scholarly journals AN OVERVIEW OF AUTOIMMUNITY IN IMPLANTATION FAILURE: A LITERATURE REVIEW

2021 ◽  
Vol 74 (3) ◽  
pp. 777-783
Author(s):  
Vladyslav O. Berestoviy ◽  
Ahmad A. Mahmood ◽  
Oleg O. Berestoviy ◽  
Valentyna G. Ginzburg ◽  
Dmytro O. Govsieiev

The aim: This review was aimed to understand the role of different types of autoantibodies like antiphospholipid, antithyroid, antisperm, antinuclear, anti-ovarian autoantibodies and heat shock protein HSP 60 in the process of implantation in the normal way of conceiving and IVF and also to estimate that how the presence of these autoantibodies affect the normal pregnancy outcome. Materials and methods: This review process performed in the obstetrics and gynaecology postgraduate department, Bogomolets national medical university, Kyiv, Ukraine. It was a review of already published papers not to need the ethical board committee's approval. By following the literature review guidelines, this paper was written and searched for relevant studies regarding autoantibodies and implantation, published in medical literature till 2020 were included in this review process. The search is done for studies published till 2020 in the English language from the Medline database, including Google Scholar, PubMed, Web of Science and Cochrane library database. Conclusions: Our recent work found that the involvement of APA, ANA and/or ATA in recipients of oocyte donations did not affect their pregnancy outcomes. Some researchers did not give any clear conclusion about these risks, and some stated that the use of some immunodepressant agents could be useful to reduce the harmful effects of these autoantibodies associated with implantation failure. Each autoantibody has a different mechanism of action to create the pathological state, some have direct effect, and some indirectly impact implantation. In future, further high-quality studies need to be performed for better understanding.

2011 ◽  
Vol 1 (2) ◽  
pp. 32 ◽  
Author(s):  
Mohammed Mohsin Uzzaman ◽  
Muhammed Rafay Sameem Siddiqui

The most commonly encountered complication after haemorrhoidectomy is post-operative pain. Relief of this pain may aid earlier recovery. A literature search was performed examining the different surgical and medical agents for the relief of post haemorrhoidectomy pain using Pubmed, MEDLINE, EMBASE, CINAHL and Cochrane library databases. Pain can be relieved by surgical or medical agents. Surgery incorporates a risk of incontinence. A number of studies examine the role of medical agents.A variety of surgical techniques and medical agents are available to the clinician in the treatment of post haemorrhoidectomy pain. Tailored management to individual patients should ensure appropriate symptomatic control and prompt recovery.


2021 ◽  
Vol 2021 (1) ◽  
pp. 76-82
Author(s):  
I.V. Bobina ◽  
◽  
V.I. Kravtsova ◽  

The article presents not only the official data on the professor of the Department of Normal Human Anatomy at Kharkiv National Medical University, Academician of the Ukrainian Academy of Sciences of National Progress, Honorary Academician of the International Academy of Integrative Anthropology, Doctor of Medical Sciences Vladimir Viktorovich Bobin, but also the memories of students and relatives of the scientist. Shownthe portrait of an intellectual person, Teacher, a loving father and grandfather, such as Professor V.V. Bobin. In the article, the biography of the scientist is shown against the background of historical events in the country. The role of father Viktor Vladimirovich Bobin and academician Vladimir Petrovich Vorobyov in the formation of the character and scientific interests of V.V. Bobin.


2020 ◽  
pp. bmjspcare-2020-002287
Author(s):  
Sara Mone ◽  
Helen Kerr

Individuals with advanced cancer who have accurate prognostic awareness are reported to make more informed decisions about their plan of care. Despite this, it is reported that individuals do not always have accurate prognostic awareness with the rationale for this discordance unclear. The primary aim of the integrative literature review was to identify if there is concordance between actual prognosis and accurate prognostic awareness in individuals with advanced cancer. The secondary aim was to identify the rationale for any discordance between actual prognosis and prognostic awareness in individuals with advanced cancer. This is an integrative literature review using a systematic approach. Literature searches were undertaken in March 2018 in four databases; CINAHL, MEDLINE, PsycINFO and Cochrane Library. Searches were limited to between 2008 and 2018 and those written in the English language. Database searches were supplemented with papers from reference lists of included papers and grey literature. Two reviewers independently completed the literature search and independently reviewed the papers. Fourteen eligible research papers were identified. The majority of individuals with advanced cancer in the included studies did not have accurate prognostic awareness. When identified, the rationale for discordance relates to the individual not being communicated accurate prognostic information, not being able to recall prognostic conversations or prognosis being discussed in vague terms. As individuals with advanced cancer with accurate prognostic awareness make more informed decisions at a crucial time in their life trajectory, it is imperative that healthcare professionals are equipped to effectively deliver accurate prognostic information, ensuring understanding is assessed.


ELT in Focus ◽  
2019 ◽  
Vol 2 (1) ◽  
pp. 29-33
Author(s):  
Kelik Wachyudi

The research paper attempt to disentangle of (applied) linguistics in English language teaching.  In this research, I used a literature review as my method. The result revealed that the role (applied) linguistics in English language teaching is needed for language learners. As a result, English language learners have beneficial from (applied) linguistics along with study English language teaching.  The content of (applied) linguistics help language learners better to comprehend ELT.


2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Abhishek Jaiswal ◽  
Ankita Jaiswal ◽  
Surabhi Puri ◽  
Adarsh Pal

Abstract Background Inappropriate usage of antibiotics among COVID-19 patients can raise disastrous effects on antimicrobial resistance management and antibiotic stewardship programs. A study from USA reported 71% of COVID-19 patients received antibiotics while only 4% had bacterial co-infection. Similar findings were reported from a review of data from COVID-19 cases in Asia, which reported more than 70% of the patient receiving antibiotics however less than 10% on average had bacterial coinfection. The World Health Organisation discourages the use of antibiotics for mild cases of COVID-19, however they recommend it for severe cases at increased risk of secondary bacterial infection and death. This review aims to discuss the usage of antibiotics in COVID-19 patients pointing the role of bacterial coinfections, types of antibiotics used, and antibiotic resistance. Methods We systematically searched Medline, Cochrane library, Google Scholar for eligible studies published from 1st January 2020 till 29th May 2021. We included English language articles. We included patients of all age groups, in all settings. Primary outcome variable was bacterial coinfection and antimicrobial usage among COVID-19 patients. Results Less than 10% of the hospitalised COVID-19 patients had bacterial Co-infection. Antibiotics used among COVID-19 positives were moxifloxacin, ceftriaxone, azithromycin, piperacillin-tazobactam, levofloxacin, meropenem, etc. Conclusions Low proportion of COVID-19 patients had bacterial co-infection. Routine usage of antibiotics among COVID-19 positives should be discouraged. Key messages Bacterial co-infection among COVID-19 patients is low and therefore misuse of antibiotics among them should be discouraged.


2012 ◽  
Vol 16 (5) ◽  
pp. 300-305 ◽  
Author(s):  
Michael Sawchuk ◽  
Frank Spano ◽  
Wei Jing Loo ◽  
Lyn Guenther

Background: Psoriasis and vitiligo are both autoimmune diseases with an increased incidence noted in genetic relatives. They share similar trigger factors and have been observed to coexist in individuals. Objective: The purpose was to review the literature on the coexistence of psoriasis and vitiligo and to determine if there is a higher than expected prevalence of psoriasis in patients with vitiligo and vice versa. Methods: A literature review was conducted using Medline, EMBASE, and the Cochrane Library from 1968 to 2010. All articles that included reports of individuals with both psoriasis and vitiligo in the English language were documented. Results: We identified 338 articles, among which 35 case reports and 7 case series were mentioned. For each case series, the prevalence of psoriasis in patients with vitiligo, or vice versa, falls within the prevalence range of the background population on which the study was based. Conclusion: An increase in the expected prevalence of psoriasis in individuals with vitiligo, or vice versa, was not found in our study, suggesting that the coexistence of the two diseases appears to be due to chance alone. Large epidemiologic studies are required to address with certainty whether psoriasis is more common in individuals with vitiligo and vice versa. Renseignements de base: Le psoriasis et le vitiligo sont deux affections auto-immunes qui ont une incidence accrue observée chez les membres de la famille apparentée. Ils partagent des facteurs déclencheurs similaires, et des études ont démontré leur coexistence chez les personnes. Objectif: Le but était de faire une analyse documentaire sur la coexistence du psoriasis et du vitiligo et de déterminer s'il y a une prévalence plus élevée que prévu du psoriasis chez les patients atteints de vitiligo et vice versa. Méthodes: Une analyse documentaire a été effectuée en utilisant Medline, EMBASE, et la Cochrane Library de 1968 à 2010. Tous les articles comportant des rapports sur des personnes souffrant à la fois de psoriasis et de vitiligo rédigés en anglais ont été documentés. Résultats: Nous avons trouvé 338 articles, parmi lesquels 35 exposés de cas et 7 séries de cas ont été mentionnés. Pour chaque série de cas, la prévalence du psoriasis chez les patients atteints de vitiligo, ou vice versa, s'inscrit dans la fourchette de prévalence de la population de base qui a fait l'objet de l'étude. Conclusion: Notre étude n'a pas démontré une augmentation de la prévalence de psoriasis attendue chez les personnes atteintes de vitiligo, ou vice versa, ce qui suggère que la coexistence des deux affections semble être due au seul hasard. D'importantes études épidémiologiques sont nécessaires pour démontrer avec certitude que le psoriasis est plus fréquent chez les personnes atteintes de vitiligo et vice versa.


2020 ◽  
Vol 8 (01) ◽  
pp. 89-107
Author(s):  
Andi Buanasari ◽  
Esrom Kanine

Background: Psychosocial problems in adolescents are often associated with difficulty in achieving their developmental tasks sense of identity that lead them to the role of confusion. The parents play an important role in assiting and supporting the adolescents to accomplish their developmental task during this age but sometimes the emotions, attitudes or behaviors shown by parents (Expressed Emotion/ EE) were actually considered to be factors that influence the psychosocial problems in adolescents. Aim: To describe the correlation between EE in parents and psychosocial problems in adolescents. Methods: A literature review was conducted to collect English-language articles form online database such as Proquest, PubMed, Sagepub, Science Direct and Taylor & Francis about the correlation between EE and psychosocial problems in adolescents from 1985 to 2020. Results: Adolescents with psychosocial problems tend to have parents with high EE and Criticism apparently  became the most influential aspect in affecting psychosocial problems in Adolescents Conclusion: It is important to strengthen education and therapy for parents to decrease critical parenting style as an effort to promote adolescent mental health.  


2021 ◽  
Vol 15 (3) ◽  
pp. 62-71
Author(s):  
Ekaterina S. Koroleva ◽  
Valentina M. Alifirova

Scientific achievements of recent decades indicate that neurogenesis and angiogenesis are interrelated processes in the struggle for functional recovery after ischaemic stroke. This literature review presents current data on the neurovascular interactions in ischaemic stroke, and describes the role of signalling molecules and growth factors in the regulation of neurogenesis and angiogenesis, which are crucial for neuronal survival and neuroplasticity. The authors conducted a literature search for abnormal neuroblast migration into the ischaemic penumbra and the role of signalling molecules, molecular targets of angiogenesis, and role of endogenous growth factors and neurochemical markers in post-stroke vascular regulation in acute cerebral ischaemia. Relevant keywords were entered into the PubMed and Google Scholar search engines, as well as Scopus, Web of Science, MedLine, The Cochrane Library, EMBASE, Global Health, CyberLeninka, eLibrary, and other databases. Despite promising results obtained in animal models, and the data from clinical studies, deeper interrelationships between molecular and cellular interactions of neurogenesis and angiogenesis are still not entirely clear. Further study and understanding of complex interactions between neurogenesis and angiogenesis is needed to find targets for exogenous growth factor administration and changes in endogenous molecule expression for treatment of ischaemic brain injury.


2021 ◽  
Vol 74 (8) ◽  
pp. 1964-1969
Author(s):  
Lesya Lymar ◽  
Khrystyna Storozhuk

The aim: To define peculiarities of the medical students and medical PhD students’ distance learning, basing on the academic performance and survey results. Materials and methods: Forty-two medical students and thirty-eight PhD students of O.Bogomolets National medical university were randomly chosen for the study. Students’ knowledge of English was initially “ live” assessed in February, online assessments were held in April and May, concluded with the credit final assessment. Upon passing the final test the students were asked to fill in the questionnaire containing the following items: satisfaction with the distance learning, level of the distance learning hardness, comparison of distance learning by quality and understanding, choosing the best sections for the English distance learning, level of technical problems. Results: All students during the 2020 distance learning have improved their English language level: the medical students from 3.8 to 3.99, the PhD students- from 4.36 to 4.56. The questioning of both groups showed significant dissatisfaction of medical students ( 52-57% by different positions) with the distance learning. The PhD students showed higher satisfaction level (76-86% by different positions). Conclusions: The assessed groups of the O.Bogomolets National medical university improved their English knowledge level during the distance learning. The authors relate significant dissatisfaction of medical students with the distance learning to their low motivation and learning maturity. The PhD students’ higher satisfaction level may be related to the wider variability of the issues to study. The problem of distance learning of both medical and PhD students should be studied more thoroughly.


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