scholarly journals Toxicity of Soursop Leaf Powder and Its Relevance in Determining The Micronutrient Status in Formulated Complementary Food

2021 ◽  
Vol 2 (01) ◽  
pp. 13-20
Author(s):  
Ifeoma Elizabeth Mbaeyi-Nwaoha ◽  
Ebere Ani ◽  
Ngozi Chioma Okoronkwo
Keyword(s):  
Weight Gain ◽  
Food Intake ◽  
Toxicity Test ◽  
Raw Materials ◽  
Lethal Dose ◽  
Calcium Content ◽  
Iron Bioavailability ◽  
Complementary Food ◽  
Albino Rats ◽  
Hammer Mill

Complementary food was produced from blends of hungry rice (A), pigeon pea (P) and soursop leaves (S). The raw materials were washed with portable water, dried at room temperature, milled with hammer mill, fermented for 24 hours at 28 ± 2 °C (28 ± 2 °C), oven-dried at 50 °C for 12 hours, remilled, sieved to 1 mm pore size and packaged in polyethylene bags for further analysis. The samples were in the ratio of 70:30:0 (sample APS), 65:30:5 (sample APS1), 60:30:10 (sample APS2) and 55:30:15 (sample APS3). Toxicity test for lethal dose (LD50) was carried out on the soursop leaves. Bioassay was carried out with male albino rats for 28 days including acclimatization period of 7 days. Feed intake and weight gain of experimental rats were recorded daily and weekly. Blood serum was collected before and after feeding trials for analyzing bioavailability of the selected micronutrients. The data were subjected to one-way analysis of variance. Means were separated using the Duncan’s multiple range test and significance was accepted at probability level of 0.05 %. The toxicity test (LD50) indicated safety of soursop leaf as an infusion (oral administration) at lower doses of 10-1000 mg/kg body weight of rats. The bioassay revealed that food intake was significantly (p < 0.05) different among the samples in the first, second and third week. Rats that ate normal rat chow had the highest food intake while the rats that ate APS3 had the lowest food intake. Weight gain was highest in rats that ate rat chow while it was lowest in the rat that ate APS3. Bioavailability of selected micronutrient revealed that calcium content had the highest bioavailability in rats fed with rat chow and lowest in AP. Sample of APS1 had the highest iron bioavailability (47.83 %) among the fortified samples and the rat chow. Zinc had the highest bioavailability (52.86 %) in APS1. The work revealed that selected vitamins were most available in APS2 and the selected minerals were most available in sample APS1.

scholarly journals Influence of High and Low Saturated Fatty Acid-Based Diets on Weight and Body Composition of Albino Rats (Rattusnorvegicus)

2020 ◽  
Vol 5 (4) ◽  
Author(s):  
Abere DV
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Fatty Acid ◽  
Weight Gain ◽  
Food Intake ◽  
Saturated Fatty Acid ◽  
Body Weight Gain ◽  
Control Diet ◽  
Balance Model ◽  
Albino Rats

The study investigated the effect of feeding high and low saturated fatty acid based diets to feed female albino rats (Rattusnorvegicus) with a view to evaluating the effects of the fatty diets on the feeding patterns, weight and body composition of the rats. Seven months old female Rattus norvegicus were used for the experiment. The weights of the rats were taken for twelve weeks using Salter balance (Model 250). Four experimental diets were formulated which were made up of 2.5 and 5.0 g of margarine (blue band), 2.5 and 5.0 g canola oil each mixed with the basal diet. The control diet was grower feed and the resultant experimental diets were fed to the experimental rats kept in cages at the rate of 12 rats per cage. The rats were fed with the diets at the rate of 3% of body weight for a period of twelve weeks. The highest weight gain was recorded in the group fed with 5.0 g margarine, followed by 5.0 g canola, 2.5 g margarine, 2.5 g canola and least in the rats fed the control.The mean weight gain of the rats fed with 5.0 g margarine and 5.0 g canola were significantly different (p<0.05) from the mean weight of 2.5 g margarine, 2.5 g canola and the control. The food intake of the rats fed 5.0 g margarine and 5.0 g canola was also significantly different (p<0.05) from the food intake of rats fed 2.5 g margarine, 2.5 g canola and the control. The proximate composition of the carcass of the rats fed the different experimental diets showed that fat content of the rats fed 5.0 g margarine was higher than in the rats fed the other diets. The histology of the liver of rats fed 5.0 g margarine and 5.0 g canola showed greater fat accumulation in the rat’s liver compared to rats fed 2.5 g margarine, 2.5 g canola as well as the control. Rats with the highest body weight gain were considered obesity-prone; those with the lowest body weight were regarded as obesity-resistant while others were considered intermediate. The study concluded that the kind of fat consumed contributes to the weight gained by the rats.

scholarly journals A hindbrain dopaminergic neural circuit prevents weight gain by reinforcing food satiation

2021 ◽  
Vol 7 (22) ◽  
pp. eabf8719
Author(s):  
Yong Han ◽  
Guobin Xia ◽  
Yanlin He ◽  
Yang He ◽  
Monica Farias ◽  
...  
Keyword(s):  
Weight Gain ◽  
Food Intake ◽  
Neural Circuit ◽  
Neural Circuitry ◽  
Dynamic Regulation ◽  
Satiety Response ◽  
Food Satiation ◽  
Lateral Parabrachial Nucleus ◽  
Genetic Deletion ◽  
Feeding Bout

The neural circuitry mechanism that underlies dopaminergic (DA) control of innate feeding behavior is largely uncharacterized. Here, we identified a subpopulation of DA neurons situated in the caudal ventral tegmental area (cVTA) directly innervating DRD1-expressing neurons within the lateral parabrachial nucleus (LPBN). This neural circuit potently suppresses food intake via enhanced satiation response. Notably, this cohort of DAcVTA neurons is activated immediately before the cessation of each feeding bout. Acute inhibition of these DA neurons before bout termination substantially suppresses satiety and prolongs the consummatory feeding. Activation of postsynaptic DRD1LPBN neurons inhibits feeding, whereas genetic deletion of Drd1 within the LPBN causes robust increase in food intake and subsequent weight gain. Furthermore, the DRD1LPBN signaling manifests the central mechanism in methylphenidate-induced hypophagia. In conclusion, our study illuminates a hindbrain DAergic circuit that controls feeding through dynamic regulation in satiety response and meal structure.

scholarly journals Role of Ventromedial Hypothalamus in Sucrose-Induced Obesity on Metabolic Parameters

2021 ◽  
pp. 097275312110057
Author(s):  
Archana Gaur ◽  
G.K. Pal ◽  
Pravati Pal
Keyword(s):  
Insulin Resistance ◽  
Weight Gain ◽  
Food Intake ◽  
Ventromedial Hypothalamus ◽  
Female Rats ◽  
Metabolic Parameters ◽  
Male Rats ◽  
Significant Weight Gain ◽  
The Metabolic Syndrome

Background: Obesity is because of excessive fat accumulation that affects health adversely in the form of various diseases such as diabetes, hypertension, cardiovascular diseases, and many other disorders. Our Indian diet is rich in carbohydrates, and hence the sucrose-induced obesity is an apt model to mimic this. Ventromedial hypothalamus (VMH) is linked to the regulation of food intake in animals as well as humans. Purpose: To understand the role of VMHin sucrose-induced obesity on metabolic parameters. Methods: A total of 24 adult rats were made obese by feeding them on a 32% sucrose solution for 10 weeks. The VMH nucleus was ablated in the experimental group and sham lesions were made in the control group. Food intake, body weight, and biochemical parameters were compared before and after the lesion. Results: Male rats had a significant weight gain along with hyperphagia, whereas female rats did not have a significant weight gain inspite of hyperphagia. Insulin resistance and dyslipidemia were seen in both the experimental and control groups. Conclusion: A sucrose diet produces obesity which is similar to the metabolic syndrome with insulin resistance and dyslipidemia, and a VMH lesion further exaggerates it. Males are more prone to this exaggeration.

scholarly journals Neonatal nutritional programming impairs adiponectin effects on energy homeostasis in adult life of male rats

2018 ◽  
Vol 315 (1) ◽  
pp. E29-E37 ◽  
Author(s):  
Mariana Peduti Halah ◽  
Paula Beatriz Marangon ◽  
Jose Antunes-Rodrigues ◽  
Lucila L. K. Elias
Keyword(s):  
Body Weight ◽  
Adipose Tissue ◽  
Weight Gain ◽  
Food Intake ◽  
White Adipose Tissue ◽  
Energy Homeostasis ◽  
Body Weight Gain ◽  
Adult Life ◽  
Male Rats ◽  
Nutritional Programming

Neonatal nutritional changes induce long-lasting effects on energy homeostasis. Adiponectin influences food intake and body weight. The aim of this study was to investigate the effects of neonatal nutritional programming on the central stimulation of adiponectin. Male Wistar rats were divided on postnatal (PN) day 3 in litters of 3 (small litter, SL), 10 (normal litter, NL), or 16 pups/dam (large litter, LL). We assessed body weight gain for 60 days, adiponectin concentration, and white adipose tissue weight. We examined the response of SL, NL, and LL rats on body weight gain, food intake, oxygen consumption (V̇o2), respiratory exchange ratio (RER), calorimetry, locomotor activity, phosphorylated-AMP-activated protein kinase (AMPK) expression in the hypothalamus, and uncoupling protein (UCP)-1 in the brown adipose tissue after central stimulus with adiponectin. After weaning, SL rats maintained higher body weight gain despite similar food intake compared with NL rats. LL rats showed lower body weight at weaning, with a catch up afterward and higher food intake. Both LL and SL groups had decreased plasma concentrations of adiponectin at PN60. SL rats had increased white adipose tissue. Central injection of adiponectin decreased body weight and food intake and increased V̇o2, RER, calorimetry, p-AMPK and UCP- 1 expression in NL rats, but it had no effect on SL and LL rats, compared with the respective vehicle groups. In conclusion, neonatal under- and overfeeding induced an increase in body weight gain in juvenile and early adult life. Unresponsiveness to central effects of adiponectin contributes to the imbalance of the energy homeostasis in adult life induced by neonatal nutritional programming.

Phenobarbital Effects on Weight Gain and Circadian Cycling of Food Intake and Body Temperature

1980 ◽  
Vol 165 (3) ◽  
pp. 473-479 ◽  
Author(s):  
C. Peraino ◽  
C. F. Ehret ◽  
K. R. Groh ◽  
J. C. Meinert ◽  
G. D'Arcy-Gomez
Keyword(s):  
Weight Gain ◽  
Food Intake ◽  
Body Temperature

A comparison of the effects of infection with Eimeria maxima and dietary restriction on weight gain, plasma metabolites and liver glycogen in the immature fowl, Gallus domesticus

Parasitology ◽  
1982 ◽  
Vol 84 (2) ◽  
pp. 205-213 ◽  
Author(s):  
H. D. Chapman ◽  
D. L. Fernandes ◽  
T. F. Davison
Keyword(s):  
Growth Rate ◽  
Body Weight ◽  
Uric Acid ◽  
Weight Gain ◽  
Food Intake ◽  
Acute Phase ◽  
Plasma Glucose ◽  
Liver Glycogen ◽  
Plasma Metabolites ◽  
Eimeria Maxima

SUMMARYThe effects of Eimeria maxima or restricted pair-feeding on weight gain, plasma concentrations of protein, glucose, free fatty acids (FFA) and uric acid and liver glycogen were compared in immature fowl. Food intake/kg body weight and weight gain decreased during the acute phase of infection (days 5–7) while weight loss was prolonged for an extra day compared with pair-fed birds. During recovery, food intake/kg body weight of infected birds was greater than that of non-infected controls but there was no evidence for an increase in growth rate compared with controls when body weight was considered. Growth rate of pair-fed birds was greater than that of infected birds during recovery, indicating their better use of ingested food. Liver glycogen and plasma protein concentration were decreased during the acute phase of infection but the concentrations of plasma glucose, free fatty acid (FFA) and uric acid were not affected. In pair-fed birds liver glycogen was depleted, concentrations of plasma glucose and uric acid decreased and FFA increased, and these changes persisted for the remainder of the experiment. The findings are similar to those in birds whose food has been withheld and were probably due to the pattern of food intake imposed by the experimental protocol. It is concluded that the metabolic differences between infected and pair-fed birds are of doubtful significance.

Influence of particle size and microbial phytase supplementation on the performance, nutrient utilisation and digestive tract parameters of broiler starters

2009 ◽  
Vol 49 (8) ◽  
pp. 704 ◽  
Author(s):  
A. M. Amerah ◽  
V. Ravindran
Keyword(s):  
Particle Size ◽  
Weight Gain ◽  
Digestive Tract ◽  
Feed Intake ◽  
Coarse Particle ◽  
Hammer Mill ◽  
Particle Sizes ◽  
Broiler Performance ◽  
Nutrient Utilisation ◽  
Microbial Phytase

The aim of the present experiment was to examine the interaction between particle size and microbial phytase supplementation on the performance, nutrient utilisation and digestive tract development of broiler starters fed maize-based diets. The experimental design was a 2 × 2 factorial arrangement of treatments evaluating two maize particle sizes (medium and coarse) and two levels of phytase supplementation (without or with 500 phytase units/kg diet). The two particle sizes were achieved by grinding the whole maize in a hammer mill to pass through 3- and 7-mm screens, respectively. Broiler starter diets, based on maize and soybean meal, were formulated to meet recommended requirements for major nutrients, except phosphorus. Each of the four diets was fed ad libitum to six pens of eight male broilers each, from day 1 to day 21 post-hatching. Phytase supplementation increased (P < 0.001) the feed intake and weight gain, and lowered (P < 0.05) feed per gain in both medium and coarse particle size diets. Coarse grinding improved (P < 0.05) weight gain, but had no effect (P > 0.05) on feed intake and feed per gain. No interactions (P > 0.05) between phytase supplementation and particle size were observed for any of the performance parameters. Phytase supplementation increased (P < 0.001) ileal phosphorus digestibility and toe ash content of birds fed the medium particle size diet, but had no effect in those fed the coarse particle size diet. Apparent metabolisable energy and ileal digestibility of calcium and nitrogen were not influenced by particle size or phytase supplementation. The present findings suggest that the effectiveness of supplemental phytase on broiler performance is not influenced by the particle size of maize.

COMPARATIVE TECHNICAL AND ECONOMIC ESTIMATION OF THE SMALL-SCALE ON-FARM COMPOUND FEED PLANTS

2021 ◽  
pp. 59-65
Author(s):  
SERGEY V. BRAGINETS ◽  
Keyword(s):  
Net Present Value ◽  
Raw Materials ◽  
Farm Animals ◽  
Small Scale ◽  
Hammer Mill ◽  
Capital Investments ◽  
Agricultural Enterprises ◽  
Feed Production ◽  
Effi Ciency ◽  
On Farm

On-farm compound feed production from self-produced raw materials is favorable to agricultural enterprises under present-day conditions. The authors carried out a comparative technical and economic study of the conventional and modular small-scale on-farm compound feed plants with a capacity of 2 tons per hour, designed for agricultural enterprises with an average livestock population of 6…8 thousand pigs. The proposed modular plant consists of two modules – the operative storage of raw materials and the main module of grinding and mixing. Modules with installed equipment are delivered and placed on a light foundation, connected by transport equipment and with tanks for raw materials and fi nished products. The conventional factory is a technological line housed in a hangar and used for crushing, metering, and mixing raw materials. It consists of a separator, a hammer mill, weighing equipment, a mixer, containers for raw materials and fi nished products, transport, and aspiration equipment. The technical and economic analysis has shown that the erection and operation of the on-farm modular enterprise require 41% less capital investments than a traditional compound feed plant of the same capacity. The use of a small-scale modular plant will reduce operating costs by 23.8% (from 3094 to 2358 thousand rubles), increase the specifi c economic eff ect from the compound feed production by 1.6% (from 8.64 to 8.78 thousand rubles per ton) and return on margin by 4% (from 10.2 to 10.6%), reduce the payback period by 42% (from 0.8 to 0.46 years), and increase the net present value by 3% (from 66167 to 68216 thousand rubles), as compared to a conventional enterprise. The modular on-farm plants producing loose compound feed with a productivity of up to 3 tons per hour are profi table and economically sound as they can increase production effi ciency of compound feeds for farm animals.`

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