Study on Hydroxylapatite Fibroin Porous Composite

2007 ◽  
Vol 330-332 ◽  
pp. 947-950
Author(s):  
Shen Zhou Lu ◽  
Ming Zhong Li ◽  
Lun Bai
Keyword(s):  
Mechanical Properties ◽  
Porous Materials ◽  
Pore Size ◽  
Silk Fibroin ◽  
Ultrasonic Vibration ◽  
Fiber Content ◽  
Complex Materials ◽  
Porous Composite ◽  
Gel Method ◽  
Breaking Energy

The complex porous materials, Hydroxyapatite(HA)/silk fibroin, were prepared using ultrasonic vibration gel method in this paper. The mechanical properties decreased with the increase of HA while the porosity increased. The pore size become bigger than 100μm when adding silk fiber in the complex materials, and the breaking energy increased evidently from 10 to 1000 J/m2 when fiber content increased from 0 to 4 wt.%. It was observed from SEM that all composites have interconnected micropores.

Performance of a porous composite scaffold containing silk fibroin: Applied research repair on oral jaw epithelial defects

2020 ◽  
Vol 10 (4) ◽  
pp. 490-502
Author(s):  
Huajun Zhu ◽  
Chunyu Qian ◽  
Wanshu Xiao ◽  
Qiang Zhang ◽  
Zili Ge
Keyword(s):  
Mechanical Properties ◽  
Contact Angle ◽  
Silk Fibroin ◽  
Composite Scaffold ◽  
Epithelial Tissue ◽  
Porous Composite ◽  
Clinical Value ◽  
Freeze Dried ◽  
Silk Fibroin Film ◽  
Oral Epithelial

Application research on repairing oral and maxillofacial epithelial defects with filin-protein porous composite scaffold. The silk fibroin solution was synthesized by hydrothermal synthesis, and the film was prepared by stirring and pouring. Then silk fibroin film and silk fibroin freeze-dried support were prepared by stirring and smooth casting. It was characterized by FTIR, mechanical properties, dissolution detection, contact Angle and SEM. To evaluate the performance of this material in repairing rabbit oral mucosa and rabbit skin epithelial defects. The characterization shows that the material has good contact Angle, mechanical properties, dissolution and biocompatibility. It has good repair function to rabbit oral epithelial tissue and skin epithelial tissue. Silk fibroin has excellent and unique properties. It has good development prospects and great clinical value in tissue regeneration.

Preparation and Characteristics of Gradient Silk Fibroin/Hydroxyapatite Porous Composites

2009 ◽  
Vol 610-613 ◽  
pp. 1231-1236
Author(s):  
Wei Wei Xu ◽  
Jian Bing Liu ◽  
Ming Zhong Li ◽  
Shen Zhou Lu ◽  
Miao Liang Luo
Keyword(s):  
Mechanical Properties ◽  
Silk Fibroin ◽  
Bending Strength ◽  
Bone Tissue Regeneration ◽  
Gradient Material ◽  
Layer By Layer ◽  
Porous Composite ◽  
Pressing Method ◽  
Linear Gradient ◽  
Porous Composites

The gradient silk fibroin (SF)/ hydroxyapatite (HA) porous composite used for the scaffold of cartilage-bone tissue regeneration was prepared with SF powder and HA powder by layer-by-layer mould pressing method and granular NaCl as porogent. The characteristics were performed by Electron Microprobe and Energy Dispersive Spectometer (EDS). It indicated that the distribution of SF and HA presented linear gradient along the thickness direction in the materials. The porosity of composites increased with NaCl content increasing, while the density decreased. As the result of mechanical properties measurement, the bending strength and compressive strength decreased with NaCl content increasing. Compared the mechanical properties between gradient material and non-gradient material, it indicated that bending strength of gradient SF/HA porous material was higher than non-gradient SF/HA porous material’s.

Electrospun Regenerated Antheraea pernyi Silk Fibroin Scaffolds with Improved Pore Size, Mechanical Properties and Cytocompatibility Using Mesh Collectors

2021 ◽  
Author(s):  
Shengzhi Zou ◽  
Xinru Wang ◽  
Suna Fan ◽  
Xiang Yao ◽  
Yaopeng Zhang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Pore Size ◽  
Silk Fibroin ◽  
Biomedical Applications ◽  
Antheraea Pernyi

Generally, electrospun silk fibroin scaffolds collected by traditional plate always present limited pore size and mechanical properties, which may restrict their biomedical applications. Herein, regenerated Antheraea pernyi silk fibroin (RASF)...

scholarly journals Tunable Structures and Properties of Electrospun Regenerated Silk Fibroin Mats Annealed in Water Vapor at Different Times and Temperatures

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Xiangyu Huang ◽  
Suna Fan ◽  
Alhadi Ibrahim Mohammed Altayp ◽  
Yaopeng Zhang ◽  
Huili Shao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Water Vapor ◽  
Silk Fibroin ◽  
Conformational Transition ◽  
Breaking Strength ◽  
Electrospinning Technique ◽  
Structures And Properties ◽  
Regenerated Silk Fibroin ◽  
Vapor Annealing ◽  
Breaking Energy

Regenerated silk fibroin (SF) mats were fabricated using electrospinning technique, followed by mild water vapor annealing to effectively tune the structures and improve the mechanical properties of the mats at different annealing times and temperatures. The breaking strength and the breaking energy of the mats treated with water vapor at 65°C for 12 h reached 6.0 MPa and 171.7 J/kg, respectively. The conformational transition of the SF mats was significantly influenced by the treating temperature, while the influence of time was comparatively limited. The influence is consistent with the time-temperature equivalent principle and would be helpful for the preparation of water-vapor-annealed silk-based biomaterials for various applications.

scholarly journals Anti-Inflammatory Properties of Injectable Betamethasone-Loaded Tyramine-Modified Gellan Gum/Silk Fibroin Hydrogels

Biomolecules ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1456
Author(s):  
Isabel Matos Oliveira ◽  
Cristiana Gonçalves ◽  
Myeong Eun Shin ◽  
Sumi Lee ◽  
Rui Luis Reis ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Mechanical Properties ◽  
Silk Fibroin ◽  
Therapeutic Efficacy ◽  
Composite Structures ◽  
Gelation Time ◽  
Polymeric Materials ◽  
Gellan Gum ◽  
Traditional Use

Rheumatoid arthritis is a rheumatic disease for which a healing treatment does not presently exist. Silk fibroin has been extensively studied for use in drug delivery systems due to its uniqueness, versatility and strong clinical track record in medicine. However, in general, natural polymeric materials are not mechanically stable enough, and have high rates of biodegradation. Thus, synthetic materials such as gellan gum can be used to produce composite structures with biological signals to promote tissue-specific interactions while providing the desired mechanical properties. In this work, we aimed to produce hydrogels of tyramine-modified gellan gum with silk fibroin (Ty–GG/SF) via horseradish peroxidase (HRP), with encapsulated betamethasone, to improve the biocompatibility and mechanical properties, and further increase therapeutic efficacy to treat rheumatoid arthritis (RA). The Ty–GG/SF hydrogels presented a β-sheet secondary structure, with gelation time around 2–5 min, good resistance to enzymatic degradation, a suitable injectability profile, viscoelastic capacity with a significant solid component and a betamethasone-controlled release profile over time. In vitro studies showed that Ty–GG/SF hydrogels did not produce a deleterious effect on cellular metabolic activity, morphology or proliferation. Furthermore, Ty–GG/SF hydrogels with encapsulated betamethasone revealed greater therapeutic efficacy than the drug applied alone. Therefore, this strategy can provide an improvement in therapeutic efficacy when compared to the traditional use of drugs for the treatment of rheumatoid arthritis.

scholarly journals Is Dialdehyde Chitosan a Good Substance to Modify Physicochemical Properties of Biopolymeric Materials?

2021 ◽  
Vol 22 (7) ◽  
pp. 3391
Author(s):  
Sylwia Grabska-Zielińska ◽  
Alina Sionkowska ◽  
Ewa Olewnik-Kruszkowska ◽  
Katarzyna Reczyńska ◽  
Elżbieta Pamuła
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Physicochemical Properties ◽  
Silk Fibroin ◽  
Three Dimensional ◽  
Microscopy Imaging ◽  
Maximum Deformation ◽  
One Step ◽  
Chitosan Blends ◽  
Fourier Transfer Infrared Spectroscopy

The aim of this work was to compare physicochemical properties of three dimensional scaffolds based on silk fibroin, collagen and chitosan blends, cross-linked with dialdehyde starch (DAS) and dialdehyde chitosan (DAC). DAS was commercially available, while DAC was obtained by one-step synthesis. Structure and physicochemical properties of the materials were characterized using Fourier transfer infrared spectroscopy with attenuated total reflectance device (FTIR-ATR), swelling behavior and water content measurements, porosity and density observations, scanning electron microscopy imaging (SEM), mechanical properties evaluation and thermogravimetric analysis. Metabolic activity with AlamarBlue assay and live/dead fluorescence staining were performed to evaluate the cytocompatibility of the obtained materials with MG-63 osteoblast-like cells. The results showed that the properties of the scaffolds based on silk fibroin, collagen and chitosan can be modified by chemical cross-linking with DAS and DAC. It was found that DAS and DAC have different influence on the properties of biopolymeric scaffolds. Materials cross-linked with DAS were characterized by higher swelling ability (~4000% for DAS cross-linked materials; ~2500% for DAC cross-linked materials), they had lower density (Coll/CTS/30SF scaffold cross-linked with DAS: 21.8 ± 2.4 g/cm3; cross-linked with DAC: 14.6 ± 0.7 g/cm3) and lower mechanical properties (maximum deformation for DAC cross-linked scaffolds was about 69%; for DAS cross-linked scaffolds it was in the range of 12.67 ± 1.51% and 19.83 ± 1.30%) in comparison to materials cross-linked with DAC. Additionally, scaffolds cross-linked with DAS exhibited higher biocompatibility than those cross-linked with DAC. However, the obtained results showed that both types of scaffolds can provide the support required in regenerative medicine and tissue engineering. The scaffolds presented in the present work can be potentially used in bone tissue engineering to facilitate healing of small bone defects.

scholarly journals Enhancing Density-Based Mining Waste Alkali-Activated Foamed Materials Incorporating Expanded Cork

CivilEng ◽  
2021 ◽  
Vol 2 (2) ◽  
pp. 523-540
Author(s):  
Imed Beghoura ◽  
Joao Castro-Gomes
Keyword(s):  
Mechanical Properties ◽  
Compressive Strength ◽  
Pore Size ◽  
Physical And Mechanical Properties ◽  
Critical Parameters ◽  
Porous Structures ◽  
Foaming Agent ◽  
Al Powder ◽  
Highly Porous ◽  
Alkali Activated

This study focuses on the development of an alkali-activated lightweight foamed material (AA-LFM) with enhanced density. Several mixes of tungsten waste mud (TWM), grounded waste glass (WG), and metakaolin (MK) were produced. Al powder as a foaming agent was added, varying from 0.009 w.% to 0.05 w.% of precursor weight. Expanded granulated cork (EGC) particles were incorporated (10% to 40% of the total volume of precursors). The physical and mechanical properties of the foamed materials obtained, the effects of the amount of the foaming agent and the percentage of cork particles added varying from 10 vol.% to 40% are presented and discussed. Highly porous structures were obtained, Pore size and cork particles distribution are critical parameters in determining the density and strength of the foams. The compressive strength results with different densities of AA-LFM obtained by modifying the foaming agent and cork particles are also presented and discussed. Mechanical properties of the cured structure are adequate for lightweight prefabricated building elements and components.

scholarly journals Investigation of the biological activity, mechanical properties and wound healing application of a novel scaffold based on lignin–agarose hydrogel and silk fibroin embedded zinc chromite nanoparticles

RSC Advances ◽  
2021 ◽  
Vol 11 (29) ◽  
pp. 17914-17923
Author(s):  
Reza Eivazzadeh-Keihan ◽  
Hooman Aghamirza Moghim Aliabadi ◽  
Fateme Radinekiyan ◽  
Mohammad Sobhani ◽  
Farzane khalili ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Biological Activity ◽  
Silk Fibroin ◽  
Agarose Hydrogel ◽  
Novel Scaffold ◽  
Fibroin Solution ◽  
Zinc Chromite

Given the important aspects of wound healing approaches, in this work, an innovative biocompatible nanobiocomposite scaffold was designed and prepared based on cross-linked lignin–agarose hydrogel, extracted silk fibroin solution, and zinc chromite (ZnCr2O4) nanoparticles.

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