UJI STABILITAS DAN IRITASI FORMULA KRIM ANTI NYERI EKSTRAK ETANOL DAUN KELOR (Moringa oleifera)

2020 ◽  
Vol 6 (2) ◽  
pp. 273
Author(s):  
Amriani Sapra ◽  
Suwahyuni Mus ◽  
Rifka Malluka ◽  
Dwirandy Dwirandy
Keyword(s):  
Arachidonic Acid ◽  
Oryctolagus Cuniculus ◽  
Moringa Oleifera ◽  
Ethanol Extract ◽  
Alcohol Concentration ◽  
Cetyl Alcohol

Moringa oleifera leaf contains quercetin act as an analgesic by inhibiting cyclooxygenase and lipooxygenase. These enzymes interfere synthesis of prostaglandins by arachidonic acid and lead to reduce pain. This study aimed to obtain a physically stable M/A cream formula from the lyophilized ethanol extract of Moringa leaf and to determine the irritation effect. The cream prepared with variations of cetyl alcohol concentration F1 (2%), F2 (4%,) and F3 (6%). The cream stability was determined with organoleptic, homogeneity, type of emulsion, pH, viscosity, and spreadability parameters after accelerated condition. The Irritancy test was determined to the Albino Oryctolagus cuniculus. The results showed that F1 has the best stability than F2 and F3 and showed irritation index 0,5 classified as moderate irritation.

scholarly journals Moringa oleifera Extract Extenuates Echis ocellatus Venom-Induced Toxicities, Histopathological Impairments and Inflammation via Enhancement of Nrf2 Expression in Rats

2021 ◽  
Vol 28 (1) ◽  
pp. 98-115
Author(s):  
Akindele O. Adeyi ◽  
Sodiq O. Adeyemi ◽  
Enoh-Obong P. Effiong ◽  
Babafemi S. Ajisebiola ◽  
Olubisi E. Adeyi ◽  
...  
Keyword(s):  
Moringa Oleifera ◽  
Ethanol Extract ◽  
Male Rats ◽  
Blood Electrolytes ◽  
Tnf Α ◽  
Group 3 ◽  
Group 2 ◽  
Haematological Indices ◽  
Nrf2 Expression ◽  
Potential Remedy

Echis ocellatus snakebite causes more fatalities than all other African snake species combined. Moringa oleifera reportedly possesses an antivenom property. Therefore, we evaluated the effectiveness of M. oleifera ethanol extract (MOE) against E. ocellatus venom (EOV) toxicities. Thirty male rats were grouped as follows (n = 5): Group 1 (normal control received saline), groups 2 to 6 were administered intraperitoneally, 0.22 mg/kg (LD50) of EOV. Group 2 was left untreated while group 3 to 6 were treated post-envenoming with 0.2 mL of polyvalent antivenom, 200, 400, and 600 mg/kg of MOE respectively. MOE significantly (p<0.05) normalized the altered haematological indices and blood electrolytes profiles. MOE attenuated venom-induced cellular dysfunctions, characterized by a significant increase in NRF2, and concomitant downregulation of increased antioxidant enzymes (SOD and CAT) activities in the serum and heart of the treated rats. MOE normalized the elevated TNF-α and IL-1β in serum and heart tissues. Furthermore, the IgG titre value was significantly (p<0.5) higher in the envenomed untreated group compared to the MOE-treated groups. Hemorrhagic, hemolytic and coagulant activities of the venom were strongly inhibited by the MOE dose, dependently. Lesions noticed on tissues of vital organs of untreated rats were abolished by MOE. Our findings substantiate the effectiveness of MOE as a potential remedy against EOV toxicities.

scholarly journals Uji Aktivitas Antioksidan Ekstrak Air dan Ekstrak Etanol Daun Kelor (Moringa Oleifera LAM)

2017 ◽  
Vol 6 (2) ◽  
pp. 125
Author(s):  
Rizkayanti Rizkayanti ◽  
Anang Wahid M. Diah ◽  
Minarni Rama Jura
Keyword(s):  
Vitamin C ◽  
Moringa Oleifera ◽  
Water Extract ◽  
Ethanol Extract ◽  
Positive Control ◽  
Negative Control ◽  
Ic50 Value ◽  
Antioxidant Potency ◽  
Ethanol Extracts ◽  
Moringa Oleifera Lam

Moringa (moringa oleifera Lam) leaves contains many molecules as inhibitors for free radicals such as phenolic compounds (phenolic acids, flavonoids, quinones, coumarins, lignans, stilbenes, tannins), nitrogen compounds (alkaloids, amines, betalain), vitamins, terpenoids (including carotenoids), and several other endogenous metabolites as antioxidants. This study aimed to determine the antioxidant potency of water and ethanol extracts of moringa (moringa oleifera Lam) leave obtained by maceration and dekok. The concentration of free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) was analyzed using UV-Vis spectrophotometer after addition of various concentrations of Moringa leaves extracts. Various concentrations of moringa leave extracts used were 20 ppm, 40 ppm, 60 ppm and 80 ppm. Vitamin C solutions as the positive control were prepared on similar various concentrations. The negative control was prepared using DPPH solutions dissolved in absolute ethanol. The results indicated that the ethanol extract of moringa leaves prepared by maceration method showed the antioxidant potency with an IC50 value of 22.1818 ppm, but the IC50 value of water extract of moringa leaves prepared by dekok was 57.5439 ppm. While, the IC50 value of Vitamin C was 8.8084 ppm. Based on the IC50 data it can be concluded that Vitamin C is a stronger antioxidant than moringa leaves extracts.

Aktivitas Pertumbuhan Rambut Hair Tonic Ekstrak Daun Bandotan (Ageratum conyzoides L.) Pada Kelinci Jantan (Oryctolagus Cuniculus)

2021 ◽  
Vol 1 ◽  
pp. 1194-1204
Author(s):  
Khofifah Fitriani ◽  
S Slamet ◽  
Dwi Bagus Pambudi ◽  
Urmatul Waznah
Keyword(s):  
Hair Growth ◽  
Oryctolagus Cuniculus ◽  
Ethanol Extract ◽  
Positive Control ◽  
Hair Length ◽  
Ageratum Conyzoides ◽  
Significant Difference ◽  
Growth Activity ◽  
Hair Care ◽  
One Way Anova

AbstractHair loss is a disorder or disorder of hair apart from the scalp or body skin so that it interferes with various biological functions of hair on the body. Types of hair care cosmetic that is effective in dealing with hair loss are hair tonic. Hair tonic is a preparation for the treatment of the scalp and hair. Bandotan (Ageratum conyzoides L.) is used by the public as medicine and hair care. The purpose of this study was to determine the formulation of hair tonic preparations from the ethanol extract of bandotan leaves according to the requirements and hair growth activity of local male rabbits. The extraction method used the maceration method with 96% ethanol and applied hair tonic extract of bandotan leaves on the skin of local male rabbits (Oryctolagus cuniculus) which were treated as blanks without smearing, positive control (Natur), negative control hair tonic base, concentration bandotan leaf extract. (5%, 10%, 15% and 20%) for 21 days. The data obtained in the form of hair length, and hair weight. Analysis of the data obtained for hair growth activity was seen from the results of the ANOVA test and continued with the BNT test (Least Significance Different). The results of the research for evaluating hair tonic preparations included organoleptic tests, pH tests, viscosity tests, specific gravity tests, and cycling tests. Hair tonic ethanol extract of bandotan leaves has hair growth activity. Hair tonic ethanol extract of bandotan leaves with a concentration of 20% had the highest hair length and hair weight. From the results of one way ANOVA, a significant value was obtained 0.000 < 0.005, so it was concluded that there was a significant difference between treatments, and continued with the BNT test (Least Significance Different) positive control was not significantly different from hair tonic concentration of 20%.Keywords: Bandotan leaves, Hair tonic, Hair growth AbstrakKerontokan rambut adalah suatu gangguan atau kelainan rambut terlepas dari kulit kepala atau kulit tubuh sehingga mengganggu berbagai fungsi biologis rambut terhadap tubuh. Jenis kosmetik perawatan rambut yang efektif mengatasi rambut rontok adalah hair tonic. Hair tonic adalah sediaan untuk perawatan kulit kepala dan rambut. Bandotan (Ageratum conyzoides L.) digunakan oleh masyarakat sebagai obat dan perawatan rambut. Tujuan dari penelitian ini mengetahui formulasi sediaan hair tonic dari ekstrak etanol daun bandotan yang sesuai dengan persyaratan dan aktivitas pertumbuhan rambut pada kelinci jantan lokal. Metode ekstraksi menggunakan metode maserasi dengan etanol 96% dan dilakukan pengolesan hair tonic ekstrak daun bandotan pada kulit kelinci jantan lokal (Oryctolagus cuniculus) yang diberikan perlakuan sebagai blanko tanpa pengolesan, kontrol positif (Natur), kontrol negatif basis hair tonic, ekstrak daun bandotan konsentrasi (5%,10%,15% dan 20%) selama 21 hari. Data yang diperoleh berupa panjang rambut, dan bobot rambut. Analisa data yang diperoleh untuk aktivitas pertumbuhan rambut dilihat dari hasil uji ANOVA dan dilanjutkan dengan uji BNT (Beda Nyata Terkecil). Hasil penelitian untuk evaluasi sediaan hair tonic antara lain uji organoleptis, uji pH, uji viskositas, uji bobot jenis, dan uji cycling test. Hair tonic ekstrak etanol daun bandotan memiliki aktivitas pertumbuhan rambut. Hair tonic ekstrak etanol daun bandotan dengan konsentrasi 20% memiliki panjang rambut dan bobot rambut tertinggi. Dari hasil one way ANOVA didapatkan nilai signifikan 0,000 < 0,005 sehingga disimpulkan adanya perbedaan signifikan antar perlakuan, dan dilanjutkan uji BNT (Beda Nyata Terkecil) didapatkan kontrol positif tidak berbeda nyata dengan hair tonic konsentrasi 20%.Kata kunci : Daun bandotan; Hair tonic; Pertumbuhan rambut

Cosmetic Effects of Ethanol Extract from the Drumstic-tree, Moringa oleifera Leaf

KSBB Journal ◽  
2018 ◽  
Vol 33 (1) ◽  
pp. 34-40
Author(s):  
In Hae Kim ◽  
Jae Hwa Lee
Keyword(s):  
Moringa Oleifera ◽  
Ethanol Extract

scholarly journals In vivo anti-arthritic and anti-nociceptive effects of ethanol extract of Moringa oleifera leaves on complete Freund's adjuvant (CFA)-induced arthritis in rats

2018 ◽  
Vol 7 (1) ◽  
pp. 85-94 ◽  
Author(s):  
Harith Jameel Mahdi ◽  
Nurzalina Abdul Karim Khan ◽  
Mohd Zaini Bin Asmawi ◽  
Roziahanim Mahmud ◽  
Vikneswaran A/L Murugaiyah
Keyword(s):  
Moringa Oleifera ◽  
Ethanol Extract ◽  
Complete Freund’S Adjuvant ◽  
Moringa Oleifera Leaves ◽  
Freund’S Adjuvant ◽  
Complete Freund's Adjuvant ◽  
Freund's Adjuvant

scholarly journals COMPARISON OF α –GLUCOSIDASE INHIBITORY ACTIVITY OF Moringa oleifera ETHANOLIC EXTRACT

2021 ◽  
Vol 9 (Spl-2-ICOPMES_2020) ◽  
pp. S269-S273
Author(s):  
Rizky Rahmwaty Alami ◽  
◽  
Herlina Rante ◽  
Yulia Yusrini Djabir ◽  
◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Moringa Oleifera ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Positive Control ◽  
Glucosidase Inhibitor ◽  
Plant Samples

The purpose of this research was to determine the α-glucosidase enzyme inhibitory activity of Moringa oleifera plant samples collected from the three geographical areas viz., Saragi, Bacuhau, and Batumatongka of Southeast Sulawesi Indonesia. Ethanol extract of Moringa leaves was prepared by the maceration method using 95% ethanol. The estimation of α –glucosidase inhibitory activity of this extract was performed in vitro. The results of the study showed that ethanolic extract of three Moringa samples i.e. Sarangi, Bacuhau, and Batumatongka had the IC50value of 18.62, 10.18, 10.58 ppm, respectively while IC50value for the acarbose positive control was reported 11.54ppm. From the results of this study, it can be concluded that ethanolic extract of Moringa could inhibit α –glucosidase and this potential was similar to the commercial α –glucosidase inhibitor acarbose.

scholarly journals Moringa oleifera Intake during Pregnancy and Breastfeeding toward Docosahexaenoic Acid and Arachidonic Acid Levels in Breast Milk

2020 ◽  
Vol 8 (B) ◽  
pp. 757-761
Author(s):  
Karmila Sari ◽  
Saifuddin Sirajuddin ◽  
Martira Maddepungeng ◽  
Veni Hadju ◽  
Ariyanti Saleh ◽  
...  
Keyword(s):  
Arachidonic Acid ◽  
Breast Milk ◽  
Docosahexaenoic Acid ◽  
Moringa Oleifera ◽  
Food Supplement ◽  
Significance Level ◽  
Significant Difference ◽  
Low Education ◽  
The Difference ◽  
Iron Folic Acid

BACKGROUND: Moringa oleifera is a nutritional food supplement that can save lives, particularly in countries with malnourished community. Such supplement can also be provided to breastfeeding mothers so that they can produce more breast milk. AIM: This study investigated the effect of M. oleifera on pregnant and breastfeeding mothers on their breast milk’s docosahexaenoic acid (DHA) and arachidonic acid (AA) concentration. METHODS: This was a longitudinal study which was the continuity from the previous experimental study. The research sample was 64 breastfeeding mothers given Moringa leaves powder (MLP), Moringa leaves extract (MLE), or iron-folic acid (IFA). The data were analyzed using Kruskal–Wallis test with the significance level of 95% aiming to assess the difference between the breast milk’s DHA and AA level on MLP, MLE, and IFA groups. RESULTS: This research indicated that most mothers had low education level (71.9 %) and did not work (89.1%). There was no significant difference between the DHA level (p = 0.215) and AA (p = 0.914) of the breast milk among the MLP, MLE, and IFA groups. CONCLUSION: The intervention might contribute a little effect on DHA and AA level in the breast milk.

scholarly journals Antioxidant activities and simultaneous HPLC-DAD profiling of polyphenolic compounds from Moringa oleifera Lam. Leaves grown in Bangladesh

Food Research ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 401-408
Author(s):  
K.S. Ahmed ◽  
I.A. Jahan ◽  
F. Jahan ◽  
H. Hosain
Keyword(s):  
Antioxidant Activity ◽  
Moringa Oleifera ◽  
Water Extract ◽  
Ethanol Extract ◽  
Polyphenolic Compounds ◽  
Dihydroxybenzoic Acid ◽  
High Concentration ◽  
Dry Extract ◽  
Mature Leaves ◽  
Moringa Oleifera Lam

Moringa oleifera Lam. has been used as a traditional medicine for the treatment of several diseases. In this study, the antioxidant activity and simultaneous HPLC profiling of polyphenolic compounds in 80% ethanol and water extracts of M. oleifera tender and mature leaves available in Bangladesh were investigated. The 80% ethanol extract of M. oleifera tender leaves contained high concentration and more amount of 3,4- dihydroxybenzoic acid, (-) epicatechin and rosmarinic acid (201.32±1.94, 213.08±1.96 and 133.84±1.42 mg/100 g of dry extract, respectively) than that of mature leaves (82.55±1.09, 141.86±1.10 and 16.23±0.76 mg/100 g of dry extract, respectively). On the other hand, the water extract of M. oleifera tender leaves contained a high concentration of catechin hydrate, trans-ferulic acid and quercetin (530.05±1.91, 166.38±0.90 and 771.74±1.34 mg/100 g of dry extract, respectively) than that of mature leaves (207.21±0.90, 62.42±0.45 and 483.25±1.04 mg/100 g of dry extract, respectively). It was also found that 3,4-dihydroxybenzoic acid, catechol, p-coumaric acid and trans-cinnamic acid were detected only in 80% ethanol extract of M. oleifera leaves but syringic acid was identified in the water extract. In DPPH free radical scavenging activity test, IC50 values of 80% ethanol extract of tender leaves (EETL), 80% ethanol extract of mature leaves (EEML), water extract of tender leaves (WETL) and water extract of mature leaves (WEML) were found to be moderately significant (105.50±1.05, 115.00±1.14, 216.00±1.34 and 269.50±1.56 μg/mL, respectively) when compared to the IC50 value of ascorbic acid, 3.32±0.07 μg/mL. The polyphenolic compounds are responsible for antioxidant activity. On the basis of the present study, it can be suggested that the leaves show antioxidant activity and it’s contained a significant amount and different types of polyphenolic compounds. Standardized polyphenolic compounds from M. oleifera leaves could be used as a better source of natural antioxidant supplement.

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