scholarly journals A Systematic Review on Natural Antioxidant Properties of Resveratrol

2018 ◽  
Vol 13 (9) ◽  
pp. 1934578X1801300 ◽  
Author(s):  
Carmela Colica ◽  
Maja Milanović ◽  
Nataša Milić ◽  
Vincenzo Aiello ◽  
Antonino De Lorenzo ◽  
...  
Keyword(s):  
Fast Food ◽  
Red Wine ◽  
Positive Impact ◽  
Antioxidant Properties ◽  
Epidemiological Studies ◽  
Scientific Data ◽  
Plant Metabolites ◽  
Beneficial Effects ◽  
Pubmed Database ◽  
Wide Range

Polyphenols, including anthocyanins, flavonoids and stilbenes, which constitute one of the most abundant and ubiquitous groups of plant metabolites, are an integral part of the human diet. Resveratrol (3,5,4'-trihydroxystilbene), a naturally occurring polyphenol produced by some plants as a self-defence agent, has an antifungal activity. Resveratrol has been found in some plants (such as grapevine, pine and peanuts) and is considered to have beneficial effects also on human health. The number of studies on resveratrol greatly increased in PubMed database since 1997, after the anticancer effect of this molecule was first reported. The interest in resveratrol in grape was originally sparked by epidemiological studies indicating an inverse relationship between long-standing moderate consumption of red wine and the risk of coronary heart disease; this effect has been ascribed to resveratrol, which possesses diverse biochemical and physiological properties, including antiplatelet and anti-inflammatory proprieties, and provides a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, resveratrol has been described as an anti-aging compound. The consumption of resveratrol (red wine) together with a Mediterranean diet or a fast-food meal (“McDonald'sMeal”) had a positive impact on oxidized (ox-) LDL and on the expression of oxidative and inflammatory genes. Therefore, this review summarized the most important scientific data about healing and preventive potential of resveratrol, acting as cardioprotective, neuroprotective, chemopreventive and antioxidant agent.

scholarly journals A Role of Gallic Acid in Oxidative Damage Diseases: A Comprehensive Review

2019 ◽  
Vol 14 (8) ◽  
pp. 1934578X1987417 ◽  
Author(s):  
Jiayu Gao ◽  
Jiangxia Hu ◽  
Dongyi Hu ◽  
Xiao Yang
Keyword(s):  
Oxidative Damage ◽  
Gallic Acid ◽  
Metabolic Diseases ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Scientific Data ◽  
Therapeutic Effects ◽  
Human Beings ◽  
Plant Metabolites ◽  
Wide Range

Gallic acid is a trihydroxybenzoic acid of plant metabolites widely spread throughout the plant kingdom. It has characteristics of the strong antioxidant and free radical scavenging activities, and can protect biological cells, tissues, and organs from damages caused by oxidative stress. This review aims to summarize the protective roles of gallic acid and the underlying pharmacological mechanisms in the pathophysiological process of the oxidative damage diseases, such as cancer, cardiovascular, degenerative, and metabolic diseases. The studies reviewed herein showed that the main therapeutic effects of gallic acid were attributed to its antioxidant properties. It modulated various signaling pathways through a wide range of inflammatory cytokines, and enzymic and nonenzymic antioxidants. However, the available data were limited to few studies assessing the treatment effects of gallic acid in human subjects to confirm its therapeutic outcomes. Therefore, the clinical trials were urgently needed to investigate the safety and efficacy of gallic acid treatment on human beings. The scientific data summarized in this review highlighted the therapeutic potentials of gallic acid for oxidative damage diseases. It could be developed as versatile adjuvant or therapeutically lead compound in future.

Pro-/Anti-Inflammatory Bioactive Proteins and Peptides

2020 ◽  
pp. 106-141
Author(s):  
Fatma Esra Güneş
Keyword(s):  
Bioactive Peptides ◽  
Positive Impact ◽  
Antioxidant Properties ◽  
Specific Protein ◽  
Food Proteins ◽  
Protein Fragments ◽  
Beneficial Effects ◽  
Potential Benefits ◽  
Anti Inflammatory ◽  
New Generation

Bioactive peptides (BP) are specific protein fragments that can affect biological processes or substrates that have a positive impact on functions and conditions on body health. Plant and animal sources that contain physiologically active food proteins, native or processed, are rich sources of bioactive peptides. Bioactive peptides derived from food proteins have been demostrated to have variety of beneficial effects, such as anti-inflammatory and antioxidant properties. BP are accepted the new generation of biologically active regulators; they can prevent oxidation and microbial degradation in foods and furthermore improve quality of life by treating various diseases and disorders. The present review highlights the recent findings on the roles of various food-derived bioactive peptides in inflammation and oxidative stress and discuss the potential benefits and limitations of using these compounds against the burden of chronic diseases.

scholarly journals Effects of carotenoids on human immune function

1999 ◽  
Vol 58 (3) ◽  
pp. 713-718 ◽  
Author(s):  
David A. Hughes
Keyword(s):  
Immune Function ◽  
Cell Function ◽  
Immune Cell ◽  
Antioxidant Properties ◽  
The Elderly ◽  
Causative Factor ◽  
Epidemiological Studies ◽  
Wide Range ◽  
Β Carotene

Many epidemiological studies have shown an association between diets rich in carotenoids and a reduced incidence of many forms of cancer, and it has been suggested that the antioxidant properties of these compounds are a causative factor. Attention has focused on the potential role of one specific carotenoid, β-carotene, in preventing cancer, and numerous publications have described in vitro experiments and animal studies which suggest that not only can this carotenoid protect against the development of cancer, but also several other chronic diseases. Since the immune system plays a major role in cancer prevention, it has been suggested that β-carotene may enhance immune cell function. Several human trials, using dietary β-carotene supplementation with a wide range of intakes, have been undertaken to address this hypothesis. The general conclusion of these studies is that this compound can enhance cell-mediated immune responses, particularly in the elderly. The present article will review some of these human studies and, hopefully, complement the reviews of other authors associated with the present symposium, some of whom will also describe work in this area. Potential mechanisms for the effects of carotenoids on immune function will also be reviewed. Finally, possible reasons for the failure of three major prospective studies to demonstrate a beneficial effect of β-carotene supplementation on lung cancer risk will be discussed.

scholarly journals Potential Application of Probiotics in the Prevention and Treatment of Inflammatory Bowel Diseases

Ulcers ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-13 ◽  
Author(s):  
Silvina del Carmen ◽  
Alejandra de Moreno de LeBlanc ◽  
Anderson Miyoshi ◽  
Clarissa Santos Rocha ◽  
Vasco Azevedo ◽  
...  
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Antioxidant Properties ◽  
Genetically Engineered ◽  
Treatment Protocols ◽  
Host Immune Responses ◽  
Beneficial Effects ◽  
Wide Range ◽  
Prevention And Treatment ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that are naturally present in many foods and possess a wide range of therapeutic properties. The aim of this paper is to present an overview of the current expanding knowledge of the mechanisms by which LAB and other probiotic microorganisms participate in the prevention and treatment of inflammatory bowel diseases. These include changes in the gut microbiota, stimulation of the host immune responses, and reduction of the oxidative stress due to their antioxidant properties. A brief overview of the uses of genetically engineered LAB that produce either antioxidant enzymes (such as catalase and superoxide dismutase) or anti-inflammatory cytokines (such as IL-10) will also be discussed. This paper will show that probiotics should be considered in treatment protocols of IBD since they provide many beneficial effects and can enhance the effectiveness of traditional used medicines.

scholarly journals Potential Combination of Xanthone Compounds from Mangosteen Fruit (Garcinia mangostana) with Eugenol Compounds in Basic Leaf (Ocimum sanctum) as Alternative Therapy in Preeclampsia

2021 ◽  
Vol 2 (2) ◽  
pp. 113-119
Author(s):  
Muhammad Al Farisi Sutrisno
Keyword(s):  
Target Genes ◽  
Alternative Therapy ◽  
Antioxidant Properties ◽  
Biological Properties ◽  
Primary Component ◽  
Ocimum Sanctum ◽  
Garcinia Mangostana ◽  
Pilot Studies ◽  
Beneficial Effects ◽  
Wide Range

Preeclampsia is a hyperdynamic condition that is syndromed by hypertension and proteinuria after 20 weeks of pregnancy. Preeclampsia incident is the first cause of 6-8 % number morbidity/mortality maternity and fetus in the world. Preeclampsia is related to the disability of physiology adaptation that can decrease perfusion of uteroplacental. Xanthone derivatives in mangosteen have been reported to possess a wide range of biological properties, including antioxidant and antihypertensive activities. Eugenol is a primary component of basil oil. It is known for its antioxidant, antiinflammatory, and vasorelaxant actions. These beneficial effects of eugenol make it an excellent therapeutic candidate for the treatment of hypertensive disorders of pregnancy. This study wants to analyze the best available research evidence on the potential combination of xanthone compounds from mangosteen fruit (Garcinia mangostana) with eugenol compounds in basil leaf (Ocimum sanctum) as an alternative therapy in preeclampsia.  A literature review was conducted in the electronic databases PubMed and Google Scholar using the index terms "xanthone" and "eugenol" and "hypertension" and "preeclampsia." All types of studies were included for this study, such as randomized controlled trials, systematic reviews, literature reviews, and pilot studies published between 2010 and 2021. Articles which not written in English were excluded from the study. This search resulted in 10 papers. Antioxidant properties of mangosteen peel extract compounds derived from xanthone, the most significant component is α-mangosteen and γ-mangosteen. Eugenol is vasorelaxant action by increasing the expression of its target genes, Sarco/endoplasmic reticulum Ca²⁺-ATPase and adequate potassium-calcium-activated potassium channels channel, thereby relaxing vascular smooth muscle cells and decreasing blood pressure. With this review, we suggest that eugenol, which is a vasorelaxant combined with xanthone which is an antioxidant by obstructing free radical and oxidative stress, can be a potent therapeutic for preeclampsia and intend to motivate researchers (e.g., chemistry, biology, pharmaceutical, and therapeutic areas) to provide evidence of these compounds for the management of preeclampsia.

scholarly journals Quercetin Improves the Endocrine Function of Rat Testicular Tissue Under in Vitro Conditions

2021 ◽  
Vol 70 (1-2) ◽  
pp. 1-5
Author(s):  
Filip Benko ◽  
Patrik Hrnčiar ◽  
Norbert Lukáč ◽  
Róbert Kirchner ◽  
Eva Tvrdá
Keyword(s):  
Positive Impact ◽  
Endocrine System ◽  
Testicular Tissue ◽  
Endocrine Function ◽  
Enzyme Linked Immunosorbent Assay ◽  
Beneficial Effects ◽  
Wide Range ◽  
Male Hormones ◽  
The Impact

Summary Compounds of natural origin are often used for their beneficial effects on the male endocrine system and the synthesis of steroid biomolecules in testicular tissue. One of such compounds is quercetin (QUE), which belongs to the flavonoid family and is found in a wide range of vegetables, fruits and plant products. The purpose of this study is to evaluate the impact of QUE on the endocrine function of rat testicular fragments under in vitro conditions. Testicular fragments from adult Wistar rats (n=9), cultured in the D-MEM medium with different concentrations of QUE (namely 1, 10 and 100 µmol/L) for 24 h at 37°C (5% CO2), were used in the experiment conducted. Following culture, the medium was separated and the levels of cholesterol (CHOL) and male hormones were measured. CHOL values were quantified spectrophotometrically, whereas the concentrations of androstenedione (ANDRO), dehydropeiandrosterone (DHEA) and testosterone (TEST) were quantified using the enzyme-linked immunosorbent assay (ELISA) commercial kit. The results obtained indicate that 10 µmol/L QUE significantly increased (P<0.001; P<0.05) the concentrations of all the steroid biomolecules considered (CHOL, ANDRO, DHEA and TEST) when compared to the control samples. Accordingly, our findings confirm the positive impact of QUE on the endocrine function and steroidogenesis of rat testicular tissue under in vitro conditions.

scholarly journals Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3342 ◽  
Author(s):  
Xavier Montané ◽  
Oliwia Kowalczyk ◽  
Belen Reig-Vano ◽  
Anna Bajek ◽  
Krzysztof Roszkowski ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Human Health ◽  
Food Additives ◽  
Antioxidant Properties ◽  
Natural Compounds ◽  
Future Directions ◽  
Beneficial Effects ◽  
Wide Range ◽  
Cancer Initiation ◽  
Natural Drugs

The development of anticancer therapies that involve natural drugs has undergone exponential growth in recent years. Among the natural compounds that produce beneficial effects on human health, polyphenols have shown potential therapeutic applications in cancer due to their protective functions in plants, their use as food additives, and their excellent antioxidant properties. The possibility of combining conventional drugs—which are usually more aggressive than natural compounds—with polyphenols offers very valuable advantages such as the building of more efficient anticancer therapies with less side effects on human health. This review shows a wide range of trials in which polyphenolic compounds play a crucial role as anticancer medicines alone or in combination with other drugs at different stages of cancer: cancer initiation, promotion, and growth or progression. Moreover, the future directions in applications of various polyphenols in cancer therapy are emphasized.

scholarly journals Optimal nutrition: fibre and phytochemicals

1999 ◽  
Vol 58 (2) ◽  
pp. 415-419 ◽  
Author(s):  
Ian Rowland
Keyword(s):  
Cardiovascular Disease ◽  
Chronic Diseases ◽  
Resistant Starch ◽  
Functional Markers ◽  
Protective Effects ◽  
Plant Metabolites ◽  
Secondary Plant Metabolites ◽  
Beneficial Effects ◽  
Wide Range ◽  
Intense Research

There is currently intense research interest in secondary plant metabolites because of their potential preventative effects on the chronic diseases of Western societies, especially cardiovascular disease and cancer. To date most of the research has focused on the identification of plant-derived substances and their potential protective effects against specific chronic diseases. The important issue of determining the optimal intake of those substances, such that the beneficial effects are maximized without manifestation of adverse effects, has yet to be addressed in most cases. Furthermore, there are no specific functional markers that can be used to assess optimal intake, although it may be possible to use biomarkers such as serum cholesterol if the rest of the diet is strictly controlled. The present review discusses a wide range of substances associated with plants, including dietary fibre, resistant starch, oligosaccharides, phyto-oestrogens, phytosterols, flavonoids, terpenes and isothiocyanates, and attempts where possible to indicate optimal intakes and to suggest functional markers.

scholarly journals Effects of Provinols on Cardiodynamics and Coronary Flow in Islodated Rat Hearts

2016 ◽  
Vol 17 (2) ◽  
pp. 99-106
Author(s):  
Ana Popovic ◽  
Olga Pechanova ◽  
Radoslava Rehakova ◽  
Vladimir Zivkovic ◽  
Ivan Srejovic ◽  
...  
Keyword(s):  
Red Wine ◽  
Epidemiological Studies ◽  
Albino Rats ◽  
Alcohol Content ◽  
Experimental Conditions ◽  
Positive Effects ◽  
Rat Hearts ◽  
Wide Range ◽  
Wistar Albino Rats ◽  
Experimental Group

Abstract Provinols are an alcohol-free extract of red wine that contains a wide range of polyphenols. Polyphenols are a group of chemical compounds found in diverse plants. Polyphenols are considered to protect against cardiovascular disease. Although some older epidemiological studies have indicated that the positive effects of red wine on heart disease can be attributed to the alcohol content alone, there is now powerful evidence that polyphenols present in red wine are responsible for these positive effects. The hearts of male Wistar albino rats (n = 36, 12 in each experimental group, 10 weeks old, body mass 250 ± 30 g) were excised and retrogradely perfused according to the Langendorff technique at a gradually increasing perfusion pressure (40-120 cmH2O). Parameters of cardiac function (dp/dt max, dp/dt min, SLVP, DLVP, HR, CF) were measured after perfusion with three different concentrations of provinols (5 μg/ml, 10 μg/ml and 50 μg/ml). Administration of the highest dose (50 μg/ml) induced a significant increase in dp/dt max, dp/dt min, HR and CF compared with control conditions at CPP = 40 cmH2O, while an intermediate dose increased dp/dt max at the same CPP. Generally viewed, the results of the present study suggest that provinols may have a beneficial effect on the intact myocardium and coronary circulation. These findings could constitute an important step in further investigation of these polyphenols under different representative experimental conditions in the heart, as well as providing a good basis for potential clinical studies in this field.

scholarly journals Natural Polyphenols in Metabolic Syndrome: Protective Mechanisms and Clinical Applications

2021 ◽  
Vol 22 (11) ◽  
pp. 6110
Author(s):  
Shiyao Zhang ◽  
Mengyi Xu ◽  
Wenxiang Zhang ◽  
Chang Liu ◽  
Siyu Chen
Keyword(s):  
Metabolic Syndrome ◽  
Antioxidant Properties ◽  
Epidemiological Studies ◽  
Liver Fat ◽  
Protective Mechanisms ◽  
Fat Accumulation ◽  
Beneficial Effects ◽  
Natural Polyphenols ◽  
Anti Inflammatory ◽  
Polyphenol Intake

Metabolic syndrome (MetS) is a chronic disease, including abdominal obesity, dyslipidemia, hyperglycemia, and hypertension. It should be noted that the occurrence of MetS is closely related to oxidative stress-induced mitochondrial dysfunction, ectopic fat accumulation, and the impairment of the antioxidant system, which in turn further aggravates the intracellular oxidative imbalance and inflammatory response. As enriched anti-inflammatory and antioxidant components in plants, natural polyphenols exhibit beneficial effects, including improving liver fat accumulation and dyslipidemia, reducing blood pressure. Hence, they are expected to be useful in the prevention and management of MetS. At present, epidemiological studies indicate a negative correlation between polyphenol intake and MetS incidence. In this review, we summarized and discussed the most promising natural polyphenols (including flavonoid and non-flavonoid drugs) in the precaution and treatment of MetS, including their anti-inflammatory and antioxidant properties, as well as their regulatory functions involved in glycolipid homeostasis.

Sign in / Sign up

Export Citation Format

Share Document