The Differences in Transaminase Enzyme Levels among Children with Acute Diarrhea due to Rotavirus and Non-rotavirus

BACKGROUND: Diarrhea is the particular disease that still affects children in Indonesia, with rotavirus being the most common etiology among children under 5 years old. Rotavirus and non-rotavirus diarrhea can spread to the extraintestinal and localized to the liver which causes liver cell damage, thus, the level of the glutamic oxaloacetic and glutamic pyruvic transaminase enzymes increases. AIM: The objective of the study was to prove that there are differences in serum levels of glutamic oxaloacetic and glutamic pyruvic transaminase in children with acute diarrhea due to rotavirus and non-rotavirus infection. METHODS: This study used a cross-sectional design, the research subjects were children aged 6 months old until 60 months old with acute diarrhea in Denpasar Public Health Center, Sanglah, and Wangaya General Hospital within the period of March 2018 until March 2021. Statistical analysis used the Mann–Whitney. RESULTS: A total of 70 subjects were analyzed in this study. There were 24.28% of subjects with rotavirus. Each group had nearly the same degree of severity of 29.4% for rotavirus and 30.2% for non-rotavirus, with a median of serum levels of glutamic oxaloacetic transaminase (SGOT) 47 (19–261) and glutamic pyruvic transaminase (SGPT) 25 (7–217). The results of this study showed that the median difference in aspartate aminotransferase and alanine aminotransferase levels was not significant in rotavirus and non-rotavirus diarrhea (SGOT 45 [16–168], 32 [11–261], p = 0.077; (SGPT 22 [14–91], 18 [5–217], p = 0.12). CONCLUSION: This study concluded that there is a higher median level of SGOT and SGPT in children with acute diarrhea due to rotavirus infection compared to non-rotavirus infection, although it is not statistically significant.

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The The Role Of Von Willenbrand Factors As The Early Detection Of Endotel Cell Damage In Youth Ages With Obesity In The Usu Medan Campus Environment

ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat ◽

10.32734/abdimastalenta.v6i1.5865 ◽

2021 ◽

Vol 6 (1) ◽

pp. 179-181

Author(s):

Rusdiana ◽

Muhammad Syahputra ◽

Sry Suryani

Keyword(s):

Oxidative Stress ◽

Endothelial Cells ◽

Vascular System ◽

Cell Damage ◽

Single Layer ◽

Control Group ◽

Research Subjects ◽

Cross Sectional ◽

Significant Difference ◽

Obese Subjects

Preliminary : Endothelial cells are a single layer that lines the entire vascular system. Endothelial dysfunction can be triggered by several main things, namely physical stress, oxidative stress and irritant substances. Obesity triggers an inflammatory process and metabolic disorders that will lead to increased oxidative stress. Long-term oxidative stress will cause damage to cells and tissues and trigger degenerative diseases. Damage to endothelial cells is expected to be detected by examining Von Willenbrand levels so that it can prevent complications of vascular disorders early. Method: This research is descriptive with cross sectional design. Carried out from March to October 2018 on the USU Campus. The first examination was done to measure body weight and height to determine body mass index, then performed lipid profile and blood sugar levels (KGD) in the sample, then examined von Willenbrand factor levels carried out in the integrated laboratory of USU FK using the method ELISA in both the sample group and the control group. The research subjects were adolescents aged 17-25 years with BMI> 25 kg / m2Data analysis was carried out using the T-Test statistical program, comparing two groups. Result: Of the 40 obese subjects found Von Wilenbrand level values The lowest factor was 1.78 IU / ml and the highest was 35.60 IU / ml. Whereas in 40 non-obese subjects Von Wilenbrand grade values were the lowest factor of 2.01 IU / ml and the highest was 45.10 IU / ml. This difference was not statistically significant (p = 0.661).Conclusion: There was no significant difference between the levels of Von Wilenbrand Factors in obese subjects with non-obese subjectsKey Words: Obesity, endothelial cells, Von Wilenbrand Factors

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FAKTOR-FAKTOR YANG MEMPENGARUHI SUBTIPE GEJALA MOTORIK PENYAKIT PARKINSON

Human Care Journal ◽

10.32883/hcj.v5i1.649 ◽

2020 ◽

Vol 5 (1) ◽

pp. 343

Author(s):

Attiya Istarini ◽

Yuliarni Syafrita ◽

Restu Susanti

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Age At Onset ◽

Motor Symptom ◽

Disease Stage ◽

Motor Symptoms ◽

Research Subjects ◽

Cross Sectional ◽

Duration Of Disease ◽

Cross Sectional Design

Background: Parkinson's disease (PD) is a chronic neurodegenerative disease that manifests as movement disorders. Based on motor symptoms, PD is classified into subtypes of tremor and postural instability gait disorders (PIGD). The motor symptoms subtype is a predictor of disease progression, therapeutic response, and quality of life for Parkinson's patients. The purpose of this study is to identify some factors that influence motor symptoms in Parkinson's disease.Methods: This research use cross sectional design. Samples were selected by consecutive sampling method that met the inclusion and exclusion criteria. Research subjects were 58 people. Statistical analysis using SPSS. p values <0.05 were considered statistically significant.Results: This research include 58 patients, 55.2% were men with range of age 63.5 ± 8.5 years old. The mean age at onset was 57.9 ± 9.5 years and duration of disease 6.1 ± 4.6 years. Motor symptoms 53.4% dominant tremor. There was a significant relationship between disease stage and motor symptom subtypes (p <0.001). There is no relationship between the patient's age, age at onset and duration of the disease with motor symptom subtypes.Conclusions: There is a relationship between disease stage and motor symptom. The patient's age, age at onset and duration of the disease are not related to the motor symptoms of Parkinson's patients.

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Diagnostic Value of Left Ventricular Early Inflow-Outflow Index in Determining Severity of Mitral Regurgitation

Indonesian Journal of Cardiology ◽

10.30701/ijc.v38i2.729 ◽

2017 ◽

pp. 64-71

Author(s):

Vera Yulia ◽

Mefri Yanni ◽

Didik Hariyanto

Keyword(s):

Mitral Regurgitation ◽

Ejection Fraction ◽

Diagnostic Value ◽

Geometric Error ◽

Left Ventricular ◽

Cross Sectional ◽

Spectral Doppler ◽

Common Etiology ◽

Cross Sectional Design ◽

Sensitivity Specificity

Background: Determining severity of mitral regurgitation (MR) is very important, asit is related with prognosis and management of the disease. Currently, there is no goldstandard exists for quantification of MR severity using echocardiography. AmericanSociety of Echocardiography (ASE) guidelines recommend several parameters basedon integrative criteria using color and spectral Doppler and anatomic measurement.Left Ventricular Early Inflow Outflow Index (LVEIO Index) was proposed as one parameterto assess the severity of MR by omitting geometric error from regurgitantvolume method. Thus, LVEIO index offers a simple, easy and accurate measurementin determining severity of MR.Methods: This study was a diagnostic test research with cross-sectional design. Thesubjects were all patients with organic mitral regurgitation who underwent echocardiographyexamination to measure severity of MR using the LVEIO index as well asother parameters measurements based on parameters of ASE guidelines. Diagnostictest was used to determine the sensitivity, specificity, positive predictive value, negativepredictive value and accuracy of LVEIO index.Results: Of 49 patients in this study, 23 of them have severe MR and 26 are non-severeMR patients. The proportion of gender between two groups almost similar with an agerange from 56 to 61 years and the most common etiology finding was degenerative MR.Echocardiography examination showed the ejection fraction in severe MR was 63±4.2%and 64±3.9% in non-severe MR. The value of LAVI, MPAP, E-wave, VC, EROA andLVEIO index increased parallel with severity of MR (LAVI; 67±18.2 vs. 40±14.2 ml/m2,MPAP; 28±12.8 vs. 20±12.6 mmHg, E-wave 1.5±0.3 vs. 1±0.2 m/s, VC 0.8±0.3 vs.0.5±0.1 cm, EROA 0.4±0.1 vs 0,2±0,1cm2, LVEIO 9±2,4 vs. 5±1,8). The sensitivity,specificity, and accuracy of LVEIO index for diagnosis of severe MR were 86%, 84%,and 89%, respectively.Conclusion: LVEIO can be proposed as a relatively simple, easy and accurate methodin determining severity of MR.

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The Sensitivity and Specificity of Chicago Sky Blue (CSB) Dye in Comparisson with Potassium Hydroxide (KOH) Method for Superficial Dermatomycosis

Berkala Kedokteran ◽

10.20527/jbk.v16i2.9280 ◽

2020 ◽

Vol 16 (2) ◽

pp. 155

Author(s):

Amalia Nadiasari ◽

Diana Tri Ratnasari ◽

Masfufatun Masfufatun

Keyword(s):

Sensitivity And Specificity ◽

Potassium Hydroxide ◽

Pityriasis Versicolor ◽

Color Contrast ◽

Research Subjects ◽

Cross Sectional ◽

Proper Diagnosis ◽

Cross Sectional Design ◽

Sensitivity Specificity ◽

Higher Sensitivity

Abstract: Superficial dermatomycosis is a skin, nail and hair infection caused by fungal pathogen. Based on the pathogen, this infection can be divided into dermatophytosis, pityriasis versicolor and superficial candidiasis. The rapid and proper diagnosis is necessary to determine the initial theraphy and prevent the treatment delay. Superficial dermatomycosis diagnosis can be performed using anamnesis, physical examination or supporting investigation. The routine investigation method commonly use Potassium Hydroxide (KOH) because the KOH method is easy to be performed, rapid, simple and affordable. Chicago Sky Blue (CSB) is a dye to give a better color contrast to the fungi so the fungi would be easier to be detected. Objectives of this research is to observe the sensitivity and specifity difference of Chicago Sky Blue (CSB) dye and Potassium Hydroxide (KOH) methods for Superficial Dermatomycosis. The research was performed using cross sectional design analitical obsevation with 30 research subjects. The subjects consist of 15 superficial dermatomycosis patients and 15 non-superficial dermatomycosis patients. The samples were taken from the patients lesion swabs. The samples were checked using KOH and CSB, then observed by the medical analyst. The superficial dermatomycosis samples consist of mostly dermathophytosis (53.33%), then pityriasis versicolor (26.67%) and superficial candidiasis (20%). The sensitivity and specificity of KOH were 86.67% and 100%, respectively. The sensitivity and specificity of CSB were 93.33% and 100%, respectively. The CSB dye method has a higher sensitivity than KOH. The fungal elements are nicely dyed and more easily detected using CSB dye. Keywords: KOH, Chicago Sky Blue, sensitivity, specificity, superficial dermatomycosis

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Serum levels of adrenal androgens up to adrenarche in Peruvian children living at sea level and at high altitude

Journal of Endocrinology ◽

10.1677/joe.0.1360517 ◽

1993 ◽

Vol 136 (3) ◽

pp. 517-523 ◽

Cited By ~ 5

Author(s):

C. Goñez ◽

A. Villena ◽

G. F. Gonzales

Keyword(s):

Public Schools ◽

High Altitude ◽

Sea Level ◽

Serum Levels ◽

Dehydroepiandrosterone Sulphate ◽

Adrenal Androgen ◽

Adrenal Androgens ◽

Cross Sectional ◽

Low Altitude ◽

Cross Sectional Design

ABSTRACT Serum levels of adrenal androgens were measured in children of both sexes living at sea level and at high altitude using a cross-sectional design. The levels were compared in relation to age at each altitude (150 m and 3400 m above sea level), and the first significant increase in mean levels compared with values at preceding ages was assessed and defined as adrenarche. A total of 118 boys and 95 girls aged 6–12 years living at low altitude and 95 boys and 104 girls aged 7–15 years living at high altitude, all of them attending public schools, were studied. Serum dehydroepiandrosterone, dehydroepiandrosterone sulphate and androstenedione were measured by radioimmunoassay and height and weight by standard anthropometric techniques. There were two significant increases in serum levels of adrenal androgens, the first observed in children between 6 and 8 years at sea level, and between 7 and 9 years at high altitude, and the second in children between 10 and 12 years at sea level and between 12 and 15 years at high altitude. Serum adrenal androgen levels increased earlier in children at sea level than at high altitude. It is concluded that adrenarche occurs later at high altitude than at sea level. Journal of Endocrinology (1993) 136, 517–523

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Tingkat kecemasan, asupan makan, dan status gizi pada lansia di Kota Yogyakarta

Jurnal Gizi Klinik Indonesia ◽

10.22146/ijcn.23022 ◽

2015 ◽

Vol 12 (2) ◽

pp. 62 ◽

Cited By ~ 1

Author(s):

Ninna Rohmawati ◽

Ahmad Husein Asdie ◽

Susetyowati Susetyowati

Keyword(s):

Nutritional Status ◽

Dietary Intake ◽

Anxiety Level ◽

Bivariate Analysis ◽

Research Subjects ◽

Chi Square ◽

Cross Sectional ◽

Arm Span ◽

Chi Square Test ◽

Cross Sectional Design

Background: Psychological factors such as anxiety have significant contributions in determining dietary intake and nutritional status of elderly. Prevalence of malnutrition in elderly has achieved significant level.Objective: To determine the correlation between anxiety level with dietary intake and nutritional status of elderly in Yogyakarta municipality.Method: This research was observational with cross sectional design. Subjects were elderly in Yogyakarta municipality who fulfilled inclusion criteria. Research subjects consisted of 214 people. Anxiety level was measured with trait-manifest anxiety scale (T-MAS) form, dietary intake with semi-quantitative food frequency questionnaire (SQFFQ) method, and nutritional status was determined based on body mass arm span (BMA). Data were analyzed with Chi-Square test and multiple logistic regression.Results: A percentage of 26.2% subjects had moderate anxiety level. Most dominant factors that influenced anxiety level was sex (OR=3.37). Bivariate analysis showed a significant correlation between anxiety level and nutritional status (p<0.05), subjects with moderate anxiety level were more likely to have higher nutritional status (OR=3.54) and lower nutritional status (OR=2.29). Significant correlation was found between moderate anxiety level with excessive dietary intake (p<0.001; OR=6.22). Significant correlation was also found between dietary intake with nutritional status (p<0.05), subjects with excessive dietary intake were more likely to have higher nutritional status (OR=6.15).Conclusion: Significant correlation was found between anxiety level and nutritional status. Significant correlation was also found between anxiety level and dietary intake, and significant correlation was found between dietary intake and nutritional status.

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HUBUNGAN PENGETAHUAN DENGAN PEMANFAATAN KLINIK SANITASI PADA IBU BAYI DAN BALITA PENDERITA DIARE AKUT

Berkala Kedokteran ◽

10.20527/jbk.v13i1.3440 ◽

2017 ◽

Vol 13 (1) ◽

pp. 53

Author(s):

Herwinda Husnawati ◽

Syamsul Arifin ◽

Ida Yuliana

Keyword(s):

Acute Diarrhea ◽

Random Sampling ◽

P Value ◽

Chi Square ◽

Cross Sectional ◽

Systematic Random Sampling ◽

Department Of Health ◽

Low Education ◽

Chi Square Test ◽

Cross Sectional Design

Abstract: Based on data from Banjarmasin Department of Health in 2015, the highest diarrhea incident which is 1.056 cases, occurs at Puskesmas Kuin Raya Banjarmasin. There is an imbalance between diarrhea incident and visitation to sanitation clinic. Many factors are influencing someone’s behavior while knowledge is one of those. This research aimed to discover the correlation between education and sanitation clinic utilization on a mother of acute diarrhea toddlers at Puskesmas Kuin Raya Banjarmasin. This was an analytic observational study with cross sectional design. The samples were 50 mothers chosen by systematic random sampling method. The analysis was conducted by chi-square test. The result portrayed 12% of high education, 22% of fair education and 66% of low education. Meanwhile, there were 64% non-utilization and 36% utilization of sanitation clinic. The correlation p-value was 0,000 (p<0,05). In conclusion, there is a correlation between education and sanitation clinic utilization on a mother of acute diarrhea toddlers at Puskesmas Kuin Raya Banjarmasin. Keywords: acute diarrhea, sanitation clinic utilization, education Abstrak: Data Dinas Kesehatan Kotamadya Banjarmasin tahun 2015 didapatkan angka kejadian diare tertinggi sebanyak 1,056 kasus di Puskesmas Kuin Raya Banjarmasin. Terdapat kesenjangan antara angka kejadian diare dengan jumlah kunjungan ke klinik sanitasi. Banyak faktor yang mempengaruhi pemanfaatan klinik sanitasi, salah satunya adalah pengetahuan. Tujuan penelitian ini untuk mengetahui hubungan pengetahuan dengan pemanfaatan klinik sanitasi pada ibu bayi dan balita penderita diare akut di Puskesmas Kuin Raya Banjarmasin. Metode penelitian ini adalah observasional analitik dengan pendekatan cross sectional. Sampel berjumlah 50 responden dengan teknik systematic random sampling. Analisis data menggunakan uji chi-square. Hasil penelitian adalah 12% mempunyai pengetahuan tinggi, 22% berpengetahuan cukup dan 66% berpengetahuan rendah. Sementara itu, untuk pemanfaatan klinik sanitasi didapatkan hasil tidak memanfaatkan klinik sanitasi 64% dan memanfaatkan 36%. Nilai korelasi p = 0,000 (p< 0,05). Kesimpulan penelitian ini terdapat hubungan pengetahuan dengan pemanfaatan klinik sanitasi pada ibu bayi dan balita penderita diare akut di Puskesmas Kuin Raya Banjarmasin. Kata-kata kunci: diare akut, pemanfaatan klinik sanitasi, pengetahuan

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The Relation of Brain-Derived Neurotropic Factor (BDNF) Serum Level to Sub-Domain Cognitive Functions of Indonesian Schizophrenia Patients Measured by MoCA-Ina

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2019.705 ◽

2019 ◽

Vol 7 (23) ◽

pp. 4053-4058

Author(s):

Nurul Utami ◽

Elmeida Effendy ◽

Mustafa Amin

Keyword(s):

Serum Level ◽

Cognitive Functions ◽

Negative Symptoms ◽

Serum Levels ◽

Attention And Memory ◽

Cross Sectional ◽

Cross Sectional Design ◽

Neurotropic Factor ◽

Sandwich Enzyme Immunoassay ◽

Positive And Negative Symptoms

BACKGROUND: BDNF implies to the development of abnormal nerves and neurotransmission that occurred during the changes of cognitive functions. However, in determining initial diagnosis of schizophrenia, measurements focus on the presences of positive and negative symptoms, and general psychopathological features without concerning the BDNF serum, which involves in central nervous system as the main symptom of schizophrenia. AIM: To determine the relation of BDNF serum level to cognitive functions of schizophrenia patients based on sub-domain of Montreal Cognitive Assessment Indonesia Version (MoCA-Ina) METHODS: This study was carried out based on observational analysis with cross-sectional design study. The samples were collected by non-probability sampling and consecutive sampling by recruiting 65 of male schizophrenia patients at Prof. Dr. M. Ildrem Mental Hospital, Medan, North Sumatera, Indonesia. BDNF serum levels were analysed throughout quantitative sandwich enzyme immunoassay method, while the cognitive functions were conducted by performing the MoCA-Ina, which concern to attentions and concentrations, executive function, memory, languages, visuoconstructional abilities, numerical calculation, and orientation. RESULTS: The serum level of BDNF was accounted averagely for 27161.26, with 5350.37 of standard deviation. There was positive correlation with medium strength (r = 0.4 - < 0.6) in visuospatial function, attention (r = 0.437), and memory (r = 0.413). CONCLUSION: Relation between BDNF serum level and cognitive function occurred in visuospatial, attention and memory domains based on MoCA-Ina assessment.

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The Difference of sVE-Cadherin Levels between Dengue Hemorrhagic Fever Patients with Shock and without Shock

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2019.602 ◽

2019 ◽

Vol 7 (14) ◽

pp. 2277-2281 ◽

Cited By ~ 1

Author(s):

Rinang Mariko ◽

Eryati Darwin ◽

Yanwirasti Yanwirasti ◽

Sri Rezeki Hadinegoro

Keyword(s):

Dengue Virus ◽

Sample Size ◽

Dengue Hemorrhagic Fever ◽

Hypovolemic Shock ◽

Hemorrhagic Fever ◽

Total Sample ◽

Research Subjects ◽

Cross Sectional ◽

The Difference ◽

Cross Sectional Design

BACKGROUND: Dengue virus infection is an infectious disease caused by the dengue virus and transmitted by the Aedes aegypti mosquito. Dengue virus (DEN-V) consists of 4 serotypes, namely DEN-1, DEN-2, DEN-3, and DEN-4. The most feared result of DHF is death. Death in children is caused by hypovolemic shock due to plasma leakage from intravascular to extravascular space due to endothelial dysfunction. AIM: This study aims to analyse difference in sVE-Cadherin levels in Dengue Hemorrhagic Fever (DHF) with and without shock. MATERIAL AND METHODS: The method of taking samples is consecutive sampling, namely the research subjects obtained based on the order of entry in the hospital with a comparative cross-sectional design. From the results of the calculation using the sample formula, the sample size for each group is set at 32 people. So that the total sample size used for both groups is 64 people. The serum sVE-Cadherin levels using the ELISA method. The statistical test used is the independent t-test. The value of p < 0.05 was said to be statistically significant. RESULTS: The result showed that there was no difference in mean sVE-Cadherin levels between DHF patients with shock and without shock (p > 0.05). CONCLUSION: This study concluded that there was no difference in mean of sVE-Cadherin level in DHF patients with shock and without shock.

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Differences in levelFms-Like Tyrosine Kinase-1 (sFlt-1), soluble Endoglin (s-Eng), and Placental Growth Factor (PIGF) between Early Onset Preeclampsia and Late Onset Preeclampsia

Journal of Midwifery ◽

10.25077/jom.3.2.11-18.2018 ◽

2018 ◽

Vol 3 (2) ◽

pp. 11

Author(s):

Lita Nafratilova ◽

Yusrawati Yusrawati ◽

Irza Wahi

Keyword(s):

Early Onset ◽

Late Onset ◽

Serum Levels ◽

Enzyme Linked Immunosorbent Assay ◽

Cross Sectional ◽

Intrinsic Factors ◽

Significant Difference ◽

The Difference ◽

Cross Sectional Design ◽

Early Onset Preeclampsia

Early Onset Preeclampsia (EO-PE) is preeclampsia that develops before 34 weeks 'gestation, caused by intrinsic factors, while Late Onset Preeclampsia (LO-PE) is preeclampsia that develops after 34 weeks' gestation due to extrinsic and maternal factors. There is an increased production of antiangiogenic factors (sFlt-1, s-Eng and PIGF) contribute to pathophysiology of preeclampsia.This study aims to measure the difference of sFlt-1, sEng, PIGF levels between EO-PE and LO-PE. This was an observational study with cross sectional design conducted at Dr. M. Djamil, TK Hospital. III dr. Reksodiwiryo and Biomedical Laboratory FK Unand Padang from August 2017 to August 2018. The sample of this study were 26 severe preeclampsia women : 13 (EO-PE) and 13 (LO-PE), selected using consecutive sampling. Levels of sFlt-1, sEng, PIGF were examined using the enzyme-linked immunosorbent assay (ELISA) method. Statistical analysis was performed using unpaired t test and Mann-Whitney Test. Results shown that serum levels of sFlt-1 and sEng in (EO-PE) were 9.51 ± 0.71 ng / L, 1.44 ± 0.06 ng / mL, 5.79 ± 0.42 ng / mL while in PEAL it was 8, 89 ± 0.78 ng / mL, 1.35 ± 0.14 ng / mL, 6.72 ± 0.76. There were a significant difference with a value of p <0.05. The conclusion of this study is that the levels of sFlt-1 and sEng are higher in (EO-PE) than(LO-PE)and PIGF levels was lower in (EO-PE) compared to (LO-PE)

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