scholarly journals EFEKTIVITAS SALEP KOMBINASI EKSTRAK DAUN BANGUN – BANGUN (Coleus amboinicus Lour.) DAN DAUN KELAPA SAWIT (Elaeis guineensis Jacq.) SEBAGAI OBAT LUKA SAYAT

2020 ◽  
Vol 3 (1) ◽  
pp. 48-56
Author(s):  
Rika Puspita Sari
Keyword(s):  
Wound Healing ◽  
Single Dose ◽  
Elaeis Guineensis ◽  
Ethanol Extract ◽  
Rabbit Skin ◽  
Treatment Groups ◽  
Healing Wound ◽  
Elaeis Guineensis Jacq ◽  
Coleus Amboinicus ◽  
All Treatment

Bangun-bangun leaves and palm leaves contain various secondary metabolites such as tannins, alkaloids and flavonoids which can healing wound. The aim of this study was to determine the effect of ointment combination of ethanol extract of leaves of bangun- bangun (Coleus amboinicus Lour.) And ethanol extract of palm leaves (Elaeis guineensis Jacq.) In healing wound. The bangun- bangun leaves and the palm leaves are separated from the petiole and then dried in a drying cupboard so that it becomes a simplisia. Simplisia is extracted by maceration method then evaporated with a rotary evaporator and evaporated again on a water bath to produce a thick extract. Thick extracts from the leaves of bangun- bangun and palm leaves are then formulated into ointment preparations with varying concentrations. Each rabbit was shaved on its back then cleaned with 70% alcohol. Furthermore, rabbits were anesthetized using 0.5 ml Lidocain HCL as much as 0.5 ml subcutaneously. Next mark the part that will be injured with a diameter of 2 cm, by lifting the rabbit skin using tweezers and then made a wound using surgical scissors that have been sterilized first with 70% alcohol. Wound diameter measurements showed that all treatment groups from day 1 to day 23 experienced changes in wound diameter. The combination ointment of ethanol extract of leaves wake-up (EEDB) 10% and ethanol extract of palm oil leaves (EEDKS) 10% have a more effective effect in wound healing than single dose.

scholarly journals UJI EFEKTIVITAS GEL KOMBINASI EKSTRAK ETANOL DAUN BANGUN-BANGUN (Coleus amboinicus L.) DAN DAUN KELAPA SAWIT (Elaeis guieensis Jacq) SEBAGAI OBAT LUKA BAKAR TAHUN 2020

2020 ◽  
Vol 3 (1) ◽  
pp. 62-68
Author(s):  
Evi Depiana Gultom
Keyword(s):  
Wound Healing ◽  
Elaeis Guineensis ◽  
Ethanolic Extract ◽  
Rabbit Skin ◽  
Iron Plate ◽  
Treatment Groups ◽  
Single Form ◽  
Gel Preparation ◽  
Coleus Amboinicus ◽  
All Treatment

Coleus amboinicus L leaves and Elaeis guieensis Jacq leaves contain various secondary metabolites such as saponins, tannins, alkaloids and flavonoids that function in wound healing. The purpose of this study was to determine the healing effect of burns using a gel preparation combination of ethanolic extract of Coleus amboinicus L. (EECAL)  And ethanolic extract of Elaeis guineensis Jacq. (EEEGJ) In healing burns. Coleus amboinicus L leaves and Elaeis guieensis Jacq leaves contain are separated from the petiole and then dried in a drying cupboard so that it becomes a simplicia. Simplisia is extracted by maceration method then evaporated with a rotary evaporator and evaporated again on a water bath to produce a thick extract. EECAL and EEEGJ are then formulated into gel preparations with varying concentrations. Each rabbit was shaved on its back then cleaned with 70% alcohol. Furthermore, rabbits were anesthetized using 0.5 ml Lidocain HCL as much as 0.5 ml subcutaneously. Then mark the part that will be injured with a diameter of 2 cm, by lifting the rabbit skin using tweezers and then made a wound using a hot iron plate that has been sterilized beforehand with 70% alcohol. Wound diameter measurements showed that all treatment groups from day 1 to day 20 experienced changes in wound diameter. EECAL 15% and EEEGJ 10% have a more effective effect in healing of burn than in their single form.           

scholarly journals THE EFFECTIVENESS OF COLEUS AMBOINICUS LEAF EXTRACTS AS AN ANALGETIC ACTIVITY ON MICE EXPOSURED TO ACETIC ACID

2018 ◽  
Vol 11 (9) ◽  
pp. 301 ◽  
Author(s):  
Yunita Sari Pane ◽  
Sufitni Sufitni ◽  
Fitriani Lumongga ◽  
Nurfida Alrasyid ◽  
Dini Permata Sari ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Water Extract ◽  
Ethanol Extract ◽  
Mean Value ◽  
Leukocyte Migration ◽  
Leaf Extracts ◽  
Mean Values ◽  
Treatment Groups ◽  
Coleus Amboinicus ◽  
All Treatment

Objective: This study aims to observe the analgesic activity of Bangun-bangun (Coleus amboinicus) leaves by induction of pain arising from chemical excitement after exposure to acetic acid.Methods: The effectiveness test of water extract and ethanol extract of Bangun-bangun leaves as an analgesic was measured by comparing the mean of quantitative and the writhing between control and treatment group. In addition, observations on the decrease in inflammatory processes occurred by calculating the reduction in the number of leukocyte migration to the inflammatory area.Result: The decrease of excitatory pain in all treatment Groups (I-IV) were significantly different. The comparison of mean values ± SEM decreased excitatory pain Groups I-II (255.00±22.22; 88.33±14.58), p=0.000. Groups I-III (255.00±22.22; 60.00±10.04), p=0.000 and Groups I-IV (255.00±22.22; 50.83±3.09), p=0.000. On histopathology examination, all treatment groups were significantly different (p=0.006). The comparison of mean value ± SEM decrease number of leukocyte Groups I-II (31.73±5.22; 14.70±3.71), p=0.025. Groups I-III (31.73±5.22; 15.67±3.22), p=0.036 and Groups I-IV (31.73±5.22; 11.77±2.77), p=0.008. However, the comparison of decrease of excitatory of pain and number of leukocyte migration between each group did not show significantly different (p>0.05).Conclusions: This study concluded that the Bangun-bangun leaves both in the form of water extract and ethanol extract proved efficacious as a pain reliever in the mice after induction of acetic acid.

scholarly journals PERBANDINGAN EFEK PENYEMBUHAN LUKA BAKAR ANTARA GEL EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalinum Del.)DENGAN GEL EKSTRAK ETANOL DAUN KELAPA SAWIT ( Elaeis guineensis Jacq.) SERTA KOMBINASINYA PADA KELINCI TAHUN 2019

2020 ◽  
Vol 3 (1) ◽  
pp. 82-90
Author(s):  
Suventi Syafrina Ginting
Keyword(s):  
Elaeis Guineensis ◽  
Test Preparation ◽  
Ethanol Extract ◽  
Positive Control ◽  
Fourth Group ◽  
Treatment Groups ◽  
Extract Concentration ◽  
Elaeis Guineensis Jacq ◽  
Negative Controls ◽  
Palm Leaf

African leaves (Gymnanthemum amygdalinum Del.) And palm leaves (Elaeis guineensis Jacq.) Have secondary metabolites, namely alkaloids, steroids / terpenoids, flavonoids, tannins, and saponins in this study aimed to determine the effectiveness of healing burns. The extract was made by maceration method using 96% ethanol. This test used 3 rabbits, each of which had been burnt into 6 wound areas on the back of the rabbit. First group (positive control), second group (without treatment), third group gel with Arfika leaf ethanol extract concentration of 5%, fourth group gel with palm ethanol extract concentration of 7.5%, fifth group of groups gel with a combination of Arfika leaf ethanol extract concentration of 5% and 7.5% palm oil leaf ethanol extract The burns that have been made are smeared with as much test preparation as possible once a day. The next day the diameter of the wound was measured, then smeared with an adequate amount of gel. This is done until the diameter of the wound is equal to zero or the wound has been covered by new tissue. The results of testing the effectiveness of healing burns showed that all treatment groups had a faster recovery day compared to negative controls. The conclusion of this study is the combination of 5% arfika ethanol extract gel and 7.5% oil palm leaf ethanol extract is the group with the fastest fastest day on the 19th day.

scholarly journals UJI EFEK ANTIINFLAMASI KOMBINASI EKSTRAK ETANOL DAUN GYMNANTHEMUM AMYGDALINUM DEL. DAN ELAEIS GUINEENSIS JACQ.

2020 ◽  
Vol 3 (1) ◽  
pp. 1-5
Author(s):  
Wahyudi Wahyudi ◽  
Masnawati Masnawati ◽  
Ismayuni . ◽  
Sofia Rahmi ◽  
Syukur Berkat Waruwu
Keyword(s):  
Palm Oil ◽  
Elaeis Guineensis ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
The Body ◽  
Effective Dosage ◽  
Treatment Groups ◽  
Elaeis Guineensis Jacq ◽  
Anti Inflammatory

Inflammation is a response from the body to injury or infection, flavonoids contained in African leaves (Gymnanthemum Amygdalinum Del.) And palm oil leaves (Elaeis Guineensis Jacq.) have anti-inflammatory effects. This study aims to examine the anti-inflammatory effects of a combination of ethanol extracts of Gymnanthemum Amygdalinum Del. And Elaeis Guineensis Jacq. on white rat foot edema which is induced by carrageenan 1% subplantar, and effective dosage as anti-inflammatory. The extract was made by maceration method using 96% ethanol solvent. The antiinflammatory effect test was divided into 5 treatment groups. The first group (negative control) was given 0.5% CMC Na suspension, the group (positive control) was given diclofenac Na suspension 2.25 mg / kg bw, and the suspension group was a combination of African leaf extract (Gymnanthemum Amygdalinum Del.) And palm oil leaves ( Elaeis Guineensis Jacq.) Dose 200 + 62.5 mg / kg bw, 400 + 125 mg / kg bw, and 800 + 250 mg / kg bw. Inflammation volume measurements were measured using a pletismometer for 180 minutes at 30 minute intervals after 1% carrageenan was induced. The results showed that negative controls had significant differences with other treatment groups which did not show anti-inflammatory effects. In conclusion, the suspension of a combination of ethanol extract of African leaves and palm oil leaves has an effective anti-inflammatory effect at a dose of 800 + 250 mg / kg bw.

scholarly journals PENGUJIAN EFEKTIVITAS DIURETIK KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Gymnanthemum amygdalinum Del.) DAN DAUN KELAPA SAWIT (Elaeis guineensis Jacq.) PADA TIKUS JANTAN

2020 ◽  
Vol 3 (1) ◽  
pp. 106-111
Author(s):  
Delisma Simorangkir
Keyword(s):  
Leaf Extract ◽  
Elaeis Guineensis ◽  
Urine Volume ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Treatment Groups ◽  
White Rats ◽  
Group 2 ◽  
Palm Leaf

African Leaf and palm leaf crops have a secondary metabolite content such as alkaloids and flavonoids that are efficacious as diuretics. The purpose of this study is to know the effectiveness of diuretics from the combination  African leaf ethanol extract and palm leaf ethanol extract. Methods used Eksperiemental. The test of diuretic activity is conducted divided into 6 treatment groups. Each group consists of 3 tails of white rats. Group 1 (positive control) administered Furosemide 3.6 mg/kgBB, Group 2 (negative control) was given suspension Na-CMC 0.5%, group 3 without treatment as well as groups of 4.5, and 6 in a row administered a combination of African leaf extract doses and extracts Oil palm leaf ethanol in a row of "50 mg/kgBB + 67, 5mg/kgBB"; "100mg/kgBB + 135 mg/kgBB"; and "200 mg/kgBB + 270 mg/kgBB". Each mouse is then given a 20ml NaCl/kgBB as an oral loading dose. Measured urine volume is recorded every hour for 6 hours after it continues to measure urine volume. The results showed that the combination of African leaf ethanol extract dosage and palm leaf ethanol extract had a diuretic effect if it was compared with negative control. The conclusion of the study was the results of the study showed that the combination of African leaf extract dosage and palm leaf extract is the most effective dose of Group 6 (African leaf extract 200 mg/kgBB + palm leaves 270 mg/kgBB ). Because it produces the highest urine volume of 23.01 ml.

scholarly journals Nanoemulsion of flavonoid-enriched oil palm (Elaeis guineensis Jacq.) leaf extract enhances wound healing in zebrafish

2021 ◽  
Vol 1 (4) ◽  
pp. 100124
Author(s):  
Mohamad Shazeli Che Zain ◽  
Shan Lakmal Edirisinghe ◽  
Cheol-Hee Kim ◽  
Mahanama De Zoysa ◽  
Khozirah Shaari
Keyword(s):  
Wound Healing ◽  
Oil Palm ◽  
Leaf Extract ◽  
Elaeis Guineensis ◽  
Elaeis Guineensis Jacq

scholarly journals Antibacterial Activity Testing and Ethanol Extract Characterization of Oil Palm Fronds (Elaeis guineensis Jacq)

2018 ◽  
Vol 17 (9) ◽  
pp. 427-433 ◽  
Author(s):  
Dewi Febrina ◽  
Rahmi Febriyanti ◽  
Syukria Ikhsan Zam ◽  
Jully Handoko ◽  
Abdul Fatah ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Oil Palm ◽  
Elaeis Guineensis ◽  
Ethanol Extract ◽  
Oil Palm Fronds ◽  
Elaeis Guineensis Jacq ◽  
Palm Fronds

scholarly journals Gastric Histopathology of White Rats After Administration of Kedondong Leaves Extract

2019 ◽  
Vol 2 (1) ◽  
pp. 18
Author(s):  
I Wayan Sudira ◽  
I Made Merdana ◽  
Ketut Budiasa
Keyword(s):  
Inflammatory Cell ◽  
Ethanol Extract ◽  
Fatty Degeneration ◽  
Control Group ◽  
Histopathological Changes ◽  
Healthy Male ◽  
Treatment Groups ◽  
White Rats ◽  
Hematoxylin Eosin ◽  
All Treatment

This study aims to determine the effect of ethanol extract of Kedondong leaves (Spondias dulcis G. Forst) on the gastropathological histology of white rats (Mus musculus). A total of 25 healthy male white rats with weights 200-250 g were randomly divided into five groups. A control group was only given a placebo. The treatment group of kedondong leaf ethanol extract sequentially with a dose of 125, 250, 500 and 1,000 mg/kg/day for 21 days orally. On the 22nd day all of the animals were sacrificed for its the gastric, followed by processing for histopathological preparations with Hematoxylin Eosin (HE) staining. The results of the study in all treatment groups were found gastric histology changes in the form of mild inflammatory cell infiltration, mild fatty degeneration and mild necrosis. The number of mice that experienced histopathological changes differed in each group. It can be concluded that the oral administration of kedondong leaf ethanol extract with a range at a dose of 125-1000 mg/kg/d for 21 days does not cause significant histopathological structure disturbance in the stomach of male white rats.

scholarly journals In Vitro Wound Healing Potential of Flavonoid C-Glycosides from Oil Palm (Elaeis guineensis Jacq.) Leaves on 3T3 Fibroblast Cells

Antioxidants ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 326 ◽  
Author(s):  
Mohamad Shazeli Che Zain ◽  
Soo Yee Lee ◽  
Murni Nazira Sarian ◽  
Sharida Fakurazi ◽  
Khozirah Shaari
Keyword(s):  
Cell Proliferation ◽  
Wound Healing ◽  
Oil Palm ◽  
Elaeis Guineensis ◽  
Fibroblast Cells ◽  
Crude Extracts ◽  
Elaeis Guineensis Jacq ◽  
And Migration ◽  
Proliferation And Migration

Oil palm (Elaeis guineensis Jacq.) leaves (OPL) are widely available at zero cost in Southeast Asia countries, especially in Malaysia and Indonesia due to large scale oil palm plantations. OPLs contain a large amount of flavonoids in particular flavonoid C-glycosides, which are known to possess useful biological properties including antioxidant and wound healing properties. The present study aimed at evaluating the wound healing efficacy of OPL in various solvent extracts and flavonoid enriched fractions and to determine the contribution of flavonoid C-glycosides (orientin, isoorientin, vitexin and isovitexin) using in-vitro scratch assay on 3T3 fibroblast cells. Solvent crude extracts with different polarity were screened and the most active extract was subjected to acid hydrolysis. The crude and acid hydrolysed extracts were further enriched using macroporous resins, XAD7HP. UHPLC-UV/PDA and LC-MS/MS analysis were applied for identification and confirmation of flavonoid C-glycosides. The wound healing properties comprised of cell viability, cell proliferation and cell migration were studied. Allantoin was used as a positive control to compare the efficacy among the tested samples. The results revealed all OPL crude extracts, flavonoid enriched fractions and flavonoid C-glycosides were non-toxic at concentrations below 25 µg/mL and showed better cell proliferation and migration activities at low concentrations than higher concentrations.. This study also demonstrated orientin, isoorientin, vitexin and isovitexin presented in OPL extracts and flavonoid enriched fractions stimulated proliferation and migration of 3T3 fibroblast cells. Hence, these findings may pose potential therapeutic bioactive agents for wound healing by enhancing fibroblast proliferation and migration.

scholarly journals EFEK PENYEMBUHAN LUKA BAKAR GEL KOMBINASI EKSTRAK ETANOL DAUN AFRIKA (Vernonia Amygdalina) DAN EKSTRAKETANOLDAUNBANGUN–BANGUN(ColeusamboinicusLour)

2020 ◽  
Vol 3 (1) ◽  
pp. 57-61
Author(s):  
Nina Irmayanti Harahap
Keyword(s):  
Ethanol Extract ◽  
Effective Control ◽  
Vernonia Amygdalina ◽  
Positive Group ◽  
Healing Wound ◽  
Coleus Amboinicus

african leaves ( Vernonia Amygdalina )and wake-up leaves (Coleus amboinicus Lour)are plants traditional plants that are used as medicine. Leaves african which is contain flavonoid, saponin, tanin and leaves wake up which is contain flavonoid, tanin, saponin and steroid. This study to find aims out as effect healing of burns.Method : Sample in this study was african leaves and wake-up leaves which were taken purposively without comparing sampel from other regions, then extrated by maceration using ethanol 96 %. Result : Testing of rhe healing effects of burns can be divided in five treatment, positive group using biolacenton , negatif group using basis gel and the last group using the extract ethanol gel EEDA and EEDB concentrations of 4%+2,5%,8%+5%,16%+10%. Given burns to the back of rabbits length with of 2cm, and the gel is applied twice a day for 11 day and diameter measured of the wound. Conclusion : The combination of EEDA and EEDA the ethanol extract the concentration of 16% + 10% was the effective control for healing burns. When compared bioplacenton gel as a healing wound in rabbit.

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