scholarly journals Optimization of maltodextrin and carrageenan gum concentration added in spray drying process of Pouzolzia zeylanica extract by response surface methodology

2018 ◽  
Vol 17 (03) ◽  
pp. 77-85
Author(s):  
Tan D. Nguyen
Keyword(s):  
Particle Size ◽  
Response Surface Methodology ◽  
Moisture Content ◽  
Response Surface ◽  
Spray Drying ◽  
Bioactive Compounds ◽  
Mekong Delta ◽  
Physicochemical Characteristics ◽  
Central Composite ◽  
Spray Dried

Pouzolzia zeylanica is a kind of medicinal plant which is generally cultivated in Mekong Delta region. It owns many bioactive compounds that are known to possess antioxidant, antimicrobial and anticarcinogenic properties. This study aimed to optimize additional carrier concentration for spray drying of Pouzolzia zeylanica extract. Response Surface Methodology (RSM) with central composite design (CCD) was applied for optimization and investigation of the influence of maltodextrin (5÷15%, w/v) and carrageenan gum (0.06÷1.0%, w/v) concentration on the physicochemical characteristics of spray dried powder (bioactive compounds, moisture content as well as particle size distribution). The results showed that the optimum concentrations of maltodextrin and carrageenan gum were 8.8% w/v and 0.082% w/v, respectively. At these optimal conditions, the anthocyanin, flavonoid, polyphenol, tannin, moisture content and particle size of obtained spray dried powder were 5.77 mg cyanidin-3-glycoside equivalents (CE)/100 g; 29.49 mg quercetin equivalents (QE)/g; 28.35mg gallic acid equivalents (GAE)/g; 27.44 mg tannic acid equivalents (TAE)/g, 6.55% and 6.09 μm, respectively

Effects Of Variables On The Production Of Red-Fleshed Pitaya Powder Using Response Surface Methodology

2011 ◽  
pp. 15-29
Author(s):  
Mohd Azizi Che Yunus ◽  
Ching Yaw Lee ◽  
Zuhaili Idham
Keyword(s):  
Response Surface Methodology ◽  
Moisture Content ◽  
Bulk Density ◽  
Response Surface ◽  
Spray Drying ◽  
Air Temperature ◽  
Flow Rate ◽  
Feed Flow Rate ◽  
Drying Conditions ◽  
Central Composite

Teknik reka bentuk komposit pusat dalam kaedah gerak balas permukaan (RSM), telah dipilih untuk memeriksa pengaruh parameter-parameter pengeringan sembur terhadap kandungan lembapan dan ketumpatan pukal serbuk buah naga. Pemboleh ubah-pemboleh ubah tak bersandar dengan julat seperti yang disebutkan telah diuji kaji: suhu masukan (156-224°C), kadar aliran suapan (16.6-33.4 ml/min) dan kepekatan maltodextrin (31.6-48.4%). Keputusan menunjukkan bahawa data eksperimen dapat diwakili oleh bentuk polinomial tertib kedua. Bagaimanapun, hanya istilah linear mempunyai pengaruh mutlak terhadap keadaan serbuk. Parameter-parameter terbaik untuk mencapai nilai kandungan lembapan terendah adalah suhu masukan 224°C, kadar aliran suapan 22.9 ml/min dan kepekatan maltodextrin 40%, dengan jangkaan 3.88% kandungan lembapan. Nilai ketumpatan pukal yang maksimum iaitu 0.45 g/ml dicapai pada suhu masukan 156°C, kadar aliran suapan 16.6 ml/min dan kepekatan maltodextrin 48.4%. Kata kunci: Kaedah gerak balas permukaan; sembur kering; buah naga Central Composite Design technique from Response Surface Methodology (RSM) was used to investigate the effects of spray drying conditions on red-fleshed pitaya powder moisture content and bulk density. The spray drying independent variables and ranges are inlet air temperature (156-224°C), feed flow rate (16.6-33.4 ml/min) and maltodextrin concentration (31.6-48.4 %). Results showed that the data were adequately fitted to second order polynomial model. However, only linear terms proved to be significant for powder attributes. The best spray drying conditions within the experimental ranges for minimum powder moisture content of 3.88% would be inlet air temperature, feed flow rate and maltodextrin concentration of 224°C, 22.9 ml/min and 40% respectively. The maximum powder bulk density of 0.45 g/ml was obtained at inlet air temperature of 156°C, 16.6 ml/min feed flow rate and 48.4% maltodextrin concentration. Key words: Response surface methodology; spray-drying; red-fleshed pitaya

Effect of Formulations and Spray Drying Process Conditions on Physical Properties of Resveratrol Spray-Dried Emulsions

2019 ◽  
Vol 819 ◽  
pp. 246-251
Author(s):  
Pontip Benjasirimongkol ◽  
Suchada Piriyaprasarth ◽  
Pornsak Sriamornsak
Keyword(s):  
Particle Size ◽  
Moisture Content ◽  
Physical Properties ◽  
Spray Drying ◽  
Feed Rate ◽  
Water Soluble ◽  
Process Conditions ◽  
Box Behnken Design ◽  
Drying Conditions ◽  
Spray Dried

Spray-dried emulsion is one of the useful strategies to enhance dissolution properties of poorly water-soluble drug for example resveratrol. Physical properties i.e. particle size and moisture content of spray-dried emulsions could affect their quality attributes. In this study, Box-Behnken design was performed in order to determine effect of formulation and spray drying condition parameters i.e. feed rate on responses including particle size and moisture content of resveratrol spray-dried emulsions. The spray-dried emulsions were prepared by varying content of low-methoxyl pectin (LMP) and caprylic/capric glycerides (CCG) and sprayed at different feed rate. Box-Behnken design results reveled that the particle size of spray-dried emulsions was significantly influenced by the content of LMP, interactions between LMP and CCG, interactions between LMP and feed rate. LMP content showed positive relationships with the particle size. The content of CCG had negative significantly effect on moisture content of the spray-dried emulsion. Mathematical models describing the relationships between studied parameters and responses provided good predictability. Based on model, the optimal formulation was prepared using 2.6% w/w of LMP, 9% w/w of CCG, and feed rate of 6.8 mL/min and the small particle size (~5.9 μm) and low moisture content (~5.6%) were obtained. The spray-dried emulsions were successfully prepared with satisfy quality. The Box-Behnken design would be an effective tool to elucidate influence of formulation and spray drying conditions on particle size and moisture content of the spray-dried emulsions. Further, the design aided in developing and optimizing the spray-dried emulsions with specified quality.

Application of the central composite design to optimize the calcium carbonate-HPMC co-processed excipient prepared by co-spray drying

RSC Advances ◽  
2015 ◽  
Vol 5 (114) ◽  
pp. 94105-94114 ◽  
Author(s):  
JinZhi Li ◽  
Xiao Lin ◽  
Fei Wu ◽  
Lan Shen ◽  
YouJie Wang ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Calcium Carbonate ◽  
Central Composite Design ◽  
Response Surface ◽  
Spray Drying ◽  
Central Composite

The central composite design-response surface methodology provided theoretical guidance for development of co-processed excipients based on calcium carbonate and HPMC.

scholarly journals Effect of shelling speed, moisture content and number of beaters on the cleaning and recovery efficiency of a mechanized centrifugal Melon shelling machine

2021 ◽  
Vol 10 (3) ◽  
pp. 239-245
Author(s):  
Oluwabukola Belinda Aturu ◽  
Joshua Olanrewaju Olaoye ◽  
Agidi Gbabo ◽  
Ibrahim Mohammed Gana ◽  
Ndudi Efomah Andrew ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Moisture Content ◽  
Response Surface ◽  
Numerical Optimization ◽  
Recovery Efficiency ◽  
Central Composite Rotatable Design ◽  
Seed Moisture Content ◽  
Seed Moisture ◽  
Cleaning Machine ◽  
Central Composite

A response surface methodology (RSM) has been utilized for investigating the effects of the speed of shelling, melon seed moisture content and the number of beaters of a developed mechanized centrifugal melon shelling and cleaning machine. The machine shells the melon and then cleans the shelled seed from the shells and other impurities. The experiment was based on a central composite rotatable design (CCRD). The results of the experiments revealed that the highest shelling efficiency of 88.5% was obtained from a combination of a speed of 2300 rpm, moisture content of 15% (w.b) and 20 beaters, while the least efficiency of 25.11% was obtained from an interaction between a speed of 959 rpm, moisture content of 20% (w.b) and 18 beaters. Numerical optimization carried out with the goal of maximizing the shelling efficiency revealed optimum values of speed of 2200 rpm, moisture content of 12% (w.b) and 19 beaters for shelling efficiency of 88.80%. The result of this study provided standard input parameters capable of yielding high cleaning and recovery efficiency.

scholarly journals Optimization of the encapsulation of the mixture made from flesh and peel pitaya extract by spray drying

2021 ◽  
Vol 13 (3) ◽  
pp. 58-65
Author(s):  
Thi Ngoc Diep Duong ◽  
Quang Binh Hoang ◽  
Le Hanh Trang Do
Keyword(s):  
Response Surface Methodology ◽  
Spray Drying ◽  
Regression Models ◽  
Water Solubility ◽  
Total Phenolic ◽  
Optimal Conditions ◽  
Air Drying ◽  
Drying Temperature ◽  
Central Composite ◽  
Spray Dried

In this study, the optimal conditions for spray drying of the extract made from flesh and peel of red pitaya were tested using the central composite design (CCD). The response surface methodology was used to evaluate the effect of inlet air drying temperature (145 – 155°C) and concentration of maltodextrin (13-17% w/w) on the physicochemical properties of the powder. The regression models accurately predicted the retention of betacyanin (R2=0.94) and total phenolic (R2=0.95). The optimal conditions for spray drying were determined as inlet air drying temperature at 148  and 14.62% maltodextrin. Under these conditions, the spray-dried powder achieved retention of betacyanin of 68.04% and retention of total phenolic of 84.17%. The optimized sample achieved a moisture content of 4.41%, the water activity of 0.39, and the water solubility index of 97.41%.

scholarly journals Optimizing the Processing Factor and Formulation of Oat-Based Cookie Dough for Enhancement in Stickiness and Moisture Content Using Response Surface Methodology and Superimposition

Processes ◽  
2020 ◽  
Vol 8 (7) ◽  
pp. 797
Author(s):  
Mohd Salahuddin Mohd Basri ◽  
Nurain Mohd Jais ◽  
Alifdalino Sulaiman ◽  
Mohd Zuhair Mohd Nor ◽  
Nor Nadiah Abdul Karim Shah ◽  
...  
Keyword(s):  
Response Surface Methodology ◽  
Moisture Content ◽  
Response Surface ◽  
Processing Factor ◽  
Resting Time ◽  
Two Factors ◽  
Confectionery Products ◽  
Contour Plots ◽  
Predicted Model ◽  
Central Composite

Despite the utilization of dusting flour and oil to reduce dough stickiness during the production process in food industry, they do not effectively help in eliminating the problem. Stickiness remains the bane of the production of bakery and confectionery products, including cookies. In addition, the high moisture content of cookie dough is unduly important to obtain a high breaking and compression strengths (cookies with high breaking tolerance). This study was conducted in light of insufficient research hitherto undertaken on the utilization of response surface methodology and superimposition to enhance the stickiness and moisture content of quick oat-based cookie dough. The study aims at optimizating, validating and superimposing the best combination of factors, to produce the lowest stickiness and highest moisture content in cookie dough. In addition, the effect of flour content and resting time on the stickiness and moisture content of cookie dough was also investigated, and microstructure analysis conducted. The central composite design (CCD) technique was employed and 39 runs were generated by CCD based on two factors with five levels, which comprised flour content (50, 55, 60, 65, and 70%), resting time (10, 20, 30, 40, and 50 min) and three replications. Results from ANOVA showed that all factors were statistically significant at p < 0.05. Flour content between 56% and 62%, and resting time within 27 and 50 min, resulted in dough with high stickiness. High-region moisture content was observed for flour content between 60% and 70%, and within 10 and 15 min of resting time. The optimized values for flour content (V1) = 67% and resting time (V2) = 10 min. The predicted model (regression coefficient model) was found to be accurate in predicting the optimum value of factors. The experimental validation showed the average relative deviation for stickiness and moisture content was 8.54% and 1.44%, respectively. The superimposition of the contour plots was successfully developed to identify the optimum region for the lowest stickiness and highest moisture content which were at 67–70% flour content and 10–15 min resting time.

scholarly journals APPLICATION OF CENTRAL COMPOSITE DESIGN AND RESPONSE SURFACE METHODOLOGY FOR OPTIMIZATION OF METAL ORGANIC FRAMEWORK: NOVEL CARRIER FOR DRUG DELIVERY

2019 ◽  
pp. 121-127
Author(s):  
PREETI KUSH ◽  
JITENDER MADAN ◽  
PARVEEN KUMAR
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Response Surface Methodology ◽  
Central Composite Design ◽  
Response Surface ◽  
Surface Area ◽  
Metal Organic Framework ◽  
High Yield ◽  
Metal Organic ◽  
Central Composite

Objective: The aim of the present study is to optimize the synthesis method of metal-organic framework (MOF) for high yield and larger surface area with minimum size for efficient drug loading. Materials and Methods: Materials of Institute Lavoisier (MIL)-101-NH2 was synthesized by microwave-assisted hydrothermal method. Central composite design (CCD) under response surface methodology (RSM) was used for optimization. Process optimization was done by validating the model to obtain maximum surface area, maximum yield, and minimum particle size. Final obtained formulation was characterized by particle size and zeta potential, scanning electron microscopy, powder X-ray diffraction, Fourier-transform infrared spectroscopy, Brunauer–Emmett–Teller, and thermogravimetric analysis. Furthermore, gemcitabine (GEM) was used as a model drug for encapsulation in these MOFs for drug delivery carriers. Results: The results revealed that MIL-101-NH2 of average size-158 nm with high yield (70%) and high surface area (2347 m2/g) could be produced easily and reproducibly at a selected condition. This enhances the drug delivery application of the valuable MIL-101-NH2. Optimized values for these parameters were 170°C, 5.00, and 1:1:400 for temperature, pH, and reactant ratio, respectively. MIL-101-NH2 appeared as a promising carrier for GEM delivery with higher encapsulation (77.7±2%) and loading (22.6±2%). Conclusion: The results conclude that processing parameters such as temperature pH and reactant concentration obtained from CCD-RSM significantly affect the main constraints, i.e., surface area, particle size, and yield. The faster encapsulation of GEM in MOF makes them a promising carrier for drug delivery application.

Enzyme-assisted Extraction for Optimized Recovery of Phenolic Bioactives from Peganum hermala Leaves Using Response Surface Methodology

2018 ◽  
Vol 17 (4) ◽  
pp. 349-354
Author(s):  
Qadir Rahman ◽  
Anwar Farooq ◽  
Amjad Gilani Mazhar ◽  
Nadeem Yaqoob Muhammad ◽  
Ahmad Mukhtar
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Enzyme Concentration ◽  
Coumaric Acid ◽  
Assisted Extraction ◽  
Pre Treatment ◽  
Optimized Conditions ◽  
Enzyme Complexes ◽  
Hydrolysis Of ◽  
Central Composite

This study investigates the effect of enzyme formulations (Zympex-014, Kemzyme dry-plus and Natuzyme) on recovery of phenolics from Peganum hermala (harmal) leaves, under optimized conditions using response surface methodology. As compared to the other enzyme complexes, the yield (34 g/100g) obtained through Zympex-014-assisted extraction was higher under optimized conditions such as time (75 min), temperature (70°C), pH (6.5) and enzyme concentration (5 g/100 g) using central composite design (CCD). Effectiveness of Zympex-014 towards hydrolysis of P. hermala leaves cell wall was examined by analyzing the control and enzyme-treated leave residues using scanning electron microscope (SEM). GC/MS characterization authenticated the presence of quercetin (1.44), gallic acid (0.23), caffeic acid (0.04), cinnamic acid (0.05), m-coumaric acid (0.23) and p-coumaric acid (0.37 μg/g) as the potent phenolics in Zympex-014 based extract. It can be concluded from the findings of the current work that pre-treatment of P. hermala leaves with Zympex-014 significantly enhanced the recovery of phenolics that supports its potential uses in the nutra-pharamaceutical industry.

Response Surface Methodology towards Optimization of Calotropis Procera Essential oil Extraction by using Supercritical CO2.

2019 ◽  
Vol 09 ◽  
Author(s):  
Hossein Zaeri ◽  
Bahareh Kamyab Moghadas ◽  
Bijan Honarvar ◽  
Ali Shokuhi Rad
Keyword(s):  
Response Surface Methodology ◽  
Essential Oil ◽  
Response Surface ◽  
Extraction Time ◽  
Calotropis Procera ◽  
Retrieval Rate ◽  
The Family ◽  
Effects Of Temperature ◽  
Carbon Dioxide Co2 ◽  
Central Composite

: In this research, the extraction of essential oil from Calotropis Procera with the family name of Asclepiadaceae, by supercritical carbon dioxide (CO2) solvent has been investigated in detail, and the yield and chemical profile of the extracts achieved by this method were compared with those resulted by the conventional Hydro distillation method. To optimize the process parameters of CO2 supercritical extraction (SCE) of the Calotropis Procera, the Response Surface Methodology (RSM) with central composite design (CCD) was employed. The effects of temperature, pressure, and extraction time on the oil yield are considered for investigation. Results showed that the data were sufficiently fitted into the second-order polynomial model. The extraction conditions, including pressure, temperature, and extraction time, were studied between 150-200 bar, 40-50 ºC, and 50-100 min, respectively. The optimal conditions are achieved as the temperature of 47.19ºC, the pressure of 172.2 bar, and time of 86 minutes with the retrieval rate of 31.39%.

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