scholarly journals CLINICAL PROFILE OF COVID-19 PATIENTS ADMITTED IN A TERTIARY CARE COVID HOSPITAL-AN OBSERVATIONAL STUDY

2020 ◽  
pp. 15-16
Author(s):  
S. Durga Prasad ◽  
K.V. Seshaiah ◽  
K.S.S.S.Surya Prakash ◽  
N. Lavanya ◽  
Ch.Akhil Reddy ◽  
...  
Keyword(s):  
Observational Study ◽  
Viral Infections ◽  
Clinical Symptoms ◽  
Severe Disease ◽  
Tertiary Care ◽  
Care Hospital ◽  
Cross Sectional ◽  
Multiple Systems ◽  
Mild Disease ◽  
System Methodology

BACKGROUND: Since the origin of Covid-19, a plethora of symptoms have been described in the past few months, which indicate involvement of multiple systems with much more impact on the respiratory system. METHODOLOGY: We retrospectively evaluated from the medical records of 100 Covid-19 patients diagnosed with RT-PCR. It was a cross-sectional observational study of Covid-19 patients admitted in our tertiary COVID care hospital, Vijayawada, Andhra Pradesh during the period of two months i.e.,01-04-2020 to 31-05-2020. RESULTS: We observed the different clinical symptoms with varying frequency in Covid-19 patients. In our study the clinical symptoms in the descending order of frequency were fever (59%), cough (48%), diarrhoea (6%), dyspnoea (4%), running nose (3%), headache (3%), chest pain (1%). These symptoms are not specific to covid-19 but similar to those found in other viral infections. CONCLUSION: Based on clinical picture, disease has been classified as mild, moderate and severe. More than 80% patients have mild disease and will recover.14% will have severe disease and 5% will progress to respiratory failure, shock and multiorgan dysfunction.1-2% are fatal.

scholarly journals Serum β2-microglobulin levels in Coronavirus disease 2019 (Covid-19): Another prognosticator of disease severity?

PLoS ONE ◽  
2021 ◽  
Vol 16 (3) ◽  
pp. e0247758
Author(s):  
Walter Conca ◽  
Mayyadah Alabdely ◽  
Faisal Albaiz ◽  
Michael Warren Foster ◽  
Maha Alamri ◽  
...  
Keyword(s):  
Disease Severity ◽  
Viral Infections ◽  
Linear Trend ◽  
Severe Disease ◽  
Tertiary Care ◽  
Care Hospital ◽  
Mhc I ◽  
Mild Disease ◽  
Moderate Disease ◽  
Single Center Study

β2-microglobulin (β2-m), a 11.8 kDa protein, pairs non-covalently with the α3 domain of the major histocompatibility class (MHC) I α-chain and is essential for the conformation of the MHC class I protein complex. Shed β2-m is measurable in circulation, and various disorders are accompanied by increases in β2-m levels, including several viral infections. Therefore, we explored whether β2-m levels could also be elevated in Coronavirus disease 2019 (Covid-19) and whether they predict disease severity. Serum β2-m levels were measured in a cohort of 34 patients infected with SARS-CoV-2 on admission to a tertiary care hospital in Riyadh, Saudi Arabia, as well as in an approximately age-sex matched group of 34 uninfected controls. Mean β2-m level was 3.25±1.68 mg/l (reference range 0.8–2.2 mg/l) in patients (mean age 48.2±21.6) and 1.98±0.61 mg/l in controls (mean age 48.2±21.6). 17 patients (mean age 36.9± 18.0) with mean β2-m levels of 2.27±0.64 mg/l had mild disease by WHO severity categorization, 12 patients (mean age 53.3±18.1) with mean β2-m levels of 3.57±1.39 mg/l had moderate disease, and five patients (of whom 2 died; mean age 74.4±13.8) with mean β2-m levels of 5.85±1.85 mg/l had severe disease (P < = 0.001, by ANOVA test for linear trend). In multivariate ordinal regression β2-m levels were the only significant predictor of disease severity. Our findings suggest that higher β2-m levels could be an early indicator of severity of disease and predict outcome of Covid-19. As the main limitations of the study are a single-center study, sample size and ethnicity, these results need confirmation in larger cohorts outside the Arabian Peninsula in order to delineate the value of β2-m measurements. The role of β2-m in the etiology and pathogenesis of severe Covid-19 remains to be elucidated.

scholarly journals Use of monoclonal antibody therapy for nosocomial SARS-CoV-2 infection in patients at high risk for severe COVID-19: experience from a tertiary-care hospital in Germany

Infection ◽  
2021 ◽  
Author(s):  
Johanna Koehler ◽  
Barbara Ritzer ◽  
Simon Weidlich ◽  
Friedemann Gebhardt ◽  
Chlodwig Kirchhoff ◽  
...  
Keyword(s):  
High Risk ◽  
Tertiary Care Hospital ◽  
Severe Disease ◽  
Treatment Options ◽  
Tertiary Care ◽  
Antibody Therapy ◽  
Additional Treatment ◽  
Care Hospital ◽  
Cross Sectional ◽  
Asymptomatic Patients

AbstractAdditional treatment options for coronavirus disease (COVID-19) are urgently needed, particularly for populations at high risk of severe disease. This cross-sectional, retrospective study characterized the outcomes of 43 patients with nosocomial severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection with and without treatment using monoclonal SARS-CoV-2 spike antibodies (bamlanivimab or casirivimab/imdevimab). Our results indicate that treatment with monoclonal antibodies results in a significant decrease in disease progression and mortality when used for asymptomatic patients with early SARS-CoV-2 infection.

scholarly journals Role of platelet distribution width and plateletcrit in assessment of nonthrombocytopenic preeclampsia and eclampsia in a tertiary care hospital of Odisha: an observational study

2020 ◽  
Vol 9 (5) ◽  
pp. 1996
Author(s):  
Kirtirekha Mohapatra ◽  
Pranati Mohanty ◽  
Nahida Nigar Sultana
Keyword(s):  
Platelet Count ◽  
Observational Study ◽  
Severe Disease ◽  
Tertiary Care ◽  
Measurement Tool ◽  
Care Hospital ◽  
Platelet Distribution Width ◽  
Distribution Width ◽  
Platelet Indices

Background: Preeclampsia (PE) is a major cause of maternal and foetal morbidity and mortality in pregnancy. A decreased platelet count is observed during the progression of preeclampsia, and is considered a marker of the severity of preeclampsia. Considering the role of the PDW, PCT and platelet indices during the disease, the aim of this study was to evaluate the feasibility of using platelet indices as a severity marker for PE.Methods: This was a prospective, observational study, hospital-based study, from 2017-19 with 400 pregnant women being included on the basis of a predefined inclusion and exclusion criteria, through antenatal clinic, and labour room of the department of obstetrics and gynecology, S. C. B. Medical College, Cuttack, Odisha, India.Results: Study found that platelet count and plateletcrit showed a significant negative correlation with MAP whereas platelet distribution width showed a maximum positive correlation. In the preeclampsia group, subjects with PCT <0.22% were at risk of developing severe disease with a sensitivity of 53.5% and a high specificity of 85.5%. The AUC of 0.75 showed that it has a good predictability. In the eclampsia group, subjects with PCT <0.16% had a risk of developing severe disease with a sensitivity of 89.5% and specificity of 73.7%. The AUC 0.9 shows PCT to be a good predictor for assessing severity of eclampsia.Conclusions: This study suggests that platelet distribution width and plateletcrit are useful in risk evaluation of preeclampsia. These are a valid measurement tool to predict the severe progression of PE even when normal platelet counts are observed.

scholarly journals Estimation of Serum Copper in Post-menopausal Women Attending in a Tertiary Care Hospital, Bangladesh

2019 ◽  
Vol 10 (2) ◽  
pp. 110-113
Author(s):  
N Ferdous ◽  
Farzana Akonjee Mishu ◽  
Shamsunnahar ◽  
Syed Md Tanjilul Haque ◽  
ANM Ashikur Rahman Khan ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Tertiary Care ◽  
Premenopausal Women ◽  
Serum Copper ◽  
Copper Level ◽  
Care Hospital ◽  
College Hospital ◽  
Cross Sectional ◽  
Medical College ◽  
Significant Difference

Background: Nutritional needs change throughout the various stages of life. While overall caloric needs tend to decrease with age, the requirements for individual micronutrients do not decrease. In fact, the needs for some micronutrients actually increase with age. The risk of nutritional disturbances mainly trace elements deficiencies is high during postmenopause causing or intensifying serious clinical symptoms. Methods: This cross sectional study was carried out in the Department of Biochemistry, Mymensingh Medical College in collaboration with the Department of Obstetrics and Gynecology, Mymensingh Medical College Hospital during the period from July 2013 to June 2014. A total of 100 subjects were included in this study. Among them 50 apperantly healthy postmenopausal women (Case) aged between 45-60 years were considered as case and another 50 regular menstruating premenopausal women(Control) aged between 30-40 years were selected as control. Results: The mean age of cases and control groups was 50.5±2.3 years and 36.5±4.4 years respectively. In this study we found Serum Copper levels in cases and controls were 115.36±8.836 µg /dl and 90.58 ±6.315 µg/dl respectively had (p< 0.01) significant difference. Conclusion: Serum Copper level was significantly increased in postmenopausal group in comparison to premenopausal women (p< 0.01). Estimation of serum Cu level might be incorporated in every postmenopausal woman for prevention of complications. Anwer Khan Modern Medical College Journal Vol. 10, No. 2: July 2019, P 110-113

scholarly journals Drug utilization of antibiotics in post-operative cesarean section inpatients in tertiary care hospital: a prospective observational study

2020 ◽  
Vol 9 (6) ◽  
pp. 859
Author(s):  
Srinivasa B. ◽  
Basavaraj C. Kotinatot
Keyword(s):  
Caesarean Section ◽  
Observational Study ◽  
Prospective Observational Study ◽  
Tertiary Care ◽  
Essential Medicines ◽  
Care Hospital ◽  
Cross Sectional ◽  
Institutional Ethics ◽  
National Model ◽  
Rational Use Of Antibiotics

Background: The aim of this study is to evaluate the pattern and rational use of antibiotics in post-operative caesarean section (CS) inpatients in tertiary care teaching hospital, BIMS Belagavi.Methods: This cross sectional prospective observational study was conducted from December 2019 to February 2020, prior permission from institutional ethics committee was taken. Detailed data of post-operative caesarean section (CS) inpatients including age, diagnosis, line of management, complications and any adverse effects if occurred during the study was collected and entered in a specially designed proforma and MS word excel and analyzed by descriptive statistics like percentage.Results: Total 100 post-operative caesarean section inpatients were involved in the study. Most common indication for C-section was cephalopelvic disproportion. Average no of antibiotics per prescription was 3.32. Most commonly prescribed antibiotic was cefotaxime (27.71%) followed by gentamycin (25.90%) and metronidazole (24.59%). Majority (90%) of patients who admitted for ≤3 days (66%) had received combination antibiotic i.e., cefotaxime, metronidazole and gentamycin. IV fluids (21.21%) and analgesics (13.13%) were most frequently prescribed concomitant drugs. Majority (97.8%) of patients received parenteral preparation. 306 antibiotics (92.17%) used were from national model list of essential medicines (NLEM) and 332 antibiotics (100%). used were by generic name. Polypharmacy was 7.92.Conclusions: Cefotaxime was the most frequently prescribed antibiotic. Most of the antibiotics prescribed was rationally from NLEM and were by generic name.

scholarly journals A cross-sectional observational study of geriatric dermatoses in a Tertiary Care Hospital of Northern India

2019 ◽  
Vol 10 (5) ◽  
pp. 524 ◽  
Author(s):  
Reetu Agarwal ◽  
Loknandani Sharma ◽  
Ajay Chopra ◽  
Debdeep Mitra ◽  
Neerja Saraswat
Keyword(s):  
Observational Study ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Cross Sectional ◽  
Northern India

scholarly journals EPICARDIALADIPOSE TISSUE THICKNESS IN PATIENTS WITH METABOLIC SYNDROME AND ITS ASSOCIATION WITH CARDIOVASCULAR RISK FACTORS.

2020 ◽  
pp. 26-28
Author(s):  
Jayanta Saha ◽  
Kuntal Bhattacharyya ◽  
Shravan Kumar ◽  
Debarshi Jana
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Observational Study ◽  
Sample Size ◽  
Cardiovascular Risk Factors ◽  
Tertiary Care ◽  
International Diabetes Federation ◽  
Care Hospital ◽  
Cross Sectional

INTRODUCTION Metabolic syndrome is a constellation of several cardiovascular risk factors, and is defined by the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III criteria (2001) or the International Diabetes Federation (IDF) criteria (2005). 1, 2The prevalence of metabolic syndrome varies between 24.6 - 41% in different parts of Indian subcontinent and based on different criteria for metabolic syndrome. OBJECTIVES To assess epicardial adipose tissue (EAT) thickness by echocardiography in patients with metabolic syndrome, and find out if there is any association between EAT thickness and different cardiovascular risk factors. MATERIALS AND METHODS This cross-sectional observational study was conducted in a tertiary care hospital in India among patients attending the Medicine and Cardiology out-patient department (OPD) during the study period of six months from May 2018 to October 2018. Patients satisfying the diagnostic criteria of metabolic syndrome as per the IDF criteria (2005) were included in the study, as there are separate cut off points for waist circumference for South Asian population. Design: Cross-sectional observational study. Setting: Single centre study in a tertiary care teaching hospital. Participants: Initially 450 patients with metabolic syndrome as per International Diabetes Federation (IDF) criteria (2005) were screened. Patients having age above 65 years, deranged liver/renal function, ischemic heart disease, heart failure, malignancy, pregnancy, ascitis, poor echo window, history of endocrine disorders like Cushing Syndrome, glucocorticoid use, having any acute illness and those not giving consent were excluded. Final sample size was 397. For defining the normal EAT thickness in this geographic region, 50 age and gender matched healthy volunteers without any conventional cardiovascular risk factors (except age in some cases) acted as controls. Study period was six months. RESULT The mean value of EAT thickness in the control group was 2.97 (± 0.86) mm, hence the upper reference limit of EAT thickness in this study was taken as more than mean + 2SD, i.e. 4.69mm. Mean EAT thickness in patients suffering from metabolic syndrome was 5.48 ± 0.83 mm, which was significantly increased compared to controls. Taking 4.69mm as cut off, it was seen that 311 (78.34%) patients had increased EAT thickness >4.69mm. CONCLUSION Further studies with larger sample size and longitudinal design are required to establish the ability of EAT thickness to predict cardiovascular risk.

scholarly journals PREVALENCE OF COMORBIDITIES AND THEIR IMPACT ON MORTALITY IN COVID-19 PATIENTS - A CROSS SECTIONAL STUDY IN A TERTIARY CARE COVID HOSPITAL.

2020 ◽  
pp. 12-14
Author(s):  
S. Durga Prasad ◽  
K. V. Seshaiah ◽  
P. Praveen Kumar ◽  
A. Sita Kanthima ◽  
K.S.S. Harshitha ◽  
...  
Keyword(s):  
Medical Records ◽  
Severe Disease ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Rapid Progression ◽  
Care Hospital ◽  
Sectional Study ◽  
Cross Sectional ◽  
And Gender ◽  
Short Time

Background: Since the origin of novel corona virus (COVID-19) in December 2019, it engulfed more than 200 countries worldwide within short time and was declared as pandemic by WHO. Even though the overall fatality rate is low in COVID-19, presence of certain risk factors and comorbidities more likely result in severe disease and subsequent mortality. Methodology: Retrospectively we evaluated the details of total 200 COVID-19 patients from the medical records. These 200 patients include two groups. Each group consisted of 100 patients. One group consisted 100 patients who were discharged successfully after recovery from COVID-19. Second group consisted 100 patients who demised during hospital stay with COVID-19. We have studied prevalence of comorbidities and their impact on mortality in these two groups in relation to gender, severity. This was a cross sectional study of COVID-19 patients admitted from 01-04-2020 to 31-05-2020 (period of two months) in our state COVID tertiary care hospital, Vijayawada, Andhra Pradesh. Results: There was no statistically significant association between presence of comorbidities and gender in relation to mortality. There was statistically significant association between presence of comorbidities and severity of disease. The association of comorbidities and mortality was statistically significant. Conclusion: Patients with COVID-19 who have comorbidities are more likely to have severe disease course, rapid progression, increased need for admission in ICU and mortality.

scholarly journals Pattern of use of anti-hypertensive drugs amongst hypertensive patients in a tertiary care hospital: a cross sectional, observational study

2019 ◽  
Vol 9 (1) ◽  
pp. 89
Author(s):  
Sharmin Khan ◽  
Ram N. Maiti ◽  
Sekhar Mandal
Keyword(s):  
Observational Study ◽  
Calcium Channel ◽  
Treatment Guidelines ◽  
Antihypertensive Drugs ◽  
Tertiary Care ◽  
Renal Diseases ◽  
National Committee ◽  
Care Hospital ◽  
Cross Sectional ◽  
Hypertensive Patients

Background: Hypertension is one of the primary modifiable risk factors for cardiac and renal diseases and is the single most important risk factor for stroke. Despite different guidelines for management of hypertension like Joint National Committee, British Hypertension Society, National Institute for Health and Care Excellence; there are still the clouds of controversy. The objective of the study was to evaluate the prescribing pattern of antihypertensive drugs among the patients attending medicine outpatient department of a tertiary care teaching hospitalMethods: A cross-sectional, observational study was conducted in our hospital over a period of six months. Relevant information was collected from medical records of 209 hypertensive patients fulfilling inclusion criteria. The collected data were sorted and analyzed.Results: Out of 209 patients, maximum were of age group of 45-65 years (55.02%). 115 (55.02%) were male and 94 (44.97%) were female. Diabetes mellitus (24.4%) was the most common associated disease with hypertension. Most of the patients had received single antihypertensive drugs (49.28%). Among the monotherapy category calcium channel blocker (82.78%) was the most commonly prescribed antihypertensive drug class followed by angiotensin receptor blocker (36.36%). Amlodipine (81.82%) was the most common among calcium channel blockers. The most frequent fixed drug combination prescribed consisted of amlodipine and atenolol. Most of the drugs were prescribed in generic name (90.9%).Conclusions: The treatment pattern, in general, conformed to standard treatment guidelines.

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