Identification of promising objects for the synthesis of thiosulphonate derivatives of benzoquinone and hydroquinone

Benzoquinone and its reduced form hydroquinone belong to phenolic compounds and are found in living organisms in free form or in glycosides. They are active substances of some medicinal plants and have a pharmacological effect on the human body. Accordingly, their derivatives are important objects for chemical synthesis and development of new drugs. This article presents the findings of the structural design of substances with benzoquinone or hydroquinone fragment and sulfur-containing compound. By use of appropriate on-line programs a predictive screening of the biological activity and cytotoxicity of thiosulfonate derivatives of benzoquinone and hydroquinone has been conducted. It has been found that they have immense methodological potential to be synthesized by substances with a wide range of biological activities and a high value of probable activity, which substantiates the feasibility of conducting experimental studies on their biological activity, particularly anticancer.

Antioxidant effect of humic acids on rat hepatocytes

The antioxidant properties of humic acids of various origins have been investigated (from bio-humus, black soil from Ternopil region, and peat from different regions, such as: Velykyi Liubin, Drohobych and Belarus Republic). Titrimetric analysis has been shown the quantitative composition of the acidic functional groups of the obtained humic acids. According to the data of thermogravimetric analysis, the values of parameters, showing the ratio of their aliphatic to the cyclic part were determined. It was found that all obtained humic acids are characterized by high antioxidant activity: the formation of thiobarbituractive products and carbonyl groups of proteins in liver hepatocytes were decreased. The inhibition of the products of free radical formation of lipid components and proteins was better inhibited by 1% solutions of humates from vermicompost and humic acids from peat. The results indicate prospects of the humic acids for creating the means of restoring the physiological functions of biological objects in pathological conditions under conditions of free radical stress for application in cosmetic pharmaceutical products.

Influence of ultrasound on the synthesis of silver nanoparticles by galvanic replacement in sodium polyacrylate solutions

Sonogalvanic replacement and galvanic replacement synthesis of silver nanoparticles (AgNPs) by magnesium scrap in sodium polyacrylate solutions were studied. It was found that during these processes in NaPA solutions silver is practically not deposited on the magnesium surface. Sodium polyacrylate provides stabilization of AgNPs with the formation of yellow solutions with maximum absorption of ~415 nm. It is shown that sonogalvanic replacement synthesis of AgNPs occurs due to the simultaneous course of galvanic replacement by magnesium and sonoreduction of Ag (I) by radicals and reducing agents. The rate of sonogalvanic replacement synthesis of AgNPs is 20-30% higher compared to galvanic substitution by mechanical stirring.

Influence of tungsten compounds on reaction of 1-octene epoxidation by tert-butyl hydroperoxide and hydroperoxide decomposition

Catalytic ability of tungsten compounds in the reaction of hydroperoxide epoxidation of 1- octene and tert-butyl hydroperoxide decomposition was investigated. It is shown that the nature of ligand has significant effect on the catalytic activity of tungsten compounds in these reactions. It is established that boride and silicide of tungsten are the best choice for epoxidation reaction, whereas tungsten carbide exhibits poor activity. Tungsten boride is also the most active in the hydroxide decomposition reaction.

Synthesis of thiosulphonate and amino acid derivatives of benzochinone and predicted screening of their biological activity

Quinoid derivatives are attractive not only as interesting synthons for synthesis, but also as potential biologically active substances, so it is important to modify the compounds of the quinone series with different pharmacoform fragments. In this work, the structural design of chlorine and bromanyl disulfur-containing fragments, namely thiosulfonate, and chloranyl – a fragment of 4- aminobutanoic acid. Methods of synthesis were developed and physicochemical characteristics of thiosulfonate and amino acid derivatives were studied: 2,5-bis (thiosulfonate) -3,6-halogen -1,4- benzoquinones and 2,5-bis (3-carboxypropylamino) -3,6 - dichlorobenzoquinone. The prospects for the design of chlorine and bromanyl thiosulfonate fragments and chloranyl fragment of 4- aminobutanoic acid are confirmed by the results of predicting the biological activity of 5 a, b, 6 a, b, 7 using the online resource PASS Online. In particular, the substance 6a obtained by us is promising in terms of research on Antiviral (Picornavirus). The obtained results of predicted cytotoxicity screening indicate the feasibility of conducting experimental studies by in vitro methods on anticancer activity against cancer cell lines of hematopoietic and lymphoid tissue, lungs, skin, ovaries, blood, breast, kidney, colon, brain.

Functional-cost analysis of methods of regeneration of used mineral motor oils

The main methods of regeneration of used mineral motor oils, in particular physical, chemical, physicochemical methods are considered. The functional-cost analysis of methods of regeneration of the used mineral motor oils by means of branch experts is carried out. Functional-cost analysis is a method of pairwise comparisons and involves the process of ranking the selected characteristics according to the degree of importance (weight). To do this, each characteristic is assigned a certain index. As a result of the functional-cost analysis, the expediency of using technologies of vacuum distillation and hydrocracking of used oils in the processes of regeneration of used oils has been established.

Study of the composition of drugs for the treatment of diseases of the nose cavity

Drugs of group R01, according to the АTC- classification used in the treatment of diseases of the nasal cavity by composition and dosage form, were studied. The dependence of the therapeutic effect of drugs on the chemical structure of the active substance, possible combinations of active substances belonging to different pharmacological groups (sympathomimetics, corticosteroids, and antihistamines), which determine their specific effect on the human body, are analyzed. These active substances are found in both mono- and multi-component drugs. In combination drugs, other compounds of natural and synthetic origin are also used to enhance the therapeutic effect.

Formation of experience against the challenges of viral infection through the use of students knowledge of biosafy technologies, part 1

New challenges and the state of development of COVID-19 in connection with the spread of new strains of SARS-CoV-2 have been analyzed. Experience and knowledge in working with new means of protection of different types of vaccines are studied: both classic, based on inactivated virus or its fragment, and the new generation – with vector and genetic mRNA vaccines, as well as effective antiviral drugs. Biorisks and compliance with biosafety principles have been studied. The replenishment of the base of competencies for biotechnologists and pharmacists in the context of distance learning and response to the pandemic is considered. The new data were used to introduce and deepen knowledge about the new generation of vaccines and the dangers of dual use of experimental data in the development of new components of educational programs in "Biotechnology and Bioengineering" and “Pharmacy, Industrial Pharmacy”.

Phase vapor–liquid equilibrium for the solutions of diethyl selenide and diethylzinc

Using a semi-empirical Wilson’s model, the vapor-liquid equilibrium in the “diethylzinc - diethyl selenide” system is described: the activity coefficients of the solution components, the separation coefficient, the excess functions of the solution (HE, GE, TSE) are calculated, and isothermal P-X diagrams are obtained. The parameters of the Wilson’s model were calculated on the basis of our data on measuring the temperature dependence for saturated vapor pressure of high-purity samples of diethylzinc, diethyl selenide and their equimolecular solution using iterations from the mathematical software package Mathsad 14. Peculiarities of intermolecular interaction in the “diethylzinc – diethyl selenide” system and the presence of a negative deviation from Raoul's law have been found. The studied system is homogeneous in the whole concentration range. The concentration dependence of the enthalpy of mixing is alternating for the researched temperature range (280-340 K).

COMPOSITION AND PROPERTIES OF PYROCONDENSATE OF PYROLYSIS WEAR TIRES

One of the options for the disposal of worn car tires is low-temperature pyrolysis, the target product of which is pyrocondensate. The fractional composition and properties of pyrocondensate of pyrolysis of rubber waste obtained at an industrial plant are studied. The pyrocondensate was separated into gasoline and diesel fraction and residue. The composition and properties of these fractions have been studied in detail. X-ray fluorescence analysis and IR spectroscopic studies of pyrocondensate and narrow fractions isolated from it were performed.