LEVOSIMENDAN – A VALUABLE PLAYER IN THE TREATMENT OF A RIGHT-SIDED HEART FAILURE

2019 ◽  
Vol 72 (8) ◽  
pp. 1586-1591
Author(s):  
Joanna Płonka ◽  
Jarosław Bugajski ◽  
Piotr Feusette ◽  
Agata Duszańska ◽  
Marek Gierlotka
Keyword(s):  
Heart Failure ◽  
Body Weight ◽  
Current Knowledge ◽  
Signs And Symptoms ◽  
Significant Loss ◽  
The Body ◽  
Invasive Treatment ◽  
Stage 4 ◽  
Cardiovascular Capacity ◽  
Resistance To Diuretics

A 66 year-old obese man, suffering from type 2 diabetes, high blood pressure, chronic nephropathy in stage 4, permanent atrial fibrillation accompanied by bradycardia was admitted to a cardiology ward with the signs and symptoms of acute right-sided heart failure. A standard therapy was used including combined diuretics therapy. In spite of the applied methods and pharmaceuticals, no significant reduction of the body weight neither improvement in cardiovascular capacity or renal parameters were observed. Due to the ineffectiveness of the standard combined pharmacotherapy applied in the case of the acute circulatory failure, the resistance to diuretics was recognized and as a result of the above, infusion of levosimendan was decided to be applied. This therapy resulted in rich diuresis, significant loss in body weight and considerable improvement in cardiovascular capacity which allowed to continue further diagnostics and appropriate invasive treatment. The article describes current knowledge on the place of levosimendan and its application in the treatment of an right-sided heart failure.

scholarly journals P1278DIALYSIS IN TREATMENT OF CONGESTIVE HEART FAILURE

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Vesna Ristovska
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Renal Failure ◽  
Body Weight ◽  
Extracellular Volume ◽  
The Body ◽  
Oedema Formation ◽  
Water Excretion ◽  
Before And After ◽  
Sodium And Potassium

Abstract Background and Aims The advanced congestive heart failure (CHF), may provoke functional kidney disturbances with insufficient and resistant to conservative therapy water excretion. The treatment of the chronic renal failure (CRF) with active dialysis related to ultrafiltration (UF), may overcome the renal diuretics resistance with diuresis restoration and oedema elimination. The aim of the study was to define the indications for active, discontinued UF in setting of the CHF refractory to drugs, especially in the treatment of oedema. Method We investigated 12 patients, mean age 62,4+/-5,3 years, with incipient renal failure, but advanced congestive heart failure. Seven of them were males and 5 females. The indication for discontinued UF, was the severe expressed heart failure, reduced diuresis and initial renal insufficiency. In all investigated patients, before and after each UF procedure, the serum sodium and potassium, blood urea nitrogen (BUN), creatinin and osmolality were detected. The body weight, abdominal and crural parameters were noted before and after dialysis. Results The recovery was achieved in 10 patients with CHF, but 2 patients out of 12 have not demonstrated satisfactory response to UF. The biochemical features encountered to CHF patients suggest chronic hyponatriemia, hypokalemia and hypovolemia. Proteinuria range 1,2 to 3,6 g/l, was present in 6 patients. The clinical data were performed with oedema formation, reduced diuresis and dispnea. Mean UF rate achieved after several dialysis was 12,4+/- 7,6, lit. Conclusion Chronic heart failure in chronic renal patients, with severe oedemas is an indication for UF therapy, even if the values of BUN and creatinin are not increased. Reduction of the body weight and the extracellular volume, contribute for improved survival in these patients. However the risk of complications is high and not always with successful treatment.

scholarly journals Gambaran karakteristik gagal jantung pada anak di RSUP Prof. Dr. R. D. Kandou Manado

e-CliniC ◽  
2016 ◽  
Vol 4 (2) ◽  
Author(s):  
Agnes A. Anthonius ◽  
Erling D. Kaunang ◽  
Ari L. Runtunuwu
Keyword(s):  
Heart Failure ◽  
Signs And Symptoms ◽  
Health Department ◽  
The Body ◽  
Shortness Of Breath ◽  
Design Data ◽  
Cross Sectional ◽  
Patients With Heart Failure ◽  
Characteristic Features ◽  
Cross Sectional Design

Abstract: Heart failure is the inability of the heart to pump adequate blood that fulfils the metabolic demands of the body, including growth. In Indonesia, it is still difficult to find the prevalence and incidence of heart failure in children. This study was aimed to determine the characteristic features of heart failure in children at Prof. Dr. R. D. Kandou Hospital Manado. This was a retrospective descriptive study with a cross-sectional design. Data were obtained from the medical records of pediatric patients with heart failure within the period of January 2013 to August 2016 in the Child Health Department at Prof. Dr. R. D. Kandou Hospital. The results showed that there were 69 children with heart failure; the most common were females and age 12-18 years. The most common signs and symptoms were shortness of breath, fever, and cough. Heart murmurs and gallop were frequently found. Hepatomegaly, splenomegaly, ascites and edema of the legs were not commonly found. The electrocardiogram results were mostly sinus rhythm. The echocardiography results were mostly mitral regurgitation. The most common comorbid disease was rheumatic heart disease. Conclusion: At Prof. Dr. R. D. Kandou Hospital, heart failure in children was mostly found among females and age of 12-18 years. Most of the children showed shortness of breath, fever, and cough.Keywords: heart failure, child, characteristic features Abstrak: Gagal jantung merupakan ketidakmampuan jantung sebagai pompa darah untuk memenuhi secara adekuat kebutuhan metabolisme tubuh termasuk pertumbuhan. Di Indonesia sendiri masih sulit menemukan data prevalensi dan insiden gagal jantung pada anak. Penelitian ini bertujuan mengetahui gambaran karakteristik gagal jantung pada anak di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ialah deksriptif retrospektif dengan desain potong lintang. Data penelitian diambil dari rekam medik pasien anak dengan gagal jantung periode Januari 2013 sampai Agustus 2016 di Bagian Ilmu Kesehatan Anak RSUP Prof. Dr. R. D. Kandou Manado. Hasil penelitian mendapatkan 69 anak, terbanyak pada usia 12-18 tahun dan jenis kelamin perempuan. Tanda dan gejala terbanyak ialah sesak napas, demam, dan batuk. Bising jantung dan galop banyak ditemukan. Hepatomegali, splenomegali, ascites dan edema tungkai tidak banyak ditemukan. Hasil elektrokardiogram terbanyak ditemukan ialah irama sinus. Hasil ekokardiografi terbanyak ditemukan ialah regurgitasi mitral. Penyakit penyerta terbanyak ialah penyakit jantung rematik. Simpulan: Gagal jantung anak di RSUP Prof. Dr. R. D. Kandou Manado terbanyak pada usia 12-18 tahun, jenis kelamin perempuan, dengan gejala klinik sesak napas, demam, dan batuk. Kata kunci: gagal jantung, anak, gambaran karakteristik

scholarly journals MYOKINES, THEIR ROLE IN MUSCLE CONTRACTION

2021 ◽  
Vol 27 (1) ◽  
pp. 4-11
Author(s):  
Nikolay Mikhailovich Vladimirov ◽  
Keyword(s):  
Physical Activity ◽  
Body Weight ◽  
Human Body ◽  
Skeletal Muscles ◽  
Current Knowledge ◽  
Review Article ◽  
The Body ◽  
Regular Exercise ◽  
Muscular System ◽  
Exercise Muscle

Skeletal muscles are the largest organ in the human body, making up 40–50% of the total human body weight. This work is devoted to the study of physical activity on the athlete’s body. Given that the muscular system is more multifunctional than previously thought, and is able to aff ect many systems of the body through the synthesis and secretion of cytokines-classical regulators of the immune system, classifi ed as myokines. In this review article, we summarize our current knowledge of the main identifi ed and characterized myokines, focusing on their biological activity and functions. Through regular exercise, muscle-induced factors called myokines can exert and play an important role in protecting against many diseases.

scholarly journals Central and peripheral control of food intake

2017 ◽  
Vol 51 (1) ◽  
pp. 52-70 ◽  
Author(s):  
M. M. I. Abdalla
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Energy Expenditure ◽  
Current Knowledge ◽  
The Body ◽  
Therapeutic Implications ◽  
New Therapeutic Approaches ◽  
Control Food ◽  
Adiposity Signals ◽  
Control Food Intake

Abstract The maintenance of the body weight at a stable level is a major determinant in keeping the higher animals and mammals survive. Th e body weight depends on the balance between the energy intake and energy expenditure. Increased food intake over the energy expenditure of prolonged time period results in an obesity. Th e obesity has become an important worldwide health problem, even at low levels. The obesity has an evil effect on the health and is associated with a shorter life expectancy. A complex of central and peripheral physiological signals is involved in the control of the food intake. Centrally, the food intake is controlled by the hypothalamus, the brainstem, and endocannabinoids and peripherally by the satiety and adiposity signals. Comprehension of the signals that control food intake and energy balance may open a new therapeutic approaches directed against the obesity and its associated complications, as is the insulin resistance and others. In conclusion, the present review summarizes the current knowledge about the complex system of the peripheral and central regulatory mechanisms of food intake and their potential therapeutic implications in the treatment of obesity.

scholarly journals Aktivitas Antiobesitas Ekstrak Daun Katuk (Sauropus androgynus L.Merr) Pada Model Mencit Obesitas

2018 ◽  
Vol 14 (2) ◽  
pp. 137 ◽  
Author(s):  
Patonah Patonah ◽  
Elis Susilawati ◽  
Ahmad Riduan
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Weight Loss ◽  
Body Weight ◽  
Risk Factor ◽  
Normal Weight ◽  
The Body ◽  
Control Group ◽  
Treatment Groups ◽  
Organ Index

Obesitas merupakan suatu kondisi terjadinya akumulasi lemak yang berlebih dalam tubuh. Obesitas merupakan faktor resiko hipertensi, diabetes mellitus, gangguan jantung dan penyakit pembuluh darah lainnya. Upaya menurunkan obesitas dapat menurunkan resiko penyakit tersebut. Penelitian ini bertujuan untuk mengetahui aktifitas antiobesitas ekstrak daun katuk (Sauropus androgynus L.Merr) pada model mencit swiss Webster obesitas. Sebanyak 30 ekor mencit dikelompokkan secara acak menjadi 6 kelompok  yaitu kelompok normal (menerima pembawa obat), induksi (menerima pembawa obat), pembanding (menerima orlistat 15,6 mg/Kg ), dan 3 kelompok menerima ekstrak daun katuk dosis 100, 200, 400 mg/kg. Semua kelompok (kecuali kelompok normal) diinduksi obesitas dengan fruktosa dan makanan tinggi lemak selama 21 hari. Parameter yang diukur adalah bobot badan, indeks makanan, indeks feses, indeks organ, dan indeks lemak. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan antara penurunan bobot badan kelompok perlakuan yang diberi ekstrak daun katuk terhadap kelompok induksi (p<0.05). Disimpulkan bahwa ekstrak daun katuk mempunyai aktivitas antiobesitas dan ekstrak terbaik dalam menurunkan bobot badan adalah ekstrak daun katuk 400 mg/Kg . Obesity is a condition an over-accumulating of lipids in the body. The weight over than 20 % from normal weight is called obese. The main cause of obesity is the unbalance intakes and outputs of lipids in the body. Obesity is a risk factor for hypertension, diabetes, heart failure and other vascular diseases.The purpose of this study was to determine the activity of katuk leaves extracts (Sauropus androgynus L.Merr) as antiobesity on Swiss Webster mice models of obesity. A total of 30 mice were randomly divided into 6 groups and 5 mice contains each group, normal, induction, the comparator (orlistat 15.6 mg / Kg), katuk leaves extract 100, 200, and 400 mg/Kg. Parameters measured were body weight, food index, feces index, organ index and fat index. Results showed that there were significant differences in weight loss parameters between treatment groups were given the katuk leaves extract compare to the control group (p<0.05). Based on the results, it can be concluded that the katuk leaves extract has antiobesity activity and the best extract as antiobesity was katuk leaves extract dose of 400 mg / Kg.

scholarly journals Body weight, dentition and longevity in Equus przewalskii kept in the Prague Zoo (Perissodactyla: Equidae)

2016 ◽  
Vol 47 (1) ◽  
pp. 133-136
Author(s):  
Jiří Volf
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Survival Rate ◽  
Normal Condition ◽  
Body Weight Loss ◽  
Significant Loss ◽  
The Body ◽  
Pathological Changes ◽  
Equus Przewalskii ◽  
Tooth Abrasion

Abstract The survival rate in ungulates is limited by tooth-abrasion that makes it difficult for senescent individuals to feed effectively. I examined correlation between age, body weight and dentition condition in the Przewalski’s horses (Equus przewalskii) kept in the Prague Zoo. The body weight of thirty adult horses aged 2–25 years ranged 250–300 kg. The individuals older than 30 years showed a significant loss in body weight up to one third of the normal condition. However, the weight loss was less pronounced in alpha individuals. For example, the stallion “Uran” weighted 270 kg even after he reached the age of 30 years. The weight loss in senescent individuals was generally correlated with pathological changes in dentition caused by gradual abrasion of the teeth. On the contrary, only six individuals (less than 3%) kept in the Prague Zoo lived longer than 30 years, although the mare “Verona” reached the age of almost 37 years which is the highest age ever recorded in the Przewalski’s horse. Anyway, the tooth-abrasion is an important factor leading to body weight loss in the majority of the senescent Przewalski’s horses.

Endovenous laser ablation is an effective treatment for great saphenous vein incompetence in teenagers

2015 ◽  
Vol 31 (3) ◽  
pp. 198-202
Author(s):  
Piotr Terlecki ◽  
Stanislaw Przywara ◽  
Marek Iłżecki ◽  
Karol Terlecki ◽  
Piotr Kawecki ◽  
...  
Keyword(s):  
Laser Ablation ◽  
Saphenous Vein ◽  
Great Saphenous Vein ◽  
Current Knowledge ◽  
Varicose Veins ◽  
Signs And Symptoms ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Invasive Treatment ◽  
Endovenous Laser Ablation

Objectives The current knowledge of chronic venous disease in teenagers and its treatment is very limited. The aim of the study is to present our experience and the available literature data on the treatment of varicose veins in teenagers with endovenous laser ablation of the great saphenous vein. Methods Five patients, aged 15–17 years, were qualified for surgery, based on typical signs and symptoms of chronic venous disease. Minimally invasive treatment with endovenous laser ablation of the great saphenous vein was applied. Results The technical success of surgery was achieved in all patients. Over a 2-year follow-up we did not observe any case of recanalisation of the great saphenous vein, recurrence of varicose veins, or serious complications, such as deep vein thrombosis or pulmonary embolism. One patient presented with resolving of post-operative bruising, and two cases of local numbness were transient. Conclusions Endovenous laser ablation of the great saphenous vein in the treatment of chronic venous disease in teenagers is effective and safe. The method provides excellent cosmetic effects, very short recovery time and high levels of patient satisfaction.

scholarly journals CHRONIC HEART FAILURE COURSE PROGNOSIS DEPENDING ON BODY WEIGHT AND ENDOGENOUS INTOXICATION SYNDROME

2019 ◽  
Vol 72 (4) ◽  
pp. 527-531
Author(s):  
Marta O. Kondratyuk ◽  
Olena O. Sorokopud ◽  
Larysa M. Strіl’chuk ◽  
Іryna B. Zhakun ◽  
Oksana R. Slaba ◽  
...  
Keyword(s):  
Heart Failure ◽  
Body Mass Index ◽  
Body Weight ◽  
Survival Rate ◽  
Body Mass ◽  
Minimum Degree ◽  
The Body ◽  
Normal Body ◽  
Endogenous Intoxication ◽  
Lipid Metabolism Disorders

Introduction: Over the years, heart failure remains one of the most common and prognostically unfavorable conditions. The aim of our study was to determine the frequency of complications in patients with CHF depending on the body weight and intoxication syndrome of varying degrees of severity. Materials and methods: A complete clinical examination was performed in 58 patients (41 (70.6%) men and 17 (29.4%) women) with CHF. In addition to the standard examination in accordance with the protocol, the level of endogenous intoxication was determined by the level of medium-weight molecules (MWM254) and leptin. The patients were randomized into 4 groups depending on their body mass index and the degree of endogenous intoxication. Statistical processing of the results was carried out using the methods of variation statistics “Statistica 6.0”. Results: It was revealed that the worst survival rate is observed in patients with normal body mass against the background of the expressed endogenous intoxication syndrome, the best survival rate is observed provided that there are a normal body mass and endogenous intoxication of a minimum degree. An inverse correlation between the body mass index and the endogenous intoxication indicator (blood MWM) was detected. Patients with CHF should have their leptin level evaluated. An increase in its level was associated with arterial hypertension, an increase in blood glucose levels and lipid metabolism disorders. Conclusions: Increased level of blood MWM worsens the forecast of CHF. The unfavorable outcome was observed in patients with the combination of hypoleptinemia with severe endogenous intoxication.

scholarly journals Iron Deficiency in Heart Failure: Mechanisms and Pathophysiology

2021 ◽  
Vol 11 (1) ◽  
pp. 125
Author(s):  
Ridha I. S. Alnuwaysir ◽  
Martijn F. Hoes ◽  
Dirk J. van Veldhuisen ◽  
Peter van der Meer ◽  
Niels Grote Beverborg
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Iron Deficiency ◽  
Exercise Capacity ◽  
Iron Homeostasis ◽  
Current Knowledge ◽  
The Body ◽  
Physiological Processes ◽  
Underlying Causes

Iron is an essential micronutrient for a myriad of physiological processes in the body beyond erythropoiesis. Iron deficiency (ID) is a common comorbidity in patients with heart failure (HF), with a prevalence reaching up to 59% even in non-anaemic patients. ID impairs exercise capacity, reduces the quality of life, increases hospitalisation rate and mortality risk regardless of anaemia. Intravenously correcting ID has emerged as a promising treatment in HF as it has been shown to alleviate symptoms, improve quality of life and exercise capacity and reduce hospitalisations. However, the pathophysiology of ID in HF remains poorly characterised. Recognition of ID in HF triggered more research with the aim to explain how correcting ID improves HF status as well as the underlying causes of ID in the first place. In the past few years, significant progress has been made in understanding iron homeostasis by characterising the role of the iron-regulating hormone hepcidin, the effects of ID on skeletal and cardiac myocytes, kidneys and the immune system. In this review, we summarise the current knowledge and recent advances in the pathophysiology of ID in heart failure, the deleterious systemic and cellular consequences of ID.

Behavioral and Psychological Signs and Symptoms of Dementia: A Consensus Statement on Current Knowledge and Implications for Research and Treatment

1997 ◽  
Vol 8 (S3) ◽  
pp. 497-500 ◽  
Author(s):  
Sanford I. Finkel ◽  
Jorge Costa e Silva ◽  
Gene Cohen ◽  
Sheldon Miller ◽  
Norman Sartorius
Keyword(s):  
Quality Of Life ◽  
Consensus Statement ◽  
Current Knowledge ◽  
Signs And Symptoms ◽  
Significant Loss ◽  
Her Family ◽  
Costs Of Care

The behavioral (e.g., repetitive questioning, hitting) and psychological (e.g., delusions, anxieties) signs and symptoms of dementia can result in suffering, premature institutionalization, increased costs of care, and significant loss in the quality of life for the patient and his or her family and caregivers.

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