ADDRESSING COVID-19 IN KAZAKHSTAN: WHAT ARE THE EFFORTS AND CHALLENGES?

Vestnik ◽  
2021 ◽  
pp. 289-292
Author(s):  
Л.Ж. Алекешева ◽  
К.К. Тогузбаева ◽  
К.О. Джусупов

COVID-19 нанес серьезный удар по системам здравоохранения многих стран мира, включая Республику Казахстан. Чтобы справиться с пандемией, Казахстан разработал план, содержащий три стратегические цели: 1) предотвращение вспышки болезни; 2) Обеспечение оптимального ухода для всех пациентов и 3) Сведение к минимуму воздействия пандемии на системы здравоохранения, социальные услуги и экономическую деятельность. Однако неравномерное распределение финансовых ресурсов по регионам, нерегулярное потребление медицинских услуг и различия в показателях здоровья препятствуют этим усилиям. Другие проблемы - это нехватка медицинских сил, неожиданность ситуации, отсутствие знаний о коронавирусной инфекции и бессилие перед этой новой болезнью. Были трудности с массовым тестированием, поскольку стигма и страх перед карантином вынуждали людей не проходить тестирование. После отмены чрезвычайного положения и строгой изоляции страну охватила эйфория, которая привела к резкому увеличению числа случаев заболевания. Чтобы взять ситуацию под контроль в июне 2020 года был экстренно введен второй локдаун, постепенно стало уменьшаться количество больных и инфицированных. Пандемия показала, насколько хрупка и зависима система: была отложена плановая вакцинация детям до 1 года, временно приостановлено медицинское обследование и оказание медицинских услуг больным хроническими, онкологическими заболеваниями, плановая госпитализация. Многие врачи и медсестры заразились и заболели. На момент написания этой статьи эпидемиологическая ситуация в стране с COVID-19 находится под контролем и надзором, однако давать какие-либо прогнозы относительно его завершения пока рано. Казахстан готовится к вакцинации от коронавирусной инфекции, в первую очередь вакцинации должны подвергаться группы риска, медицинские и социальные работники, а также люди с хроническими заболеваниями. Пока коллективный иммунитет не сформирован, казахстанцы должны проявлять осторожность при снятии ограничений, чтобы предотвратить взрыв новых случаев заболевания. COVID-19 has strained the healthcare systems of many countries worldwide including the Republic of Kazakhstan. To cope with the pandemic, Kazakhstan mounted a plan containing three strategic objectives: 1) Preventing the outbreak of the disease; 2) Ensuring optimal care for all patients, and 3) Minimizing the impact of the pandemic on health systems, social services, and economic activities. However, the uneven distribution of financial resources across regions, irregular consumption of medical services, and inconsistent health indicators hamper these efforts. Other issues are the lack of medical forces, the unexpectedness of the situation, lack of knowledge on coronavirus infection, and powerlessness in front of this new disease. There were difficulties in mass testing as stigma and fear from quarantine forced people not to get tested. The euphoria enveloped the country after abolishing the emergency state after an intense lockdown which resulted in increased cases. A second lockdown was urgently introduced in June 2020 to take control of the situation. The number of patients and those infected gradually began to decline. The pandemic showed the fragility and inter-dependence of the health system- planned vaccinations against many infectious diseases were postponed. Medical examination and provision of medical services to patients with chronic, oncological diseases, planned hospitalization were temporarily halted. Many doctors and nurses became infected and ill. The country's COVID-19 epidemiological situation is somewhat under the control and supervision as of this writing. However, to give any forecasts for its completion is still too early. Kazakhstan is preparing to vaccinate against coronavirus infection. First of all, risk groups, medical and social workers, and people with chronic diseases should be subject to vaccination. Until herd immunity is not formed, Kazakhstanis must keep caution when the restrictions are taken off to prevent an explosion of new disease cases.

Author(s):  
Satish Sankaran ◽  
Jyoti Bajpai Dikshit ◽  
Chandra Prakash SV ◽  
SE Mallikarjuna ◽  
SP Somashekhar ◽  
...  

AbstractCanAssist Breast (CAB) has thus far been validated on a retrospective cohort of 1123 patients who are mostly Indians. Distant metastasis–free survival (DMFS) of more than 95% was observed with significant separation (P < 0.0001) between low-risk and high-risk groups. In this study, we demonstrate the usefulness of CAB in guiding physicians to assess risk of cancer recurrence and to make informed treatment decisions for patients. Of more than 500 patients who have undergone CAB test, detailed analysis of 455 patients who were treated based on CAB-based risk predictions by more than 140 doctors across India is presented here. Majority of patients tested had node negative, T2, and grade 2 disease. Age and luminal subtypes did not affect the performance of CAB. On comparison with Adjuvant! Online (AOL), CAB categorized twice the number of patients into low risk indicating potential of overtreatment by AOL-based risk categorization. We assessed the impact of CAB testing on treatment decisions for 254 patients and observed that 92% low-risk patients were not given chemotherapy. Overall, we observed that 88% patients were either given or not given chemotherapy based on whether they were stratified as high risk or low risk for distant recurrence respectively. Based on these results, we conclude that CAB has been accepted by physicians to make treatment planning and provides a cost-effective alternative to other similar multigene prognostic tests currently available.


2021 ◽  
pp. 14-20
Author(s):  
Б.Н. БИЩЕКОВА ◽  
Ж.С. БЕГНИЯЗОВА ◽  
Н.Ж. ДЖАРДЕМАЛИЕВА ◽  
А.М. МУХАМЕДОВА ◽  
Ф.А. АРИФОВА ◽  
...  

Статья посвящена одной из актуальных проблем современного акушерства на сегодняшний день. Проведен анализ публикаций, посвященных особенностям течения новой коронавирусной инфекции во время беременности, родов и послеродового периода. Коронавирусная болезнь - это новое заболевание, характеризующееся быстрым прогрессированием и увеличением числа зараженных и смертей с момента его идентификации в Китае в декабре 2019 года. Данное заболевание вызвано новым, неизвестным ранее коронавирусом SARSCoV-2, который впервые был зафиксирован в Китае, когда появились случаи пневмонии неизвестной этиологии. С тех пор новой инфекции был подвержен весь мир. Среди групп риска на заражение COVID-19 особое место занимают беременные женщины. Известно, что сама по себе беременность, хоть и является физиологическим состоянием, сопровождается изменениями ряда органов и систем, в том числе и иммунной. В силу этого восприимчивость к ряду инфекций во время беременности значительно возрастает. Конечно, могут быть ограничения в связи с коронавирусной инфекцией. Но при правильной организации режима отдыха, физических нагрузок и образа жизни (социальном дистанцировании и соблюдении методов гигиены и защиты) можно преодолеть эти трудности. The article is devoted to one of the urgent problems of modern obstetrics today. The goal is to review the current data on the characteristics of the course of the new coronavirus infection during pregnancy, childbirth and the postpartum period. Coronavirus disease is a new disease characterized by rapid progression and an increase in the number of infections and deaths since its identification in China in December 2019. This disease is caused by a new, previously unknown coronavirus SARSCoV-2, which was first recorded in China, when cases of pneumonia of unknown etiology appeared. Since then, the whole world has been exposed to the new infection. Pregnant women occupy a special place among the risk groups for COVID-19 infection. It is known that pregnancy itself, although it is a physiological state, is accompanied by changes in a number of organs and systems, including the immune system. Because of this, the susceptibility to a number of infections during pregnancy increases significantly. Of course, there may be restrictions due to coronavirus infection. But with the correct organization of the rest regime, physical activity and lifestyle (social distancing and adherence to hygiene and protection methods), these difficulties can be overcome.


Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 2807-2807 ◽  
Author(s):  
Marie Sebert ◽  
Valérie Vidal ◽  
Virginie Eclache ◽  
Sylvain Thepot ◽  
Thorsten Braun ◽  
...  

Abstract Abstract 2807 Background: hypomethylating agents, especially AZA, have become the reference treatment of higher risk MDS, but the prognostic value of baseline cytogenetics on response to AZA, and the impact of cytogenetic response (CyR) on outcome in responders remain uncertain. Methods: Between Jan 2005 and Nov 2011, we treated at our center155 consecutive MDS patients (pts), including FAB RAEB-T / WHO AML with 20–30% blasts, with AZA (75 mg/m2/d x7 d every 4 weeks, for a median of 6 cycles). Karyotype at onset of AZA was evaluable in 143 pts, and abnormal in 95 (66%) pts. Median age was 74 years and IPSS high: 51, int2: 58, int 1: 14, NA: 20. 65 (42%) pts achieved hematological IWG 2006 response, including 28 (18%) CR, 8 (5%) PR, 13 (8%) Marrow CR, 16 (10%) stable with HI. With a median follow up of 28 months, median OS was 16 months. Results: Of the 95 pts with abnormal karyotype, 47 had −7/del(7q) including 9 isolated −7/del (7q), 37 had del(5q)/-5 including only 3 isolated del(5q)/-5,26 had +8 including 9 isolated +8, 9 had abnormalities leading to del (17p)(6 of them had complex karyotype), 16 had del (20q)and 44 had complex karyotype (>= 3 abnormalities). Response and OS according to cytogenetics are summarized in table 1. None of the cytogenetic abnormalities studied (complex, normal, del20q, 17p, del5q/-5,7/del (7q) or +8) had a significant impact on response to AZA. Presence of del (17p) (median 7 vs 18 mo, p= 0.0001), del5q/-5 (12.5 vs 20 mo, p= 0.0008), −7/del (7q) (9.7 vs 20 mo, p=0.02) or complex karyotype (12 v 20 mo, p=0.002) was associated with significantly shorter OS. Among pts with complex karyotype, there was a trend for shorter OS for pts when 17p abn (median 6.7 vs 12.5 mo, p=0.12) del (5q)/-5 (9 v 21 mo, p=0.16) or −7/del (7q) (7 v 17 mo, p=0.06) abnormality was part of the complex karyotype. By contrast, isolated −7/del (7q) (21 vs 16 mo, p=0.3) and +8 (all+8:20 vs 14 mo, p=0.48; isolated +8:23 vs 16 mo, p=0.92) had no significant impact on OS. According to IPSS cytogenetic risk, response rates and CR rates were similar across the 3 groups, but OS was significantly longer in the good risk category (p=0.04) (table 1). Cytogenetics could be reclassified using new IPSS-R cytogenetic groups in 138 pts (Shanz, JCO, 2011) in 1 very good, 52 (38%) good, 24 (17%) int, 30 (22%) poor and 31 (23%) very poor. According to this IPSS-R cytogenetic classification, response rates and CR rates were similar across the 4 main groups. Median OS was 20.6 mo, 23 mo, 14 mo and 12 mo in the good, int, poor and very poor risk groups respectively (p= 0.037). 66 of the pts with baseline cytogenetic abnormalities had cytogenetic analysis at treatment evaluation, after 4 to 6 cycles of AZA, of whom 32 had achieved hematological response. In those 32 pts, 34% achieved complete CyR(CCyR), none partial CyR, 37% had stable cytogenetics (and the remaining pts had cytogenetic failure). In those 32 pts, achievement of CCyR had no significant impact on OS (p=0.36) but the number of pts was relatively small. In a landmark analysis performed at D100 in pts with baseline cytogenetic abn, achieving CCyR was not associated with an OS advantage compared to stable cytogenetics (median 22 vs 17 mo, p=0.82). Of note, only 1 patient with baseline cytogenetic abn (+8) who did not achieve hematological response achieved CCyR, of 6 months duration, before disease progression. Conclusion: Baseline cytogenetic findings were strong predictors of survival in patients with MDS treated with AZA, while impact on response was limited. In hematological responders with baseline cytogenetic abnormalities, achieving cytogenetic response was not was associated with an OS advantage, butthe number of patients analyzed may have been insufficient to conclude. Disclosures: Gardin: celgene: Honoraria. Fenaux:Amgen: Honoraria, Research Funding; Celgene: Honoraria, Research Funding; Janssen: Honoraria, Research Funding; Roche: Honoraria, Research Funding; GSK: Honoraria, Research Funding; Novartis: Honoraria, Research Funding.


Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Joel N Briard ◽  
Rahel T Zewude ◽  
Mahesh Kate ◽  
Ken Butcher ◽  
Laura C Gioia

Introduction: The impact of prehospital triage of stroke mimics to designated stroke centers may be considerable, yet little information exists regarding stroke mimics in the prehospital setting. We aimed to describe the rate and clinical characteristics of neurological and non-neurological stroke mimics transported by Emergency Medical Services (EMS) to the Emergency Department (ED) for acute stroke evaluation. Methods: A retrospective, cross-sectional, observational analysis of a centralized EMS database of patients transported by EMS to the ED for suspected stroke during an 18-month period. Hospital charts and neuroimaging were utilized to determine the final diagnosis (acute stroke, stroke mimic, as well as specific underlying diagnoses). Results: A total of 960 patients were transported by EMS to the ED with suspected stroke, among whom 405 (42.2%) were stroke mimics (mean age ± SD: 66.9 ± 17.1 years; 54% male). Stroke mimics were neurological in origin in 223 (55.1%) patients and non-neurological in 182 (44.9%). Most common neurological diagnoses were seizures (n=44,19.7%), migraines (n=42,18.8%) and peripheral neuropathies (n=25, 11.2%). Most common non-neurological mimics included cardiovascular (15.9%), psychiatric (11.9%), and infectious (8.9%) diagnoses. Neurological mimics were younger (64.1 ± 17.3 years) than non-neurological mimics (70.5 ± 16.1 years, p<0.001). Median prehospital Glasgow Coma Scale scores were similar between groups (15 vs. 15, p=0.26). Mean prehospital systolic blood pressure was slightly higher in neurological (147.8±24.2 mmHg) than non-neurological mimics (141.2±26.2 mmHg, p=0.01). Conclusions: Stroke mimics represent a substantial number of patients transported by EMS for suspected stroke, with a considerable amount being non-neurological in origin. Prospective prehospital studies are warranted to help refine prehospital identification of acute stroke and thus minimize the number of stroke mimics transported by EMS for acute stroke evaluation.


2021 ◽  
Vol 11 (1) ◽  
pp. 94
Author(s):  
Jiyoung Kim ◽  
Choongrak Kim ◽  
Song Yi Park

The purpose of this retrospective observational study was to identify the impact of COVID-19 on emergency medical services (EMS) processing times and transfers to the emergency department (ED) among patients with acute stroke symptoms before and during the COVID-19 pandemic in Busan, South Korea. The total number of patients using EMS for acute stroke symptoms decreased by 8.2% from 1570 in the pre-COVID-19 period to 1441 during the COVID-19 period. The median (interquartile range) EMS processing time was 29.0 (23–37) min in the pre-COVID-19 period and 33.0 (25–41) minutes in the COVID-19 period (p < 0.001). There was a significant decrease in the number of patients transferred to an ED with a comprehensive stroke center (CSC) (6.37%, p < 0.001) and an increase in the number of patients transferred to two EDs nearby (2.77%, p = 0.018; 3.22%, p < 0.001). During the COVID-19 pandemic, EMS processing time increased. The number of patients transferred to ED with CSC was significantly reduced and dispersed. COVID-19 appears to have affected the stroke chain of survival by hindering entry into EDs with stroke centers, the gateway for acute stroke patients.


2020 ◽  
pp. 226-233
Author(s):  
Zh.T. Alpysbayeva ◽  

The author presents the results of a comprehensive assessment of working conditions and functional systems of the body of workers in the conditions of by-product coke production. Harmful factors of the working environment negatively impacting on the health indicators of workers, which is reflected in the high values of morbidity with temporary disability. Quantitative criteria for identifying risk groups and disability were determined depending on the professional group, work experience, gender and age. To calculate the risk range, the method of rationing of intensive indicators was used, which makes it possible to assess the effect of production on the morbidity of workers, as well as to use the results obtained for a comprehensive integral assessment of the likelihood of the risk of disability in the studied professional groups. Ranges of risk have been obtained, which will help to identify "risk groups" among workers requiring examination and preventive measures. Equations of multiple regressions for complex integral risk assessment are obtained, risk forecast for the studied professional groups is calculated. The developed mathematical model and equations of multiple regressions make it possible to calculate the stress levels of the functional systems of the body, to quickly assess the performance of a person both at the time of examination and in production conditions. The proposed method for assessing the impact of working conditions on health indicators can be used at mining enterprises when certifying workplaces and assessing working conditions. The developed methodological recommendations are used in the educational process to improve the quality of scientific research, to analyze the results obtained, as well as in production to simplify the procedure for assessing the impact of harmful production factors on workers and the scientific organization of labor.


2021 ◽  
Vol 9 ◽  
Author(s):  
Magdalena Tuczyńska ◽  
Maja Matthews-Kozanecka ◽  
Ewa Baum

Background: COVID-19 pandemic caused by SARS-CoV2 has seriously impacted the global economy. Medical facilities around the world were not prepared for the enormous challenges posed by the growing number of patients each day, the shortage of personal protective equipment, and insufficient numbers of medical staff. Governments have tried to counteract the impact of the pandemic, but the measures taken have not always been sufficient to maintain access to and quality of health services at the same level as before the pandemic. The disruption of health services has resulted in more and more research reports from different parts of the world on the accessibility of health services during the COVID-19 pandemic.Methodology: This review article presents 21 selected scientific studies on access to health services in different regions of the world. Articles were found in PubMed, GoogleScholar, Medline, and ScienceDirect databases, then grouped, and significant data were extracted from each article. The results were summarized in a table.Results: The range of limited health services included a variety of specialties, including primary care, psychiatry, orthopedics, cardiology, neurosurgery, and more. Methods used in the studies were based on retrospective analysis or on the subjective assessment of patients in the form of a questionnaire or interview. Most authors claimed a decrease in accessibility to health services during the COVID-19 pandemic compared to the pre-pandemic period, including a decrease in planned surgeries, doctor appointments, patient admission to hospital or ER, and access to medicines. Additionally, some authors observed an increase in the mortality rate. One of the few medical services that have expanded rapidly during the pandemic was online appointments.Conclusions: The COVID-19 pandemic has most certainly affected the accessibility of health services worldwide. Lessons should be learned to prevent inaccessibility to medical services, especially as experts predict another wave of COVID-19 cases.


Author(s):  
Xinhua Yu

AbstractBackgroundProactive interventions have halted the pandemic of coronavirus infected disease in some regions. However, without reaching herd immunity, the return of epidemic is possible. We investigate the impact of population structure, case importation, asymptomatic cases, and the number of contacts on a possible second wave of epidemic through mathematical modelling.MethodsWe built a modified Susceptible-exposed-Infectious-Removed (SEIR) model with parameters mirroring those of the COVID-19 pandemic and reported simulated characteristics of epidemics for incidence, hospitalizations and deaths under different scenarios.ResultsA larger percent of old people leads to higher number of hospitalizations, while a large percent of prior infection will effectively curb the epidemic. The number of imported cases and the speed of importation have small impact on the epidemic progression. However, a higher percent of asymptomatic cases slows the epidemic down and reduces the number of hospitalizations and deaths at the epidemic peak. Finally, reducing the number of contacts among young people alone has moderate effects on themselves, but little effects on the old population. However, reducing the number of contacts among old people alone can mitigate the epidemic significantly in both groups, even though young people remain active within themselves.ConclusionReducing the number of contacts among high risk populations alone can mitigate the burden of epidemic in the whole society. Interventions targeting high risk groups may be more effective in containing or mitigating the epidemic.


2021 ◽  
Vol 12 ◽  
Author(s):  
Samy Hakroush ◽  
Désirée Tampe ◽  
Peter Korsten ◽  
Björn Tampe

BackgroundThe coronavirus disease-2019 (COVID-19) pandemic impacted healthcare services for kidney disease patients. Lockdown and social distancing were mandated worldwide, resulting in closure of medical services. The diagnosis of various kidney diseases may have been delayed during the COVID-19 pandemic because non-urgent tests and visits were postponed due to closure of medical services during the lockdown.MethodsWe here report the impact of the COVID-19 pandemic on a total number of 209 native kidney diseases requiring renal biopsy for diagnosis in a retrospective observational study from a tertiary hospital in Germany.ResultsThe lockdown period in March and April 2020 primarily affected patients admitted to the normal medical ward with a compensatory increased rate of renal biopsies in the postlockdown phase. In addition, there was a shift toward more patients admitted with hemoglobinuria during the COVID-19 pandemic. This phenomenon of an increased number of patients with hemoglobinuria during the COVID-19 pandemic was specifically observed in a subgroup with hypertensive nephropathy requiring renal biopsy and associated with increased proteinuria, not attributed to the COVID-19 lockdown period itself.ConclusionTo our knowledge, this is the first report of identifying a subpopulation susceptible to closure of medical services during the COVID-19 pandemic and diagnostic delay of specific kidney diseases. Therefore, the COVID-19 pandemic should be regarded as a risk factor especially in patients with diseases other than COVID-19 primarily admitted to the normal medical ward.


Author(s):  
Anna Davydovich ◽  
T. Shmeleva

The article considers the trends in the development of the medical services market in the Krasnodar Territory in the conditions of the spread of coronavirus infection, analyzes their impact on the activities of primary medical organizations, presents the development directions of the medical services market in the region in the conditions of the spread of COVID-19. Based on the results of the sociological study, trends in the development of the medical services market in the region in the context of the spread of coronavirus infection were identified: the introduction of new methods for diagnosing coronavirus infection (CT, tests), repurposing, hiring (reducing) medical personnel, refurbishing (refurbishing) a medical organization, treating patients with COVID-19, changing the financial situation of primary medical organizations, expanding the list of medical services. The directions of development of the market of medical services of the region in conditions of COVID-19 distribution are proposed. The purpose of the study is to determine the direction of development of the medical services market in the Krasnodar Territory in the conditions of the spread of COVID-19. The achievement of the goal of the study predetermined the setting and consistent solution of the following interrelated tasks:  according to the results of a sociological study, highlight trends in the development of the medical services market in the Krasnodar Territory in the conditions of the spread of coronavirus infection;  analyze the impact of trends on primary health care organizations in the region;  to offer directions for the development of the medical services market of the Krasnodar Territory in the conditions of the spread of coronavirus infection. When compiling a review of literary sources on the topic of the study, the method of content analysis was applied. Analytical results of the assessment of trends in the development of the medical services market in the Krasnodar Territory in the context of the spread of COVID-19 were obtained using statistical and sociological methods of research - a survey and questionnaire of representatives of medical organizations of the primary level of the region. The results obtained during the study will be useful in the development of strategic documents and initiatives for the development of the medical services market in the Krasnodar Territory in the conditions of COVID-19 distribution.


Sign in / Sign up

Export Citation Format

Share Document