Evaluation of the Impact of the Whole-body Cryotherapy Treatment on the Functional Condition of the Knee Joints in Patients with Rheumatoid Arthritis

Introduction: Rheumatoid arthritis (RA) is a chronic disease that leads to disability of patients. The use of the whole-body cryotherapy treatment for RA patients provides analgesic and anti-inflammatory effects and improves their efficiency. Aim: Assessment of the effect of the whole-body cryotherapy treatment on the functional state of knee joints for patients with RA. Material and Method: The study was conducted on a group of 30 RA patients, who underwent a series of 10 whole-body cryotherapy treatment. The effectiveness and efficiency of the applied therapy was assessed on the basis of: the VAS scale, the Laitinen scale, the assessment of the range of motion, muscle strength with the MicroFet dynamometer and the Up and Go test. Results: As a result of the applied whole-body cryotherapy treatment, a reduction in the intensity of pain, measured with the VAS scale and the Laitinen scale, and a reduction in the duration of morning stiffness by about 55% were found. There was an increase in the range of motion and muscle strength. The time needed to perform the Up and Go test was reduced by 17%. Conclusions: The whole-body cryotherapy treatment is an effective analgesic method of physiotherapy for patients with RA. It provides an improvement in the functional state, increases the range of motion, muscle strength and improves the gait function.

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The Effect of Repeated Whole-Body Cryotherapy on Sirt1 and Sirt3 Concentrations and Oxidative Status in Older and Young Men Performing Different Levels of Physical Activity

Antioxidants ◽

10.3390/antiox10010037 ◽

2020 ◽

Vol 10 (1) ◽

pp. 37

Author(s):

Gabriela Wojciak ◽

Jadwiga Szymura ◽

Zbigniew Szygula ◽

Joanna Gradek ◽

Magdalena Wiecek

Keyword(s):

Physical Activity ◽

Young Men ◽

Oxidative Status ◽

Whole Body ◽

Stress Index ◽

Blood Levels ◽

Long Distance ◽

Antioxidant Defence ◽

Whole Body Cryotherapy ◽

The Impact

Background: The activity of antioxidant enzymes and sirtuins (Sirt) decreases along with age, which is counteracted by aerobic training. Sirtuins increase antioxidant defence. Whole-body cryotherapy (WBC) increases total antioxidant capacity (TAC) in young men. The aim of our study was to assess the impact of 24 WBC treatments on the blood concentration of selected sirtuins and the level of antioxidant defence as well as oxidative stress index of training and non-training men depending on age. Methods: The study involved 40 males. In each group, there were 10 non-training older and young men (60 NTR and 20 NTR), and 10 older and young long-distance runners (60 TR, 20 TR). During an 8-week period, participants underwent 24 WBC treatments (3 min −130 °C), which were performed three times a week (Monday, Wednesday, Friday). The concentrations of Sirt1, Sirt3, TAC, total oxidative status and the activity of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx) in the blood were determined before 1 WBC and after 1 WBC, 12 WBC and 24 WBC. Results: After 1 WBC, the activity of GPx and the concentration of Sirt1 and TAC in 60 TR and TAC in 60 NTR increased. After 12 WBC, the level of Sirt1 in 20 NTR and SOD in 20 TR increased. After 24 WBC, the level of Sirt1 increased in 60 TR and in 20 NTR, Sirt3 in 60 TR and SOD in 20 TR. Conclusions: Cryogenic temperatures increase blood levels of Sirt1 and Sirt3 and systemic antioxidant defence in men, but the effect is dependent on age, level of performed physical activity and the number of applied treatments.

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Effect of Whole-Body Cryotherapy on Morphological, Rheological and Biochemical Indices of Blood in People with Multiple Sclerosis

Journal of Clinical Medicine ◽

10.3390/jcm10132833 ◽

2021 ◽

Vol 10 (13) ◽

pp. 2833

Author(s):

Bartłomiej Ptaszek ◽

Aneta Teległów ◽

Justyna Adamiak ◽

Jacek Głodzik ◽

Szymon Podsiadło ◽

...

Keyword(s):

Multiple Sclerosis ◽

Neurological Diseases ◽

Venous Blood ◽

Whole Body ◽

Controlled Study ◽

Control Group ◽

Blood Indices ◽

Rheological Indices ◽

Whole Body Cryotherapy ◽

The Impact

The aim of this study was to examine and assess the impact of a series of 20 whole-body cryotherapy (WBC) treatments on the biochemical and rheological indices of blood in people with multiple sclerosis. In this prospective controlled study, the experimental group consisted of 15 women aged 34–55 (mean age, 41.53 ± 6.98 years) with diagnosed multiple sclerosis who underwent a series of whole-body cryotherapy treatments. The first control group consisted of 20 women with diagnosed multiple sclerosis. This group had no intervention in the form of whole-body cryotherapy. The second control group consisted of 15 women aged 30–49 years (mean age, 38.47 ± 6.0 years) without neurological diseases and other chronic diseases who also underwent the whole-body cryotherapy treatment. For the analysis of the blood indices, venous blood was taken twice (first, on the day of initiation of whole-body cryotherapy treatments and, second, after a series of 20 cryotherapy treatments). The blood counts were determined using an ABX MICROS 60 hematological analyzer (USA). The LORCA analyzer (Laser–Optical Rotational Cell Analyzer, RR Mechatronics, the Netherlands) was used to study the aggregation and deformability of erythrocytes. The total protein serum measurement was performed using a Cobas 6000 analyzer, Roche and a Proteinogram-Minicap Sebia analyzer. Fibrinogen determinations were made using a Bio-Ksel, Chrom-7 camera. Statistically significant differences and changes after WBC in the levels of red blood cells (RBC), hemoglobin (HGB), hematocrit (HCT), elongation index, total extend of aggregation (AMP), and proteins (including fibrinogen) were observed. However, there was no significant effect of a series of 20 WBC treatments on changes in blood counts, rheology, and biochemistry in women with multiple sclerosis. Our results show that the use of WBC has a positive effect on the rheological properties of the blood of healthy women.

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IMPACT OF WHOLE BODY CRYOTHERAPY ON THE BLOOD PLASMA VISCOSITY AND FIBRINOGEN CONCENTRATION IN WOMEN WITH RHEUMATOID ARTHRITIS

Journal of Kinesiology and Exercise Sciences ◽

10.5604/01.3001.0012.1432 ◽

2017 ◽

Vol 27 (79) ◽

pp. 85-89

Author(s):

Bartłomiej Ptaszek ◽

Jakub Marchewka ◽

Aneta Teległów

Keyword(s):

Rheumatoid Arthritis ◽

Blood Plasma ◽

Treatment Time ◽

Venous Blood ◽

Body Height ◽

Plasma Viscosity ◽

Whole Body ◽

Fibrinogen Concentration ◽

Plasma Parameters ◽

Whole Body Cryotherapy

Study aim: The aim of this study was to assess the effects of whole body cryotherapy on the plasma viscosity and fibrinogen in women with rheumatoid arthritis. Study group: The study groups consisted of 10 womens with rheumatoid arthritis, aged 57.2 ± 9.4, who underwent systemic cryotherapy treatments (3 min treatment time, -120°C chamber temperature, 10 treatment sessions, 5 times a week). Their average body height was 165.5 ± 4.6 cm, weight 68.5 ± 4.9 kg and BMI 24.8 ± 2.2 kg/m2. In order to analyse plasma parameters, venous blood samples were drawn from the participants of the study twice. The first study was held on the day of beginning treatments and the second test was conducted after a series of 10 treatments. Methodology: The viscosity of the blood plasma was determined in the viscometer (type D-52159 Roetgen, Myrenne Co., Germany). Determination of plasma fibrinogen was performed using the Bio-Ksel, Chrom – 7 camera. Results: Analysing the average values of plasma viscosity and fibrinogen in women with rheumatoid arthritis before and after whole body cryotherapy, no statistically significant differences were found. Conclusions: Regular usage of cryotherapy treatments (whole body cryotherapy) not affect the levels of fibrinogen and plasma viscosity in women with rheumatoid arthritis.

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Effects of Whole-Body Cryotherapy in Comparison with Other Physical Modalities Used with Kinesitherapy in Rheumatoid Arthritis

BioMed Research International ◽

10.1155/2015/409174 ◽

2015 ◽

Vol 2015 ◽

pp. 1-7 ◽

Cited By ~ 15

Author(s):

Małgorzata Gizińska ◽

Radosław Rutkowski ◽

Wojciech Romanowski ◽

Jacek Lewandowski ◽

Anna Straburzyńska-Lupa

Keyword(s):

Rheumatoid Arthritis ◽

Tumor Necrosis ◽

Rehabilitation Program ◽

Whole Body ◽

Study Group ◽

Clinical Parameters ◽

Positive Effects ◽

Whole Body Cryotherapy ◽

Necrosis Factor ◽

Physical Modalities

Whole-body cryotherapy (WBC) has been frequently used to supplement the rehabilitation of patients with rheumatoid arthritis (RA). The aim of this study was to compare the effect of WBC and traditional rehabilitation (TR) on clinical parameters and systemic levels of IL-6, TNF-αin patients with RA. The study group comprised 25 patients who were subjected to WBC (−110°C) and 19 patients who underwent a traditional rehabilitation program. Some clinical variables and levels of interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) were used to assess the outcomes. After therapy both groups exhibited similar improvement in pain, disease activity, fatigue, time of walking, and the number of steps over a distance of 50 m. Only significantly better results were observed in HAQ in TR group (p< 0.05). However, similar significant reduction in IL-6 and TNF-αlevel was observed. The results showed positive effects of a 2-week rehabilitation program for patients with RA regardless of the kind of the applied physical procedure.

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Decreased Oxidative Stress in Male Patients with Active Phase Ankylosing Spondylitis Who Underwent Whole-Body Cryotherapy in Closed Cryochamber

Oxidative Medicine and Cellular Longevity ◽

10.1155/2018/7365490 ◽

2018 ◽

Vol 2018 ◽

pp. 1-9 ◽

Cited By ~ 10

Author(s):

Agata Stanek ◽

Armand Cholewka ◽

Tomasz Wielkoszyński ◽

Ewa Romuk ◽

Aleksander Sieroń

Keyword(s):

Oxidative Stress ◽

Superoxide Dismutase ◽

Ankylosing Spondylitis ◽

Antioxidant Status ◽

Active Phase ◽

Post Treatment ◽

Whole Body ◽

Male Patients ◽

Whole Body Cryotherapy ◽

The Impact

Objective. The aim of the study was to estimate the impact of whole body cryotherapy (WBC) on oxidative stress when performed in a closed cryochamber on patients with ankylosing spondylitis (AS). Material and methods. The effect of ten WBC procedures lasting 3 minutes a day with a subsequent 60-minute session kinesiotherapy on oxidative stress in male AS patients (WBC group n=16) was investigated. To assess the disease activity, the Bath Ankylosing Spondylitis Diseases Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) were calculated. The WBC group was compared to the kinesiotherapy only (KT; n=16) group. The routine parameters of oxidative stress (antioxidant enzymatic and nonenzymatic antioxidant status, lipid peroxidation products, total oxidative status (TOS), and oxidative stress index (OSI)) were estimated one day before the beginning and one day after the completion of the research program. Results. After the completion of the treatment in the WBC group, a significant decrease of oxidative stress markers (TOS and OSI) and a significant increase of total antioxidant status were observed. The erythrocyte activity of glutathione peroxidase, glutathione reductase decreased significantly in both groups, but the differences of activity of that enzymes prior to post treatment values (Δ) in the KT group were significantly higher as compared to the WBC group. The activity of erythrocyte catalase and plasma ZnCu isoenzyme of superoxide dismutase showed a decreased tendency; erythrocyte total superoxide dismutase activity showed an increased tendency in the WBC group after the completion of the treatment. The BASDAI and BASFI decreased significantly in both groups, but the differences of value indexes prior to post treatment (Δ) were significantly higher in the WBC than KT group. Conclusion. WBC performed in a closed cryochamber decreases oxidative stress and improves BASDAI and BASFI indexes in male patients during the active phase of ankylosing spondylitis.

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Decreased Lipid Profile and Oxidative Stress in Healthy Subjects Who Underwent Whole-Body Cryotherapy in Closed Cryochamber with Subsequent Kinesiotherapy

Oxidative Medicine and Cellular Longevity ◽

10.1155/2019/7524878 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10 ◽

Cited By ~ 5

Author(s):

Agata Stanek ◽

Ewa Romuk ◽

Tomasz Wielkoszyński ◽

Stanisław Bartuś ◽

Grzegorz Cieślar ◽

...

Keyword(s):

Oxidative Stress ◽

Lipid Profile ◽

Healthy Subjects ◽

Whole Body ◽

Stress Index ◽

Stress Markers ◽

Total Antioxidant ◽

Whole Body Cryotherapy ◽

The Impact ◽

And Oxidative Stress

Objective. The aim of the study was to estimate the impact of whole-body cryotherapy (WBC) and subsequent kinesiotherapy on oxidative stress and lipid profile when performed in a closed cryochamber on healthy subjects. Material and Methods. The effect of ten WBC procedures lasting 3 minutes a day followed by a 60-minute session kinesiotherapy on oxidative stress and lipid profile in healthy subjects (WBC group, n=16) was investigated. The WBC group was compared to the kinesiotherapy only (KT; n=16) group. The routine parameters of oxidative stress (antioxidant enzymatic and nonenzymatic antioxidant status, lipid peroxidation products, total oxidative status (TOS), and oxidative stress index (OSI)) and lipid profile were estimated one day before the beginning and one day after the completion of the research program. Results. After treatment, in the WBC group, a significant decrease of oxidative stress markers (TOS and OSI) and a significant increase of total antioxidant capacity were observed. The activity of plasma SOD-Mn and erythrocyte total SOD increased significantly in the WBC group. In the KT group, the erythrocyte activity of total SOD, CAT, and GR decreased significantly after the treatment. The levels of T-Chol and LDL-Chol decreased significantly after treatment in both groups, but the observed decrease of these lipid parameters in the WBC group was higher in comparison to the KT group. The level of TG decreased significantly after treatment in the WBC group only. Conclusion. WBC performed in a closed cryochamber followed by kinesiotherapy improves lipid profile and decreases oxidative stress in healthy subjects.

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Whole-Body Cryotherapy Decreases the Levels of Inflammatory, Oxidative Stress, and Atherosclerosis Plaque Markers in Male Patients with Active-Phase Ankylosing Spondylitis in the Absence of Classical Cardiovascular Risk Factors

Mediators of Inflammation ◽

10.1155/2018/8592532 ◽

2018 ◽

Vol 2018 ◽

pp. 1-11 ◽

Cited By ~ 17

Author(s):

Agata Stanek ◽

Armand Cholewka ◽

Tomasz Wielkoszyński ◽

Ewa Romuk ◽

Aleksander Sieroń

Keyword(s):

Oxidative Stress ◽

Risk Factors ◽

Cardiovascular Risk ◽

Ankylosing Spondylitis ◽

Disease Activity ◽

Cardiovascular Risk Factors ◽

Whole Body ◽

Markers Of Inflammation ◽

Whole Body Cryotherapy ◽

The Impact

Objective. The aim of the study was to estimate the impact of whole-body cryotherapy (WBC) on cardiovascular risk factors in patients with ankylosing spondylitis (AS). Material and Methods. We investigated the effect of WBC with subsequent kinesiotherapy on markers of inflammation, oxidative stress, lipid profile, and atherosclerosis plaque in male AS patients (WBC group). To assess the disease activity, the BASDAI and BASFI were also calculated. The results from the WBC group were compared with results from the kinesiotherapy (KT) group. Results. The results showed that in the WBC group, the plasma hsCRP level decreased without change to the IL-6 level. The ICAM-1 level showed a decreasing tendency. The CER concentration, as well as the BASDAI and BASFI, decreased in both groups, but the index changes of disease activity were higher in the WBC than KT patients. Additionally, in the WBC group, we observed a decrease in oxidative stress markers, changes in the activity of some antioxidant enzymes and nonenzymatic antioxidant parameters. In both groups, the total cholesterol and LDL cholesterol, triglycerides, sCD40L, PAPP-A, and PLGF levels decreased, but the parameter changes were higher in the WBC group. Conclusion. WBC appears to be a useful method of atherosclerosis prevention in AS patients.

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Modelling of power supplies reliability in aspect of their technical and functional state

Journal of Konbin ◽

10.1515/jok-2017-0025 ◽

2017 ◽

Vol 42 (1) ◽

pp. 191-208

Author(s):

Tadeusz Dąbrowski ◽

Jerzy Chmiel ◽

Adam Rosiński

Keyword(s):

Functional State ◽

Power Supply ◽

Functional Condition ◽

The State ◽

Power Supplies ◽

The Impact

Abstract The article presents issues related to the modeling of reliability of power supply in terms of their technical and functional condition. There are designated relations allowing to determine the probability of staying the power supply in the state: full suitability, incomplete suitability and unsuitability. There is also examined the impact of time restore of the state of full suitability for the value of the probability of staying the power supply in the state of incomplete suitability.

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The impact of altered hands function on working ability of patients with systemic sclerosis

Vojnosanitetski pregled ◽

10.2298/vsp170705041v ◽

2020 ◽

Vol 77 (1) ◽

pp. 70-78

Author(s):

Predrag Vidakovic ◽

Nemanja Damjanov

Keyword(s):

Systemic Sclerosis ◽

Muscle Strength ◽

Range Of Motion ◽

Work Ability ◽

Working Capacity ◽

Working Ability ◽

Limited Mobility ◽

Finger Joints ◽

Hand Functions ◽

The Impact

Background/Aim. Hand impairment in systemic sclerosis (SSc) patients is the most frequent manifestation of this progressive disease and often cause problems in daily activities and working ability. The correlation of altered hand functions in patients with SSc and their impact on working ability is not fully explained. The objective of this study is to assess the impact of altered hand functions of patients with SSc on their working ability. Methods. We assessed 20 patients with SSc (17 females, 3 males), with mean age of 45.5 ? 11.9 years (min 29, max 69, Med 44.0 years). The movements of fingers, wrist and forearm were examined by measuring active range of motion of the hand and fingers, muscle strength of the fingers, the skin lesions by modified Rodnan score, the function of the fingers, hands and forearms by the Hand Mobility in Scleroderma (HAMIS) test, as well as the condition of the capillaries in the fingers by capillaroscopy and working capacity by Work Ability Index (WAI). Results. Reduced strength on at least one tested muscle, was established in all patients, thickening of the skin on the hands in 14/20 (70%) and the fingers in 19/20 (95%), ?scleroderma type? capillary changes in 15/17 (85%), decreased range of motion in finger joints in 16/20 (80%) of the patients. Also, 14/20 (70%) of subjects reported problems at work [decrease performance achieved in 8/20 (40%), reduction of working hours in also 8/20 (40%), leaving out some of the work in 14/20 (70%), and investing of extra effort in 15/20 (75%)]. By means of WAI, work ability assessment questionnaire, it was found that the working capacity was reduced in 11/20 (55%) of our patients. None of the patients was in the group of the most serious cases, the ?poor? category; in the ?moderate? category there were 6/20 (30%), while 5/20 (25%) of the patients were in the group with minimally reduced working capacity (?good? category). There was a statistically significant correlation between the thickened skin on the fingers (p < 0.05), reduced muscle strength in the fingers (p < 0.002) and limited mobility of the individual finger joints (p < 0.05), with information on reduced working capacity obtained by means of WAI questionnaire and with answers to questions about problems at work. Conclusion. The thickened skin on the fingers, reduced fingers muscle strength and limited mobility of certain finger joints in patients with SSc cause decreasing working capacity for all jobs that include manual activities.

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Impact of Cortisol on Reduction in Muscle Strength and Mass: A Mendelian Randomization Study

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/clinem/dgab862 ◽

2021 ◽

Author(s):

Shunsuke Katsuhara ◽

Maki Yokomoto-Umakoshi ◽

Hironobu Umakoshi ◽

Yayoi Matsuda ◽

Norifusa Iwahashi ◽

...

Keyword(s):

Muscle Strength ◽

Grip Strength ◽

Lean Mass ◽

Bayesian Model Averaging ◽

Mendelian Randomization ◽

Association Studies ◽

Whole Body ◽

Genome Wide Association Studies ◽

Mass Estimate ◽

The Impact

Abstract Purpose Prolonged exposure to pathological cortisol, as in Cushing’s syndrome causes various age-related disorders including sarcopenia. However, it is unclear whether mild cortisol excess, for example, accelerates sarcopenia due to aging or chronic stress. We performed a Mendelian randomization (MR) analysis to assess whether cortisol was causally associated with muscle strength and mass. Methods Three single nucleotide polymorphisms associated with plasma cortisol concentrations in the CORtisol NETwork consortium (n = 12,597) were used as instrumental variables. Summary statistics with traits of interest were obtained from relevant genome-wide association studies. For the primary analysis, we used the fixed-effects inverse-variance weighted analysis accounting for genetic correlations between variants. Results One standard deviation (SD) increase in cortisol was associated with SD reduction in grip strength (estimate, -0.032; 95% confidence interval [CI] -0.044 ~ -0.020; P = 3e-04), whole-body lean mass (estimate, -0.032; 95%CI, -0.046 ~ -0.017; P = 0.004), and appendicular lean mass (estimate, -0.031; 95%CI, -0.049 ~ -0.012; P = 0.001). The results were supported by the weighted-median analysis, with no evidence of pleiotropy in the MR-Egger analysis. The association of cortisol with grip strength and lean mass was observed in women but not in men. The association was attenuated after adjusting for fasting glucose in the multivariable MR analysis, which was the top mediator for the association in the MR-Bayesian model averaging analysis. Conclusion This MR study provides evidence for the association of cortisol with reduced muscle strength and mass, suggesting the impact of cortisol on the development of sarcopenia.

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