scholarly journals Evaluation of hepatoprotective activity of Hexafite in D-galactosamine hepatitis, antioxidant activity of the drug and its ingredients

2020 ◽  
Vol 64 (11) ◽  
pp. 70-76
Author(s):  
Ekaterina V. Ferubko ◽  
◽  
Anatoly A. Lapin ◽  
Tamara D. Dargaeva ◽  
Valery N. Zelenkov ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Liver Injury ◽  
Biochemical Study ◽  
Medical Science ◽  
Free Radical Oxidation ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Mentha Piperita ◽  
White Rats ◽  
Active Substances

The expansion of research to find sources for obtaining new effective and safe medicines of plant origin, including those used in gastroenterological practice, is a pressing task of medical science, considering that the range of medicinal plant drugs used in practical health care is more than 40%. The results of the biochemical study of the hepatoprotective and choleretic activities of a Hexafite multicomponent extract obtaining from following types of raw materials: flowers of Helichrysum arenarium L. and Tanacetum vulgare L., fruits of Rosa sp., leaves of Urtica dioica L. and Mentha piperita L. and radices of Glycyrrhiza glabra L. were received. It is established that Hexafite per os administration of dose of 250 mg/kg to non-linear white rats with D-galactozamine induced liver injury has hepatoprotective and choleretic effects, exceeding Allocholum effect by some data. Pharmacotherapeutic effect of the extract in model of liver injury is due to the presence in it of a complex of biologically active substances, primarily compounds of phenolic nature. The inhibitory effect of Hexafite on free radical oxidation of lipids, stabilization of the biological membranes of liver cells with a subsequent increase in the functional activity of the liver is provided due to their dominant content. The obtained research results argue the expediency of the use of Hexafite containing biologically active substances of a phenolic nature in the prevention and treatment of liver diseases. It is shown that the collection of bile action and the plants included in it have antioxidant activity in vitro. The experiment revealed a synergistic effect on the manifestation of the total antioxidant activity of the collection.

scholarly journals COMPOSITION OF BIOLOGICALLY ACTIVE SUBSTANCES OF THE HORSE CHESTNUT (AECULUS HIPPOCASTANUM L.)

ÈKOBIOTEH ◽  
2021 ◽  
Vol 4 (1) ◽  
pp. 33-39
Author(s):  
V.P. Kurchenko ◽  
◽  
N.V. Sushinskaya ◽  
K.I. Maiorava ◽  
E.I. Tarun ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Antioxidant Activity ◽  
Phenolic Compounds ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Horse Chestnut ◽  
Hazard Class ◽  
Active Substances

The study of the composition of biologically active substances, alcoholic extracts from flowers of Aeculus hippocastanum L. According to the results of HPLC-MS and GC-MS analyzes, the extract contains the main amounts of phenolic compounds: quercetin, epicatechin, kaempferol. In addition, the extract contains fatty acids and their esters, alcohols, 3-deoxy-d-manno lactone, 1,2,3,5-cyclohexantethrol, α-methyl-mannofuranoside, γ sitosterol. Antioxidant activity of an extract from flowers of A. hippocastanum is associated with the peculiarities of the compositionof biologically active substances. The toxological-hygienic assessment of flowers of this species in acute and subacute experiments showed that it belongs to the 4th hazard class (low hazard).

scholarly journals Biotechnological aspects of obtaining biologically active substances of Adonis vernalis

2021 ◽  
Vol 4 (1) ◽  
pp. 126-130
Author(s):  
V. R. Hamada ◽  
Keyword(s):  
Antioxidant Activity ◽  
Biological Activity ◽  
Raw Materials ◽  
Callus Cultures ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
In Vitro Cultivation ◽  
Plant Raw Materials ◽  
Active Substances

This article shows the possibility of using a biotechnological method to obtain biologically active compounds based on in vitro cultivation of callus cultures. The callus biomass of Adonis vernalis was obtained in vitro by using the biotechnological method. The extracts based on callus biomass of Adonis vernalis were obtained. The content of flavonoids and phenolic compounds was determined. The antioxidant activity of callus biomass of Adonis vernalis has also been studied. The research results show that the content of biologically active substances and biological activity in callus biomass does not differ from plant raw materials.

STUDY OF WOUND-HEALING EFFECTS OF EXTRACTS OF CERTAIN PLANTS OF THE ARID ZONE

2021 ◽  
Vol 1 (3) ◽  
pp. 335-342
Author(s):  
A.S. Baimukhambetova ◽  
◽  
M.A. Egorov ◽  
A.K. Azhikova ◽  
D.K. Magzanova ◽  
...  
Keyword(s):  
Wound Healing ◽  
Plant Species ◽  
Tissue Repair ◽  
Arid Zone ◽  
Glycyrrhiza Glabra ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
White Rats ◽  
Glycyrrhiza Glabra L ◽  
Active Substances

In an experiment on white rats, the regenerating effect of biologically active substances of plant species growing in the Astrakhan region was shown: Achillea micrantha Willd., Helichrysum arenarium, Glycyrrhiza glabra L., Helichrysum nogaicum Tzvel. The article presents data from planimetric studies of damaged skin. The results obtained make it possible to consider extracts as the basis of tissue repair stimulants, as well as to recommend them as anti-inflammatory and wound healing agents.

scholarly journals The use of ultrasonic extraction in the technology of functional drinks based on plant raw materials

2021 ◽  
Vol 845 (1) ◽  
pp. 012114
Author(s):  
M V Manukovskaya ◽  
I P Shchetilina ◽  
Y N Pisklyukova ◽  
E A Klimova ◽  
M I Korystin
Keyword(s):  
Antioxidant Activity ◽  
Vitamin C ◽  
Human Body ◽  
Raw Materials ◽  
Ultrasonic Extraction ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Plant Raw Materials ◽  
Organoleptic Characteristics ◽  
Active Substances

Abstract The development of targeted drinks is a priority in the field of healthy eating. For their production, plant raw materials are actively used, containing a wide variety of biologically active substances. The presence of these ingredients helps to improve many physiological processes in the body, as well as to increase its immune status. Numerous studies have confirmed the high efficiency of ultrasonic effects on various technological processes. Ultrasonic extraction was carried out at t = 20 °C and an ultrasonic wave frequency of 22 kHz. As a result of research, it was found that with ultrasound exposure, an equilibrium state is achieved within 15 minutes. In order to develop new recipes for drinks, natural raw materials, their chemical composition and the effects on the human body have been studied. The selected ingredients in a certain quantitative ratio made it possible to obtain drinks with improved bio-corrective properties, which allows satisfying the daily requirement of the human body for biologically active substances. Ultrasonic exposure has a positive effect on the organoleptic characteristics of the drink and the aftertaste, as evidenced by the comparative organoleptic evaluation of the samples. The functional properties of the developed drinks have been confirmed experimentally. In the drinks, the following were determined: the content of macronutrients, antioxidant activity, the content of vitamin C, the duration of the shelf life. The use of the method of ultrasonic extraction in the technology of preparing drinks allows one: to reduce the preparation time by half, to reduce the amount of raw materials by 15 %, to increase the content of macronutrients by 45 %, to increase the content of vitamin C by 35 %, to increase the antioxidant activity by 45-50 %, increase stability during storage by 50 – 60 %, increase organoleptic characteristics. The results obtained prove the intensifying effect of ultrasonic exposure in the production of functional drinks.

scholarly journals Optimization of Extraction of Polyphenolic Compounds from Medicinal Lungwort (Pulmonaria officinalis L.)

2020 ◽  
pp. 36-45
Author(s):  
Lyubov S. Dyshlyuk ◽  
Anastasia M. Fedorova ◽  
Vyacheslav F. Dolganyuk ◽  
Alexander Yu. Prosekov
Keyword(s):  
Antioxidant Activity ◽  
Alcohol Concentration ◽  
Polyphenolic Compounds ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
High Yield ◽  
Operating Parameters ◽  
Extraction Temperature ◽  
Antioxidant Power ◽  
Active Substances

Medicinal plants are potential natural sources of biologically active substances that have geroprotective properties, slowing down the aging process. Vegetable raw materials are used as antioxidants in the food industry. Pulmonaria officinalis L. has a high content of biologically active substances. The purpose of this work is to determine the operating parameters for extracting the maximum amount of biologically active substances from Pulmonaria officinalis L. by extracting ethanol and finding sources of natural antioxidants.The antioxidant activity of several ethanol extracts of Pulmonaria officinalis L. – 30-70% with a step of 10 ethanol obtained from the dried root culture of the medicinal plant of biologically active substances was determined. The total content of polyphenols, flavonoids and proanthocyanidins was estimated. According to the data obtained, the relationship between the values determined for the biologically active substances presented and the values of antioxidant activity was revealed. Extracts of Pulmonaria officinalis L. showed a high yield of polyphenolic compounds-889.39±4.29 mcg of Gallic acid/ml, flavonoids-728.90±6.98 mcg of rutin/ml, proanthocyanidins-211.65±5.31 mcg of catechin/ml at an ethyl alcohol concentration of 60% and an extraction temperature of 50°C in 4 hours. The antioxidant activity using 2 methods: A spectrophotometric method DPPH (2,2-diphenyl-1-picrylhydrazyl) and the FRAP method (iron reducing/antioxidant power) was investigated. During DPPH spectrophotometric analysis, the antioxidant activity is equal to 86.96% for polyphenols, 75.47% for flavonoids, and 51.25% for proanthocyanidins. FRAP analysis showed that extracts with operating parameters had a pronounced antioxidant activity (tэ= 4 ч; Tэ= 50°C; Сэ= 60%)и (tэ= 5 ч; Tэ= 60°C; Сэ, = 70%).

scholarly journals VARIATION OF CHEMICAL COMPOSITION OF FRUITS OF BOG BLUEBERRY (VACCINIUM ULIGINOSUM L.) WHEN INTRODUCING

2018 ◽  
pp. 107-114
Author(s):  
Татьяна (Tat'yana) Ивановна (Ivanovna) Снакина (Snakina) ◽  
Татьяна (Tat'yana) Абдулхаиловна (Аbdulkhailovna) Кукушкина (Kukushkina)
Keyword(s):  
Biochemical Study ◽  
West Siberia ◽  
Botanical Garden ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Forest Steppe ◽  
Planting Material ◽  
Wide Range ◽  
Pharmaceutical Industries ◽  
Active Substances

Bog blueberry berries are a source material for food and pharmaceutical industries. However, industrial harvesting of bog blueberry is hardly carried out as plants grow in hard-to-access areas and safekeeping of berries is low during transportation to the processing plants.Special-purpose plantations of bog blueberry at the processing plants may solve the problem. To do this would require planting material noted for a high content of biologically active substances. Central Siberian Botanical Garden is a leading center of introduction and breeding of blueberry in Russia.In this connection, biochemical study of dry substance, ascorbic acid, sugars, acids, anthocyans, catechins, pectins and protopectins of berries of promising bog blueberry forms was conducted in the forest-steppe zone of West Siberia in 2011–2015.The results of research showed a wide range of variability of chemical characters due to individual peculiarities of bog blueberry forms and weather conditions in various years. Protopectins, catechins and pectins exhibited the greatest interannual distinctions.Bog blueberry samples with the greatest content of biologically active substances which can be recommended as planting material for creation of production plantations were revealed.

EFFECT OF SORPTION-DETOXIFYING COMPLEXES ON THE ACCUMULATION OF CADMIUM AND LEAD IN ORGANS AND TISSUES OF WHITE RATS

2021 ◽  
Vol 1 (4) ◽  
pp. 514-520
Author(s):  
Lyubov L. Zakharova ◽  
◽  
Natalia A. Brichko ◽  
Georgy А. Zhorov ◽  
Viktor N. Obryvin ◽  
...  
Keyword(s):  
Ecological Factors ◽  
The Body ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Farm Animals ◽  
Pharmacological Agents ◽  
Animal Products ◽  
White Rats ◽  
Cadmium And Lead ◽  
Active Substances

The environmental consequences of technogenic pressure pose a real threat to the health of the population and animals. The main danger to humans is the presence of pollutants of radiation and chemical nature in food. The production of animal products that meet the regulatory requirements, and the ensure of veterinary and sanitary welfare in regions with increased anthropogenic load is impossible without the use of effective methods of reduce the intake and accumulation of pollutants in the organism of animals. Therefore, in areas with a difficult environmental situation, when performing general detoxification, it is necessary to use a wider range of pharmacological agents, including antioxidants, immunomodulators, vitamin and mineral supplements and other biologically active substances that compensate for the negative effects that develop in the body as a result of exposure to harmful ecological factors, contribute to the restoration of health, increase the productivity of farm animals and product quality. In this regard, the combined use of anti-toxic and biologically active substances in the composition of sorption-detoxifying complexes is rational. As a result of testing the effectiveness of seven samples of sorption-detoxifying complex compositions in terms of their effect on the accumulation of Cd and Pb in the body of white rats, it was found that studied formulations reduce their intake to organs and tissues by 1.2-2.9 times, depending on the composition of the detoxifier, both separately and with the presence of heavy metals when combined with radioactive substances in the feed.

scholarly journals The Content of Secondary Metabolites and Antioxidant Activity of Wild Strawberry Fruit (Fragaria vescaL.)

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Magdalena Dyduch-Siemińska ◽  
Agnieszka Najda ◽  
Jan Dyduch ◽  
Magdalena Gantner ◽  
Kamila Klimek
Keyword(s):  
Antioxidant Activity ◽  
Phenolic Acids ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Strawberry Fruit ◽  
Dpph Radical ◽  
Dried Fruits ◽  
Wild Strawberry ◽  
Neutralization Ability ◽  
Active Substances

Chemical analyses carried out in 2011–2013 aimed at evaluating the contents of flavonoids, free phenolic acids, tannins, anthocyanins, and antioxidant activity (%) by means of DPPH radical neutralization ability in fresh and air-dried fruits of three wild strawberry cultivars. Examinations revealed differences in contents of biologically active substances determined in raw versus dried material depending on the cultivar. Mean concentrations of flavonoids and tannins were highest in raw fruits of “Baron von Solemacher” cv., which amounted to 1.244 mg·g−1and 6.09%, respectively. Fresh fruits of “Regina” cv. were characterized by the highest average content of phenolic acids and anthocyanins: 4.987 mg·g−1and 0.636 mg·100 g−1. The pattern of mean contents of biologically active substances analyzed in air-dried fruits was similar. Significant differences in abilities to neutralize the DPPH radical to diphenylpicrylhydrazine by extracts made of examined wild strawberry fruits were also indicated.

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