Pro-/Anti-Inflammatory Bioactive Proteins and Peptides

2022 ◽  
pp. 566-593
Author(s):  
Fatma Esra Güneş
Keyword(s):  
Bioactive Peptides ◽  
Positive Impact ◽  
Antioxidant Properties ◽  
Specific Protein ◽  
Food Proteins ◽  
Protein Fragments ◽  
Beneficial Effects ◽  
Potential Benefits ◽  
Anti Inflammatory ◽  
New Generation

Bioactive peptides (BP) are specific protein fragments that can affect biological processes or substrates that have a positive impact on functions and conditions on body health. Plant and animal sources that contain physiologically active food proteins, native or processed, are rich sources of bioactive peptides. Bioactive peptides derived from food proteins have been demostrated to have variety of beneficial effects, such as anti-inflammatory and antioxidant properties. BP are accepted the new generation of biologically active regulators; they can prevent oxidation and microbial degradation in foods and furthermore improve quality of life by treating various diseases and disorders. The present review highlights the recent findings on the roles of various food-derived bioactive peptides in inflammation and oxidative stress and discuss the potential benefits and limitations of using these compounds against the burden of chronic diseases.

Pro-/Anti-Inflammatory Bioactive Proteins and Peptides

2020 ◽  
pp. 106-141
Author(s):  
Fatma Esra Güneş
Keyword(s):  
Bioactive Peptides ◽  
Positive Impact ◽  
Antioxidant Properties ◽  
Specific Protein ◽  
Food Proteins ◽  
Protein Fragments ◽  
Beneficial Effects ◽  
Potential Benefits ◽  
Anti Inflammatory ◽  
New Generation

Bioactive peptides (BP) are specific protein fragments that can affect biological processes or substrates that have a positive impact on functions and conditions on body health. Plant and animal sources that contain physiologically active food proteins, native or processed, are rich sources of bioactive peptides. Bioactive peptides derived from food proteins have been demostrated to have variety of beneficial effects, such as anti-inflammatory and antioxidant properties. BP are accepted the new generation of biologically active regulators; they can prevent oxidation and microbial degradation in foods and furthermore improve quality of life by treating various diseases and disorders. The present review highlights the recent findings on the roles of various food-derived bioactive peptides in inflammation and oxidative stress and discuss the potential benefits and limitations of using these compounds against the burden of chronic diseases.

scholarly journals Food-Derived Bioactive Peptides on Inflammation and Oxidative Stress

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Subhadeep Chakrabarti ◽  
Forough Jahandideh ◽  
Jianping Wu
Keyword(s):  
Oxidative Stress ◽  
Chronic Diseases ◽  
Bioactive Peptides ◽  
Antioxidant Properties ◽  
Food Proteins ◽  
Beneficial Effects ◽  
Pathological Conditions ◽  
Inflammatory Processes ◽  
Potential Benefits ◽  
And Oxidative Stress

Chronic diseases such as atherosclerosis and cancer are now the leading causes of morbidity and mortality worldwide. Inflammatory processes and oxidative stress underlie the pathogenesis of these pathological conditions. Bioactive peptides derived from food proteins have been evaluated for various beneficial effects, including anti-inflammatory and antioxidant properties. In this review, we summarize the roles of various food-derived bioactive peptides in inflammation and oxidative stress and discuss the potential benefits and limitations of using these compounds against the burden of chronic diseases.

scholarly journals Molecular and Biochemical Pathways of Catalpol in Alleviating Diabetes Mellitus and Its Complications

Biomolecules ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 323
Author(s):  
Subrat Kumar Bhattamisra ◽  
Hui Min Koh ◽  
Shin Yean Lim ◽  
Hira Choudhury ◽  
Manisha Pandey
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Complications ◽  
Inflammatory Markers ◽  
Phosphoenolpyruvate Carboxykinase ◽  
Neuroprotective Effect ◽  
Antioxidant Properties ◽  
Beneficial Effects ◽  
Ppar Γ ◽  
High Glucose Condition ◽  
Anti Inflammatory

Catalpol isolated from Rehmannia glutinosa is a potent antioxidant and investigated against many disorders. This review appraises the key molecular pathways of catalpol against diabetes mellitus and its complications. Multiple search engines including Google Scholar, PubMed, and Science Direct were used to retrieve publications containing the keywords “Catalpol”, “Type 1 diabetes mellitus”, “Type 2 diabetes mellitus”, and “diabetic complications”. Catalpol promotes IRS-1/PI3K/AKT/GLUT2 activity and suppresses Phosphoenolpyruvate carboxykinase (PEPCK) and Glucose 6-phosphatase (G6Pase) expression in the liver. Catalpol induces myogenesis by increasing MyoD/MyoG/MHC expression and improves mitochondria function through the AMPK/PGC-1α/PPAR-γ and TFAM signaling in skeletal muscles. Catalpol downregulates the pro-inflammatory markers and upregulates the anti-inflammatory markers in adipose tissues. Catalpol exerts antioxidant properties through increasing superoxide dismutase (sod), catalase (cat), and glutathione peroxidase (gsh-px) activity in the pancreas and liver. Catalpol has been shown to have anti-oxidative, anti-inflammatory, anti-apoptosis, and anti-fibrosis properties that in turn bring beneficial effects in diabetic complications. Its nephroprotective effect is related to the modulation of the AGE/RAGE/NF-κB and TGF-β/smad2/3 pathways. Catalpol produces a neuroprotective effect by increasing the expression of protein Kinase-C (PKC) and Cav-1. Furthermore, catalpol exhibits a cardioprotective effect through the apelin/APJ and ROS/NF-κB/Neat1 pathway. Catalpol stimulates proliferation and differentiation of osteoblast cells in high glucose condition. Lastly, catalpol shows its potential in preventing neurodegeneration in the retina with NF-κB downregulation. Overall, catalpol exhibits numerous beneficial effects on diabetes mellitus and diabetic complications.

scholarly journals Studies on Immunomodulatory Effect of Casein Phospho Peptide Isolated from Cultured Dairy Product

2020 ◽  
pp. 28-40
Author(s):  
Indumathi Mullaiselvan ◽  
Vijayarani Kanagaraj ◽  
Saranya Sekar ◽  
Baskaran Dharmar ◽  
Rathnapraba Sambandan
Keyword(s):  
Amino Acid ◽  
Bioactive Peptides ◽  
Mononuclear Cells ◽  
Dairy Product ◽  
Fermented Milk ◽  
Specific Protein ◽  
Immunomodulatory Effect ◽  
Peripheral Blood Mononuclear ◽  
Protein Fragments ◽  
Ft Ir

Bioactive peptides have been defined as specific protein fragments that have an impact on body functions or conditions and may ultimately influence health. Fermented milk is a dairy product which has abundance of bioactive peptides. In this study, Casein Phospho peptide (CPP) was isolated by enzymatic hydrolysis of fermented milk using trypsin. The molecular weight of the Casein Phospho peptide was 3.5 KDa. The anti-bacterial activity of Casein Phospho peptide was determined using four pathogens such as, Escherichia coli, Bacillus cereus, Staphylococcus aureus and Salmonella enterica. Casein phospho peptide formed a zone of inhibition against the pathogens. The bioactive peptides were characterized using Fourier Transform Infra-Red Spectroscopy (FT-IR), Casein Phospho peptide had aliphatic amine, acetyl amino I and acetyl amino II functional groups. The HPLC analysis of Casein Phospho peptide revealed that the major amino acid present was L- Glutamic acid and the amino acid present in lesser concentration was Leucine. Peripheral Blood Mononuclear Cells (PBMCs) were isolated from human blood and the cells were treated with Casein Phospho peptide to assess the immunomodulatory effect. Casein Phospho peptide was able to produce a higher concentration of IL-10 anti-inflammatory cytokines when treated with PBMCs.

scholarly journals Perspectives on the Potential Benefits of Antihypertensive Peptides towards Metabolic Syndrome

2020 ◽  
Vol 21 (6) ◽  
pp. 2192 ◽  
Author(s):  
Forough Jahandideh ◽  
Jianping Wu
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Bioactive Peptides ◽  
Renin Angiotensin System ◽  
Angiotensin System ◽  
Physiological Models ◽  
Beneficial Effects ◽  
Potential Benefits ◽  
Antihypertensive Peptides

In addition to the regulation of blood pressure, the renin-angiotensin system (RAS) also plays a key role in the onset and development of insulin resistance, which is central to metabolic syndrome (MetS). Due to the interplay between RAS and insulin resistance, antihypertensive compounds may exert beneficial effects in the management of MetS. Food-derived bioactive peptides with RAS blocking properties can potentially improve adipose tissue dysfunction, glucose intolerance, and insulin resistance involved in the pathogenesis of MetS. This review discusses the pathophysiology of hypertension and the association between RAS and pathogenesis of the MetS. The effects of bioactive peptides with RAS modulating effects on other components of the MetS are discussed. While the in vivo reports on the effectiveness of antihypertensive peptides against MetS are encouraging, the exact mechanism by which these peptides infer their effects on glucose and lipid handling is mostly unknown. Therefore, careful design of experiments along with standardized physiological models to study the effect of antihypertensive peptides on insulin resistance and obesity could help to clarify this relationship.

scholarly journals Inflammation and Oxidative Stress in Chronic Kidney Disease—Potential Therapeutic Role of Minerals, Vitamins and Plant-Derived Metabolites

2019 ◽  
Vol 21 (1) ◽  
pp. 263 ◽  
Author(s):  
Shara Francesca Rapa ◽  
Biagio Raffaele Di Iorio ◽  
Pietro Campiglia ◽  
August Heidland ◽  
Stefania Marzocco
Keyword(s):  
Oxidative Stress ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Antioxidant Properties ◽  
Small Sample ◽  
Beneficial Effects ◽  
Antioxidant Agents ◽  
Antioxidative Agents ◽  
Anti Inflammatory ◽  
And Oxidative Stress

Chronic kidney disease (CKD) is a debilitating pathology with various causal factors, culminating in end stage renal disease (ESRD) requiring dialysis or kidney transplantation. The progression of CKD is closely associated with systemic inflammation and oxidative stress, which are responsible for the manifestation of numerous complications such as malnutrition, atherosclerosis, coronary artery calcification, heart failure, anemia and mineral and bone disorders, as well as enhanced cardiovascular mortality. In addition to conventional therapy with anti-inflammatory and antioxidative agents, growing evidence has indicated that certain minerals, vitamins and plant-derived metabolites exhibit beneficial effects in these disturbances. In the current work, we review the anti-inflammatory and antioxidant properties of various agents which could be of potential benefit in CKD/ESRD. However, the related studies were limited due to small sample sizes and short-term follow-up in many trials. Therefore, studies of several anti-inflammatory and antioxidant agents with long-term follow-ups are necessary.

scholarly journals A Systematic Review on Natural Antioxidant Properties of Resveratrol

2018 ◽  
Vol 13 (9) ◽  
pp. 1934578X1801300 ◽  
Author(s):  
Carmela Colica ◽  
Maja Milanović ◽  
Nataša Milić ◽  
Vincenzo Aiello ◽  
Antonino De Lorenzo ◽  
...  
Keyword(s):  
Fast Food ◽  
Red Wine ◽  
Positive Impact ◽  
Antioxidant Properties ◽  
Epidemiological Studies ◽  
Scientific Data ◽  
Plant Metabolites ◽  
Beneficial Effects ◽  
Pubmed Database ◽  
Wide Range

Polyphenols, including anthocyanins, flavonoids and stilbenes, which constitute one of the most abundant and ubiquitous groups of plant metabolites, are an integral part of the human diet. Resveratrol (3,5,4'-trihydroxystilbene), a naturally occurring polyphenol produced by some plants as a self-defence agent, has an antifungal activity. Resveratrol has been found in some plants (such as grapevine, pine and peanuts) and is considered to have beneficial effects also on human health. The number of studies on resveratrol greatly increased in PubMed database since 1997, after the anticancer effect of this molecule was first reported. The interest in resveratrol in grape was originally sparked by epidemiological studies indicating an inverse relationship between long-standing moderate consumption of red wine and the risk of coronary heart disease; this effect has been ascribed to resveratrol, which possesses diverse biochemical and physiological properties, including antiplatelet and anti-inflammatory proprieties, and provides a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, resveratrol has been described as an anti-aging compound. The consumption of resveratrol (red wine) together with a Mediterranean diet or a fast-food meal (“McDonald'sMeal”) had a positive impact on oxidized (ox-) LDL and on the expression of oxidative and inflammatory genes. Therefore, this review summarized the most important scientific data about healing and preventive potential of resveratrol, acting as cardioprotective, neuroprotective, chemopreventive and antioxidant agent.

scholarly journals Natural Polyphenols in Metabolic Syndrome: Protective Mechanisms and Clinical Applications

2021 ◽  
Vol 22 (11) ◽  
pp. 6110
Author(s):  
Shiyao Zhang ◽  
Mengyi Xu ◽  
Wenxiang Zhang ◽  
Chang Liu ◽  
Siyu Chen
Keyword(s):  
Metabolic Syndrome ◽  
Antioxidant Properties ◽  
Epidemiological Studies ◽  
Liver Fat ◽  
Protective Mechanisms ◽  
Fat Accumulation ◽  
Beneficial Effects ◽  
Natural Polyphenols ◽  
Anti Inflammatory ◽  
Polyphenol Intake

Metabolic syndrome (MetS) is a chronic disease, including abdominal obesity, dyslipidemia, hyperglycemia, and hypertension. It should be noted that the occurrence of MetS is closely related to oxidative stress-induced mitochondrial dysfunction, ectopic fat accumulation, and the impairment of the antioxidant system, which in turn further aggravates the intracellular oxidative imbalance and inflammatory response. As enriched anti-inflammatory and antioxidant components in plants, natural polyphenols exhibit beneficial effects, including improving liver fat accumulation and dyslipidemia, reducing blood pressure. Hence, they are expected to be useful in the prevention and management of MetS. At present, epidemiological studies indicate a negative correlation between polyphenol intake and MetS incidence. In this review, we summarized and discussed the most promising natural polyphenols (including flavonoid and non-flavonoid drugs) in the precaution and treatment of MetS, including their anti-inflammatory and antioxidant properties, as well as their regulatory functions involved in glycolipid homeostasis.

scholarly journals Bioactive Properties of Breads Made with Sourdough of Hull-Less Barley or Conventional and Pigmented Wheat Flours

2021 ◽  
Vol 11 (7) ◽  
pp. 3291
Author(s):  
Simone Luti ◽  
Viola Galli ◽  
Manuel Venturi ◽  
Lisa Granchi ◽  
Paolo Paoli ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Bioactive Peptides ◽  
Antioxidant Compounds ◽  
Low Molecular Weight ◽  
Beneficial Effects ◽  
Baked Goods ◽  
Inflammatory Status ◽  
Anti Inflammatory ◽  
Stressed Cells ◽  
Pathway Inhibition

Functional and nutritional properties of baked goods can be enhanced by the use of sourdough fermentation, which is defined as a mixture of water and flour fermented by lactobacilli (LAB) and yeasts. Previous data highlighted the ability of sourdoughs obtained with selected LAB strains and commercial flour to produce bioactive peptides equipped with antioxidant and anti-inflammatory properties. More recently, it has been proven that choosing the most suitable combination of selected LAB and high-functional-value flours greatly increase the amount of low-molecular-weight antioxidant compounds responsible for improving the nutritional value of the products. This work aimed to isolate bioactive peptides both from sourdoughs and baked breads obtained with pigmented wheat and barley and a selected combination of LABs. Soluble water extracts were obtained, and low-molecular-weight peptides were isolated. Antioxidant activity was detected by assaying the intracellular ROS production in stressed cultured macrophages, treated with peptides. Moreover, anti-inflammatory activity, highlighted by NFkB pathway inhibition and by COX2 reduction in stressed cells, was demonstrated for peptides obtained from breads. The results allowed the conclusion that the combination of flours and LAB used in the present manuscript led to the production of bakery products with beneficial effects on oxidative and inflammatory status.

scholarly journals Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6899
Author(s):  
Georgiana Cicalău ◽  
Petru Babes ◽  
Horia Calniceanu ◽  
Adelina Popa ◽  
Gabriela Ciavoi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Periodontal Disease ◽  
Antioxidant Properties ◽  
Treatment Strategies ◽  
Stem Bark ◽  
Potential Benefits ◽  
Therapeutic Properties ◽  
Anti Inflammatory ◽  
New Treatment ◽  
Magnolia Officinalis

Periodontal disease and diabetes mellitus are two pathologies that are extremely widespread worldwide and share the feature of chronic inflammation. Carvacrol is a phenolic monoterpenoid, produced by a variety of herbs, the most well-known of which is Origanum vulgare. Magnolol is a traditional polyphenolic compound isolated from the stem bark of Magnolia officinalis, mainly used in Chinese medicine. The purpose of this paper is to review the therapeutic properties of these bioactive compounds, in the treatment of periodontitis and diabetes. Based on our search strategy we conducted a literature search in the PubMed and Google Scholar databases to identify studies. A total of one hundred eighty-four papers were included in the current review. The results show that carvacrol and magnolol have anti-inflammatory, antioxidant, antimicrobial, anti-osteoclastic, and anti-diabetic properties that benefit both pathologies. Knowledge of the multiple activities of carvacrol and magnolol can assist with the development of new treatment strategies, and the design of clinical animal and human trials will maximize the potential benefits of these extracts in subjects suffering from periodontitis or diabetes.

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