scholarly journals APPLICATION OF ANTIBIOTICS AND PROBIOTICS FOR PREVENTION OF ANTIBIOTIC-ASSOCIATED DISBIOSIS IN PATIENTS WITH GENERALIZED PERITONITIS AND ENTERAL DYSFUNCTION SUPPORTS STAFF AWARENESS

2021 ◽  
Vol 74 (3) ◽  
pp. 508-511
Author(s):  
Viktor P. Polyovyy ◽  
Ruslan I. Sydorchuk ◽  
Larysa Ya. Fedonyuk ◽  
Oleksand V. Rotar ◽  
Pavlo V. Polyovyy ◽  
...  
Keyword(s):  
Preventive Measure ◽  
Probiotic Strain ◽  
Positive Influence ◽  
Control Group ◽  
Study Group ◽  
Acute Peritonitis ◽  
Generalized Peritonitis ◽  
Systemic Antibiotic Therapy ◽  
Intestinal Dysbiosis ◽  
Probiotic Strains

The aim: To clarify the efficacy of probiotics use as a preventive measure for post-antibiotic treatment in acute peritonitis and increase staff awareness related to antibiotic and probiotic use. Materials and methods: The study design included determination of the proper antibiotic and probiotic strain combination and clinical application of probiotic strains. The control group consisted of 63 (48.46%) patients who underwent traditional multimodal treatment of peritonitis and the study group of 67 (51.54%) individuals, with inclusion of different antibiotic/probiotic combinations. Results: Prior to antimicrobial therapy 67.7% patients of both groups’ patients had severe dysbiosis, proving dysbiosis as a sign of peritonitis. S. boulardii showed widest resistance spectrum and was used for probiotic therapy in study group. Intestinal dysbiosis grades distribution in control group significantly worsened, while in study group ratio of severe dysbiosis significantly dropped from 58.2% to 38.8% with significant growth of grade II dysbiosis to 61.2%. No visible differences in disease course and clinical picture, duration or complications rate between study and control groups were observed. Conclusions: Most of probiotic strains lack antibacterial resistance that makes meaningless their use during systemic antibiotic therapy of acute peritonitis. It is characterized by harsh changes of intestinal microbiota (severe intestinal dysbiosis). While probiotic strains showed antibiotic tolerance, their use presented no significant clinical efficacy, though high level of positive influence on intestinal dysbiosis was observed.

Low Bacterial Diet in Patients with Cytopenia after Intensive Chemotherapy for Hematological Malignancy: A Study of Efficacy and Costs.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 5548-5548
Author(s):  
Harry C. Schouten ◽  
Peter Terporten ◽  
Maartje Harbers ◽  
Riette van Boxtel ◽  
Alphons Kessels ◽  
...  
Keyword(s):  
Primary Outcome ◽  
Preventive Measure ◽  
Secondary Outcome ◽  
Control Group ◽  
Study Group ◽  
Risk Of Infection ◽  
Outcome Parameter ◽  
Societal Costs ◽  
Gram Negative ◽  
To Receive

Abstract Patients with hematological malignancies who receive intensive chemotherapy usually develop a period of cytopenia, during which there is an increased risk of infection. In order to reduce the risk of infection several preventive measures have been adopted. Fundamentally, all of these measures were designed to prevent either acquisition of Gram negative rods or fungal pathogens from the environment, or the translocation of these potential pathogens across the mucosal barrier of the gut. The evidence for the necessity of low bacterial diet as an infection preventive measure is weak. Therefore, in this randomized, controlled study the question whether normal hospital diet is equivalent in efficacy to low bacterial diets, given as an infection preventive measure during treatment of cytopenic patients, was addressed. Intestinal colonization by aerobic Gram negative rods and yeasts has been chosen as primary endpoint. In addition, the occurrence of infections and the total costs of hospital care have been documented, in order to identify potential cost savings by the use of either diet. The patients were randomized into two groups: one group (Study group) to receive antimicrobial prophylaxis (AP) and low-bacterial diet, the other (Control group) to receive the same AP and normal hospital diet. The primary outcome parameter is colonization of faeces with Gram-negative rods or Candida species. Degree of colonization was calculated as [∑ 10log (CFU/g feces)] x [duration of episode] /[number of days on which feces culture were taken]. Next, an analysis of variance was performed taking several factors into account, such as the use of antibiotics. As secondary outcome parameters all infections, and therapeutic use of antibiotics were registered; moreover, total societal costs were calculated for each patient starting at first hospitalization until 28 days after the last discharge. In the study group 10 patients were included and evaluable, in the control group 10 patients were included and 9 evaluable. The number of cycles studied, defined as the period from starting antibiotic prophylaxis until leukocyte counts had recovered to 1000 /mm3 or higher, was 21 in the study group, and 18 in the control group. The median number of days per cycle was 28 (range 17–43) days for the study group, and 34 (range 19–60) days for the control group (NS). Regarding the primary outcome parameter, gut colonization by yeasts or Gram negative rods, no statistically significant differences between treatment groups were observed. With respect to infections as secondary outcome parameter, neither the number of days with fever nor the number of days, during which antibiotics were administered therapeutically, was different between the study and control group of patients. The numbers of fungal infections were no cases of invasive aspergillosis (IA) in the study group, 2 episodes of possible aspergillosis in the control group, and in both groups one episode of candidemia. Regarding the total societal costs no statistically significant differences were measured between normal diet and low-bacterial diet. The results indicate that low-bacterial diet and normal hospital diet are equivalent regarding colonization with yeasts and Gram negative rods, infections and total societal costs.

The administration of probiotics and synbiotics in immune compromised adults: is it safe?

2015 ◽  
Vol 6 (1) ◽  
pp. 3-17 ◽  
Author(s):  
M. Van den Nieuwboer ◽  
R.J. Brummer ◽  
F. Guarner ◽  
L. Morelli ◽  
M. Cabana ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Adverse Events ◽  
Food Studies ◽  
Probiotic Strain ◽  
Control Group ◽  
Culture Study ◽  
Serious Adverse Events ◽  
Probiotic Strains ◽  
The Common

This study aimed to systematically evaluate safety of probiotics and synbiotics in immune compromised adults (≥18 years). Safety was analysed using the Common Terminology Clinical Adverse Events (CTCAE version 4.0) classification, thereby providing an update on previous reports using the most recent available clinical data (2008-2013). Safety aspects are represented and related to number of participants per probiotic strain/culture, study duration, dosage, clinical condition and selected afflictions. Analysis of 57 clinical studies indicates that probiotic and/or synbiotic administration in immune compromised adults is safe with regard to the current evaluated probiotic strains, dosages and duration. Individuals were considered immune compromised if HIV-infected, critically ill, underwent surgery or had an organ- or an autoimmune disease. There were no major safety concerns in the study, as none of the serious adverse events (AE)s were related, or suspected to be related, to the probiotic or synbiotic product and the study products were well tolerated. Overall, AEs occurred less frequent in immune compromised subjects receiving probiotics and/or synbiotics compared to the control group. In addition, the results demonstrated a flaw in precise reporting and classification of AE in most studies. Furthermore, generalisability of conclusions are greatly limited by the inconsistent, imprecise and potentially incomplete reporting as well as the variation in probiotic strains, dosages, administration regimes, study populations and reported outcomes. We argue that standardised reporting on adverse events (CTCAE) in ‘food’ studies should be obligatory, thereby improving reliability of data and re-enforcing the safety profile of probiotics.

scholarly journals Effects of art therapy on stress and anxiety of employees

2010 ◽  
Vol 64 (1-2) ◽  
pp. 85-91 ◽  
Author(s):  
Dace Visnola ◽  
Dagmāra Sprūdža ◽  
Mārīte Ārija Baķe ◽  
Anita Piķe
Keyword(s):  
Art Therapy ◽  
Preventive Measure ◽  
Control Group ◽  
Study Group ◽  
Stress Indicator ◽  
Situational Anxiety ◽  
Before And After ◽  
Final Stress ◽  
The Mean

Effects of art therapy on stress and anxiety of employees The study was designed to determine if art therapy has any effect on the stress and anxiety of employees. The results demonstrated that before and after art therapy in the study group, the level of the stress indicator (cortisol) over twenty-four hours and also the state of anxiety decreased significantly (P < 0.05). The mean final stress level and situational anxiety for the study group were significantly lower (P < 0.05) than those for the control group. No significant changes were found for trait anxiety in any of the groups. These findings suggest that art therapy for employees is a preventive measure for a person to understand stress situations and to be capable to manage their anxiety, react adequately and to cope with stress, thus improving the quality of life by creative means.

scholarly journals The role of yogurt enriched with lactobacillus rhamnosus GG culture in dental caries prevention

2022 ◽  
pp. 1-1
Author(s):  
Isidora Neskovic ◽  
Aleksandra Maletin ◽  
Jelena Brakoc ◽  
Bojan Petrovic ◽  
Sanja Vujkov ◽  
...  
Keyword(s):  
Milk Fat ◽  
Lactobacillus Rhamnosus ◽  
Probiotic Strain ◽  
Study Groups ◽  
Plaque Index ◽  
Mixed Dentition ◽  
Control Group ◽  
Study Group ◽  
Lactobacillus Rhamnosus Gg

Introduction/Objective. Contemporary tendencies suggest that probiotics can significantly reduce the prevalence of caries in children, so it can be considered that they have a positive effect on general and oral health. Lactobacillus rhamnosus GG (LGG) is a probiotic culture of particular importance in preventive dentistry. The aim was to assess the effects of consumption of probiotic strain Lactobacillus rhamnosus GG on the dental plaque accumulation in children with mixed dentition. Methods. Research included 90 children with mixed dentition (5-12 years old). First study group consumed 200 ml of Lactobacillus rhamnosus GG-enriched yogurt (B-Activ LGG, Dukat) daily for a period of 14 days, while the remaining 30 formed the second study group who consumed 200 ml of yogurt (Jogurt 1,5% milk fat, Imlek) with manually added powder from probiotic capsule (Wayaforte LGG capsule, Medis) daily for14 days. The control group consisted of 30 children who had regular diet during examination period. Silness-L?e plaque index and saliva pH (pH-Fix-0-14, Macherey-Nagel) were determined at baseline and also upon intervention completion. Results. An increase in pH values was observed in both study groups. In general sample, there is a significant decrease of mean plaque index values (p ? 0.001). Both study groups had significant decrease of mean plaque index values on the baseline and after 14 days consumption of yogurt. In the control group the number of subjects with decrease plaque index values did not correlate and no association was found. Conclusion. Consistent consumption of LGG culture-enriched yogurt inhibits dental film accumulation and promotes saliva pH increase in children with mixed dentition.

scholarly journals The influence of probiotic strain L. casei 01 on biogenic amines concentrations in fermented sausages Herkules

2009 ◽  
Vol 57 (5) ◽  
pp. 41-48
Author(s):  
Radka Burdychová
Keyword(s):  
Biogenic Amines ◽  
Storage Period ◽  
Probiotic Strain ◽  
Positive Influence ◽  
Hplc Method ◽  
Fermented Sausages ◽  
Probiotic Strains ◽  
Negative Controls ◽  
Dry Sausages ◽  
And Storage

In this work, the influence or probiotic strainL. casei01 (Sacco, Italy) on biogenic amines concentrations during fermentation, ripening and storage of fermented sausages “Herkules” was studied. Two amounts of probiotic culture were added into sausages, 0,25 % and 0,40 %, respectively. Negative controls without probiotic were also made. Dry sausages were taken from two different producers (A, B). Determination of biogenic amines tyramine, histamine, putrescine and cadaverine concentration was used using HPLC method with UV detection. The content of biogenic amines was monitored during fermentation (0–28 days) and storage (28–49) of fermented sausages.In both producers, when 0,25 % of probiotic strains was added, the numbers ofL. caseireached 104CFU/g during the fermentation (0–28) and they remained relatively constant during the sto­ra­ge (28–49). When 0,40 % of probioticL. casei01 was added, the amount ofL. caseicells were around 106 CFU/g during the whole fermentation and storage period.A positive influence on the reduction of biogenic amines was observed in both producers. In negative controls without probiotic, the higher concentration of tyramine, histamine, putrescine and ca­da­ve­ri­ne was detected in comparison with probiotic sausages.Differences between dry sausages with 0,25 % and 0,40 % probioticL. casei01 were also determined. In producer A, the concentration of putrescine and cadaverine in 0,40 % probiotic sausages were statistically lower in comparison with probiotic sausages where 0,25 %L. caseiwas applied. In producer B, the concentration of all monitored biogenic amines were statistically lower in 0,40 % probiotic sausages when compared with 0,25 % probiotic sausages.

Utilization of the Feto-Maternal triage Program in Maternity Hospitals Of Baghdad City

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Wisam M. Muttaleb ◽  
Ezedeen F. Baha’aldeen
Keyword(s):  
Waiting Time ◽  
Positive Influence ◽  
Control Group ◽  
Study Group ◽  
Flow Sheet ◽  
Age Group ◽  
Mean Waiting Time ◽  
Maternity Hospitals ◽  
Significant Difference ◽  
The Impact

Objectives:   To evaluate the impact of fate-maternal triage program upon laboring women's outcomes. Methods: Quazi- experimental design was conducted upon laboring women seeking  for care in Baghdad hospitals The study was conducted At Baghdad hospitals, which in both sides Al-Kargh (13 hospital) and Al-Resafa(23 hospital). The sample of the study consist of 280 laboring women, 140 women for each control and study group who are attending to the labor room in selected hospitals. Questionnaire format conducted as a flow sheet. It is designed and developed by the researcher depending on the feto-maternal triage index of AWHONN'S and Manchester triage system with some modification done by a researcher.  Results:the mean age for both groups is 29.85 ± 8.64. More than a quarter of participants in the study group are within the age group of (21-25) years-old (n = 40; 28.6%), followed by those who are in the age group of (31-35) years-old (n = 36; 25.7%). For the control group, more than a third are in the age group of (21-25) years-old (n = 47; 33.6%), followed by those who are in the (31-35) years-old (n = 33; 23.6%).Concerning participants’ BMI, more than two-fifths in the study group are overweight (n = 61; 43.6%),for the control group, more than two-fifths in the study group are overweight (n = 61; 43.6%).More than a third of participants in the study group reported that the waiting time is (10-20) minutes and (21-30) minutes (n = 53; 37.9%) for each of them,For the control group, more than two-fifths reported that the waiting time is (31-60) minutes (n = 58; 41.4%).The mean waiting time for the control group is greater than that of the study group (1.68, 1.32) respectively. also more than a third of participants in the study group reported that the severity of cases are very urgent and emergency cases (n = 44; 31.4%), (n=23; 16.4%) respectively for each of them. For the control group, more than half of participants reported that the severity of case is very urgent and emergency cases (n = 44; 33.6 %),(n=20;14.3) respectively.There is a statistically significant difference in the mothers’ complications between the study and the control groups (χ2 = 13.755, df = 1, p-value = .000). This indicates a positive influence of the program in reducing the mother's complications. Conclusion: The study shows that the positive influence of the program in triage the cases according to its severity and according to the levels used in the triage.  

Analysis of risk factors for omental herniation associated with removal of peritoneal catheters

1997 ◽  
Vol 6 (6) ◽  
pp. 430-436 ◽  
Author(s):  
B Copnell ◽  
JD Best ◽  
B Capewell
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Cardiac Surgery ◽  
Peritoneal Dialysis ◽  
Preventive Measure ◽  
Control Group ◽  
Study Group ◽  
Intraperitoneal Bleeding ◽  
Omental Herniation

BACKGROUND: Peritoneal catheters may be used routinely in children undergoing cardiac surgery. Removal of the catheter is often complicated by omental herniation, which can cause intraperitoneal bleeding, peritonitis, and bowel obstruction. Instillation of saline into the catheter before removal is used in some institutions as a preventive measure, but the practice has never been investigated. OBJECTIVE: To determine the effectiveness of instilling saline into peritoneal catheters before their removal in reducing the occurrence of omental herniation and to determine risk factors for omental herniation. METHODS: A total of 404 patients with peritoneal catheters in place were randomized to either the control or the study group. The study group (n = 204) had saline (1 mL/kg; maximum, 10 mL) instilled into the catheter before the catheter was removed; the control group (n = 200) did not. Extrusion or no extrusion of omentum was recorded. Other data collected included the child's weight, the length of time the catheter was in place, whether peritoneal dialysis was performed, and whether the child was pharmacologically paralyzed when the catheter was removed. RESULTS: Extrusion of omentum occurred in 39% of the study group and in 33% of the controls. Results of logistic regression analysis suggested that omental herniation was more common in smaller children, children whose catheters remained in place longer, and children who were not pharmacologically paralyzed when the catheter was removed. CONCLUSIONS: Instillation of saline does not appear to reduce the occurrence of omental herniation. Further research into strategies to reduce this complication is recommended.

scholarly journals STUDY OF THE PROBIOTIC STRAIN OF LACTOBACILLUS REUTERI ON PIGLETS IN THE POST-HARVEST PERIOD

PIG-BREEDING ◽  
2021 ◽  
pp. 61-64
Author(s):  
A.N. OVCHAROVA ◽  
◽  
O.V. SOFRONOVA ◽  
L.L. POLYAKOVA ◽  
K.S. OSTRENKO ◽  
...  
Keyword(s):  
Lactobacillus Reuteri ◽  
Specific Resistance ◽  
Live Weight ◽  
Probiotic Strain ◽  
Control Group ◽  
Nonspecific Resistance ◽  
Probiotic Strains ◽  
Simultaneous Decrease ◽  
Feed Costs ◽  
Stimulation Of

The article presents data on the study of the effectiveness of a probiotic based on two strains of Lactobacillus reuteri on the indicators of nonspecific resistance and productivity of weaned piglets. The normalization of the digestive tract microflora under the action of probiotics, manifested in an increase in the number of lactobacilli and bifidobacteria, with a simultaneous decrease in the number of salmonella, as well as the stimulation of non-specific immunity, together led to an increase in the growth rate of piglets. At the end of the experiment, the live weight of piglets treated with Lactobacillus reuteri was 9.3% higher and the average daily gains were 15.8% higher than the control group. At the same time, feed costs per 1 kg of growth decreased by 13.6%. This allows the use of probiotic strains of Lactobacillus reuteri in the diet of piglets to increase non-specific resistance and growth indicators in the post-weaning period.

Pretreatment with Methylprednisolone Improves Myocardial Protection during On-Pump Coronary Artery Bypass Surgery

2015 ◽  
Vol 18 (4) ◽  
pp. 171 ◽  
Author(s):  
Tolga Demir ◽  
Mehmet Umit Ergenoglu ◽  
Hale Bolgi Demir ◽  
Nursen Tanrikulu ◽  
Mazlum Sahin ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Myocardial Protection ◽  
Troponin T ◽  
Artery Bypass ◽  
Control Group ◽  
Study Group ◽  
Cabg Surgery ◽  
Anti Inflammatory ◽  
Pump Coronary Artery Bypass

<strong>Background</strong>: This study was undertaken to determine whether methylprednisolone could improve myocardial protection by altering the cytokine profile toward an anti-inflammatory course in patients undergoing elective coronary artery bypass grafting (CABG) surgery with cardiopulmonary bypass (CPB).<br /><strong>Methods</strong>: Forty patients who were scheduled for elective CABG surgery were randomized into two groups: the study group (n = 20), who received 1 g of methylprednisolone intravenously before CPB, and the control group (n = 20), who underwent a standard CABG surgery without any additional medication. Blood samples were withdrawn prior to surgery (T1) and then 4 hours (T2), 24 hours (T3), and 36 hours (T4) after CPB. Plasma levels of interleukin (IL)-6, IL-10, creatine kinase isoenzyme MB (CK-MB), cardiac troponin-t (cTnT), and blood glucose as well as neutrophil counts were measured at each sampling time. <br /><strong>Results</strong>: A comparison of patients between both groups revealed significantly high levels of IL-6 in the control group at T2, T3, and T4 with respect to T1 (T2: P &lt; .001; T3: <br />P &lt; .001; T4: P &lt; .001). IL-10 levels were significantly higher in the study group at T2 compared with the control group <br />(P = .007). CK-MB levels were significantly lower in the study group than in the control group at T4 (P = .001). The increase of cTnT was higher in the control group at T3 and T4 compared with the study group (T3: P = .002; T4: P = .001).<br /><strong>Conclusions</strong>: This study demonstrates that methylprednisolone is effective for ensuring better myocardial protection during cardiac surgery by suppressing the inflammatory response via decreasing the levels of IL-6 and by increasing anti-inflammatory activity through IL-10.<br /><br />

CARDIOVASCULAR RISK FACTORS PECULIARITIES IN MEN UNDER 60 YEARS OLD WITH MYOCARDIAL INFARCTION AND CHRONIC INFLAMMATORY LUNG DISEASES

2020 ◽  
pp. 21-25
Author(s):  
Tupitsyn V.V. ◽  
Bataev Kh.M. ◽  
Men’shikova A.N. ◽  
Godina Z.N.
Keyword(s):  
Risk Factors ◽  
Myocardial Infarction ◽  
Heart Disease ◽  
Cardiovascular Risk ◽  
Digestive System ◽  
Control Group ◽  
Study Group ◽  
Type I ◽  
Internal Organs ◽  
History Of

Relevance. Information about the cardiovascular diseases risk factors (CVD RF) for in men with chronic lung inflam-matory pathology (CLID) is contradictory and requires clarification. Aim. To evaluate the peculiarities of CVD RF in men under 60 years of age with CLID in myocardial infarction (MI) to improve prevention. Material and methods. The study included men aged 19-60 years old with type I myocardial infarction. Patients are divided into two age-comparable groups: I - the study group, with CLID - 142 patients; II - control, without it - 424 patients. A comparative analysis of the frequency of observation of the main and additional cardiovascular risk fac-tors in groups was performed. Results. In patients of the study group, more often than in the control group we observed: hereditary burden of is-chemic heart disease (40.8 and 31.6%, respectively; p = 0.0461) and arterial hypertension (54.2 and 44.6%; p = 0.0461), frequent colds (24.6 and 12.0%; p = 0.0003), a history of extrasystoles (19.7 and 12.7%; p = 0.04); chronic foci of infections of internal organs (75.4 and 29.5%; p˂0.0001), non-ulcer lesions of the digestive system (26.1 and 14.6%; p = 0.007), smoking (95.1 and 66.3%; p˂0.0001), MI in winter (40.8 and 25.9%; p = 0.006). Less commonly were observed: oral cavity infections (9.2 and 23.6%; p˂0.0001); hypodynamia (74.5 and 82.5%; p = 0.0358), over-weight (44.4 and 55.2%; p = 0.0136), a subjective relationship between the worsening of the course of coronary heart disease and the season of the year (43.7 and 55.2%; p = 0.0173) and MI - in the autumn (14.1 and 21.9%; p = 0.006) period. Conclusions. The structure of CVD RF in men under 60 years of age with CLID with MI is characterized by the pre-dominance of smoking, non-ulcer pathology of the digestive system, frequent pro-student diseases, meteorological dependence, a history of cardiac arrhythmias and foci of internal organ infections. It is advisable to use the listed factors when planning preventive measures in such patients.

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