scholarly journals New findings of clusters of petroglyphes on Canozero (period 2017–2019).

2020 ◽  
Vol 11 (1-2020) ◽  
pp. 85-109
Author(s):  
Vadim A. Likhachev ◽  
Keyword(s):  
New Findings ◽  
Made In ◽  
Stylistic Diversity

For the period 2017–2019 five new groups of petroglyphs and a significant number of previously unknown ones in already documented panels of petroglyphs were revealed on the rocky islands of the Kanozero Lake. The discovery of petroglyphs was facilitated by the use of photogrammetric techniques, as well as careful night photographing of rocks with petroglyphs. This publication presents findings of five new panels with more than 40 petroglyphs in total. These findings expand our ideas about the stylistic diversity of the Kanozero petroglyphs, about the range of heights above level of the lake on which stylistically close petroglyphs were made. In this work, new motifs and compositions of rock carvings are introduced, both having analogues and previously nottypical of Kanozero.

GDNF Therapy: Can We Make It Work?

2021 ◽  
pp. 1-4
Author(s):  
Anders Björklund
Keyword(s):  
Gene Therapy ◽  
Transcription Factor ◽  
Signaling Pathway ◽  
Therapeutic Potential ◽  
Threshold Level ◽  
New Findings ◽  
The Status ◽  
Interesting Discussion ◽  
Postmortem Studies ◽  
Made In

In two recent postmortem studies, Jeffrey Kordower and colleagues report new findings that open up for an interesting discussion on the status of GDNF/NRTN signaling in patients with Parkinson’s disease (PD), adding an interesting perspective on the, admittedly very limited, signs of restorative effects previously seen in GDNF/NRTN-treated patients. Their new findings show that the level of the GDNF signaling receptor Ret is overall reduced by about 65% relative to non-PD controls, and most severely, up to 80%, in nigral neurons containing α-synuclein inclusions, accompanied by impaired signaling downstream of the Ret receptor. Notably, however, the vast majority of the remaining nigral neurons retained a low level of Ret expression, and hence a threshold level of signaling. Further observations made in two patients who had received AAV-NRTN gene therapy 8–10 years earlier suggest the intriguing possibility that NRTN is able to restore Ret expression and upregulate its own signaling pathway. This “wind-up” mechanism, which is likely to depend on an interaction with dopaminergic transcription factor Nurr1, has therapeutic potential and should encourage renewed efforts to turn GDNF/NRTN therapy into success, once the recurring problem of under-dosing is resolved.

scholarly journals Shedding Light on Hexaquarks

2018 ◽  
Vol 46 ◽  
pp. 1860033 ◽  
Author(s):  
M. Bashkanov ◽  
T. Skorodko ◽  
H. Clement ◽  
D. P. Watts
Keyword(s):  
Internal Structure ◽  
Large Set ◽  
Physical Size ◽  
Decay Channels ◽  
Quantum Numbers ◽  
New Findings ◽  
Reaction Channels ◽  
Experimental Side ◽  
Multiquark States ◽  
Made In

Several new findings in the four, five and six quark systems reheat the interest in the field of multiquark states (beyond the trivial [Formula: see text] and [Formula: see text]). A lot of progress has recently been made in the 6q sector, on both the theoretical and experimental side. A resonance like structure observed in double-pionic fusion to the deuteron, at M = 2.38 GeV with [Formula: see text] = 70 MeV and [Formula: see text] has been consistently observed in a wealth of reaction channels, supporting the existence of a resonant dibaryon state - the [Formula: see text]. These studies include measurement of all the principle strong decay channels in pn collisions in the quasifree mode by the WASA-at-COSY and HADES collaborations. The internal structure of the [Formula: see text] is largely unknown. It can contain various ”hidden color” 6q configurations, [Formula: see text] molecular states with angular momentum L = 0,2,4,6 as well as meson-assisted dressed dibaryon structures. The large set of experimental data obtained to date gives some constraints on the internal structure of the [Formula: see text] dibaryon, but does not settle the issue. The [Formula: see text] is the only multiquark state which can be produced copiously at current facilities, offering unique access to information beyond its basic quantum numbers, particularly its physical size and internal structure.

scholarly journals Sampling and Characterization of the Environmental Fungi in the Provincial Historic Archive of Pinar Del Río, Cuba

2020 ◽  
Vol 1 (8) ◽  
pp. 404-420
Author(s):  
Sofia Borrego ◽  
Alian Molina ◽  
Tamara Abrante
Keyword(s):  
Respiratory Tract ◽  
Human Health ◽  
Culture Media ◽  
Airborne Fungi ◽  
New Findings ◽  
Del Rio ◽  
Positive Results ◽  
Made In

It has been reported that there is a correlation between indoor airborne fungi and the biodeterioration of valuable documents in archives, libraries and museums, and that these fungi can also cause effects on human health if there are immunological problems or the time of exposure to these environments of low quality is long. The aims of this study were quantifying and characterizing the mycobiota of the indoor air in three repositories of the Provincial Historical Archive of Pinar del Río, Cuba and assessing its impact on the human health. The samplings were made in two different months corresponding to the years 2016 and 2017, one belonging to the rainy season and the other to the season of the little rain using a SAS biocollector and appropriate culture media to isolate fungi. The fungal concentrations and the Indoor/Outdoor (I/O) ratios obtained revealing that the repositories showed good quality environments. In both isolations Cladosporium was the predominant genus followed by Penicillium in the first sampling and Fusarium in the second isolation. The genera Aureobasidium, Sepedonium, Trichaegum and Wallemia were new findings for the Cuban archives. The pathogenic attributes studied showed that 30% of the isolates have spores so small that they can penetrate into the respiratory tract into the alveoli; 10.7% of the taxa obtained in the first isolation and 13.3% of the taxa detected in the second sampling also showed positive results to four virulence tests analyzed "In vitro" (growth at 37°C, hemolytic activity, phospholipase activity and respiratory tract level to which the spores can penetrate). These virulence factors (pathogenic attributes) evidence the risk that environmental fungi represent for the health of personnel in this archive.

scholarly journals Reflective Design in Action: A Collaborative Autoethnography of Faculty Learning Design

TechTrends ◽  
2021 ◽  
Author(s):  
Shawn Bowers ◽  
Yu-Ling Chen ◽  
Yvette Clifton ◽  
Melissa Gamez ◽  
Heidi Hubbard Giffin ◽  
...  
Keyword(s):  
Approaches To Learning ◽  
Faculty Members ◽  
Course Delivery ◽  
University Faculty ◽  
Learning Design ◽  
Design Changes ◽  
New Findings ◽  
Reflective Design ◽  
Design Solutions ◽  
Made In

AbstractResearch on how university faculty design courses has been limited and marked by modest detail on faculty design processes. Addressing this gap, seven faculty members supported by an educational developer at a teaching-intensive university used collaborative autoethnography (CAE) to explain how university faculty engage in reflective, iterative approaches to learning design. Collaborative analysis and interpretation of systematically collected data drawn from individual experiences in learning design reveal how faculty use reflection as a tool in learning design to recognize problems, devise solutions and constructively process emotions. Through reflection, faculty identify design solutions that are responsive to circumstances during course delivery, capture reasoning that informs design solutions for future course iterations and accurately gauge the appropriate timing of design changes based on factors such as scale and feasibility. This article offers detailed ethnographic evidence and new findings that enrich our understanding of claims made in previous interview-based studies of faculty design.

scholarly journals HST/STIS imaging of Fomalhaut: New main belt structure and confirmation of Fomalhaut b's eccentric orbit

2013 ◽  
Vol 8 (S299) ◽  
pp. 204-207 ◽  
Author(s):  
P. Kalas ◽  
J. R. Graham ◽  
M. P. Fitzgerald ◽  
M. Clampin
Keyword(s):  
Hubble Space Telescope ◽  
Main Belt ◽  
Contrast Imaging ◽  
Nearby Star ◽  
High Contrast Imaging ◽  
Reflected Light ◽  
New Findings ◽  
Low Mass ◽  
Dust Ring ◽  
Made In

AbstractHigh contrast imaging observations with the Hubble Space Telescope show that the nearby star Fomalhaut is surrounded by a dusty debris belt and a candidate planet, Fomalhaut b, located just inside the edge of the belt. Fomalhaut b has unexpected characteristics, such as a relatively blue spectrum, leading to the hypothesis that the detected object is a low-mass planet hosting a giant planetary dust ring or cloud seen in reflected light. Here we present new HST/STIS observations made in 2010 and 2012 that authenticate the existence of Fomalhaut b. Our MCMC analysis of four epochs of astrometry spread over eight years indicate that the orbit has a~170 AU and e~0.85. Fomalhaut b's orbit is apsidally aligned with the main belt, and periapse is located approximately ~30 AU south of the star. We also show the existence of a ~50 AU wide azimuthal dust depletion in the dust belt. These new findings provide a revised picture of Fomalhaut as a dynamically complex system, where the orbit of Fomalhaut b and the belt structure signify the presence of additional massive planets orbiting the star.

scholarly journals ON THE QUESTION OF THE BASIC PERIODIZATION OF IMITATIONS OF THE ROMAN IMPERIAL DENARII IN THE CHERNYAKHIV CULTURE AREA: THE CONCEPT OF TWO «WAVES»

2021 ◽  
pp. 121-135
Author(s):  
Olexandr Kasperovich ◽  
Gintautas Yushkauskas
Keyword(s):  
Large Scale ◽  
Common View ◽  
Culture Area ◽  
Analytical Scheme ◽  
Roman Coins ◽  
New Findings ◽  
The Common ◽  
Second Wave ◽  
Made In

Imitations of Roman coins, the findings of which are very numerous and diverse in Ukraine, have already attracted the attention of researchers. The material accumulated over the last two decades, when taking into account its scale and diversity, allows us to state that imitations of Roman coins in the area of Chernyakhiv culture, is an unique and large-scale phenomenon, visible on the imaginary «map» of ancient numismatics. In this context, the growing number of new findings of imitations actualizes the task of more detailed and meaningful categorization of the accumulated material, in order to create a certain integral «canvas» of such a phenomenon as the imitations of Roman coins from the area of Chernyakhiv culture. The article is devoted to the improvement of the existing typology and periodization of imitations of Roman imperial denarii, which were made in the area of Chernyakhiv culture during the II - IV centuries. To solve this problem, the authors proposed and used an analytical scheme, consisting of a set of classification parameters for the typology of imitations of Roman coins in the area of Chernyakhiv culture. The use of this scheme allowed to form «profiles» and to substantiate the presence in the general set of imitations of two large, non-intersecting groups («waves») of imitations. Further analysis allowed to describe and compare these two «waves» of imitation in more detail. It was found that the first «wave» refers to the period of gradual entry of the Roman silver coins into the area of Chernyakhiv culture (II - early III century), which significantly clarifies the common view, according to which all imitations belong to the second half of the III century or even later. The second «wave» of imitations really refers to the second half of the III - early IV century, as it was established in the literature. Thus, the results of the study substantiated a comprehensive approach to the classification of imitations of Roman coins in the area of Chernyakhiv culture and significantly clarified the chronological framework of their production. In the future, the concept of two «waves» and the analytical scheme proposed by the authors may contribute to a more accurate classification and periodization of the whole array of imitations of Roman coins, which were made in the area of Chernyakhiv culture

scholarly journals New functions for the proprioceptive system in skeletal biology

2018 ◽  
Vol 373 (1759) ◽  
pp. 20170327 ◽  
Author(s):  
Ronen Blecher ◽  
Lia Heinemann-Yerushalmi ◽  
Eran Assaraf ◽  
Nitzan Konstantin ◽  
Jens R. Chapman ◽  
...  
Keyword(s):  
Muscle Spindles ◽  
Human Condition ◽  
Severe Phenotype ◽  
Golgi Tendon Organs ◽  
Musculoskeletal Development ◽  
New Findings ◽  
Spinal Curve ◽  
Tendon Organs ◽  
And Function ◽  
Made In

Muscle spindles and Golgi tendon organs (GTOs) are two types of sensory receptors that respond to changes in length or tension of skeletal muscles. These mechanosensors have long been known to participate in both proprioception and stretch reflex. Here, we present recent findings implicating these organs in maintenance of spine alignment as well as in realignment of fractured bones. These discoveries have been made in several mouse lines lacking functional mechanosensors in part or completely. In both studies, the absence of functional spindles and GTOs produced a more severe phenotype than that of spindles alone. Interestingly, the spinal curve phenotype, which appeared during peripubertal development, bears resemblance to the human condition adolescent idiopathic scoliosis. This similarity may contribute to the study of the disease by offering both an animal model and a clue as to its aetiology. Moreover, it raises the possibility that impaired proprioceptive signalling may be involved in the aetiology of other conditions. Overall, these new findings expand considerably the scope of involvement of proprioception in musculoskeletal development and function.This article is part of the Theo Murphy meeting issue ‘Mechanics of development’.

Muscarinic Signaling in the Central Nervous System

1996 ◽  
Vol 84 (1) ◽  
pp. 173-189 ◽  
Author(s):  
Marcel E. Durieux
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cardiovascular Actions ◽  
New Findings ◽  
The Central Nervous System ◽  
Subtype Selective ◽  
Made In

During the last decade, major advances have been made in our understanding of the physiology and pharmacology of CNS muscarinic signaling. It is time to emphasize that the well-known peripheral parasympathetic and cardiovascular actions represent only one component of muscarinic signaling. Interestingly, many new findings have the potential to influence the practice of anesthesiology. Inhibition of muscarinic signaling may explain some of the anesthetic state, and subtype-selective drugs may allow wider perioperative manipulation of CNS muscarinic systems. The next years will doubtlessly see progress in this area, and our specialty may well reap the benefits.

Deposition practices in Iron Age France: new light on old discoveries

Antiquity ◽  
2018 ◽  
Vol 92 (361) ◽  
pp. 239-241
Author(s):  
Manuel Fernández-Götz
Keyword(s):  
Nineteenth Century ◽  
Iron Age ◽  
Late Nineteenth Century ◽  
Field Methods ◽  
Easy Task ◽  
New Information ◽  
Scientific Analysis ◽  
New Findings ◽  
Late Nineteenth ◽  
Made In

Dealing with information coming from nineteenth-century discoveries is not always an easy task for archaeologists, and it can prove particularly problematic for iconic findings that have come to characterise entire periods or cultural horizons. Information is very often fragmentary, and in most cases, field methods and recording techniques are not up to present-day standards. A careful re-examination of old collections can, however, often be as fruitful as new findings. This is exemplified by the volumes under review here, which reassess two of the most important archaeological discoveries made in the late nineteenth-century in France: the bronze hoard of Launac in Languedoc and the grave of La Gorge-Meillet in Champagne. In addition to summarising existing knowledge, the volumes also provide new information coming from modern scientific analysis, as well as re-evaluations of certain find categories.

scholarly journals 2018 Yearbook of Neurorestoratology

2019 ◽  
Vol 1 (1) ◽  
pp. 11-20 ◽  
Author(s):  
Hongyun Huang ◽  
Hari Shanker Sharma ◽  
Lin Chen ◽  
Hooshang Saberi ◽  
Gengsheng Mao
Keyword(s):  
Clinical Trials ◽  
Clinical Studies ◽  
Neurological Diseases ◽  
Evidence Based ◽  
Policy Makers ◽  
New Developments ◽  
Medical Practices ◽  
New Findings ◽  
Standard Designs ◽  
Made In

The Neurorestoratology discipline is getting worldwide attention from the clinicians, basic scientists, students and policy makers alike. Accordingly, this year too, the discipline has made profound advances and great achievements for the benefit of the mankind. In this report, of the 2018 Neurorestoratology Yearbook, salient features of new developments are summarized. This Yearbook consists 3 key themes namely (i) the new findings on pathogenesis of neurological diseases or degeneration; (ii) the new mechanisms of neurorestorative aspects; and (iii) the achievements and progresses made in the clinical field of neurorestorative therapies. The new trend has emerged in clinical studies that are based on greater levels of evidence-based medical practices both in clinical therapies and clinical trials based on standard designs.

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