scholarly journals Analysis of inflammatory markers in patients with abnormal circadian rhythm of blood pressure

2021 ◽  
Author(s):  
Néstor Agra ◽  
Ana Teresa Afonso ◽  
Antón Sande ◽  
Ignacio Veleiro ◽  
José Enrique Paz ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Circadian Rhythm ◽  
Inflammatory Markers ◽  
Antihypertensive Drugs ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Inflammatory Status ◽  
Retrospective Data Analysis ◽  
Cross Sectional Design

IntroductionInflammatory status could play a role in alterations of blood pressure (BP) circadian rhythm. The aim of our study is to compare levels of usual inflammatory markers in patients with and without circadian BP abnormalities.Material and methodsThis is a cross-sectional design study with retrospective data analysis which included patients from an Internal Medicine Department with normal and high BP levels older than 18 years who were separated into two groups according to the circadian profile of BP (dipper and non-dipper) based on the results of 24-hour ambulatory BP monitoring. Patients were assessed for demographic characteristics and cardiovascular risk factors. We considered as inflammatory markers the platelet count (PTC), erythrocyte sedimentation rate (ESR), ultra-sensitive C-reactive protein, ferritin, fibrinogen, and uric acid.ResultsThe study included 551 patients (mean age of 54 years, 47% women). The non-dipper group had a higher percentage of individuals with higher ESR (OR = 1.77, 95% CI: 1.23–1.55, p = 0.001), uric acid (OR = 1.50, 95% CI: 1.04–2.16, p = 0.028) and fibrinogen (OR = 1.72, 95% CI: 1.18–2.51, p = 0.001) and a higher percentage of patients with higher PTC (OR = 0.54, 95% CI: 0.37–0.78, p = 0.005). These results were independent of age, waist circumference, presence of arterial hypertension, diabetes or hyperlipidemia, and use of antihypertensive drugs including renin angiotensin aldosterone system blockers.ConclusionsPatients with impaired circadian BP rhythm were associated with an unfavorable inflammatory status independently of BP levels. This fact could play a role in the prognostic differences observed between dipper and non-dipper patients.

scholarly journals Serum High Sensitive C - reactive protein in Male Smokers of Bangladesh

2015 ◽  
Vol 10 (1) ◽  
pp. 36-40
Author(s):  
Shamima Jahan ◽  
Qaz Shamima Akhter
Keyword(s):  
Blood Pressure ◽  
Cross Sectional Study ◽  
Healthy Male ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Inflammatory Status ◽  
Hs Crp ◽  
High Level ◽  
Apparently Healthy

Background: Smoking may cause systemic inflammation, and high level of serum high sensitive Creactive protein may be found in smoker as an indicator of inflammation.Objective: To assess the serum high sensitive C - reactive protein level in male smokers of Bangladesh.Methods: The present cross sectional study was carried out in the Department of Physiology, Dhaka Medical College, Dhaka between July 2013 and June 2014. Hundred apparently healthy male regular cigarette smokers aged 20 to 40 years who smokes at least 5 sticks of cigarette per day for the last 5 years were included as study group. They were further divided in to 5-10 years, 11-15 years, 16-20 years and 1-10 cigarette sticks, 11- 20 cigarette sticks, more than 20 cigarette sticks/day depending on the duration of smoking and also according to consumption of number of sticks/day respectively. Age matched 100 apparently healthy male nonsmokers were included for control. To assess their inflammatory status, serum hs-CRP level was estimated by particles enhanced immunonephelometry using BN Systems in the Department of Microbiology & Immunology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. In addition, BMI and blood pressure were measured by standard method to observe their association with smoking.Results: The mean serum hs-CRP level was significantly higher in male smokers than that of non smokers which was progressively increased with duration of smoking and number of cigarette sticks consumed per day. Again, mean BMI was significantly lower and diastolic blood pressure was significantly higher in male smokers than those of non smokers.Conclusion: The result of this study can be concluded that serum hs-CRP level progressively increases with duration of smoking and number of cigarette sticks consumed per day in male smokers.Bangladesh Soc Physiol. 2015, June; 10(1): 36-40

THE RELATIONSHIP OF NUTRITIONAL STATUS TO URIC ACID LEVEL IN COMMUNITY OF PONDOK PESANTREN AL-HIDAYAH, NGAWI

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Marselli Widya Lestari ◽  
Tri Wahyuni Bintarti
Keyword(s):  
Uric Acid ◽  
Nutritional Status ◽  
Gouty Arthritis ◽  
Extracellular Fluid ◽  
Boarding School ◽  
Clinical Syndrome ◽  
Bivariate Analysis ◽  
Cross Sectional ◽  
Knowledge And Attitude ◽  
Cross Sectional Design

Gout or Gouty Arthritis is a degenerative disease. Gouty arthritis is a clinical syndrome that is caused by deposition of purine crystals in the tissues, due to levels of uric acid (hyperuricemia) in the extracellular fluid that passes through saturation. The etiology of gout arthritis included age, sex, history of medication, obesity, consumption of purine and alcohol. Aging is an important risk factor for men and women. This study uses an analytical-descriptive approach with cross-sectional design. This study was conducted to obtain a relationship between nutritional status and uric acid levels in the community in the area of ​​Al-Hidayah Islamic Boarding School, Ngawi. This research was conducted in Majasem Village, Kendal District, Ngawi Regency, starting from 7 June - 31 August 2018. The results showed that there was a relationship between nutritional status and uric acid levels in the community in the area of ​​Al-Hidayah Islamic Boarding School, Ngawi (p=0,008). Suggestions for further research are bivariate analysis based on gender, knowledge and attitude to response to diet so that other factors that influence can be seen clearly

THE USE OF MEDICINES IN TREATING HYPERTENSION IN HUE UNIVERSITY HOSPITAL

2016 ◽  
pp. 76-84
Author(s):  
Khoa Bao Chau Thai ◽  
Thi Hong Phuong Vo
Keyword(s):  
Blood Pressure ◽  
Channel Blocker ◽  
Enzyme Inhibitor ◽  
Antihypertensive Drugs ◽  
Good Prognosis ◽  
Target Blood Pressure ◽  
University Hospital ◽  
Key Words Hypertension ◽  
Cross Sectional ◽  
Positive Effects

Background: Hypertension is a common condition in the world as well as in Viet Nam. If hypertension isn’t treated well, it can cause many serious complications. Controlling target blood pressure will bring positive effects on reducing mortality rate and also disabilities caused by diseases related to hypertension. Objectives: (1) Analyzing the use of medicines in treating hypertension. (2) Evaluating the effects of medicine usage in treating hypertension at the hospital of Hue University of Medicine and Pharmacy. Materials and methods: 388 patients were diagnosed as having hypertension with inpatient care at the Cardiovascular Department of Hue University of Medicine and Pharmacy’s hospital, using cross-sectional descriptive study methods. Results: All antihypertensive drugs in the research were contained in the antihypertensive list recommended by Vietnamese Society of Cardiology. Angiotensin converting enzyme inhibitor and calcium channel blocker were the two most popular drug groups (96.6% and 71.4%, respectively). The rate of using multi-therapy regimens was higher than the rate of using uni-therapy regimens in both initial therapies (64.7%>35.3%) and final therapies (61.9%>38.1%). The rate of patients having interactions between antihypertensive drugs and the other kinds of drugs was 7.5%. The rate of patients having reasonable prescriptions was 84.3%. Evaluating the effects of medicine usage in treatments showed that the rate of patients reaching target blood pressure before leaving the hospital was 67.3%. Most patients were evaluated as having good prognosis after treatment, up to 81.7%. Conclusions: All antihypertensive drugs in the research were contained in the antihypertensive list recommended by Vietnamese Society of Cardiology. The rate of using multi-therapy regimens was higher than the rate of using uni-therapy regimens. The rate of drug interactions was quite low; most patients were evaluated as having good prognosis after treatment. Key words: hypertension, antihypertensive drugs.

scholarly journals Diet quality in relation to the risk of hypertension among Iranian adults: cross-sectional analysis of Fasa PERSIAN cohort study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Amir Motamedi ◽  
Maryam Ekramzadeh ◽  
Ehsan Bahramali ◽  
Mojtaba Farjam ◽  
Reza Homayounfar
Keyword(s):  
Blood Pressure ◽  
Cohort Study ◽  
Diet Quality ◽  
Dietary Diversity ◽  
Antihypertensive Drugs ◽  
Healthy Eating Index ◽  
Cross Sectional ◽  
Common Chronic Disease ◽  
History Of ◽  
Prevention Of Hypertension

Abstract Background Hypertension is a common chronic disease with various complications and is a main contributing factor to cardiovascular disease (CVD). This study aimed to assess the association of diet quality, assessed by dietary diversity score (DDS), Mediterranean dietary score (MDS), diet quality index-international (DQI-I), and healthy eating index-2015 (HEI-2015) with the risk of hypertension. Methods This study recruited a total of 10,111 individuals (45.14% male) with mean age of 48.63 ± 9.57 years from the Fasa Cohort Study, Iran. Indices of diet quality, including MDS, HEI-2015, DQI-I, and DDS were computed by a 125-item Food Frequency Questionnaire. Participants were diagnosed as hypertensive if they had a diastolic blood pressure (DBP) ≥90 mmHg, systolic blood pressure (SBP) ≥140 mmHg,, or used antihypertensive drugs. Results Hypertension was prevalent in 28.3% of the population (21.59% in males and 33.74% in females). In the whole population, after adjustment for potential covariates, including daily energy intake, age, gender, physical activity, smoking, family history of hypertension, body mass index, and the level of education, higher adherence to the MDS (OR: 0.86, 95%CI = 0.75–0.99) and HEI-2015 (OR: 0.79, 95%CI = 0.68–0.90) was significantly associated with decreased risk of hypertension. The protective effect of HEI-2015 against hypertension remained significant for both males (OR: 0.80, 95%CI = 0.64–0.99) and females (OR: 0.78, 95%CI = 0.66–0.94), while, for MDS, this relationship disappeared in the subgroup analysis by gender. DQI-I and DDS were not related to the odds of hypertension. Conclusions Adhering to MDS and HEI-2015 diets could contribute to the prevention of hypertension.

scholarly journals An observational study on patient compliance and adverse drug reactions of antihypertensives drugs in a tertiary care center of Bihar

2021 ◽  
Vol 6 (4) ◽  
pp. 190-193
Author(s):  
Mrityunjay Kumar Pandit ◽  
Kumar Gaurav ◽  
Jeetendra Kumar
Keyword(s):  
Blood Pressure ◽  
Combination Therapy ◽  
Antihypertensive Drugs ◽  
Care Center ◽  
Adult Population ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
High Dose ◽  
Cross Sectional ◽  
Institutional Ethics

Hypertension is among the most common non-communicable and lifestyle disease in our country that affects adult population of both the genders from all socio-economic backgrounds and urban and rural population. In-spite of this, early diagnosis and appropriate treatment are suboptimal. Adherence of prescribed treatment has been studied in patients of hypertension in this study. : An observational and cross-sectional study was conducted in the Department of Pharmacology, Jawahar Lal Nehru Medical College and Hospital, Bhagalpur, Bihar. Prior to the initiation of the study, clearance was obtained from the Institutional Ethics Committee. Study period was between January 2021 and June 2021.A predesigned pretested interview schedule was used to collect the data from the 247 study participants. This schedule contained information related to socio-demographic variables, comorbidity, a format to assess the compliance to antihypertensive drugs prescribed and any adverse event. : A significant improvement in maintain optimal in blood pressure was observed in patients treated with one pill per day as compared to patients prescribed with two and three pills per day. Compliance was significantly better in patients in combination therapy as compared to monotherapy. : Low dose combination therapy has been stated to be more effective than high dose monotherapy in controlling blood pressure. It shows better compliance and lesser incidence of side-effects.

scholarly journals High Sensitivity CReactive Protein (hsCRP) Level on Premature Rupture of Membrane (PROM) at Term Pregnancy

2017 ◽  
pp. 12-15
Author(s):  
Meily Manoppo ◽  
Hermie MM Tendean ◽  
Joice MM Sondakh
Keyword(s):  
High Sensitivity ◽  
C Reactive Protein ◽  
Term Pregnancy ◽  
Premature Rupture ◽  
Cross Sectional ◽  
Reactive Protein ◽  
Significant Difference ◽  
Hs Crp ◽  
Cross Sectional Design ◽  
Parametric Statistical Test

Objective: To compare the level of high sensitivity C-Reactive Protein (hs-CRP) on patients with premature rupture of membranes (PROM) at term pregnancy. Methods: The study was cross-sectional design. The data collection included age, parity, gestational age, birth weight, and APGAR score on 28 pregnant women at term pregnancy consisting of 14 subjects of Premature Rupture of Membrane (PROM) less than 12 hours and the remaining one was equal or more than 12 hours. We took blood samples from the subjects for the examination of hs-CRP level. Data were analyzed using non-parametric statistical test and processed using Statistical Package for Social Sciences (SPSS) version 20. Results: The mean hs-CRP level on PROM <12-hour and 12-hour group was 12.9 and 17.8 mg/l. There was not significant difference on hs-CRP level between both of group at term pregnancy (p=0.734). Conclusion: The level of hs-CRP does not have association with the incidence of PROM. [Indones J Obstet Gynecol 2017; 5-1: 12-15] Keywords: high sensitivity C-Reactive Protein, premature ruptures of membranes, term pregnancy

scholarly journals Konsumsi makanan tinggi natrium, kesukaan rasa asin, berat badan, dan tekanan darah pada anak sekolah

2016 ◽  
Vol 12 (3) ◽  
pp. 89
Author(s):  
Heni Hendriyani ◽  
Enik Sulistyowati ◽  
Astidio Noviardhi
Keyword(s):  
Blood Pressure ◽  
Food Consumption ◽  
Junior High School ◽  
Later Life ◽  
Normal Weight ◽  
Bivariate Analysis ◽  
Chi Square ◽  
Cross Sectional ◽  
Level Data ◽  
Cross Sectional Design

Background: It is a fact that natrium consumption relates to hypertension and the risk of heart disease and stroke. Even though it is common happened in later life, hypertension can be started in early age.Objective: The aim of the study is to identify salty food preference, high natrium food consumption, natrium intake, weight and its correlation with blood pressure among schoolchildren.Method: The study used cross-sectional design. There were 151 samples from junior high school chosen by purposive sampling. Food salty level data was assessed by eating the snack with three different salt concentration. High and low natrium source food and natrium intake data were taken using semi-quantitative food frequency questionnaire. Blood pressure was measured by sphygmomanometer digital. Bivariate analysis was used Chi-square and Rank Spearman test.Results: The study revealed that 74,2% children prefer snack with the salt level above recommendation (> 0,5 gr salt per portion ). There were 22,5% children have natrium intake from food only ≥2000 mg (above recommendation). As much as 35,8% children fall into hypertension category based on their blood pressure (BP) level. There was a significant relationship between high natrium food consumption score with natrium intake (p=0,002). There were significant correlation between weight with systolic and diastolic BP ((p=0,000 r=-0,549 and p=0,000 r=-0,412). There were no correlation between atrium intake with systolic and diastolic BP (p=0,764;  r= 0,0025 and p=0,819 r=0,19).Conclusion: Healthy food and maintaining normal weight information and education must be done for children as early as possible.

scholarly journals PREVENTIVE CARDIOLOGY, PRECLINICAL DIAGNOSES: OLD PROBLEMS – NEW APPROACHES

2017 ◽  
Vol 4 (1) ◽  
pp. 5-8
Author(s):  
T.V. Ashcheulova ◽  
O.A Kochubiei O.A ◽  
T.G. Ovrakh
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Inflammatory Markers ◽  
C Reactive Protein ◽  
Preventive Cardiology ◽  
Reactive Protein ◽  
Novel Approaches ◽  
New Guidelines

PREVENTIVE CARDIOLOGY, PRECLINICAL DIAGNOSES: OLD PROBLEMS – NEW APPROACHESAshcheulova T.V., Kochubiei O.A., Ovrakh T.GThe article discusses the new Guidelines on cardiovascular disease prevention in clinical practice (2016) which summarized novel approaches of detection of such risk factors as overweigh, obesity, abdominal obesity, smoking, dyslipidemia (cholesterolemia, triglyceridemia), blood pressure (BP) levels, glucose, insulin, insulin resistance, inflammatory markers, such as c-reactive protein, which can be widely used in practice.KeyWords: Cardiovascular disease, preventive cardiology, risk assessment and stratification, strategy for prevention of cardiovascular diseases. ПРЕВЕНТИВНА КАРДІОЛОГІЯ, ДОКЛІНІЧНА ДІАГНОСТИКА: СТАРІ ПРОБЛЕМИ - НОВІ ПІДХОДИАщеулова Т.В., Кочубєй О.А., Оврах Т.Г. У статті розглядаються нові рекомендації з профілактики серцево-судинних захворювань в клінічній практиці (2016 г.), що узагальнюють нові підходи виявлення таких факторів ризику, як надмірна маса тіла, ожиріння, абдомінальне ожиріння, куріння, дисліпідемія (холестеринемія, тригліцеридемія),  артеріальний тиск (АТ), рівень глюкози, інсуліну, резистентність до інсуліну, запальні маркери, такі як С-реактивний білок, які можуть знайти широке застосування у практичній охороні здоров’я.Ключові слова: Серцево-судинні захворювання, профілактична кардіологія, оцінка і стратифікація ризику, стратегія профілактики серцево-судинних захворювань. ПРЕВЕНТИВНАЯ КАРДИОЛОГИЯ, ДОКЛИНИЧЕСКАЯ ДИАГНОСТИКА: СТАРЫЕ ПРОБЛЕМЫ - НОВЫЕ ПОДХОДЫАщеулова Т.В., Кочубей О.А., Оврах Т.Г. В статье рассматриваются новые рекомендации по профилактике сердечно-сосудистых заболеваний в клинической практике (2016 г.), обобщены новые подходы выявления таких факторов риска, как избыточная масса тела, ожирение, абдоминальное ожирение, курение, дислипидемия (холестеринемия, гипертриглицеридемия), повышение артериального давления, уровень глюкозы, инсулина, резистентность к инсулину, маркеры воспаления, такие как С-реактивный белок, которые могут найти широкое применение в практическом здравоохранении.Ключевые слова: сердечно-сосудистые заболевания, профилактическая кардиология, оценка и стратификация риска, стратегия профилактики сердечно-сосудистых заболеваний. 

scholarly journals THE RELATIONSHIP OF NUTRITIONAL STATUS TO URIC ACID LEVEL IN COMMUNITY OF PONDOK PESANTREN AL-HIDAYAH, NGAWI

2019 ◽  
Vol 3 (1) ◽  
pp. 41-46
Author(s):  
Marselli Widya Lestari ◽  
Tri Wahyuni Bintarti
Keyword(s):  
Uric Acid ◽  
Nutritional Status ◽  
Gouty Arthritis ◽  
Extracellular Fluid ◽  
Boarding School ◽  
Clinical Syndrome ◽  
Bivariate Analysis ◽  
Cross Sectional ◽  
Knowledge And Attitude ◽  
Cross Sectional Design

Gout or Gouty Arthritis is a degenerative disease. Gouty arthritis is a clinical syndrome that is caused by deposition of purine crystals in the tissues, due to levels of uric acid (hyperuricemia) in the extracellular fluid that passes through saturation. The etiology of gout arthritis included age, sex, history of medication, obesity, consumption of purine and alcohol. Aging is an important risk factor for men and women. This study uses an analytical-descriptive approach with cross-sectional design. This study was conducted to obtain a relationship between nutritional status and uric acid levels in the community in the area of Al-Hidayah Islamic Boarding School, Ngawi. This research was conducted in Majasem Village, Kendal District, Ngawi Regency, starting from 7 June - 31 August 2018. The results showed that there was a relationship between nutritional status and uric acid levels in the community in the area of Al-Hidayah Islamic Boarding School, Ngawi (p=0,008). Suggestions for further research are bivariate analysis based on gender, knowledge and attitude to response to diet so that other factors that influence can be seen clearly.

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