scholarly journals Long and short revolutions towards the Neolithic in western Anatolia and Aegean

2019 ◽  
Vol 46 ◽  
pp. 68-83
Author(s):  
Barbara Horejs
Keyword(s):  
Environmental Conditions ◽  
Social Life ◽  
Cultural Practices ◽  
Current Knowledge ◽  
Raw Material ◽  
Western Anatolia ◽  
Economic Strategies ◽  
Material Procurement ◽  
Similarities And Differences

This paper provides an overview of our current knowledge about the transformation towards the Neolithic in western Anatolia and the Aegean, and offers a narrative for their interpretation. Within the longue durée perspective of the long revolution in the Near East, the first millennia of the Holocene of the Aegean and western Anatolia are contrasted with each other. Economic strategies, environmental conditions, technologies, raw material procurement and cultural practices in the Aegean Mesolithic and the Pre-Neolithic times in western Anatolia are analysed to classify potential similarities and differences. The evidence of new cultural and symbolic practices, eco-nomies, and technologies in the seventh millennium is discussed as the paradox of a short revolu-tion embedded in a long-term process of interaction, knowledge-transfer and adaptation, setting the scene for the Neolithic pioneers establishing a new social life.

scholarly journals Long and short revolutions towards the Neolithic in western Anatolia and Aegean

2019 ◽  
Vol 46 ◽  
pp. 68-83
Author(s):  
Barbara Horejs
Keyword(s):  
Environmental Conditions ◽  
Social Life ◽  
Cultural Practices ◽  
Current Knowledge ◽  
Raw Material ◽  
Western Anatolia ◽  
Economic Strategies ◽  
Material Procurement ◽  
Similarities And Differences

This paper provides an overview of our current knowledge about the transformation towards the Neolithic in western Anatolia and the Aegean, and offers a narrative for their interpretation. Within the longue durée perspective of the long revolution in the Near East, the first millennia of the Holocene of the Aegean and western Anatolia are contrasted with each other. Economic strategies, environmental conditions, technologies, raw material procurement and cultural practices in the Aegean Mesolithic and the Pre-Neolithic times in western Anatolia are analysed to classify potential similarities and differences. The evidence of new cultural and symbolic practices, eco-nomies, and technologies in the seventh millennium is discussed as the paradox of a short revolu-tion embedded in a long-term process of interaction, knowledge-transfer and adaptation, setting the scene for the Neolithic pioneers establishing a new social life.

scholarly journals Characterizing the pigments and paints of prehistoric artists

2021 ◽  
Vol 13 (11) ◽  
Author(s):  
Inés Domingo ◽  
Annalisa Chieli
Keyword(s):  
Cultural Practices ◽  
Raw Materials ◽  
Rock Art ◽  
Raw Material ◽  
Special Focus ◽  
Analytical Strategies ◽  
Material Procurement ◽  
Analytical Approaches ◽  
Critical Overview

AbstractThis paper offers a broad and critical overview of current discussions on the potential uses and the characterization of pigments in prehistory, with a special focus on prehistoric rock art. Today, analytical approaches to pigments and paints allow us to go beyond the identification of the elemental and molecular composition of these archaeological remains, to explore also raw material procurement, transformation and use strategies of interest to investigate the technological and socio-cultural practices of prehistoric artists and their change over space and time. The paper also summarizes the palette of prehistoric artists, as well as the techniques and analytical strategies used to date to characterize prehistoric pigments and paints (colours, raw materials, binders and recipes) used in prehistoric rock art.

scholarly journals Conversation Analysis: Opening Sequences and Ritual Expressions of Informal Mobile Phone Calls between Saudis

2019 ◽  
Author(s):  
Mohammad Mahzari
Keyword(s):  
Mobile Phone ◽  
Conversation Analysis ◽  
Social Life ◽  
Cultural Practices ◽  
Study Data ◽  
Phone Calls ◽  
Similarities And Differences ◽  
Landline Telephone ◽  
Saudi Arabic ◽  
The Impact

Much work of studying opening conversations has been conducted on landline telephone calls; whereas, mobile phone conversations have received less attention by researchers despite of the dominance of using mobile phone in our social life. Informed by conversation analysis (CA) approach, this study aims to identify the opening sequences and ritual expressions of informal mobile phone conversations among Saudi friends and relatives. Another goal is that to identify whether the opening sequences of mobile phone are similar or different from the landline telephone. The study will answer the following questions: what are the opening sequences and ritual expressions of mobile phone? And what are the similarities and differences between mobile phone and landline telephone in terms of the opening sequences. Thirty audio-recorded and transcribed mobile phone conversations served as the data source for this study. Data were analyzed qualitatively and quantitatively by using the CA approach. Findings showed that the majority of opening sequences of mobile phone calls were reduced to three sequences: summons answer, greeting exchanges, and how-are-you exchanges due the impact of caller ID. In addition, the sequence of identification/recognition can be found when the caller does not know the callee or the number is silent. Therefore, mobile phone and landline telephone have similarities and differences in the opening sequences in general. However, the differences observed can be a reason of the cultural practices for language use more than the effect of medium used in communication such as landline telephone and mobile phone in Saudi Arabic. Finally, more data are needed to investigate gender differences.

scholarly journals The Organisation of Cultural and Social Life in Selected Successful Villages

2019 ◽  
Vol 67 (3) ◽  
pp. 324-342
Author(s):  
Vladimír Bahna
Keyword(s):  
Social Life ◽  
Development Strategies ◽  
The Other ◽  
High Rate ◽  
Social Activities ◽  
Key Factors ◽  
Other Hand ◽  
Similarities And Differences ◽  
The Village

Abstract This paper compares the methods of organisation of cultural and social life in three municipalities which were awarded the “Village of the Year” title, namely the municipalities of Oravská Lesná, Liptovská Teplička and Spišský Hrhov. The research in these three municipalities suggests several historical and socio-economic similarities between the villages of Oravská Lesná and Liptovská Teplička, which contrasts with the situation in Spišský Hrhov. These similarities and differences between the municipalities are also manifested at the level of their cultural and social life and development strategies. On one hand, we have the traditional mountainous villages with stable long-term and internally driven demography; on the other hand, a changing municipality with a high rate of immigration. In the former case, activities related to the identity of a traditional municipality are being developed, while in the latter case, the identity of the municipality is being actively created also through new cultural and social activities. The key factors of the municipalities’ cultural and social life in both cases are initiative inhabitants and proactive self-governments open to their initiatives.

Sex-specific embryonic origin of postnatal phenotypic variability

2013 ◽  
Vol 25 (1) ◽  
pp. 38 ◽  
Author(s):  
R. Laguna-Barraza ◽  
P. Bermejo-Álvarez ◽  
P. Ramos-Ibeas ◽  
C. de Frutos ◽  
A. P. López-Cardona ◽  
...  
Keyword(s):  
Sex Ratio ◽  
Environmental Conditions ◽  
Developmental Plasticity ◽  
Current Knowledge ◽  
Phenotypic Variability ◽  
Early Embryo ◽  
Preimplantation Embryos ◽  
Adult Health ◽  
Long Term Effects

Preimplantation developmental plasticity has evolved in order to offer the best chances of survival under changing environments. Conversely, environmental conditions experienced in early life can dramatically influence neonatal and adult biology, which may result in detrimental long-term effects. Several studies have shown that small size at birth, which is associated with a greater risk of metabolic syndrome, is largely determined before the formation of the blastocysts because 70%–80% of variation in bodyweight at birth has neither a genetic nor environmental component. In addition, it has been reported that adult bodyweight is programmed by energy-dependent process during the pronuclear stage in the mouse. Although the early embryo has a high developmental plasticity and adapts and survives to adverse environmental conditions, this adaptation may have adverse consequences and there is strong evidence that in vitro culture can be a risk factor for abnormal fetal outcomes in animals systems, with growing data suggesting that a similar link may be apparent for humans. In this context, male and female preimplantation embryos display sex-specific transcriptional and epigenetic regulation, which, in the case of bovine blastocysts, expands to one-third of the transcripts detected through microarray analysis. This sex-specific bias may convert the otherwise buffered stochastic variability in developmental networks in a sex-determined response to the environmental hazard. It has been widely reported that environment can affect preimplantation development in a sex-specific manner, resulting in either a short-term sex ratio adjustment or in long-term sex-specific effects on adult health. The present article reviews current knowledge about the natural phenotypic variation caused by epigenetic mechanisms and the mechanisms modulating sex-specific changes in phenotype during early embryo development resulting in sex ratio adjustments or detrimental sex-specific consequences for adult health. Understanding the natural embryo sexual dimorphism for programming trajectories will help understand the early mechanisms of response to environmental insults.

ASSESSMENT OF KIDNEY FUNCTIONAL RESERVE ON THE BACKGROUND OF ANTI-AGGREGATE THERAPY IN CHRONIC KIDNEY DISEASE II-III STAGE

2020 ◽  
Vol 6 (1) ◽  
pp. 49-54
Author(s):  
Khabib Barnoev ◽  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Comparative Study ◽  
Early Stage ◽  
Raw Material ◽  
Functional Reserve ◽  
Functional Reserves ◽  
Term Administration ◽  
Antiaggregant Therapy

The article presents the results of a study to assess the functional reserve of the kidneys against the background of a comparative study of antiaggregant therapy dipyridamole and allthrombosepin in 50 patients with a relatively early stage of chronic kidney disease. Studies have shown that long-term administration of allthrombosepin to patients has resulted in better maintenance of kidney functional reserves. Therefore, our research has once again confirmed that diphtheridamol, which is widely used as an antiaggregant drug in chronic kidney disease, does not lag behind the domestic raw material allthrombosepin

scholarly journals Impact of mobile stroke units

2021 ◽  
pp. jnnp-2020-324005
Author(s):  
Klaus Fassbender ◽  
Fatma Merzou ◽  
Martin Lesmeister ◽  
Silke Walter ◽  
Iris Quasar Grunwald ◽  
...  
Keyword(s):  
Cost Efficiency ◽  
Current Knowledge ◽  
Vascular Imaging ◽  
Vessel Occlusion ◽  
Stroke Units ◽  
Stroke Treatment ◽  
Stroke Research ◽  
Mobile Stroke Unit ◽  
Novel Strategy

Since its first introduction in clinical practice in 2008, the concept of mobile stroke unit enabling prehospital stroke treatment has rapidly expanded worldwide. This review summarises current knowledge in this young field of stroke research, discussing topics such as benefits in reduction of delay before treatment, vascular imaging-based triage of patients with large-vessel occlusion in the field, differential blood pressure management or prehospital antagonisation of anticoagulants. However, before mobile stroke units can become routine, several questions remain to be answered. Current research, therefore, focuses on safety, long-term medical benefit, best setting and cost-efficiency as crucial determinants for the sustainability of this novel strategy of acute stroke management.

scholarly journals Cardiac Cell Therapy: Insights into the Mechanisms of Tissue Repair

2021 ◽  
Vol 22 (3) ◽  
pp. 1201
Author(s):  
Hsuan Peng ◽  
Kazuhiro Shindo ◽  
Renée R. Donahue ◽  
Ahmed Abdel-Latif
Keyword(s):  
Stem Cell ◽  
Immune Responses ◽  
Tissue Repair ◽  
Molecular Mechanisms ◽  
Clinical Evidence ◽  
Current Knowledge ◽  
Cell Delivery ◽  
Cardiac Cell Therapy ◽  
Stem Cell Treatment

Stem cell-based cardiac therapies have been extensively studied in recent years. However, the efficacy of cell delivery, engraftment, and differentiation post-transplant remain continuous challenges and represent opportunities to further refine our current strategies. Despite limited long-term cardiac retention, stem cell treatment leads to sustained cardiac benefit following myocardial infarction (MI). This review summarizes the current knowledge on stem cell based cardiac immunomodulation by highlighting the cellular and molecular mechanisms of different immune responses to mesenchymal stem cells (MSCs) and their secretory factors. This review also addresses the clinical evidence in the field.

scholarly journals Fusarium basal rot: profile of an increasingly important disease in Allium spp.

2021 ◽  
Author(s):  
Dung Le ◽  
Kris Audenaert ◽  
Geert Haesaert
Keyword(s):  
Disease Management ◽  
Cultural Practices ◽  
Current Knowledge ◽  
Management Strategies ◽  
Future Directions ◽  
Basal Rot ◽  
Major Constraint ◽  
Fusarium Basal Rot ◽  
Chemical Pesticides ◽  
Important Disease

AbstractFusarium basal rot (FBR) is a soil-borne disease that affects Allium species worldwide. Although FBR has long been recognized as a major constraint to the production of economically important Allium species, information that could support disease management remains scattered. In this review, the current knowledge on the causal agents, symptomology and epidemiology, impact, and management strategies of FBR is synthesized. We highlight that FPR is associated with different complexes of several Fusarium species, of which Fusarium oxysporum and F. proliferatum are the most prevalent. These pathogenic complexes vary in composition and virulence, depending on sites and hosts, which can be challenging for disease management. Research to improve disease management using chemical pesticides, resistance cultivars, biocontrol agents, and cultural practices has achieved both promising results and limitations. Finally, research needs and future directions are proposed for the development of effective FBR management strategies.

scholarly journals Hymenoptera Venom Immunotherapy: Immune Mechanisms of Induced Protection and Tolerance

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1575
Author(s):  
Ajda Demšar Luzar ◽  
Peter Korošec ◽  
Mitja Košnik ◽  
Mihaela Zidarn ◽  
Matija Rijavec
Keyword(s):  
Current Knowledge ◽  
Allergic Diseases ◽  
Hymenoptera Venom ◽  
Venom Immunotherapy ◽  
Effector Cells ◽  
Immune Mechanisms ◽  
Protection Mechanisms ◽  
Sting Challenge ◽  
Effectiveness Data

Hymenoptera venom allergy is one of the most severe allergic diseases, with a considerable prevalence of anaphylactic reaction, making it potentially lethal. In this review, we provide an overview of the current knowledge and recent findings in understanding induced immune mechanisms during different phases of venom immunotherapy. We focus on protection mechanisms that occur early, during the build-up phase, and on the immune tolerance, which occurs later, during and after Hymenoptera venom immunotherapy. The short-term protection seems to be established by the early desensitization of mast cells and basophils, which plays a crucial role in preventing anaphylaxis during the build-up phase of treatment. The early generation of blocking IgG antibodies seems to be one of the main reasons for the lower activation of effector cells. Long-term tolerance is reached after at least three years of venom immunotherapy. A decrease in basophil responsiveness correlates with tolerated sting challenge. Furthermore, the persistent decline in IgE levels and, by monitoring the cytokine profiles, a shift from a Th2 to Th1 immune response, can be observed. In addition, the generation of regulatory T and B cells has proven to be essential for inducing allergen tolerance. Most studies on the mechanisms and effectiveness data have been obtained during venom immunotherapy (VIT). Despite the high success rate of VIT, allergen tolerance may not persist for a prolonged time. There is not much known about immune mechanisms that assure long-term tolerance post-therapy.

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