PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN BAWANG DAYAK (Eleutherine Palmifolia L. Merr) TERHADAP KADAR GULA DARAH MENCIT PUTIH (Mus muscullus) YANG DIINDUKSI GLUKOSA

2020 ◽  
Vol 5 (2) ◽  
pp. 288-297
Author(s):  
Eka Kumalasari ◽  
◽  
Syifa Maharani ◽  
Aditya Maulana Perdana Putra ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Test Group ◽  
Ethanol Extract ◽  
Negative Control ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Control Group Design ◽  
Post Test ◽  
Sugar Levels

Diabetes Mellitus (DM) is a collection of metabolic symptoms that arise in a person caused by an increase in blood glucose due to damage to insulin secretion or resistance to insulin or both. Diabetes mellitus medication can be either parenteral or oral which can cause side effects in long-term use such as mild diarrhea, bloating, fatigue acidosis, even hypoglycemic renal impairment. To prevent it can use alternative medicine using Dayak onion (Eleutherine palmifolia (L) Merr.). One of the active substances contained in the Dayak onion is the flavonoids. Flavonoids have antidiabetic activity through their functions as antioxidants. The study aims to determine the activity of Dayak scallion Extract (Eleutherine palmifolia (L) Merr.) To decrease blood sugar levels (Mus muscullus), which is glucose-induced. The research was conducted with research draft pre and post test with control group design. The mice used amounted to 25 male white mice that were divided into 5 groups i.e. negative control (CMC Na 0.5%), control positive (Glibenklamid 3 mg/kgBB), Dayak onion-leaf ethanol extract at a dose of 50 mg/kgBB, 100 mg/kgBB and 200 mg/kgBB. Observations of the decrease in blood sugar levels of each test group were conducted on the same day, 30 minutes, 60 and 90 after hyperglycemia. Results showed that Dayak onion leaves ethanol extract had activity as a lowering of blood sugar levels in glucose-induced white mice

scholarly journals EFEKTIFITAS KAPSUL MENGKUDU (Morinda citrifolia) TERHADAP PENURUNAN KADAR GULA DARAH PADA PASIEN DIABETES MELLITUS DI RS BRAWIJAYA

2017 ◽  
Vol 10 (01) ◽  
Author(s):  
Yuni Irianti ◽  
Ngadiani Ngadiani
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Alternative Hypothesis ◽  
Morinda Citrifolia ◽  
Control Group ◽  
Control Group Design ◽  
Significant Difference ◽  
Patients With Diabetes ◽  
Post Test ◽  
Sugar Levels

We report the supplementation of noni (Morinda citrifolia) to decrease blood sugar levels in patients with diabetes mellitus Brawijaya Hospital Surabaya, and noni problems whether supplementation is effective in reducing blood sugar levels in diabetes patients mellitus.The goal of this study was to determine the effectiveness of capsule morinda to decrease blood sugar levels in patients with Diabetes Mellitus in Brawijaya Hospital Surabaya. This type of research is to ekperimem quasi control group design with pre-test and post test. The population in this study are patients with diabetes mellitus in hospital outpatient Brawijaya. The sampling technique with a number of 60 people who were divided into 30 groups of control (can drug from a doctor) and 30 in the experimental group (can medicine from the doctor and consumption of noni capsules) .Instrumen this study is the laboratory results of random blood sugar levels with the tools glucometer ( gluko Dr). Data analysis was performed using univariate and bivariate (parametric test, Kolmogorov-Smirnov test z and Independent T-Test). From the results, no significant difference the difference in the results of pre-test and post-test in the control group and the experiment is p = 0.020 (<0.05), then the alternative hypothesis (Ha) is accepted (the results are meaningful). It is concluded that supplementation of noni effective in helping to decrease blood sugar levels of patients with diabetes mellitus, it is advisable to consume noni capsules and routine checks of blood sugar levels so that the blood sugar levels under control.

scholarly journals EFEKTIVITAS JENIS-JENIS MADU (MADU HUTAN, MADU KELULUT DAN MADU TERNAK) TERHADAP KADAR GULA DARAH”

2020 ◽  
Vol 11 (1) ◽  
pp. 12-20
Author(s):  
Adinda Febriyanti ◽  
Cau Kim Jiu ◽  
Sri Ariyanti
Keyword(s):  
Diabetes Mellitus ◽  
Health Center ◽  
Blood Sugar ◽  
Metabolic Diseases ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
Sugar Levels

Background: Diabetes Militus is a group of metabolic diseases characterized by hyperglycemia or an increase in blood sugar that occurs due to abnormal insulin secretion. Diabetes Mellitus in the world is one of the health problems that cause death. IDF data (2013) says Indonesia is the seventh largest country in the case of Diabetes Militus. Diabetes Militus in West Kalimantan Province increased from 0.6% in 2007 to 0.8% in 2013, this number increased compared to 2012, which was 4866 cases (Pontianak City Service 2014 in Salim, I.O, 2016). Based on 30 samples taken from the Purnama Public Health Center, 15 men and 15 women were found to suffer from Diabetes Militus type 2. With a poor lifestyle so that when carrying out research many were found with more weight. Purpose: Effectiveness of Types of Honey (Forest Honey, Kelulut Honey and Livestock Honey) Against Blood Sugar Levels Research Methods: Descriptive Quantitative with a sample of 30 respondents using a quasi-experimental design with a pre-test and post-test nonequivalent control group design. Research Results: The results showed that all honey can reduce blood sugar levels, especially forest honey. The results of data analysis using Anova statistical test obtained p value Pre test 0.52> α: 0.05 and Post test 0.113> α: 0.05 showed that there were no significant values ​​of the three types of honey on the decrease in blood sugar levels. Conclusion: Based on the results of the study concluded that there was no effectiveness of the types of honey (forest honey, honey kelulut and livestock honey) to reduce blood sugar levels in the Purnama Community Health Center Keywords: Honey, Blood Sugar Levels   ABSTRAK Latar Belakang: Diabetes Militus adalah sekelompok penyakit metabolik yang ditandai dengan hiperglikemia atau peningkatan gula darah yang terjadi akibat sekresi insulin abnormal. Diabetes Mellitus di dunia adalah salah satu masalah kesehatan yang menyebabkan kematian. Data IDF (2013) mengatakan Indonesia adalah Negara terbesar ketujuh dalam kasus Diabetes Militus. Diabetes Militus di Provinsi Kalimantan Barat meningkat dari 0,6% pada tahun 2007 menjadi 0,8% pada tahun 2013, jumlah ini meningkat dibandingkan tahun 2012, yaitu 4866 kasus (Layanan Kota Pontianak 2014 di Salim, I.O, 2016). Berdasarkan 30 sampel yang diambil dari Pusat Kesehatan Masyarakat Purnama, 15 priadan 15 wanita ditemukan menderita Diabetes Militus tipe 2. Dengan gaya hidup yang buruk sehingga ketika melakukan penelitian banyak ditemukan yang lebih berat. Tujuan: Efektivitas Jenis-jenis Madu (Madu Hutan, Madu Kelulut dan Madu Ternak) Terhadap Kadar Gula Darah Metode Penelitian: Deskriptif Kuantitatif dengan sampel 30 responden menggunakan desain kuasi eksperimen dengan pre-test dan post-test nonequivalent control group design. Hasil Penelitian: Hasil penelitian menunjukkan bahwa semua madu dapat mengurangi kadar gula darah, terutama madu hutan. Hasil analisis data menggunakan uji statistic Anova diperoleh nilai p Pre test 0,52> α: 0,05 dan Post test 0,113> α: 0,05 menunjukkan bahwa tidak ada nilai signifikan ketiga jenis madu terhadap penurunan kadar gula darah. Kesimpulan: Berdasarkan hasil penelitian disimpulkan bahwa tidak ada efektifitas jenis-jenis madu (madu hutan, madu kelulut dan madu ternak) untuk menurunkan kadar gula darah di Puskesmas Purnama

scholarly journals UJI EFEKTIFITAS BIOLARVASIDA EKSTRAK ETANOL BUAH LAMPESU (Baccaurea lanceolata) TERHADAP LARVA INSTAR III Culex quinquefasciatus

2020 ◽  
Vol 3 (3) ◽  
pp. 7
Author(s):  
Dea Alfani Nandjan
Keyword(s):  
Culex Quinquefasciatus ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Chemical Insecticide ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
Infection Disease

Filariasis is chronic infection disease caused by worm and carried by Culex quinquefasciatus mosquito. One of theways to controlling mosquitoes vectors are use biolarvacide or chemical insecticide. Chemical insecticide causingresistance Culex quinquefasciatus larvae and toxic for human. This research aim to determine the biolarvacideeffectiviteness of ethanol extract lampesu fruit (Baccaurea lanceolata) to Culex quinquefasciatus larvae instars III.This study was true experimental with a Post test-only control group design. This study used 700 larvae instars III ofCulex quinquefasciatus divided into 7 groups consentration of 0,2%, 0,4%, 0,6%, 0,8% and 1%, the positive control(abate) and negative control (aquadest). The observation was did after treatment in 3 hours, 6 hours, 12  hours and 24hours. The experiment is replicated four times. At 24 hours exposure concentration of 0,6% the test larvae mortalityreached 38% and at concentration of 1% the test larvae mortality reached 30%. In this stuy the concentration of1,531 % was effective to kill larvae with of 50% mortality(LC50) and concentration of 10,729 % was effective to killlarvae with of 90% mortality(LC90). Ethanol Ekstract of Lampesu Fruit (Baccaurea lanceolata) not effective asbiolarvacide ofCulex quinquefasciatus larvae instars III.

scholarly journals EFEK HIDROTERAPI PADA PENURUNAN KADAR GULA DARAH SESAAT (KGDS) TERHADAP PENDERITA DIABETES MELITUS TIPE 2

2012 ◽  
Vol 36 (2) ◽  
pp. 202
Author(s):  
Elmatris Sy ◽  
Esy Afrianti ◽  
Nelwati Bahri ◽  
Yuniarti Yuniarti
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Oral Therapy ◽  
Intervention Group ◽  
Control Group ◽  
Control Group Design ◽  
Total Respondent ◽  
Quasi Experimental ◽  
Sugar Levels

AbstrakHidroterapi atau terapi air putih merupakan metode perawatan danpenyembuhan dengan menggunakan air putih untuk mendapatkan manfaat terapisdalam penanganan penyakit. Diabetes Mellitus adalah salah satu penyakitdegeneratif, yang mana perlu suatu upaya untuk menekan terjadinya peningkataninsiden penyakit tersebut. Penelitian ini bertujuan untuk mengetahui efekhidroterapi terhadap penurunan kadar gula darah sesaat pada penderita DM tipe 2.Metode penelitian ini adalah quasi eksperimen dengan pendekatan control groupdesign with pretest and posttest. dengan teknik pengambilan sampel yangdigunakan adalah non probability sampling dengan pendekatan purposivesampling. Total responden adalah 27 orang, 15 responden untuk kelompok kontroldan 12 orang kelompok intervensi. Hasil penelitian menunjukan bahwa kurangdari separoh (40%) responden yang mengalami penurunan kadar gula darah sesaat(KGDS) setelah pemberian terapi oral, dan didapatkan semua responden (100%)mengalami penurunan KGDS setelah diberikan terapi oral dan hidroterapi. Dapatdisimpulkan bahwa Terdapat pengaruh hidroterapi pada penderita diabetes melitustipe 2 yang diberi terapi oral, ini terlihat terdapatnya perbedaan yang signifikandengan p = 0,00 (p<0,05) dari rata-rata kadar gula darah sesaat (KGDS) antarakelompok intervensi (pemberian terapi oral dan hidfroterapi) dan kelompokkontrol (hanya pemberian terapi oral).Kata kunci: Hidroterapi, kadar gula darah sesaat, dan diabetes mellitusAbstractHydrotherapy or water therapy is a method of treatment and healing withwater for get the profit therapeutic in the treatment of disease. Diabetes Mellitus isa degenerative disease, which need an effort to suppress the increased incidenceof the disease. This the aims of the research to determine the effect ofhydrotherapy to decrease blood sugar random diabetes mellitus type 2 patients.The method of this research is a quasi experimental control group design approachwith pretest and posttest. the sampling techniques used is non probabilitysampling with purposive sampling approach. Total respondent are 27 peoples, 15respondents for the control group and 12 intervention group. The results ofresearch is less than half (40%) of respondents have a decrease in content bloodsugar random (CBSR) after giving oral therapy, and all the respondents (100%)have a decrease in content blood sugar random (CBSR) after be given oral therapy202ARTIKEL PENELITIANand hydrotherapy. There is an influence of hydrotherapy to patients diabetesmellitus type 2 who was given oral therapy, it can seen have of a significantdifference with p = 0,00 (p < 0,05) in the average content blood sugar random(CBSR) between the intervention group (given hidfroterapi therapy and oraltherapy) and control group (only therapy oral).Key word : Hydrotherapy, instantaneous blood sugar levels, and diabetes mellitus203

scholarly journals Antidiabetic effect of 2-(4- [(2-hydroxyacetyl benzyl) ketoamino]-phenyl amino-methyl)- hydrobenzophenon on Alloxan induced rats

2020 ◽  
Vol 11 (4) ◽  
pp. 7425-7428
Author(s):  
Vurimi Bhopal Chandra ◽  
Kudagi B L ◽  
Madhavulu Buchineni ◽  
Pathapati Rama Mohan ◽  
Anjani Devi Nelavala
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Albino Rats ◽  
Average Weight ◽  
Free Access ◽  
High Blood Glucose ◽  
Sugar Levels ◽  
Wistar Albino Rats

Diabetes Mellitus is known as a syndrome, a collection of disorders with high blood glucose level & glucose intolerance as its feature, either because of insulin deficiency or insulin impairment or both. Diabetes Mellitus, based on insulin, is broadly classified into two types. Type one indicates the distraction of pancreatic β - cells that leads to diabetes mellitus, in which insulin is necessary to prevent ketoacidosis, coma, death. Type two diabetes is characterized by disorders of insulin resistance & secretion. Male Wistar albino rats with an average weight of 180-250 g were used in this study. With a 12 hours’ light and dark period, they were kept under normal conditions (room temperature 24-27oC and humidity 60-65 %). The free access of drinking water & pellet diet to male Wistar albino rats was allowed, as per the CPCSEA guidelines. Anti-diabetic activity of Compound 2-(4- [(2-hydroxyacetyl benzyl) ketoamino]-phenyl amino-methyl)- hydrobenzophenon, male Wistar albino rats were divided into four different groups. 1ml of blood samples were collected directly into anticoagulant bottles from the tail vein & later plasma was collected after centrifugation. Blood sugar levels were determined by spectrophotometer. There was a significant decrease in blood sugar levels in Alloxan + Glibenclamide and Alloxan + Compound groups on compared to control. The present self-funded study concludes that antidiabetic activity of 2-(4- [(2-hydroxyacetyl benzyl) ketoamino]-phenyl amino-methyl)- hydrobenzophenon in Alloxan induced diabetic rats significantly shows decreed blood sugar levels when compared to the control group.

scholarly journals Pengaruh Puasa Ramadhan terhadap Kadar Gula Darah pada Pasien Diabetes Mellitus Tipe II

2019 ◽  
Vol 1 (1) ◽  
pp. 191-204
Author(s):  
Riandi Alfin ◽  
Busjra Busjra ◽  
Rohman Azzam
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Type Ii Diabetes ◽  
Intervention Group ◽  
Type Ii Diabetes Mellitus ◽  
Control Group ◽  
Type Ii ◽  
Ramadan Fasting ◽  
Post Test ◽  
Sugar Levels

The purpose of this research is to know the influence of Ramadan Fasting towards blood sugar levels in diabetics in the health center in West Java of Purwakarta. The design of this research uses quasi experiment of pre and post test with the control group, the method uses Purposive sampling done by the sum of 36 samples of respondents. The results of this research are using Independent T-test fast differences in blood sugar levels after fasting Ramadaan in the control group and the intervention group obtained the value of p = 0.039 < α = 0.05. Conclusion the results of this study showed the presence of the influence of fasting of Ramadan towards blood sugar levels in type II diabetes mellitus patients in Healty Center of Purwakarta. It can be concluded that fasting during Ramadan can be used as an alternative diet method that has positive benefits if it is run by type II diabetes mellitus patients which can reduce blood sugar to be more stable.  Keywords: Ramadhan Fasting, Blood Glukose Level, Diabetic Mellitus Type II

scholarly journals Pengaruh Pemberian Ekstrak Garcinia Mangostana terhadap Kadar Gula Darah pada Penderita Diabetes Mellitus di Desa Satrean Maron Probolinggo

2020 ◽  
Vol 3 (2) ◽  
pp. 71-75
Author(s):  
Nurul Laili ◽  
Roi'sah Roi'sah ◽  
Nafolion Nur Rahmat
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Random Sampling ◽  
Simple Random Sampling ◽  
T Test ◽  
Control Group ◽  
Garcinia Mangostana ◽  
Post Test ◽  
Sugar Levels ◽  
Paired T Test

AbstrakPenyakit diabetes mellitus merupakan salah satu penyakit penyakit tidak menular (PTM) yang membutuhkan penannganan tepat untuk proses penyembuhan. Penyakit tersebut jika tidak diobati akan menyebabkan timbulnya komplikasi yang dapat membahayakan penderita. Cara yang dilakukan untuk mencegah timbulnya komplikasi adalah melalui pengobatan. Salah satu jenis pengobatan yang digunakan adalah pengobatan herbal yaitu Garcinia Mangostana. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak Garcinia Mangostana terhadap kadar gula darah penderita diabetes mellitus. Metode penelitian ini menggunakan quasy-experiment dengan desain pre-test and post-test with control group. Pengambilan sampel menggunakan simple random sampling, berdasarkan rumus perhitungan sampel, maka diperoleh sampel sebanyak 36 penderita diabetes mellitus. Instrumen yang digunakan dalam penelitian ini berupa alat cek gula darah untuk mengukur kadar gula darah sewaktu. Uji statistic “paired T-Test” menggunakan media komputer program “Windows SPSS 17”. Data pengukuran berupa data rasio yaitu nilai kadar gula darah sewaktu dalam mg/dl. Hasil analisa data menunjukkan pada kelompok perlakuan memiliki nilai p=0,001, hal tersebut berarti ada pengaruh pemberian kulit manggis terhadap kadar gula darah, sedangkan pada kelompok kontrol memiliki nila p=0,166. Sehingga dapat disimpulkan bahwa Garcinia Mangostana efektif dalam menurunkan kadar gula darah  pada penderita diabetes mellitus. Kata kunci: diabetes mellitus, garcinia mangostana, kadar gula,  penderita.  AbstractDiabetes mellitus is one of the non-communicable diseases (PTM diseases) that requires proper response to the healing process. The disease if left untreated will cause complications that can endanger the patient. The way to prevent complications is through treatment. One type of treatment used is herbal medicine, Garcinia Mangostana. The purpose of this study was to determine the effect of giving Garcinia Mangostana extract to blood sugar levels of people with diabetes mellitus. This research method used quasy-experiment with the design of pre-test and post-test with control group. Sampling using simple random sampling, based on the sampel calculation formula, obtained sampels of 36 people with diabetes mellitus. The instrument used in this study is a blood sugar check tool to measure blood sugar. Test the "paired T-Test" statistic using the computer media program "Windows SPSS 17". Measurement data in the form of ratio data, namely the value of blood sugar levels when in mg /dl. The results showed that there was an effect of giving mangosteen peel to blood sugar levels in patients with diabetes mellitus with a value of p = 0.001. Keywords: diabetes mellitus, garcinia mangostana, sugar levels, patients 

scholarly journals Activities Of Fermented Maman (Cleome Gynandra L) On Blood Sugar Level In Hyperglycemic White Rats

2019 ◽  
Author(s):  
LILY RESTUSARI ◽  
Muharni ◽  
Fitri Fitri
Keyword(s):  
Blood Sugar ◽  
Control Group ◽  
Control Group Design ◽  
White Rats ◽  
Cleome Gynandra ◽  
Metformin Group ◽  
Anti Cancer ◽  
Post Test ◽  
Sugar Levels ◽  
Better Than

Pre Print :Cleome Gynandra L. (called as “Maman” in Riau) is a traditional medicine used for diabetes, anti-aging, anti-cancer and cardiovascular diseases prevention. This study was carried out to determine the activities of Fermented Maman on blood sugar levels in hyperglycemic male white rats. The research was an experimental research, using the Post Test Only Control Group Design, that carried out 5 months at Riau Ministry of Health Poltekkes Laboratory. The data analysis using Multivariate ANOVA and continued with Duncan multiple range test.The results of the study indicate that Fermented Maman can reduce blood sugar levels but, the metformin group had a higher reduction compared to the control group negative, positive and Fermented Maman. Metformin reduces blood sugar levels better than Fermented Maman. It is necessary to add the time of Fermented Maman and research used metformin with simultaneous fermentation in groups of male white rats with dosage variations.

THE EFFECT BETWEEN DIABETES MELLITUS DIABETES AMONG CHANGES BLOOD SUGAR LEVELS AT Dr. H. MARZOEKI MAHDI HOSPITA BOGOR

2019 ◽  
Vol 10 (2) ◽  
pp. 11-19
Author(s):  
Harun Harun Al Rasid ◽  
Ami Ami Oetami Wiharjo
Keyword(s):  
Diabetes Mellitus ◽  
Blood Sugar ◽  
Bivariate Analysis ◽  
Control Group ◽  
P Value ◽  
Control Group Design ◽  
Continuous Increase ◽  
Number Of Patients ◽  
Patients With Diabetes ◽  
Sugar Levels

In 2012 diabetes mellitus is the cause of death from 1,5 million (WHO,2016). The population of diabetes mellitus (DM) in indonesia is currently ranked fifth in tyhe world. In 2013 people with diabetes mellitus in the homeland reaches 8.554.155 people. The continuous increase in the number of patients with diabetes mellitus and the magnitudeof the cost of treatment due to complications, then the best effort is prevention. Exercise of physical exercise is an early attempt to prevent, control, and overcome diabetes. Type of Quasi Experimenta research with Non Randomited Pretest and Posttest Control Group Design methods. Research location in RS Dr. H. Marzoeki Mahdi dated 26 April 2017 number of sample counted 32 respondents with diabetes mellitus with sample Purposive Sampling. Tools used in date collection are Accu-Chek Akctive and observation sheet. Technique of date analysis is bivariate analysis with SPSSM program. The influence of diabetes mellitus gymnastics on changes in blood sugar levels in Dr. H. Marzoeki Mahdi Hospital in 2017. The ntervention group of blood sugas levels before gymnastics and after gymnastics decreased 24,69 mg/dL, in the control group of blood sugar levels on the first day and the fourth day increased 10,56 mg/dL. Statistical test results using Independent T Test obtained P value = 0,000 which means P value <0,05 means the influence of diabetes gymnastics to changes in blood sugar levels in people with diabetes mellitus in Dr. H. Marzoeki Mahdi Hospital. This research is expected

scholarly journals Potential of Cocoa Ethanol Extract Toward Nematocyst Tubul Firing Inhibition of Physalia Utriculus Toxin In Vitro

2019 ◽  
Vol 5 (2) ◽  
pp. 30
Author(s):  
Sarwendah Siswi Winasis ◽  
Al Munawir ◽  
Adelia Handoko
Keyword(s):  
Normal Control ◽  
Ethanol Extract ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Control Group ◽  
Control Group Design ◽  
Average Percentage ◽  
Post Test

There was estimated 150 million envenomation cases due to jellyfish stings occur globally every year. 100 from 10,000 jellyfish species in the world known to be dangerous, one them is Physalia utriculus. The aim of this study was to determine the potential of cocoa (Theobroma cacao L.) ethanol extract toward nematocyst tubul firing inhibition of jellyfish (Physalia utriculus) toxin in vitro. The method was true experimental design with post test only control group design. The study divided into 8 groups: 1 normal control, 1 positive control, 1 negative control, and 5 treatments grups by giving cocoa ethanol extract with concentration 20%, 2%, 0.2%, 0.02%, 0.002%. The observation was made by calculating the percentage number of firing nematocysts. The result showed average percentage of firing nematocyst in the normal control group was 42.50 ± 3.18, positive control group was 37.97 ± 5.57, negative control group was 52.44 ± 2.98, and treatment group which given with cocoa ethanol extract 20%, 2%, 0.2%, 0.02%, 0.002% were 48.24 ± 5.37; 40.62 ± 7.10; 29.45 ± 5.39; 37.60 ± 9.78; 41.11 ± 3.92, respectively. The One Way Annova statistical results test show significance value 0.001 (p≤0.05). The conclusion of this study was the cocoa ethanol extract with concentration 0.2% has most potential to inhibit the jellyfish (P. utriculus) nematocyst tubule firing in vitro. Keywords: Physalia utriculus, cocoa, toxin, jellyfish

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