scholarly journals Morphological Features Of Microvascular Tissue Of The Brain At Hemorrhagic Stroke

Author(s):  
Kamalovamalika Ilkhomovna ◽  
◽  
Islamov Shavkat Eriyigitovich ◽  
Khaidarov Nodir Kadyrovich ◽  
◽  
...  

Hemorrhagic stroke is less common than ischemic stroke and is heavier and in most cases has an adverse outcome in the form of death of a patient or permanent disability.Recently, there has been a tendency to increase the frequency of GI, which is increasingly found at a younger age. GI is based on a rupture of blood vessels, the development of hemorrhage and as a consequence - the formation of cerebral edema, ischemia of brain tissue, violation of the integrity of GBS, imbalance of the neuroimmune system, as well as violation of the function of other systems and organs.

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Maria Estefina Siwi ◽  
Diana Lalenoh ◽  
Harold Tambajong

Abstract: Hermorrhagic stroke is a disease caused by rupture of blood vessels of the brain that causes bleeding intro the brain parenchym tissue, cerebrospinal space around the brain or combination of both. Cause of death from hemorrhagic stroke is presence of complications or other comorbodities, like cerebral edema were reported the highest cause of death of hemorrhagic stroke. This study aimed to determine the profile of patients with hemorrhagic stroke in ICU, using descriptive retropective method. The samples were Prof. Dr. R.D. Kandou Manado ICU’s patients with hemorrhagic stroke based on the data in the medical record from December 2014 – November 2015. Hemorrhagic stroke mortality rate is very high (89%). From total 35 samples were examined, there 4 survivors (11%) and 31 deaths (89%), which consisted of 24 males (69%) and 11 females (31%). Most patients are 45-59 years old.Keywords: hemorrhagic stroke, ICUAbstrak: Stroke hemoragik adalah penyakit yang disebabkan oleh pecahnya pembuluh darah otak yang menyebabkan keluarnya darah ke jaringan parenkim otak, ruang serebrospinalis disekitar otak atau kombinasi keduanya. Penyebab kematian dari stroke hemoragik sendiri adalah adanya komplikasi atau penyakit penyerta lainnya, salah satu contohnya yaitu edema serebri yang dilaporkan merupakan penyebab kematian terbanyak. Penelitian ini bertujuan untuk mengetahui profil pasien stroke hemoragik yang dirawat di ICU RSUP Prof. Dr. R.D. Kandou Manado, menggunakan metode penelitian deskriptif retrospektif. Besar sampel ditentukan dengan metode non probability sampling yaitu purposive sampling. Sampel penelitian adalah pasien ICU RSUP Prof. Dr. R.D. Kandou Manado dengan diagnosa stroke hemoragik berdasarkan data di bagian Rekam Medik periode Desember 2014 sampai November 2015. Angka mortalitas stroke hemoragik sangatlah tinggi (89%). Total 35 sampel yang diteliti dengan 4 orang yang selamat (11%) dan 31 orang meninggal dunia (89%), terdiri dari 24 orang laki-laki (69%) dan 11 orang perempuan (31%). Sebagian besar adalah pasien umur 45-59 tahun.Kata kunci: stroke hemoragik, ruang rawat intensif


Author(s):  
Dedy Budi Kurniawan ◽  
Mokhamad Fahmi Rizki Syaban ◽  
Arinal Mufidah ◽  
Muhammad Unzila Rafsi Zulfikri ◽  
Wibi Riawan

Stroke is one of the leading causes of morbidity and mortality in all ages. Ischemic stroke activates excitotoxic glutamate cascade leading to brain tissue injury. Saccharomyces cerevisiae is a unicellular yeast widely found in nature. S. cerevisiae is neuroprotective and able to increase the differentiation of hematopoietic stem cells (HSCs) into neuronal cells. it may increase levels of neuroprotectant BDNF in the brain tissue, therefore increase the protection of neurons. BDNF may prevent glutamate-driven excitotoxicity by reducing glutamate levels. This study uses a randomized post-test only controlled group design. In this in vivo study, rodent models of ischemic stroke were divided into five groups comprising of the negative control group, positive control group, intervention group 1 (18mg/kgBW), intervention group 2 (36mg/kgBW) and intervention group 3 (72 mg/kgBW). Groups treated with Saccharomyces cerevisiae extract showed significantly increased BDNF levels in the brain tissue, and the expression of the glutamate level was significantly reduced (P <0.05) compared to the positive control group. Thus Saccharomyces cerevisiae has a promising potential to become a therapy against ischemic stroke disease. however further research is needed regarding the efficacy and toxicity of Saccharomyces cerevisiae.


Vestnik ◽  
2021 ◽  
pp. 29-34
Author(s):  
Д.А. Митрохин ◽  
М.М. Ибрагимов ◽  
Б.Р. Нурмухамбетова ◽  
Н.Ш. Буйракулова ◽  
В.В. Харченко ◽  
...  

Значимость биоэлектрической активности головного мозга в оценке функционального состояния нервной системы при цереброваскулярных заболеваниях широко известна. В настоящей работе показана характеристика биоэлектрической активности головного мозга у больных, перенесших острое нарушение мозгового кровообращения. В данной статье приведены данные о том, что у больных в остром и раннем восстановительном периодах церебрального инсульта биоэлектрическая активность головного мозга характеризовалась, в основном, десинхронным и дезорганизованным типами электроэнцефалограммы. Вместе с тем, отмечались, выраженная дельта и тета активность, а также единичные острые волны, спайки, преимущественно в пораженном полушарии головного мозга, реже в контралатеральном полушарии, межполушарная асимметрия, повышение мощности спектров в сторону преобладания медленных волн. Показатели индекса когерентности по всем отведениям были снижены, что свидетельствует о нарушении функциональных межполушарных взаимосвязей. Более значительное повышение индекса когерентности в дельта и тета диапазонах у пациентов, перенесших геморрагический инсульт, может указывать на более грубые межполушарные нарушения, в сравнении с ишемическим инсультом. Результаты исследования относительной спектральной плотности мощности диапазонов показали, что при геморрагическом инсульте отмечена более высокая дельта и бета активность, а также более значительное снижение мощности альфа ритма, в сравнении с ишемическим инсультом. В тоже время, отмечается повышение интегрального индекса диапазона низкочастотной медленно-волновой активности, особенно выраженное у больных с геморрагическим инсультом р<0,05. The significance of bioelectric activity of the brain in assessing the functional state of the nervous system in cerebrovascular diseases is widely known. In this paper, the characteristics of the bioelectric activity of the brain in patients with acute cerebral circulatory disorders are shown. This article presents data that in patients with acute and early recovery periods of cerebral stroke , the bioelectric activity of the brain was characterized mainly by desynchronous and disorganized types of electroencephalogram. At the, same time, pronounced delta and theta activity was noted , as well as single acute waves, spikes, mainly in the affected hemisphere of the brain, less often in the contralateral hemisphere, interhemispheric asymmetry, increased spectral power in the direction of predominance of slow waves. The coherence index values for all leads were reduced, which indicates a violation of functional interhemispheric relationships. A more significant increase in the coherence index in the delta and theta ranges in patients who have had a hemorrhagic stroke may indicate more severe interhemispheric disorders compared to ischemic stroke. The results of the study of the relative spectral power density of the ranges showed, that in hemorrhagic stroke, there was a higher delta and beta activity, as well as a more significant decrease in the power of the alpha rhythm, in comparison with ischemic stroke. At the same time, there is an increase in the integral index of the range of low-frequency slow-wave activity, especially pronounced in patients with hemorrhagic stroke p < 0.05.


2015 ◽  
Vol 9 (1) ◽  
pp. 0-0 ◽  
Author(s):  
Бантыш ◽  
B. Bantysh ◽  
Макишева ◽  
R. Makisheva ◽  
Субботина ◽  
...  

The morphological changes in the brain tissue of Wistar rats of different ages after intramuscular insulin injection in the dose of 1 IU/kg are typical for the hypoxic lesions of nervous tissue. The brain of rats at the age of 1-2 months responds to increased deposition of glycogen, moderate swelling around the cells and blood vessels. The effect of insulin on the brain Mature rats at the age of 5-7 months leads to vasodilatation, more pronounced swelling around the cells and blood vessels, hypertrophy of cells, aggregation and diabetes of red blood cells. The severity of ischemic changes significantly increased in the brain of old rats at the age of 20-24 months. These old rats had the senile dendrites, the widespread hypertrophic degenerative changes, i.e. flask-shaped vasodilation, hyperemia. In most of the visual fields are detected capillaries with the presence of aggregation on the side erythrocytes, signs of micro thrombosis, hemorrhage areas. The authors note that there is a loss of tone and tortuosity of the small arterioles, widespread swelling around the cells and around the blood vessels. Morphological signs of brain reaction on insulin injection reflect the death of cortical neurons, marked swelling of the brain tissue, disruption of vascular permeability, the thrombus formation and hemorrhages.


2020 ◽  
Vol 11 (SPL4) ◽  
pp. 1616-1620
Author(s):  
Rohini Agrawal ◽  
Prashant Amale ◽  
Shilpa Deshpande ◽  
Manish Deshmukh ◽  
Priti Bhoyar ◽  
...  

Stroke is a Central Nervous System (CNS) disorder which occurs due to the obstruction in the brain blood flow. Stroke is mainly of two types, such as ischemic and hemorrhagic stroke. Ischemic stroke (80%) caused due to obstruction of blood flow through Middle Cerebral Artery (MCA) and characterized by a decreased supply of oxygen and glucose to CNS. In comparison, Hemorrhagic stroke (20%) mainly occurs due to the rupturing of blood vessels. Epidemiologically, it is the common reason of death after cancer and affecting millions of global population. There are many risk factors such as hypertension; hypercholesterolemia etc. which can exaggerate the condition of stroke. Various conventional therapies like Antiplatelets, Thrombolytic are available, but, there is a need to obtain a therapeutic approach that can provide prevention as well as a cure for the stroke. So the present review is primarily focused on epigenetic approach for ischemic stroke by Endogenous Transplantation of Neural Stem/Progenitor Cells (NSPCs). This, in turn, will decrease the level of REST protein at the genetic level and enhance the activity of Na+-Ca+ exchanger activity and lowers the excitotoxicity.


2000 ◽  
Vol XXXII (3-4) ◽  
pp. 76-76
Author(s):  
J. Yrjanheikki ◽  
T. Tikka ◽  
R. Keinanen ◽  
G. Goldsteins ◽  
P. H. Chan ◽  
...  

One of the reasons for the insufficient effectiveness of treatment of acute ischemic stroke may be secondary inflammation of the brain tissue, which, according to the results of modern studies, significantly worsens the consequences and outcome of the disease.


Author(s):  
S Sumijan ◽  
Y Yuhandri ◽  
Wendi Boy

Brain bleeding can occur because of the outbreak of the blood vessels in the brain which culminated into hemorrhagic stroke or stroke due to bleeding. Hemorrhagic Stroke occurs when there is a burst of blood vessels result from some trigger factor. Segmentation techniques to Scanner computed tomography images (CT scan of the brain) is one of the methods used by the radiologist to detect brain bleeding or congenital abnormalities that occur in the brain. This research will determine the area of the brain bleeding on each image slice CT - scan every patient, to detect and extract brain bleeding, so it can calculate the volume of the brain bleeding. The detection and extraction bleeding area of the brain is based on the hybrid thresholding method.


F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 2044 ◽  
Author(s):  
Tomoko Kitago ◽  
Rajiv R. Ratan

Intracerebral hemorrhage (ICH), a form of brain bleeding and minor subtype of stroke, leads to significant mortality and long-term disability. There are currently no validated approaches to promote functional recovery after ICH. Research in stroke recovery and rehabilitation has largely focused on ischemic stroke, but given the stark differences in the pathophysiology between ischemic and hemorrhagic stroke, it is possible that strategies to rehabilitate the brain in distinct stroke subtypes will be different. Here, we review our current understanding of recovery after primary intracerebral hemorrhage with the intent to provide a framework to promote novel, stroke-subtype specific approaches.


Author(s):  
Kuldeep . ◽  
A. S. Prashanth ◽  
S. G. Chavan

Vata Vyadhi is considered one among the Ashta Maha Gada as told by Acharya’s. Out of all Nanatmaja Vata Vyadhis, the disease Pakshaghata is considered superior among the other Vataja disorders. In modern era, the Lakshana’s of Pakshaghata is closely resembles the disease Hemiplegia. In Hemiplegia, symptoms appears due to the Ischemia of Brain tissue which is an end result of improper blood supply to the brain either due to thrombus, embolism or may be due to rupture of any cerebral blood vessels. Acharya Bhela, has considered Pakshaghata as one among the Asthi Majjagata Roga’s. Acharya Sushruta also states that, the Mastulunga Majja is nothing but it is Majjadhara Kala. So, here an attempt has been made to evaluate the efficacy of Brimhana Nasya along with Shamanoushadi’s for the management of Pakashaghata.


2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Yeu-Sheng Tyan ◽  
Ming-Chi Wu ◽  
Chiun-Li Chin ◽  
Yu-Liang Kuo ◽  
Ming-Sian Lee ◽  
...  

We propose an ischemic stroke detection system with a computer-aided diagnostic ability using a four-step unsupervised feature perception enhancement method. In the first step, known as preprocessing, we use a cubic curve contrast enhancement method to enhance image contrast. In the second step, we use a series of methods to extract the brain tissue image area identified during preprocessing. To detect abnormal regions in the brain images, we propose using an unsupervised region growing algorithm to segment the brain tissue area. The brain is centered on a horizontal line and the white matter of the brain’s inner ring is split into eight regions. In the third step, we use a coinciding regional location method to find the hybrid area of locations where a stroke may have occurred in each cerebral hemisphere. Finally, we make corrections and mark the stroke area with red color. In the experiment, we tested the system on 90 computed tomography (CT) images from 26 patients, and, with the assistance of two radiologists, we proved that our proposed system has computer-aided diagnostic capabilities. Our results show an increased stroke diagnosis sensitivity of 83% in comparison to 31% when radiologists use conventional diagnostic images.


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