scholarly journals The application of a selenium fertiliser for the correction of marginal deficiencies in grazing sheep

1999 ◽  
Vol 70 (3) ◽  
Author(s):  
S.W.P. Cloete ◽  
F.E. Van Niekerk ◽  
M. Young ◽  
G.D. Van der Merwe ◽  
J. Clark
Keyword(s):  
Whole Blood ◽  
Sodium Selenite ◽  
Dry Matter ◽  
Liver And Kidney ◽  
Poorly Soluble ◽  
Se Deficiency ◽  
Ram Lambs ◽  
Grazing Sheep ◽  
Lamb Growth ◽  
Se Status

A commercial fertiliser, consisting of a poorly soluble barium selenate core with a coating of highly soluble sodium selenite, was evaluated in 2 trials for the provision of selenium (Se) to grazing sheep. The fertiliser was administered at a level of 1 kg per hectare to 3 of 6 kikuyu paddocks during 1995 and 1996 in Trial 1, while the other paddocks were left untreated. The Se status of SA mutton merino ram lambs, as reflected by whole blood, liver and kidney Se concentrations, was elevated (P<0.01) for at least 5 months after application of the fertiliser. Whole blood and liver Se concentrations of animals grazing unfertilised control paddocks were indicative of a subclinical Se deficiency at times (<100 ng Se/mℓ whole blood and <300 mg Se/kg liver dry matter). In Trial 2, 4 of 7 paddocks on which an oat fodder crop was established were treated with the Se fertiliser during 1995 and 1997. The remaining 3 paddocks were left unfertilised as controls. Groups of 10-15 pregnant SA mutton merino ewes were introduced to these paddocks within 2 weeks of parturition. These ewes and their progeny utilised these paddocks for a mean (+SD) period of 41+8 days after parturition. The whole blood Se concentrations of these ewes and their offspring were elevated (P < 0.01) relative to their contemporaries utilising control paddocks. No suggestion of a subclinical Se deficiency was discernible in animals grazing control paddocks, although whole blood Se levels approached 100 ng Se/mℓ during 1997. The application of Se fertiliser did not result in improvements in ewe reproduction or lamb growth. There was a suggestion of an improvement (P = 0.21) in mean (+SE) lamb survival on paddocks receiving Se fertiliser compared to control paddocks (71.5 + 4.6 % vs 62.2 + 5.3 % respectively).

scholarly journals Comparison of organic and inorganic forms of selenium in the mother and kid relationship in goats

2012 ◽  
Vol 57 (No. 8) ◽  
pp. 361-369 ◽  
Author(s):  
L. Pavlata ◽  
L. Mišurová ◽  
A. Pechová ◽  
R. Dvořák
Keyword(s):  
Glutathione Peroxidase ◽  
Whole Blood ◽  
Sodium Selenite ◽  
Dry Matter ◽  
Control Group ◽  
Individual Trial ◽  
Significant Difference ◽  
The Individual ◽  
Se Status

The goal of the experiment was to compare the effect of four different forms of selenium (Se) &minus; sodium selenite (SS), lactate-protein selenium complex (SL), selenium enriched yeast (SY), and selenium-proteinate (SP) supplemented to pregnant goats on Se concentration and glutathione peroxidase (GSH-Px) activity in the blood of goats on the day of delivery and also on Se concentration and GSH-Px activity in the blood of newborn kids. The experiment involved 33 pregnant goats of White Short-haired breed. The supplementation started 6 weeks before the parturition. The goats were divided into 5 groups: control group&nbsp;C, not supplemented, and 4 trial groups (SL, SP, SS, SY), which received Se in the above stated forms by the means of supplemented pellets (300 g per animal per day) at a rate 900 &mu;g Se/kg of dry matter. The average Se concentrations in the blood of the goats were 79.6 &mu;g/l in group C, 152.6 &mu;g/l in group SL, 167.1&nbsp;&mu;g/l in group SP, 144.9 &mu;g/l in group SS, and 152.9 &mu;g/l in group SY. Selenium concentrations in all 4 trial groups were significantly higher (P &lt; 0.01) than in control group, however no significant difference was found between individual trial groups. Likewise, the activity of GSH-Px in goat blood increased significantly in all supplemented groups compared to the controls; however we did not discover any significant differences in activity of GSH-Px between the individual selenium-supplemented groups. The Se concentrations in the blood of kids were significantly (P &lt; 0.01) higher in the selenium-supplemented groups (SL &ndash; 94.9&nbsp;&mu;g/l, <br />SP &ndash; 87.5 &mu;g/l, SS &ndash; 87.6 &mu;g/l, SY &ndash; 92.5 &mu;g/l) than in the control group (C &ndash; 49.4 &mu;g/l), but we did not discover any differences between the individual experimental groups. The activity of GSH-Px in the blood of the kids tended towards higher values in the supplemented groups than in the control group, but the values were significantly higher (P &lt; 0.05) only in groups SY and SL. We have found significant correlation between GSH-Px activity and Se concentration in the blood of goats (r = 0.86) and newborn kids (r = 0.95). Likewise, there was significant correlation between Se concentration in the blood of goats and their kids (r&nbsp;= 0.74). We discovered that the kids are reaching physiologically only about 60% of Se status in whole blood in comparison with their mothers. Our results are suggesting that all the above forms of Se were similarly utilised and transferred into the foetus in the goats. &nbsp;

scholarly journals PSIII-24 Selenium requirement of turkeys based on tissue selenium concentration and selenoprotein activity and transcript expression

2019 ◽  
Vol 97 (Supplement_2) ◽  
pp. 177-178
Author(s):  
Rachel M Taylor ◽  
Roger A Sunde
Keyword(s):  
Selenium Concentration ◽  
Transcript Expression ◽  
Life Stages ◽  
Growth Data ◽  
Turkey Poults ◽  
Liver And Kidney ◽  
Tissue Selenium ◽  
Se Deficiency ◽  
Commercial Turkey ◽  
Se Status

Abstract Selenium (Se) is an essential and toxic trace mineral in animal diets. The current NRC turkey Se requirement is 0.2 µg Se/g diet for all life stages, higher than the published rat and mouse requirements. The studies that form the basis for the turkey requirement were performed over 50 years ago and based on prevention of Se-deficiency disease. With the genetic improvement of commercial turkey flocks and emerging new Se status biomarkers, we fed day-old male poults a Se-deficient (0.005 µg/g), vitamin E-adequate torula-based diet supplemented with graded levels of Se, from 0 to 5 µg/g, for 28 days. Poults supplemented with <0.05 µg/g had reduced growth, but there was no effect of high Se on growth. Se biomarkers responded hyperbolically to increasing dietary Se and reached plateaus at or before 0.4 µg/g. In deficiency, liver and kidney Se fell to <10% of Se-adequate levels. Activities of plasma GPX3; liver, kidney, pancreas and muscle GPX1; and liver, kidney, muscle and gizzard GPX4 all decreased to <10% in Se deficiency and reached plateau levels by 0.4 µg/g. In the same tissues, ≤6 out of 24 selenoprotein transcripts were downregulated to 2X Se-adequate levels in poults fed up to 5 µg/g diet. Liver Se increased to 5.6X Se-adequate levels with 5 µg/g diet. We conclude that the dietary Se level to maximize Se status biomarkers in growing turkey poults is 0.4 µg Se/g diet, double the current NRC requirement. Transcript expression is maximized at lower dietary Se levels than enzyme activities of the corresponding selenoproteins. Lastly, based on growth data, the turkey appears resistant to excess dietary Se, suggesting FDA Se supplementation limits can be safely raised. (Funded by USDA Hatch 1013496)

Supplementing selenium yeast to diets with adequate concentrations of selenium: Selenium status, thyroid hormone concentrations and passive transfer of immunoglobulins in dairy cows and calves

2009 ◽  
Vol 89 (1) ◽  
pp. 111-122 ◽  
Author(s):  
K M Koenig ◽  
K A Beauchemin
Keyword(s):  
Thyroid Hormone ◽  
Dairy Cows ◽  
Whole Blood ◽  
Dry Matter ◽  
Basal Diet ◽  
Passive Transfer ◽  
Selenium Yeast ◽  
Maternal Supplementation ◽  
Selenized Yeast ◽  
Se Status

The objective of this study was to investigate whether supplementing organic Se yeast to diets with relatively high basal concentrations of Se was more effective than inorganic Se for improving Se status of dairy cows and their calves. Forty Holstein cows (primiparous and multiparous) were fed total mixed rations (TMR) supplemented with 0.3 mg kg-1 of Se (dry matter basis) as either selenized yeast (Se yeast) or sodium selenite from 60 d before the expected calving date until 60 d in milk (DIM). Cows were fed diets containing 0.38 to 0.40 mg Se kg-1 with no supplemental Se for 90 d before receiving the dietary Se treatments. The Se concentration of the TMR supplemented with Se ranged from 0.62 to 0.81 mg kg-1. Blood was collected from cows at 60 and 30 d before the expected calving date, at calving, and at 15, 30 and 60 DIM, and from their calves at 24 h and 56 d of age. Milk was collected at calving (colostrum) and at 15, 30 and 60 DIM. At birth, calves were removed from the dam and fed colostrum in an amount equivalent to 10% of their body weight within 12 h. Whole blood Se concentration averaged 11% greater (P < 0.05) in cows fed Se yeast compared with selenite (291 vs. 262 ± 4.5 ng mL-1) and serum Se concentration averaged 13% greater in cows fed Se yeast (128 vs. 113 ± 5.3 ng mL-1). Maternal supplementation of Se yeast increased (P < 0.05) the Se status of calves by increasing whole blood (252 vs. 211 ± 16 ng mL-1), serum (94 vs. 75 ± 4.7 ng mL-1), and colostrum (245 vs. 174 ± 5.8 ng mL-1) Se concentration by 19, 25 and 41%, respectively. There was, however, no beneficial effect (P > 0.10) of Se source on thyroid hormone concentrations or the passive transfer of immunoglobulins to the calf. Supplemental organic Se yeast increased the Se status of dairy cows and the transfer of Se to their calves even though the Se concentration of the basal diet was adequate (? 0.3 mg kg-1). Key words: Selenized yeast, selenium, thyroid hormone, immunoglobulin, dairy cows

scholarly journals The effect of inorganic and organically bound forms of selenium on glutathione peroxidase activity in the blood of goats

2011 ◽  
Vol 56 (No. 2) ◽  
pp. 75-81 ◽  
Author(s):  
L. Pavlata ◽  
L. Misurova ◽  
A. Pechova ◽  
R. Dvorak
Keyword(s):  
Glutathione Peroxidase ◽  
Lactobacillus Acidophilus ◽  
Whole Blood ◽  
Sodium Selenite ◽  
Complex Form ◽  
Biologically Active ◽  
Glutathione Peroxidase Activity ◽  
The Difference ◽  
Se Status

The goal of the experiment was to compare the effect of supplementation of inorganic and the new organically bound (lactate-protein selenium complex) form of selenium (Se) in feed for goats. The 31 goats were split into three groups: control (C) without Se supplementation, AN group administered sodium selenite, ORG group administered lactate-protein selenium complex (Selene Chelate, Agrobac, Czech Republic) produced by cultivation of Lactobacillus acidophilus on a substrate containing natrium selenite. The total Se intake in goats was 0.15 mg in group C, and 0.43 mg in the groups AN and ORG. The effect of Se supplementation was assessed based on the determination of Se concentration and the activity of glutathione peroxidase (GSH-Px) in whole blood. Samples were taken before the beginning of Se supplementation, 14 and 30 days after the start of supplementation, and then two and three months after the beginning of supplementation. Average Se concentrations in the blood of goats in individual groups (C, AN, ORG) before the start of supplementation were 109.6 &plusmn; 34.3, 117.5 &plusmn; 34.7, and 105.4 &plusmn; 43.6 &mu;g/l respectively, and the activity of GSH-Px in whole blood was 745.3 &plusmn; 289.2, 810.7 &plusmn; 280.4, and 791.0 &plusmn; 398.1 &mu;kat/l respectively. While in group C goats neither the Se concentration nor the GSH-Px activity changed substantially during the experiment, in the goats in the experimental groups there was a statistically significant increase (P &lt; 0.01) in both Se concentrations and the GSH-Px activities. At the end of the experiment Se concentrations in the blood of AN and ORG groups amounted to 168.5 &plusmn; 12.2 and 168.8 &plusmn; 26.8 &mu;g/l. The GSH-Px activities in goats supplemented with Se also increased significantly over the course of the experiment (at the end of the experiment it was 1178.0 &plusmn; 127.3 in the AN group and 1030.1 &plusmn; 152.3 &mu;kat/l in the ORG group), and the difference between the groups was significant (P = 0.038). Regarding the dynamics of GSH-Px activity changes during the monitored period, a markedly quicker increase in GSH-Px activity was recorded in the AN group &ndash; one month after the beginning of Se supplementation, compared to three months after the beginning of Se supplementation in the ORG group. The results thus show that the effects of supplementation with selenite and the lactate-protein selenium complex are similar with regard to Se status, but that the increase in GSH-Px activity occurred much faster with selenite, which therefore appears to be a more biologically available form of selenium for creation of biologically active selenoproteins.

scholarly journals Selenium status highly regulates selenoprotein mRNA levels for only a subset of the selenoproteins in the selenoproteome

2009 ◽  
Vol 29 (5) ◽  
pp. 329-338 ◽  
Author(s):  
Roger A. Sunde ◽  
Anna M. Raines ◽  
Kimberly M. Barnes ◽  
Jacqueline K. Evenson
Keyword(s):  
Thioredoxin Reductase ◽  
Selenium Deficiency ◽  
Underlying Mechanism ◽  
Pcr Analysis ◽  
Mrna Levels ◽  
Nonsense Mediated Decay ◽  
Liver And Kidney ◽  
Se Deficiency ◽  
Selenoprotein Mrnas ◽  
Se Status

Gpx (glutathione peroxidase)-1 enzyme activity and mRNA levels decrease dramatically in Se (selenium) deficiency, whereas other selenoproteins are less affected by Se deficiency. This hierarchy of Se regulation is not understood, but the position of the UGA selenocysteine codon is thought to play a major role in making selenoprotein mRNAs susceptible to nonsense-mediated decay. Thus in the present paper we studied the complete selenoproteome in the mouse to uncover additional selenoprotein mRNAs that are highly regulated by Se status. Mice were fed on Se-deficient, Se-marginal and Se-adequate diets (0, 0.05 and 0.2 μg of Se/g respectively) for 35 days, and selenoprotein mRNA levels in liver and kidney were determined using microarray analysis and quantitative real-time PCR analysis. Se-deficient mice had liver Se concentrations and liver Gpx1 and thioredoxin reductase activities that were 4, 3 and 3% respectively of the levels in Se-adequate mice, indicating that the mice were Se deficient. mRNAs for Selh (selenoprotein H) and Sepw1 (selenoprotein W) as well as Gpx1 were decreased by Se deficiency to <40% of Se-adequate levels. Five and two additional mRNAs were moderately down-regulated in Sedeficient liver and kidney respectively. Importantly, nine selenoprotein mRNAs in liver and fifteen selenoprotein mRNAs in the kidney were not significantly regulated by Se deficiency, clearly demonstrating that Se regulation of selenoprotein mRNAs is not a general phenomenon. The similarity of the response to Se deficiency suggests that there is one underlying mechanism responsible. Importantly, the position of the UGA codon did not predict susceptibility to Se regulation, clearly indicating that additional features are involved in causing selenoprotein mRNAs to be sensitive to Se status.

scholarly journals Dietary Selenium Regulates microRNAs in Metabolic Disease: Recent Progress

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1527
Author(s):  
Xin Huang ◽  
Yu-Lan Dong ◽  
Tong Li ◽  
Wei Xiong ◽  
Xu Zhang ◽  
...  
Keyword(s):  
Physiological State ◽  
Essential Element ◽  
Dietary Factors ◽  
Regulatory Mechanisms ◽  
Metabolic Risk ◽  
Messenger Rnas ◽  
Immune Disorders ◽  
Se Deficiency ◽  
Safety Range ◽  
Se Status

Selenium (Se) is an essential element for the maintenance of a healthy physiological state. However, due to environmental and dietary factors and the narrow safety range of Se, diseases caused by Se deficiency or excess have gained considerable traction in recent years. In particular, links have been identified between low Se status, cognitive decline, immune disorders, and increased mortality, whereas excess Se increases metabolic risk. Considerable evidence has suggested microRNAs (miRNAs) regulate interactions between the environment (including the diet) and genes, and play important roles in several diseases, including cancer. MiRNAs target messenger RNAs to induce changes in proteins including selenoprotein expression, ultimately generating disease. While a plethora of data exists on the epigenetic regulation of other dietary factors, nutrient Se epigenetics and especially miRNA regulated mechanisms remain unclear. Thus, this review mainly focuses on Se metabolism, pathogenic mechanisms, and miRNAs as key regulatory factors in Se-related diseases. Finally, we attempt to clarify the regulatory mechanisms underpinning Se, miRNAs, selenoproteins, and Se-related diseases.

Effect of selenium supplementation on survival, liveweight and wool weight of young sheep on Kangaroo Island, South Australia

1979 ◽  
Vol 19 (101) ◽  
pp. 689 ◽  
Author(s):  
SK Walker ◽  
GP Hall ◽  
DH Smith ◽  
RW Ponzoni ◽  
GJ Judson
Keyword(s):  
Total Dose ◽  
Whole Blood ◽  
Sodium Selenite ◽  
South Australia ◽  
Selenium Concentration ◽  
Mortality Rates ◽  
Selenium Supplementation ◽  
First Year ◽  
Weaning Weight ◽  
Fleece Weight

The responses in liveweight, wool weight and survival, to selenium supplementation, were studied in young sheep from weaning to yearling age. The experiment was conducted over three years. In the first year, one sodium selenite supplementation rate was used (total dose 46.5 mg). During the following two years two supplementation rates were administered (total doses 46.5 mg and 93 mg). Mean concentrations of selenium in whole blood in unsupplemented sheep varied from 0.19-0.56 pmol l-l and from 0.20-0.44 pmol l-1 in the two years in which concentrations were measured. Supplementation, which commenced at lamb marking, increased the selenium concentration in sheep at weaning and thereafter. Selenium supplementation improved the break-of-season weight (P < 0.01) and yearling weight (P < 0.01 ) but not weaning weight (0.05 < P < 0.1 ). Hogget fleece weight was improved (P < 0.01 ) and mortality reduced (P < 0.01) by selenium supplementation. There was a treatment x year interaction in mortality rates (P < 0.01 ). There were no significant differences between the two supplementation rates

Selenium in Pediatric Nutrition

PEDIATRICS ◽  
1991 ◽  
Vol 87 (3) ◽  
pp. 339-351
Author(s):  
Richard E. Litov ◽  
Gerald F. Combs
Keyword(s):  
Age Groups ◽  
Signs And Symptoms ◽  
Infants And Children ◽  
Keshan Disease ◽  
National Academy Of Sciences ◽  
Maple Syrup ◽  
Clinical Impairment ◽  
Se Deficiency ◽  
Se Status

Se is an essential nutrient that provides antioxidant protection in concert with vitamin E. Several selenoproteins have been identified, but only one, SeGSHpx, has a known function, that of neutralizing toxic hydroperoxides. Plasma Se concentration, being responsive to changes in Se intake, is the most practical and widely used measure of nutritional Se status. The plasma Se concentrations of the majority of healthy infants and children fall within the range of 50 to 150 µg/L. Although SeGSHpx activity measures the metabolically functional form of Se, the lack of a standardized analytical method has limited its usefulness as an index of nutritional Se status. Se deficiency was first observed in animals, but it is now recognized to occur in humans. Two human diseases associated with severe nutritional Se deficiency have been reported from China: a juvenile cardiomyopathy named Keshan disease and a chondrodystrophy named Kaschin-Beck disease. Long-term TPN, which provides negligible amounts of intrinsic Se, has been demonstrated in some cases to result in biochemical and clinical impairment. Although there are no consistent signs and symptoms characteristic of TPN-associated Se deficiency, in addition to the low blood selenium levels, some patients will experience leg muscle pain and altered serum transaminase and creatine kinase activities. These manifestations of Se deficiency usually take years to develop. Recent information about the amount of dietary Se needed to maximize plasma SeGSHpx activity in adult men has allowed for better estimates of the Se requirement for humans. Recommended daily dietary allowances published recently by the National Academy of Sciences have been revised for infants and children in this paper by making appropriate adjustments for the protein requirements of these age-groups. These recommended intakes for Se can generally be met by consuming adequate amounts of cereals, meat, eggs, dairy products, human milk, and infant formula, which are good sources of highly available Se and are of low risk of providing excess amounts of Se. Suboptimal Se intakes by pregnant women may predispose their infants to low Se status at birth, which in turn may affect the infants' ability to maintain adequate Se status during the first few months of life. In those situations where protein intake is restricted, such as in phenylketonuria and maple syrup urine disease, Se-supplemented formulas should be used. The most critical situation for Se supplementation is in pediatric patients receiving long-term TPN therapy. When supplementing with Se, consideration must be given to the amount and form of Se to be used; with long-term TPN therapy, plasma Se levels should be monitored.

Sampling only ten microliters of whole blood for the quantification of poorly soluble drugs: Itraconazole as case study

2017 ◽  
Vol 1479 ◽  
pp. 161-168 ◽  
Author(s):  
Justine Thiry ◽  
Brigitte Evrard ◽  
Gwenaël Nys ◽  
Marianne Fillet ◽  
Miranda G.M. Kok
Keyword(s):  
Whole Blood ◽  
Poorly Soluble Drugs ◽  
Poorly Soluble

scholarly journals Impact of long-term supplementation of zinc and selenium on their content in blood and hair in goats

2011 ◽  
Vol 56 (No. 2) ◽  
pp. 63-74 ◽  
Author(s):  
L. Pavlata ◽  
M. Chomat ◽  
A. Pechova ◽  
L. Misurova ◽  
R. Dvorak
Keyword(s):  
Blood Plasma ◽  
Whole Blood ◽  
Average Concentration ◽  
The Other ◽  
Control Group ◽  
Selenium Yeast ◽  
Hair Samples ◽  
The Impact ◽  
Se Status

This paper evaluates the impact of long-term supplementation of different forms of zinc (Zn) and selenium (Se) on the content of these substances in the blood and hair of goats. Two analogous supplementation experiments were performed. 37 goats divided into four groups were used in the first trial with the Zn supplementation. Group A (n = 10) was a control group (with no Zn administered). A further three groups (B, C, D) were supplemented with Zn in various forms. Group B (n = 9) with zinc oxide, Group C (n = 9) with zinc lactate and Group D (n = 9) with zinc chelate. The second trial with Se supplementation was carried out on 20 goats divided into four groups. Group E (n = 5) was a control group. The other three groups were administered Se. Group F (n = 5) was supplied with a selenium lactate-protein complex, Group G (n = 5) with sodium selenite and Group H (n = 5) with selenium yeast. Three months later blood and hair samples were taken from all animals and Zn and Se concentrations were determined in whole blood, plasma, and hair. Glutathione peroxidase (GSH-Px) activity was determined in the Se supplementation trial group. At the end of the trial the Zn concentrations in plasma and whole blood were without major differences between the groups. The plasma concentration of Zn did not increase from the initial value at the start of the trial. In hair the average concentration of Zn was 95.2&ndash;100.0 mg/kg<br />in all groups. No conclusive relation was confirmed between the values of Zn in hair and its concentration in blood. The Se concentration in whole blood (&micro;g/l) at the end of trial in supplemented groups (F &ndash; 188.8 &plusmn; 24.6; G &ndash; 197.2 &plusmn; 10.9; H &ndash; 190.1 &plusmn; 26.3) was significantly higher (P &lt; 0.01) than in the control group (E &ndash; 103.1 &plusmn; 23.5). Similarly, the activity of GSH-Px (&micro;kat/l) was significantly higher in all supplemented groups (F &ndash; 872.3 &plusmn; 94.8; G &ndash; 659.5 &plusmn; 176.4; H &ndash; 839.8 &plusmn; 150.8) than in the control group (E &ndash; 379.1 &plusmn; 63.5). Se content in hair (&micro;g/kg) was higher also in all trial groups (F &ndash; 242.3 &plusmn; 41.5; G &ndash; 200.5 &plusmn; 46.9; H &ndash; 270.0 &plusmn; 106.8) than in the control group (E &ndash; 174.7 &plusmn; 38.0). However, it was significantly (P &lt; 0.05) higher only in Group F. A conclusive correlation was identified between the Se concentration in whole blood and its content in hair (r = 0.54; P &lt; 0.05; n = 20). Based on the results it can be concluded that none of the supplemented forms of Zn increased its concentration in blood, plasma and hair. On the other hand, the administration of Se led to an increase in the Se concentration in blood, increased the activity of GSH-Px in whole blood and the Se content in hair. Based on the proven correlation and regression relation between the Se concentration in blood and its content in hair, hair can be considered as a suitable material for the diagnosis of long-term Se status in goats. Goats with sufficient Se status are those that have more than 160 &micro;g/kg of Se in hair dry weight.

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