scholarly journals Sphingolipids in ischemic stroke

2022 ◽  
Vol 17 (4) ◽  
pp. 93-100
Author(s):  
A. A. Rogozhina
Keyword(s):  
Mass Spectrometry ◽  
Ischemic Stroke ◽  
Point Of View ◽  
Important Task ◽  
Inflammatory Focus ◽  
New Biomarkers ◽  
Acute Event

Determination of new biomarkers involved in the pathogenesis of ischemic stroke is an extremely important task from the point of view of identifying possible mechanisms for preventing the occurrence of an acute event, better diagnosis, and influencing the stages of pathogenesis to reduce the inflammatory focus. Sphingolipids belong to new biomarkers of atherosclerosis, which are involved in inflammation, apoptosis, and ischemia. The widespread introduction of mass spectrometry has made it possible to study sphingolipids in more detail. This review aims to summarize the available data on the role of sphingolipids in ischemic stroke.

scholarly journals Determination of Mammalian Lignans in Biological Samples by Modified Gas Chromatography/Mass Spectrometry

2007 ◽  
Vol 90 (3) ◽  
pp. 641-646 ◽  
Author(s):  
Ajay Bommareddy ◽  
Bhanu L Arasada ◽  
Duane P Mathees ◽  
Chandradhar Dwivedi
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Gas Chromatography Mass Spectrometry ◽  
Serum Samples ◽  
Selected Ion Monitoring ◽  
Beneficial Effects ◽  
Chromatography Mass Spectrometry ◽  
Flaxseed Meal

Abstract Lignans in flaxseed have been part of the human diet for centuries. In 1955, the isolation and structure of the lignan derivative secoisolariciresinol diglucoside (SDG) was reported. The biological role of SDG and mammalian lignan metabolites enterodiol and enterolactone was initially reported 20 years later. Experimental evidences showed the beneficial effects of lignans on breast, colon, and thyroid cancer. A modified gas chromatography/mass spectrometry (GC/MS) assay was developed for lignans in serum and colon samples of rats fed flaxseed meal. The method developed for the analysis of metabolites involves extraction and derivatization of samples and quantitative analysis by selected ion monitoring using GC/MS. The levels of lignan metabolites enterodiol and enterolactone were determined to be 0.013 and 0.23 M in serum samples and 0.008 and 1.63 M in colon samples.

The Role of Fundamental Knowledge in Solving Problems of the Subject Area “Technology”(From the Point of View of the Project of the Concept of Teaching)

2018 ◽  
Vol 6 (3) ◽  
pp. 9-15
Author(s):  
С. Кутепов ◽  
S. Kutepov
Keyword(s):  
Subject Area ◽  
Economic Education ◽  
Point Of View ◽  
Technological Education ◽  
Hand Tools ◽  
Professional Self ◽  
The Subject ◽  
And Behavior

long-awaited Concept of teaching the subject area “Technology”, the project of which is analyzed in the article,defi nes the problems facing the teacher. The author illustrates these problems and the characterized directions of teaching the subject area “Technology” with the possible fragments of the content of technological education. The author shows which information should be used at the stage of the development of schoolchildren’s basic application skills of the main types of hand tools (electrical including) as a resource for solving technological problems which are the priority results of the mastering the subject area “Technology”. The article suggests the knowledge necessary for ecological education of schoolchildren, formation of their world outlook, provided that the interdisciplinary relations are established. The problems of the environmentally friendly production organically associated with the problems of modern economy allow us to solve the problem of economic education. The article proves that the subject of “Technology” is supposed to create certain patterns of thinking and behavior of schoolchildren, introduce them into the world of professions, and ensure professional self-determination of schoolchildren.

Determination of lignans and isoflavonoids in human female plasma following dietary supplementation

1994 ◽  
Vol 142 (2) ◽  
pp. 251-259 ◽  
Author(s):  
M S Morton ◽  
G Wilcox ◽  
M L Wahlqvist ◽  
K Griffiths
Keyword(s):  
Mass Spectrometry ◽  
Dietary Supplementation ◽  
Ion Exchange Chromatography ◽  
Exchange Chromatography ◽  
Gas Chromatography Mass Spectrometry ◽  
Soya Flour ◽  
Human Female ◽  
Asian Populations

Abstract Plasma levels of the lignans enterodiol and enterolactone, and also the isoflavonic phyto-oestrogens daidzein, equol and genistein, are reported for postmenopausal Australian women consuming a traditional diet supplemented with linseed, soya flour or clover sprouts. Analysis was performed by gas chromatography-mass spectrometry, after enzymatic hydrolysis and ion-exchange chromatography. Following linseed supplementation, combined levels of enterolactone and enterodiol reached 500 ng/ml, whereas after soya flour or clover sprouts the respective concentrations of equol, daidzein and genistein reached 43, 312 and 148 ng/ml. Not all subjects were able to produce equol from daidzein. The possible relationship and role of these weak dietary oestrogens as restraining factors in the development of hormone-dependent cancers in Asian populations is discussed. Journal of Endocrinology (1994) 142, 251–259

The "age" of plutonium particles

2001 ◽  
Vol 89 (1) ◽  
Author(s):  
M. Wallenius ◽  
G. Tamborini ◽  
L. Koch
Keyword(s):  
Mass Spectrometry ◽  
Nuclear Weapons ◽  
Secondary Ion Mass Spectrometry ◽  
Age Determination ◽  
Important Task ◽  
Nuclear Facilities ◽  
Ion Mass Spectrometry ◽  
Secondary Ion

Age determination of plutonium particles is a highly important task in view of the pending cut-off treaty for nuclear weapons materials. By collecting particles from the vicinity or inside the nuclear facilities and determining their ages, it is possible to monitor the observance of the cut-off agreement.In this study, the age determination of Pu particles was demonstrated by Secondary Ion Mass Spectrometry (SIMS). To determine the ionisation efficiency difference of Pu and U, standard Pu materials with known ages were analysed. Finally, the age determination of two real Pu samples was demonstrated.

scholarly journals RENOVATION OF ROOF STRUCTURE OF HISTORICAL BUILDING – CASE STUDY

2021 ◽  
Vol 6 (2) ◽  
pp. 71-81
Author(s):  
Marcela Spišáková ◽  
Daria Mokrenko
Keyword(s):  
Point Of View ◽  
Historic Buildings ◽  
Historical Buildings ◽  
Historical Building ◽  
Roof Structure ◽  
Historical Monuments ◽  
Cost Parameters

On the present, the problem of renovation of historical buildings is becoming more and more actual. The role of society is to protect and renovate the historical monuments. The presented article focuses on the problem of renovation of historic buildings from a structural, technological and cost point of view. During the solution of the case study "Renovation of roof structure of the Old Town Hall in Košice", a variant solution of the historic roof renovation was designed in accordance with the principles of historical buildings renovation. Subsequently, the evaluation of the technological and cost parameters for renovation; and determination of the optimal variant for renovation of the historical roof was processed through the methods of multicriterial analysis.

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