scholarly journals Impact of the Neuregulin rs35753505 C/T Polymorphisms on Neuregulin 1 Levels in Preterm Infants

2019 ◽  
Vol 7 (12) ◽  
pp. 1931-1934
Author(s):  
Bugis Mardina Lubis ◽  
Sjarif Hidajat Effendi ◽  
Ratna Akbari Ganie ◽  
Oke Rina Ramayani
Keyword(s):  
Preterm Infants ◽  
Cross Sectional Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
P Value ◽  
Nucleotide Polymorphisms ◽  
Gene Encoding ◽  
Cross Sectional ◽  
Neuregulin 1 ◽  
Organ Systems ◽  
The Impact

BACKGROUND: Neuregulin (NRG) 1 plays an important role in the development of various organ systems in human. Single nucleotide polymorphisms rs35753505 C/Tof the gene encoding NRG1 evident as allele C and T with genotypes of CT, CC, and TT are believed to have an impact on NRG1 levels.AIM: To determine the impact of the NRGrs35753505 C/T polymorphisms on NRG1 levels in preterm infants.METHODS: A cross-sectional study was conducted from February to December 2018, whereas 48 eligible preterm infants with a gestational age of 32- < 37 weeks were enrolled. An umbilical cord blood specimen was collected for determination of NRG1 levels with enzyme-linked immunosorbent assay (ELISA) and NRG1 polymorphisms with polymerase chain reaction (PCR). Statistical analysis was performed with 95%CI and P value of < 0.05 was considered statistically significant.RESULTS: Median value of NRG1 levels (174.4 pg/ml) served as a cut off value. NRG 1 polymorphisms composed distribution of CC (31%), CT (42%), TT (27%) genotypes and distribution of C and T alleles were 52% and 48%. The median NRG1 levels in CC and CT genotypes were significantly lower compared to TT genotype (151.1 pg/ml vs 407.2 pg/ml, P = 0.005 and 159.1 pg/ml vs 407.2 pg/ml, P = 0.009). Subjects with C allele had significantly lower median NRG1 levels than T allele (151.1 pg/ml vs 407.2 pg/ml, P = 0.002). Subjects with CC and CT genotypes had higher risk to develop lower NRG1 levels compared to TT genotype (OR = 8.25, P = 0.016 and OR = 10.74, P = 0.005, respectively).CONCLUSION: Allele C is associated with lower NRG1 levels. Preterm infants with CC and CT genotypes pose a higher risk to have lower NRG1 levels.

scholarly journals Tinnitus: The Sound of Stress?

2018 ◽  
Vol 14 (1) ◽  
pp. 264-269 ◽  
Author(s):  
Patricia Ciminelli ◽  
Sergio Machado ◽  
Manoela Palmeira ◽  
Mauro Giovanni Carta ◽  
Sarah Cristina Beirith ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Progressive Increase ◽  
Cross Sectional Study ◽  
P Value ◽  
Cross Sectional ◽  
Mean Values ◽  
Subjective Tinnitus ◽  
Stress Symptoms ◽  
The Impact

Background: Emotional stress is frequently associated with otologic symptoms as tinnitus and dizziness. Stress can contribute to the beginning or worsening of tinnitus. Objective: The objective of the study is to evaluate the presence of stress symptoms in patients with chronic, subjective tinnitus, and correlate its presence to annoyance associated with tinnitus. Methods: This is a cross-sectional study. One hundred and eighty patients with chronic, subjective tinnitus were included. Patients answered the Tinnitus Handicap Inventory (THI) to evaluate the impact of tinnitus in the quality of life and answered the Lipp's inventory symptoms of stress for adults (ISSL). The data obtained was organized using Excel® 2010, mean values, linear regression and p-value were calculated. Results: Of the 180 patients included in the study, 117 (65%) had stress symptoms, 52 of the 117 (44%) were in the resistance phase and 23 of the 117 (20%) in the exhaustion phase, the remaining was in the alert phase. There was a clear progressive increase in stress as THI raised, with more impact of tinnitus in quality of life. Conclusion: The presence of stress symptoms, measured by ISSL was observed in most of our patients with chronic subjective tinnitus, specially in the resistance and exhaustion phases and it is directly associated with tinnitus annoyance.

scholarly journals THE IMPACT OF MEDICATION ADHERENCE ON HEALTH-RELATED QUALITY OF LIFE OF DIABETIC PATIENTS IN THE KINGDOM OF SAUDI ARABIA: FINDINGS FROM A CROSS-SECTIONAL STUDY

2020 ◽  
Vol 17 (34) ◽  
pp. 867-873
Author(s):  
Dhfer ALSHAYBAN ◽  
Royes JOSEPH
Keyword(s):  
Quality Of Life ◽  
Medication Adherence ◽  
Cross Sectional Study ◽  
P Value ◽  
Diabetic Patients ◽  
Health State ◽  
Cross Sectional ◽  
Related Quality ◽  
The Impact

Diabetes is a common chronic disease that is considered as one of the fastest-growing health problems in the world. Adherence to medications could be an important factor in reducing these complications and improving the quality of life. The purpose of this research was to assess the impact of treatment adherence on health-related quality of life in patients with type 2 diabetes. A multicenter cross-sectional study was carried out among 368 diabetes patients. General Medication Adherence Scale was used to assess the adherence level and EuroQol-5D to assess the quality of life. The results show that 19%, 21%, and 23% of patients had maintained low medication adherence due to patient’s intentional or unintentional behavior due to additional diseases or pills burden and due to financial constraints, respectively. Overall, 43% (n=162) participants had maintained high medication adherence, and 37% (n=138) had maintained low medication adherence to antidiabetic drugs. Nearly one-third (31%) of patients with high overall adherence had perfect health state in comparison with 4% among patients with low adherence. Further, the lower proportion (21%) of patients with high overall adherence had perfect health state in comparison with that among patients with low adherence (34%). In addition to the overall adherence, the association was statistically significant for the domains related to non-adherence due to the patient’s intentional or unintentional behavior (p-value 0.001) and non-adherence due to additional diseases or pills burden (p-value 0.001) after taking into account of socio-demographic and clinical characteristics. In conclusion, the findings suggest that the policymakers should establish an intervention to improve adherence to diabetic treatment, and thus improve the quality of life for the type 2 diabetic patients.

scholarly journals Pattern analysis of S. haematobium infection and elimination in the area of Alsuki, Sudan

2021 ◽  
Vol 8 (3) ◽  
pp. 1059
Author(s):  
Rawia A. Abdelshafie ◽  
Abdalla I. Abdalla Mohamed
Keyword(s):  
Risk Factors ◽  
Statistical Analysis ◽  
Health Program ◽  
Pattern Analysis ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Cross Sectional ◽  
The People ◽  
The Impact

Background: The aim of this study was to determine the current conditions of children of the selected area, for the purpose of measuring the new effective health program for schistosomiasis disease eliminations and obtain the prevalence intensity and risk factors of S. haematobium among school children in the study area.Methods: A descriptive cross-sectional study was used to screen school going children of all the ages from five randomly selected schools from Alsuki region. A statistical analysis derived from data formulated based on 1062 samples aged between 6 and 15 years attending the selected schools during the period testing within 6 months were enrolled.Results: The impact of health awareness program was measured usefully and the responded factor for reducing the Schistosomiasis diseases was significantly became less than (0.05). Therefore, the actual qualified fitting degree and applicability was significantly becoming (p value=0.001).Conclusions: This research concluded that the prediction of Schistosomiasis diseases due to the risk Ratio of the collected data for those who did not attended awareness over the people who attended program became (0.248).

scholarly journals Assessment of the Impact of Mood on Food Intake and BMI Among Secondary Female Students in Al Madinah Almunawarah, KSA

2018 ◽  
Vol 3 (2) ◽  
Keyword(s):  
Body Weight ◽  
Dietary Intake ◽  
Negative Mood ◽  
Cross Sectional Study ◽  
Female Students ◽  
P Value ◽  
Food Diary ◽  
Cross Sectional ◽  
Lifestyle Questionnaire ◽  
The Impact

Introduction: Eating healthy is one of the essential things that should be taught at a young age. Obesity among adolescent or young girls is increasing dramatically. Psychological factors like mood swings can contribute to increased dietary intake and eventually to obesity. Aims: To explore the impact of mood on dietary intake and development of obesity Design: A cross-sectional study was conducted on a hundred female students aged from 13 to 15 years old. Students were selected randomly from three private secondary schools located in Al-Madinah. Students who matched the inclusion criteria were allowed to participate. A health and lifestyle questionnaire was distributed as well as a food diary to record their food consumption and mood over the upcoming three days (two school days and one weekend day). Weight and height were measured and BMI was obtained and compared to percentile BMI for age according to WHO. Results: A cross-sectional analysis determined the association between negative mood and intake of the following: calories: p value (0.02), fat: p value (0.01) and carbohydrates (0.01) respectively. Moreover, analysis also determined the association between BMI percentile (obese and overweight students) and intake of all of the following; fat (p=0.001), carbs (p=0.014) and kcal (p=0.006). Conclusion: Negative mood among students or adolescents could contributes to increase consumption of fat, carbs and energy and could lead to increasing body weight, compared to students with positive mood which could lead them to consume less fat, carbs and calories and then not effect body weight.

scholarly journals Seroprevalence of Chikungunya (CHIK) Infection during Non Epidemic Periods in Chennai, Southern India

2021 ◽  
Author(s):  
Kaliyamoorthy Kayalvili ◽  
Murugan Duraivel ◽  
Elangovan Nivedhitha ◽  
Subramanian Arul Selvan
Keyword(s):  
Disease Transmission ◽  
Statistical Significance ◽  
Cross Sectional Study ◽  
Southern India ◽  
Enzyme Linked Immunosorbent Assay ◽  
P Value ◽  
Chi Square ◽  
Monsoon Period ◽  
Cross Sectional ◽  
Igm Antibody

Introduction: Chikungunya (CHIK) infection has caused many outbreaks in India with more than 13 lac people affected by the disease. Epidemics of CHIK infection occur during post monsoon period when there is a high vector density. Evidences on the prevalence of CHIK infection during non epidemic periods are limited. Aim: To determine the seroprevalence of CHIK infection during non epidemic periods among patients attending fever clinic in Chennai, Southern India. Materials and Methods: This cross-sectional study was done in 180 suspected cases of CHIK infection between the months of September 2014 and February 2015. A 5 mL of blood samples were collected from the suspected cases and serum was separated to detect for the presence of CHIK-IgM antibody by using CHIK-IgM antibody capture Enzyme Linked Immunosorbent Assay (ELISA) kit. Chi-square test was done to find out the statistical significance with p-value <0.05 kept as statistically significant. Results: The seroprevalence of CHIK infection during non epidemic periods was found to be 5.5% (10/180). Fever and joint pain were the major complaints present in all the study population. All the seronegative cases were tested for the presence of other infections and it was found that 13% were positive for typhoid, 9% were positive for leptospirosis, 4% for malaria and 2% for dengue infections. Conclusion: There are no vaccines or specific medications available till date. Prevention is the only effective approach against the disease. Even though the prevalence of CHIK infection is low during non epidemic periods, strict vector control and elimination of mosquito breeding sites are very important in controlling the disease transmission.

scholarly journals Proposed Classification of Periampullary Diverticulum and its Role on Performing ERCP and Post ERCP Complication

2020 ◽  
Author(s):  
Hasan Salmanroghani ◽  
Mohammad Hassan Rouzegari ◽  
Mahmud Baghbanian
Keyword(s):  
Success Rate ◽  
Cross Sectional Study ◽  
Intestinal Wall ◽  
P Value ◽  
Complication Rates ◽  
Cross Sectional ◽  
Type 3 ◽  
The Impact

Introduction: Duodenal diverticula are pouches of the mucosa, submucosa, and scattered muscle cells that extend through the intestinal wall. In this study, we aimed to classify the papilla position according to presence of PAD and evaluate the impact of papilla position on the success rate and post ERCP complication in the patients with PAD. Methods: This cross-sectional study was performed on 1260 patients with bile duct problems underwent ERCP. Patients with diverticulum were considered as the first group and the patients without diverticulum as the second group. In this study, SPSS Version 18 software, Chi-square and Students T-test were used, respectively. Results: 239 patients had peripheral diverticula. The mean age of participants was 68.9±10.3. In 239 patients with diverticulum Type 1=48.2%, Type 2 =37.6%, Type 3 =5.1%, Type 4 =9.1% the success rate in Type 1 was 97% (p-value: 0.003). In the patients with type 3, the cannulation was difficult and had a low success rate, with more complications. Conclusion: Classification of PAD can predict success rate in the patients with PDA, and can predict post ERCP complication rates.

scholarly journals Ghrelin levels in hypertensive obese and normotensive obese subjects.

2021 ◽  
Vol 28 (08) ◽  
pp. 1142-1146
Author(s):  
Zehra Niazi ◽  
◽  
Sundus Tariq ◽  
Muhammad Azhar Saeed ◽  
Sana Akram ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cross Sectional Study ◽  
Ghrelin Level ◽  
Enzyme Linked Immunosorbent Assay ◽  
P Value ◽  
Cross Sectional ◽  
The Social ◽  
Significant Difference ◽  
Minimum Age ◽  
Obese Subjects

Objective: The purpose was to determine the ghrelin level, its effect and relationship with blood pressure levels in obese subjects. Study Design: Comparative Cross Sectional study. Settings: General OPD of Madinah Teaching Hospital (MTH) and District Head Quarter hospital Faisalabad (DHQ). Period: 2019 to 2020. Material & Methods: Blood samples were collected from hypertensive and compared with the normotensive obese (BMI >30). Ghrelin level was measured by Enzyme-linked immunosorbent assay (ELISA). Statistical analysis was done on Statistical Package for the Social Science (SPSS) 20 software. Mean ±SD has been given for quantitative variables. Independent sample t test was used for comparisons. Significance has been chosen as p ≤ 0.05. Results: Total 114 obese patients were selected for this study, of which 57 were hypertensive and 57 were normotensive. Minimum age was 30 years and maximum age was 60 years with mean age 39.35 ± 10.08 years. Mean age of hypertensive obese was 43.42 ± 10.46 years and mean age of normotensive was 35.28 ± 7.87 years. Statistically significant difference of mean fasting ghrelin levels between hypertensive obese and normotensive obese was noted with p value 0.013. Conclusion: Obese persons with elevated circulating concentration of ghrelin may be susceptible to the progression of increasing blood pressure.

scholarly journals Nursing Duty Hours’ Length and the Perceived Outcomes of Care

2018 ◽  
Vol 10 (4) ◽  
pp. 1 ◽  
Author(s):  
Mu'taman Khalil Jarrar ◽  
Hamzah Abdul Rahman ◽  
Abdulaziz M. Sebiany ◽  
Mahdi S AbuMadini ◽  
Hj. Masnawaty S ◽  
...  
Keyword(s):  
Night Shift ◽  
Cross Sectional Study ◽  
Poor Quality ◽  
Care Quality ◽  
P Value ◽  
Cross Sectional ◽  
Policy Makers ◽  
Duty Hours ◽  
Outcomes Of Care ◽  
The Impact

BACKGROUND & OBJECTIVE: Working long shifts are associated with fatigue, medical errors and poor outcomes of care. However, there is a lack of guide that can provide policy-makers the optimal duty length in the Malaysian hospitals. The study aims to investigate the impact of nursing duty hours’ length on the quality and safety of care delivered in the “Medical-Surgical Wards” in Malaysia.METHOD: Cross-sectional study was carried out on 12 private hospitals. Data was collected, through questionnaires, from 652 nurses (61.8 % response rate). Stratified random sampling was used in the study. Regression analyses were conducted to explore the impact of the nursing duty hours’ length on the care quality and safety.FINDINGS: The length of nurses’ duty hours is not significantly affecting care quality (F = 1.27 and P value = 0.28) and patient safety (F = 1.81 and P value = 0.13), at p<0.05 significance level.CONCLUSION: Nurse working in hospitals with 10-hours night shift had perceived poor quality (B=-0.11, t=-1.64, p=0.10); and unsafe care (B=-0.17, t=-2.40, p=0.02). Policy makers in Malaysian hospitals can benefit from the study by restructuring duty hours’ length in their hospital.

Anxiety and depression during pregnancy in the era of COVID-19

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Rasha E. Khamees ◽  
Omima T. Taha ◽  
Tamer Yehia M. Ali
Keyword(s):  
Pregnant Women ◽  
Depression Scale ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Anxiety And Depression ◽  
P Value ◽  
Cross Sectional ◽  
Kuwait University ◽  
Multiparous Women ◽  
The Impact

Abstract Objectives This study aimed to evaluate anxiety and depression in pregnant women during this global disease. Methods This was a cross-sectional study recruiting 120 pregnant women. The study was conducted at the outpatient clinic of a tertiary hospital. We recruited women attending for antenatal care. Anxiety was evaluated using an Arabic validated Kuwait University Anxiety Scale (KUAS). Depression was evaluated using a validated Arabic form of the Edinburgh Postnatal Depression Scale (EPDS). Results The study included 48 (40%) nulliparous and 72 (60%) multiparous women. The mean KUAS scores for nulliparous and multiparous women were 45.27±10.78 and 47.28±10.62. Both nulliparous and multiparous women had a fairly high possibility of depression. Fifty-three (44.2%) of them reported scores ≥ of 14. Ninety-three (77.5%) women thought that COVID-19 pandemic would affect their pregnancies. There was a significant association between the number of women reporting fear related to the COVID-19 pandemic and their KUAS and EPDS scores (p-value <0.001 each). Conclusions COVID-19 affected the mental health of pregnant women to a great extent. Care should be directed to measures that would decrease the impact of this pandemic on vulnerable populations.

scholarly journals Impact of malocclusion severity on the quality of life of non-white adolescents

2021 ◽  
Vol 26 (suppl 3) ◽  
pp. 5233-5240
Author(s):  
Juliana Andrade de Lacerda ◽  
Técia Mendes Daltro Borges ◽  
Marcelo de Castro Meneguim ◽  
Mario Vedovello Filho ◽  
Milton Santamaria Júnior ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Health Impact ◽  
Cross Sectional Study ◽  
P Value ◽  
White Adolescents ◽  
Cross Sectional ◽  
Deep Bite ◽  
The Impact

Abstract The aim of this study was to evaluate the impact of malocclusion severity on the oral health-related quality of life (OHRQoL) of non-white adolescents. A cross-sectional study was conducted with 585 non-white Brazilian adolescents (12-15 years). The Dental Aesthetic Index (DAI) was used for the clinical assessment of malocclusion and Oral Health Impact Profile (OHIP-14) on OHRQoL. Deep bite and transverse occlusal relationships were assessed in association with the DAI. The adolescents with DAI 3 and 4 were distributed into 4 groups: G1 - individuals without transverse occlusal relationships or deep bite; G2 - individuals with only posterior crossbite; G3 - individuals with only deep bite; and G4 - individuals with Brodie bite. The backward stepwise procedure was used to select variables on each level, eliminating variables with a p≤0.20. From the logistic regression analyses, the adjusted odds ratios were estimated with the respective 95% confidence intervals. The adolescents with severe malocclusion divided into the G2, G3 and G4 showed p-value of 0.0501, 0.1475, and 0.5407, respectively, but did not remain in the final model. Malocclusion severity had no impact on the OHRQoL of non-white adolescents.

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