scholarly journals The Effectiveness of Autologous Serum and Single-dose Oral Doxycycline in the Treatment of Acne Vulgaris: A Pilot Clinical Trial

2021 ◽  
Vol 9 (B) ◽  
pp. 1602-1606
Author(s):  
Muhammad Nasrum Massi ◽  
Muhlis Yunus ◽  
Anis Irawan Anwar ◽  
Khairuddin Djawad ◽  
Siswanto Wahab ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Single Dose ◽  
Acne Vulgaris ◽  
Chronic Inflammatory Disease ◽  
Wilcoxon Test ◽  
Autologous Serum ◽  
Treatment Groups ◽  
Oral Doxycycline ◽  
Before And After ◽  
Dose Oral

Introduction: Acne vulgaris is a chronic inflammatory disease that occurs with various factors, both intrinsic and extrinsic. Treatment of choice can vary from topical, systemic or a combination of both depending on the degree of severity. Recently, treatment using products from human blood has been widely studied, including in the field of dermatology as it has a unique composition. Objective: to assess the effectiveness of autologous serum and single-dose oral doxycycline in the treatment of acne vulgaris Methods: this clinical trial compared two groups which received autologous serum only and autologous serum combined with single dose of oral 200 mg doxycycline, respectively. Photographic pictures and number of lesions (blackheads, papules, pustules) were compared before and after application using Wilcoxon test. Results: A total of 20 participants participated in this study. Both treatment groups showed significant decrease in lesion count (p <0.01). However, the group which received autologous serum and single dose of oral doxycycline showed superior improvement of inflammatory acne lesions. Conclusion: autologous serum and single dose of oral doxycycline was superior to autologous serum only in the treatment acne lesions. Keywords: Acne Vulgaris, Doxycycline, Autologous Serum

scholarly journals The Effect of Oral Probiotic on the Interleukin-10 Serum Levels of Acne Vulgaris

2019 ◽  
Vol 7 (19) ◽  
pp. 3249-3252 ◽  
Author(s):  
Tissan Rahmayani ◽  
Imam Budi Putra ◽  
Nelva Karmilla Jusuf
Keyword(s):  
Gastrointestinal Tract ◽  
Side Effect ◽  
Acne Vulgaris ◽  
Skin Inflammation ◽  
Serum Levels ◽  
Interleukin 10 ◽  
Wilcoxon Test ◽  
Psychological Burden ◽  
Before And After ◽  
The Relationship

BACKGROUND: Acne vulgaris is a chronic inflammatory skin disorder that commonly found in pilosebaceous units which can have an impact on the patient’s psychological burden. The relationship between dermatology and mental health is increasingly understood by the evidence shows that functional integrity and microbes in the gastrointestinal tract may play a role in mediating skin inflammation and emotional behaviour. The gut-brain-skin theory was first described in 1930 by Stokes and Pillsbury, became the basis of many current studies that look for clinical implications of the relationship between the gastrointestinal tract, brain and skin in acne vulgaris. Probiotics are live microorganisms which can provide a healthy effect to the hosts when consumed in adequate amounts. AIM: To determine the effect of oral probiotic on the interleukin-10 serum levels in acne vulgaris and also to determine the side effect of oral probiotic on acne vulgaris. METHODS: This is a pre-experimental clinical study with a pretest-posttest design involving 33 subjects with acne vulgaris. The subjects in this study were measured for IL-10 serum levels before and after oral probiotic was given for 30 days. This research has been approved by the Health Research Ethics Commission of the Faculty of Medicine, Universitas Sumatera Utara. RESULTS: This study found an increase in serum IL-10 levels after oral probiotic in acne vulgaris. The value of serum IL-10 levels before oral probiotic administration was 5.27 ± 1.49 pg/ml, while the value of serum IL-10 levels after oral probiotic administration was 6.19 ± 1.68 pg/ml) with p values obtained through Wilcoxon test was 0,0001 (p < 0.05). The side effect of oral probiotic found in this study is bloating that was found in 2 subjects within the first week using oral probiotic. CONCLUSION: Oral probiotic trigger elevated IL-10 serum levels of acne vulgaris. This study supports previous studies that suggested oral probiotic can be considered as adjuvant acne vulgaris therapy and its side effect is quite safe and tolerable.

scholarly journals Manual therapy in the treatment of facial wrinkles and sagging: a quantitative-qualitative randomized clinical trial

2020 ◽  
pp. 1-4
Author(s):  
Aline de Souza Massulo Garcia ◽  
Dilane Braga da Silva ◽  
Vanessa Daniele Ferreira Gonçalves ◽  
Alessandra Couto de Camargo Ferreira
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Manual Therapy ◽  
Therapy Group ◽  
Wilcoxon Test ◽  
Average Score ◽  
Control Group ◽  
Evaluation Instrument ◽  
Before And After ◽  
Therapy Protocol

Background: Manual therapy has emerged as an option for facial rejuvenation treatment due to its effects on connective tissue. Objectives: The aim of the study was to verify the effectiveness of the manual therapy protocol in attenuating wrinkles and facial sagging. Methods: This is a quantitative-qualitative, randomized clinical trial. The study included female volunteers, aged between 40 and 50 years, distributed in 2 groups: Manual therapy group (MTG) and Control group (CG). The protocol used consisted of: lymph node decongestion, sliding massages, fast and vigorous movements, and traction on the fasciae. The evaluation instrument was through photos, in which they were analyzed by Dermato-functional specialists through a scale that graduates the wrinkles. The Shapiro-Wilk normality test was used to analyze the symmetry of the results by the Gauss curve. Pre- and post-intervention differences between the groups were determined using the non-parametric Wilcoxon test. Results: The average score obtained in the graduation of wrinkles and signs of aging in the manual therapy group showed significant differences in all regions of the face before and after treatment. And there was a decrease in the score, which shows improvement in the reduction of wrinkles and signs of aging, especially in the upper third. In contrast, in the control group, the average remained before and after the follow-up by the research, showing that there were no significant changes in this group. Conclusion: The manual therapy protocol showed significant results in reducing the signs of aging, such as fine lines and wrinkles, being another option to be applied in clinics.

scholarly journals Rhodomyrtone as a New Natural Antibiotic Isolated from Rhodomyrtus tomentosa Leaf Extract: A Clinical Application in the Management of Acne Vulgaris

Antibiotics ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 108
Author(s):  
Suttiwan Wunnoo ◽  
Siwaporn Bilhman ◽  
Thanaporn Amnuaikit ◽  
Julalak C. Ontong ◽  
Sudarshan Singh ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Side Effects ◽  
Clinical Assessment ◽  
Leaf Extract ◽  
Acne Vulgaris ◽  
Treated Group ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Treatment Groups ◽  
Rhodomyrtus Tomentosa

Rhodomyrtone, a plant-derived principal compound isolated from Rhodomyrtus tomentosa (Myrtaceae) leaf extract, was assessed as a potential natural alternative for the treatment of acne vulgaris. The clinical efficacy of a 1% liposomal encapsulated rhodomyrtone serum was compared with a marketed 1% clindamycin gel. In a randomized and double-blind controlled clinical trial, 60 volunteers with mild to moderate acne severity were assigned to two groups: rhodomyrtone serum and clindamycin gel. The volunteers were instructed to apply the samples to acne lesions on their faces twice daily. A significant reduction in the total numbers of acne lesions was demonstrated in both treatment groups between week 2 and 8 (p < 0.05). Significant differences in acne numbers compared with the baseline were evidenced at week 2 onwards (p < 0.05). At the end of the clinical trial, the total inflamed acne counts in the 1% rhodomyrtone serum group were significantly reduced by 36.36%, comparable to 34.70% in the clindamycin-treated group (p < 0.05). Furthermore, a commercial prototype was developed, and a clinical assessment of 45 volunteers was performed. After application of the commercial prototype for 1 week, 68.89% and 28.89% of volunteers demonstrated complete and improved inflammatory acne, respectively. All of the subjects presented no signs of irritation or side effects during the treatment. Most of the volunteers (71.11%) indicated that they were very satisfied. Rhodomyrtone serum was demonstrated to be effective and safe for the treatment of inflammatory acne lesions.

Oral administration of alpha-lipoic acid did not affect lipid peroxidation and antioxidant biomarkers in rheumatoid arthritis patients

2019 ◽  
Vol 89 (1-2) ◽  
pp. 13-21 ◽  
Author(s):  
Sousan Kolahi ◽  
Elham Mirtaheri ◽  
Bahram Pourghasem Gargari ◽  
Alireza Khabbazi ◽  
Mehrzad Hajalilou ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Trial ◽  
Lipid Peroxidation ◽  
Oral Administration ◽  
Lipoic Acid ◽  
Treated Group ◽  
Chronic Inflammatory Disease ◽  
Controlled Clinical Trial ◽  
Alpha Lipoic Acid ◽  
Before And After

Abstract. Rheumatoid arthritis (RA) is a chronic inflammatory disease in which oxidative stress could play a substantial pathological role. Alpha-lipoic acid (ALA) has been known as a “universal” and “ideal” antioxidant. The purpose of this study was to investigate the effects of oral administration of Alpha-lipoic acid (ALA) on lipid peroxidation and antioxidant biomarkers in Rheumatoid arthritis (RA) patients. The study was a randomized, double-blinded, placebo-controlled clinical trial. 70 RA patients were randomized 1:1 to two groups using blocked randomization method and received 1200 mg/day ALA or placebo for 8 weeks. Fasting blood samples were obtained before and after the intervention to analyze total antioxidant capacity (TAC), antioxidant enzymes [superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and arylesterase (ARE) activities] and malondialdehyde (MDA). We observed significant increase in serum TAC (0.11 mmol/L; p=0.033) and ARE (13.76 U/mL; p=0.046) and significant decline in MDA (−0.36 nmol/L; p=0.002), in ALA group. However, these changes in ALA-treated group were not statistically significant when compared with placebo-treated group (p > 0.05). Also, within- and between-group differences of whole blood SOD and GSH-Px were not statistically significant (p > 0.05). In conclusion, unexpectedly, ALA therapy did not affect the oxidative status of RA patients in the present clinical trial. It seems that more comprehensive clinical trials in RA patients are still warranted to clarify the effectiveness of ALA which has been known as a potent antioxidant.

Effects of an Exercise Therapy Targeting Knee Kinetics on Pain, Function, and Gait Kinetics in Patients With Knee Osteoarthritis: A Randomized Clinical Trial

2020 ◽  
pp. 1-19
Author(s):  
Hamid Reza Bokaeian ◽  
Fateme Esfandiarpour ◽  
Shahla Zahednejad ◽  
Hossein Kouhzad Mohammadi ◽  
Farzam Farahmand
Keyword(s):  
Clinical Trial ◽  
Knee Osteoarthritis ◽  
Exercise Therapy ◽  
Treadmill Walking ◽  
Knee Adduction Moment ◽  
Medial Knee ◽  
Treatment Groups ◽  
Knee Kinetics ◽  
Before And After ◽  
And Function

In this study, the effects of an exercise therapy comprising yoga exercises and medial-thrust gait (YogaMT) on lower-extremity kinetics, pain, and function in patients with medial knee osteoarthritis were investigated. Fifty-nine patients were randomly allocated to three treatment groups: (a) the YogaMT group practiced yoga exercises and medial thrust gait, (b) the knee-strengthening group performed quadriceps- and hamstring-strengthening exercises, and (c) the treadmill walking group practiced normal treadmill walking in 12 supervised sessions. The adduction and flexion moments of the hip, knee, and ankle; pain intensity; and 2-min walking test were assessed before and after treatment and at 1-month follow-up. The YogaMT group experienced a significant reduction in knee adduction moment. All groups showed significant improvement in pain and function. The YogaMT may reduce medial knee load in patients with knee osteoarthritis in the short term. A larger clinical trial is required to investigate the long-term outcomes of this intervention.

Quality of Life and Self-Esteem in Patients with Acne Vulgaris before and after Treatment, a Clinical Trial Study

2019 ◽  
Vol 4 (1) ◽  
pp. 55-62
Author(s):  
Hamideh Molaei ◽  
Sima Noohi ◽  
Masood Davoodi ◽  
Fatemeh Ghanbarian ◽  
◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Acne Vulgaris ◽  
Self Esteem ◽  
Before And After

scholarly journals Comparison of efficacy and safety of oral azithromycin and oral doxycycline in acne vulgaris

2019 ◽  
Vol 8 (5) ◽  
pp. 913
Author(s):  
Marya Ahsan ◽  
Rahul Ranjan ◽  
Shalini Chandra ◽  
Kumar Mayank
Keyword(s):  
Adverse Effects ◽  
Acne Vulgaris ◽  
Optimal Dose ◽  
Chronic Inflammatory Disease ◽  
P Value ◽  
Severe Acne ◽  
Oral Doxycycline ◽  
Group A ◽  
Group B ◽  
Oral Azithromycin

Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit with considerable psychosocial impact. Oral azithromycin or oral doxycycline can be used for the management of moderate and severe acne vulgaris. However, there is no consensus on which antibiotic is superior and the optimal dose for management.Methods: A prospective randomized interventional study was carried out among 120 patients of moderate to severe acne vulgaris. The patients were randomized into group A and B. While group A was prescribed oral azithromycin 500 mg three times a week, group B was given oral doxycycline 100 mg daily for 12 weeks. Topical clindamycin twice daily application was also given. Global Acne Grading Scale (GAGS) score was recorded at baseline and at 2nd, 4th, 8th and 12th weeks.Results: GAGS score at baseline in azithromycin (n = 53) and doxycycline (n = 55) group was 31.98±4.49 and 30.63±3.78 respectively (p value >0.05). 83.91±6.83% (p <0.001) and 81.87±6.75% (p <0.001) improvement was seen in azithromycin group and doxycycline group after 12 weeks of treatment. However, there was no difference in the GAGS score between the groups at any follow-up (p value >0.05). 15.09% patients in azithromycin group and 20% patients in doxycycline group reported adverse effects. The most commonly reported adverse effect was diarrhoea. All adverse effects were of ‘mild’ category and causality assessment was ‘possible’.Conclusions: Oral azithromycin is equally efficacious but safer alternative to oral doxycycline for the management of acne vulgaris.

scholarly journals Pengaruh Konsumsi Sari Buah Jambu Merah dan Madu terhadap Kenaikan Nilai HB pada Ibu Hamil di Tempat Praktek Mandiri Bidan Muarofah Surabaya

2020 ◽  
Vol 10 (1) ◽  
pp. 36-40
Author(s):  
Ratna Indriyani ◽  
Aulia Aulia ◽  
Maulana Widi Andrian ◽  
Emdat Suprayitno
Keyword(s):  
Pregnant Women ◽  
Preventive Treatment ◽  
Wilcoxon Test ◽  
Average Level ◽  
Control Group ◽  
Treatment Groups ◽  
Before And After ◽  
Post Test ◽  
Equivalent Control ◽  
Pregnant Mothers

ABSTRAK Pregnancy is one of the Physiology things but, in the process of pregnancy not a little pregnant mothers that experienced the problem like Anemia disease.  The Aim of the research is To Known the effect in giving the red Guava juice and honey into the e  knhancement  HB level for the Pregnant Women in semester two and semester Three by the Light anemia. The method employed in this research was Experimental Quasy by Up Design Non equivalent Control Group pre test and post test design . the instrument or the sample of this research is the pregnant mothers in semester two and semester three consists of 32 as informants and they are will divide into the two groups as follows: 16 Respondent in treatment groups and 16 respondent in control groups. The technique that used in this research was accidental sampling. The data was collected by using observation task. The data will analyse by using Wilcoxon test. The result of the research that the level of Pregnant mother’s HB before Giving the Red Guava Juice and honey is in the average level of 9,81. The HB level of pregnant mother’s after Giving the Red Guava Juice and honey most of the levels of Pregnant Mother’s HB was increased in the treatment group in the average level of 10,25 gr %, while in the control group have no found the differentiated of the HB level before and after the treatment in average level of 9,81 gr % by the result of the Wilcoxon test analyse p=0,000 (p<0,05).  Based on the previous analysis above writer would like to draw some conclusion as follows: the sicnificant influence in giving the Red Guava Juice and honey to increase the HB levels of pregnan mother’s. its expected all the pregnant women to Check up routine about the HB level to knowing early the Anemia’s effect in Pregnancy so that it cawill be taken by the Preventive treatment Keyword: Anemia, Hb, pregnant mother

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