidazole complexes were identified and mapped against functional groups.

In vitro study of antimicrobial and cell viability on newly synthesized bioglass-based bone grafts: Effects of selenium and silver additions

2018 ◽  
Vol 232 (10) ◽  
pp. 1039-1047
Author(s):  
B Aksakal ◽  
M Demirel
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Antibacterial Activity ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Cell Viability ◽  
Fourier Transform Infrared Spectroscopy ◽  
Fourier Transform Infrared ◽  
E Coli ◽  
Scanning Electron

Selenium (Se)- and Silver (Ag)-doped Bioglass®-based biografts were synthesized using the sol–gel method. Fourier-transform infrared spectroscopy, inductively coupled plasma mass spectrometry, scanning electron microscopy and energy-dispersive X-ray analyses were carried out in order to examine mechanostructure of synthesized bioglass-based bioceramics. The effects of Se and Ag additions on cell viability were investigated via cytotoxicity and antibacterial activity analysis, respectively. The bacteria of Escherichia coli ( E. coli, JM103) and Gram-positive Staphylococcus aureus ( S. aureus, ATCC29293) were used to perform the antibacterial tests. Moreover, cell viability studies were conducted using the Saos-2 osteoblast cells by performing dimethylthiazol diphenyltetrazolium bromide assay. It was observed that while (PO4)3− and (CO3)2− peaks were observed in Fourier-transform infrared spectroscopy analyses, crystallinity also increased with increasing amount of AgNO3 addition into the Bioglass®. In addition, it was determined from scanning electron microscopy images that small irregular thin lamellar grain distribution was formed in synthesized B45Ag5Se20 and B30Ag10Se15 biografts. From antibacterial activity tests, it was determined that while some grafts was affected by E. coli, which is a Gram-negative, however, some did not affect the Gram-positive S. aureus and had antimicrobial activity on E. coli and S. aureus. According to the cell viability tests, it was found that the synthesized grafts did not have toxic effect on living cells. While the cell growth was greater for some grafts, however, some others had lower growth.

APPLICATIONS OF CHITOSAN-SULFATHIAZOLE AS ANTIMICROBIAL AGENT

2018 ◽  
Vol 28 (2) ◽  
pp. 429-432
Author(s):  
Dilyana Zvezdova
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Antimicrobial Agent ◽  
Defense Mechanisms ◽  
Solvent Casting ◽  
Casting Method ◽  
Gram Negative ◽  
Positively Charged

Chitosan, a hydrophilic biopolymer industrially obtained by N-deacetylation of chitin, can be applied as an antimicrobial agent. It highlights the applications of chitosan as an antimicrobial agent against fungi, bacteria, and viruses and as an elicitor of plant defense mechanisms. A series of novel chitosan-sulfathiazole nanocomposite (CSFZ) films were prepared by using solvent casting method for wound healing application. Fourier transform infrared spectroscopy (FTIR) was employed to ascertain the interaction between negatively charged sulfathiazole and positively charged chitosan. Moreover, the antibacterial activity of the films was investigated against gram positive and gram negative microorganisms. It was found that all CSFZ films showed good inhibitory activity against all the tested bacteria as compared to control. The above analysis suggested that the CSFZ films could be used as potential candidates for wound healing application.

Detecting antimicrobial resistance in Escherichia coli using benchtop attenuated total reflectance-Fourier transform infrared spectroscopy and machine learning

The Analyst ◽  
2021 ◽  
Vol 146 (20) ◽  
pp. 6211-6219
Author(s):  
Hewa G. S. Wijesinghe ◽  
Dominic J. Hare ◽  
Ahmed Mohamed ◽  
Alok K. Shah ◽  
Patrick N. A. Harris ◽  
...  
Keyword(s):  
Machine Learning ◽  
Escherichia Coli ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Antimicrobial Resistance ◽  
Fourier Transform Infrared Spectroscopy ◽  
Attenuated Total Reflectance ◽  
Total Reflectance ◽  
E Coli ◽  
Machine Learning Model

ATR–FTIR with a machine learning model predicts ESBL genotype of unknown E. coli strains with 86.5% AUC.

scholarly journals Synthesis of different α, β- unsaturated oxazolone derivatives

2019 ◽  
Vol 9 (1) ◽  
pp. 124-127
Author(s):  
Pallavi L Phalke
Keyword(s):  
Antibacterial Activity ◽  
Infrared Spectroscopy ◽  
Melting Point ◽  
Acetic Anhydride ◽  
Thin Layer ◽  
Sodium Acetate ◽  
E Coli ◽  
Nucleophilic Reagents ◽  
Formed Product ◽  
Layer Chromatography

Acetyl glycine were prepared from glycine acetic anhydride and then 2, 4-disubstituted Oxazol-5-one were prepared from acetyl glycine, substituted aldehydes, acetic anhydride, and sodium acetate as a catalyst. The formed product is evaluated and characterized by thin layer chromatography, infrared spectroscopy and melting point. The, β- unsaturated shows ability to react with various nucleophilic reagents for synthesis of new fused oxazole compounds. Keywords: glycine, acetic anhydride, aldehyde Sodium acetate, Oxazolone, E. coli, Antibacterial Activity.

scholarly journals Antibacterial activity and effects of aromatic derivatives on denture base polymerization.

2019 ◽  
Vol S (1) ◽  
pp. 24-27
Author(s):  
Ammar AG. Alhamdani ◽  
◽  
Arjwan M. Shuker ◽  
Inas A. Jawad ◽  
◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Oral Cavity ◽  
Polymerization Process ◽  
Negative Effects ◽  
Denture Base ◽  
Plant Extraction ◽  
Methacrylate Monomer ◽  
Methyl Methacrylate Monomer

This study assessed the effect of copolymerization on the microbiota of the oral cavity. The plant extraction was converted into aromatic derivatives, which were added to methyl methacrylate monomer. Fourier transform infrared spectroscopy spectra showed no negative effects of these additives on the polymerization process. All the assayed derivatives displayed some degree of antibacterial activity.

Antibacterial Activities of Biosynthesized ZnO Nanoparticles Using Leaf and Fruit Extracts of Neolamarckia cadamba

2021 ◽  
Vol 21 (12) ◽  
pp. 6168-6182
Author(s):  
Saee Gharpure ◽  
Rachana Yadwade ◽  
Shuana Mehmood ◽  
Balaprasad Ankamwar
Keyword(s):  
Antibacterial Activity ◽  
Zno Nanoparticles ◽  
Leaf Extract ◽  
Antibacterial Properties ◽  
Fruit Extract ◽  
E Coli ◽  
Fruit Extracts ◽  
Before And After ◽  
Micro Organisms ◽  
Antibacterial Potential

Zinc oxide nanoparticles have been biosynthesized with the help of Neolamarckia cadamba leaf and fruit extracts. ZnO nanoparticles were tested for antibacterial activity before and after calcination against Gram positive (Staphylococcus aureus, Bacillus subtilis) as well as Gram negative micro-organisms (Escherichia coli, Pseudomonas aeruginosa) within the concentration range 0.625–10 mg/mL with the help of well diffusion technique. Higher antibacterial potential has been observed in ZnO nanoparticles synthesized using leaf extract in comparison with those synthesized using fruit extract. Increased antibacterial activity was observed before calcination as compared to after calcination. ZnO synthesized using leaf extract were observed to show significant antibacterial potential against E. coli, S. aureus along with P. aeruginosa before calcination as well as against E. coli after calcination. Similarly, ZnO nanoparticles synthesized using fruit extract exhibited antibacterial activity against E. coli and P. aeruginosa before calcination and against E. coli after calcination. Both the ZnO nanoparticles before and after calcination did not show any antibacterial activity against B. subtilis. Thus, ZnO nanoparticles can serve a dual purpose by its application as an antibacterial agent against susceptible micro-organisms as well as biocompatible carrier system for drug delivery applications in case of non-antibacterial properties by virtue of its inertness as well as easy disposal.

scholarly journals Study on Europium-Doped Hydroxyapatite Nanoparticles by Fourier Transform Infrared Spectroscopy and Their Antimicrobial Properties

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Simona-Liliana Iconaru ◽  
Mikael Motelica-Heino ◽  
Daniela Predoi
Keyword(s):  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Fourier Transform Infrared Spectroscopy ◽  
Antimicrobial Properties ◽  
Fourier Transform Infrared ◽  
Nanocrystalline Powders ◽  
E Coli ◽  
Antimicrobial Studies ◽  
Ft Ir ◽  
First Time

Fourier transform infrared spectroscopy (FT-IR) analysis was conducted on europium-doped hydroxyapatite,Ca10-xEux(PO4)6(OH)2nanocrystalline powders (Eu:HAp) with0≤xEu≤0.2. Antimicrobial studies were also performed for the first time on Eu:HAp. The antimicrobial properties of Eu:HAp nanoparticles with0≤xEu≤0.2on Gram-negative (E. coli ATCC 25922,Pseudomonas aeruginosa 1397) and Gram-positive (Staphylococcus aureus 0364,Enterococcus faecalis ATCC 29212) bacteria systems and a species of fungus (Candida albicans ATCC 10231) were reported. Our study demonstrates that the antimicrobial activity of Eu:HAp nanoparticles is dependent on the europium concentration.

scholarly journals PYRAZOLINE SYNTHESIS THROUGH A CHALCONE INTERMEDIATE

2018 ◽  
Vol 2 (4) ◽  
pp. 59-62
Author(s):  
Md Hedaitullah ◽  
Ramanpreet Walia ◽  
Iqbal Khalid ◽  
Balwan Singh ◽  
Asif Hussain
Keyword(s):  
Antibacterial Activity ◽  
Staphylococcus Epidermidis ◽  
Drug Research ◽  
Diffusion Method ◽  
Gram Negative Bacteria ◽  
Pharmacological Activities ◽  
Gram Positive ◽  
E Coli ◽  
Gram Positive Bacteria ◽  
Antibacterial Potential

Pyrazoline derivatives, being used as potential medicinal agents, possess many important pharmacological activities and therefore they are useful materials in drug research. A series of these derivatives HT- 1 to HT- 6 containing  5-4-(chlorophenyl)-1,3-diphenyl- 4,5-dihydro-1H-pyrazole derivatives were synthesized, structures were confirmed using melting point, IR, NMR and MS and evaluated for their antibacterial activity using disc diffusion method at concentration 2mg/ml. The reference used was Amikacin and mostly, all synthesized compounds exhibited a significant antibacterial activity against Staphylococcus aureus (MTCC No. 96) as Gram positive bacteria, Staphylococcus epidermidis(MTCC No. 435) as Gram positive and Escherichia coli (MTCC No. 739) as Gram negative bacteria. It was observed that HT-1 and HT-2 possess good antibacterial potential against S. aureus, HT- 5 against S.epidermidis and HT-1 and HT-4against E. coli.

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