MICROBIOLOGICAL MONITORING OF INTRAHOSPITAL INFECTION IN SURGICAL HOSPITAL

Vestnik ◽  
2021 ◽  
pp. 235-239
Author(s):  
А.Т. Аубакирова ◽  
Г.Б. Абдилова ◽  
Г. Сатылганкызы ◽  
К.Т. Катаева ◽  
А.Е. Бекмухамедова
Keyword(s):  
Nosocomial Infections ◽  
External Environment ◽  
Point Of View ◽  
Epidemiological Surveillance ◽  
Evidence Based ◽  
Hospital Infections ◽  
E Coli ◽  
Microbiological Monitoring ◽  
Positive Results ◽  
Epidemiological Situation

За 2020 год было обследовано на носительство патогенного стафилакокка - 144 человека. По стационару за год было проведено 5666 операций, (прооперировано больных - 5197), зарегистрировано осложнений - 88 (1,6%). На микробиологические исследования были взяты пробы из воздуха - 446, смывы 2686, материалы на стерильность - 842 и на носительство 445 проб. По результатам микробиологического мониторинга с внешней среды в основном высевался условно патогенный стафилакокк в 54 % случаях от всех положительных результатов и бактерии группы кишечной палочки в 15,5 % случаев соответственно. При проведении анализа обследования пациентов на микрофлору отмечено, что по стационару исследовано бактериологически - 26,2% пациентов (всего пролечено - 5824, обследовано - 1524, выявлено положительных результатов - 768 - 50,4 %). Анализ выделенной микрофлоры у пациентов показал, что наибольший процент приходится на выявления клебсиеллы (19,3%), стрептококков (18,5 %), золотистого стафилакокка (15,1%), синегнойной палочки (4,0%). В 21,2 % случаев высев кандида, это указывает на то, что пациенты получают большое количество антибиотиков, а также не в полном объеме проводится противогрибкового лечения. Проведенный мониторинг нозокомиальных инфекций важны с позиции эпидемиологического надзора, так как они создают предпосылки для планирования научно-обоснованных мер борьбы и профилактики госпитальных инфекций. Постоянный микробиологический мониторинг внутрибольничной инфекции повысит выявление групп и факторов риска возникновения внутрибольничной инфекций, определить во время предвестников осложнения эпидемиологической обстановки, оценить и прогнозировать эпидемиологические ситуации. In 2020, 144 people were examined for the carriage of pathogenic staphylococcus. In the hospital, 5666 operations were performed during the year (5197 patients were operated on), complications were registered - 88 (1.6%). For microbiological studies, samples were taken from the air - 446, washes - 2686, materials for sterility - 842 and 445 samples for carrier. According to the results of microbiological monitoring from the external environment, conditionally pathogenic staphylococcus was mainly sown in 54% of cases of all positive results and bacteria of the E. coli group in 15.5% of cases, respectively. When analyzing the examination of patients for microflora, it was noted that 26.2% of patients were bacteriologically examined in the hospital (in total, 5824 were treated, 1524 were examined, positive results were found - 768 - 50.4%). The analysis of the isolated microflora in patients showed that the largest percentage is due to the detection of Klebsiella (19.3%), streptococci (18.5%), Staphylococcus aureus (15.1%), Pseudomonas aeruginosa (4.0%). In 21.2% of cases of Candida sowing, this indicates that patients receive a large amount of antibiotics, and also that antifungal treatment is not fully carried out. The monitoring of nosocomial infections is important from the point of view of epidemiological surveillance, since they create the prerequisites for planning evidence-based measures to combat and prevent hospital infections. Continuous microbiological monitoring of nosocomial infections will increase the identification of groups and risk factors for nosocomial infections, determine during the harbingers of complications of the epidemiological situation, assess and predict epidemiological situations

scholarly journals Results of studying disinfectant-resistance of bacteria, excreted from patients in microbiological provision of epidemiological surveillance of hcai at multitype medical institution

2018 ◽  
Vol 35 (5) ◽  
pp. 42-50
Author(s):  
D. D. Nesterova ◽  
A. N. Neshataev ◽  
N. V. Lukyanenko ◽  
A. A. Petrova ◽  
V. V. Prokopyev ◽  
...  
Keyword(s):  
Correct Choice ◽  
Epidemiological Surveillance ◽  
Clinical Material ◽  
E Coli ◽  
Microbiological Monitoring ◽  
Acinetobacter Spp ◽  
Surgical Unit ◽  
Positive Results ◽  
Resistant Microorganism ◽  
Disinfectant Resistance

Aim. To improve microbiological monitoring of disinfectant-resistance of microorganisms, excreted from clinical material in epidemiological surveillance of HCAI. Materials and methods. Over the period from 2012 to 2016, while conducting resistance monitoring, 3320 investigations of clinical material were performed. The number of studied microorganisms was 1557. The number of excreted disinfectant-resistant microorganism strains was 337. The studies of microorganisms from clinical material for resistance were realized to 48 disinfectants of 15 groups with different reactants. Results. During the present study it was established that microbiological monitoring, oriented for continuous monitoring of microorganisms circulation will permit to increase the number of studies in 2016 by 2.6 times, to reduce the total number of disinfectant-resistant flora in 2016 by 62 %. The greatest weight of excreted cultures was in the units of surgical profile – 48.8 %, resuscitation profile – 30 %, therapeutic one – 21.2 %. Clinical material, from which positive results were obtained, was determined by scourage (from 43.5 % in the surgical unit to 74.8 % in therapeutic), blood sterility (from 2.7 % in therapeutic units to 31.4 % in resuscitation units). Microflora, excreted from clinical material is presented predominantly by P. aeruginosa – 24.0 %, Kl. pneumoniae – 30.0 %, E. coli – from 12.9 to 22.1 %, St. aureus – from 3.0 to 7.6 %. The studies regarding disinfectant-resistance to 48 items from 15 groups of chemical compounds are the evidence of growing resistance to QAC, including QAC + amines – 24.7 %, QAC + aldehyde-containing – 6.8 %, chlorine-containing – 21.9 %. The highest resistance to disinfectants used was in Acinetobacter spp., Kl. pneumoniae, P. aeruginosa, E. coli. Conclusions. The developed algorithm of microbiological study, based on software, permitted to form the database, to monitor epidemiologically significant microorganisms and correct choice of disinfectants and disinfection tactics.

“Aspirin - resistance”? A few critical considerations on definition, terminology, diagnosis, clinical value, natural course of atherosclerotic disease, and therapeutic consequences

VASA ◽  
2011 ◽  
Vol 40 (6) ◽  
pp. 429-438 ◽  
Author(s):  
Berent ◽  
Sinzinger
Keyword(s):  
Platelet Function ◽  
Point Of Care ◽  
Aspirin Resistance ◽  
Point Of View ◽  
Evidence Based ◽  
Platelet Function Tests ◽  
Clinical Value ◽  
Vascular Events ◽  
Therapeutic Consequences ◽  
Function Tests

Based upon various platelet function tests and the fact that patients experience vascular events despite taking acetylsalicylic acid (ASA or aspirin), it has been suggested that patients may become resistant to the action of this pharmacological compound. However, the term “aspirin resistance” was created almost two decades ago but is still not defined. Platelet function tests are not standardized, providing conflicting information and cut-off values are arbitrarily set. Intertest comparison reveals low agreement. Even point of care tests have been introduced before appropriate validation. Inflammation may activate platelets, co-medication(s) may interfere significantly with aspirin action on platelets. Platelet function and Cox-inhibition are only some of the effects of aspirin on haemostatic regulation. One single test is not reliable to identify an altered response. Therefore, it may be more appropriate to speak about “treatment failure” to aspirin therapy than using the term “aspirin resistance”. There is no evidence based justification from either the laboratory or the clinical point of view for platelet function testing in patients taking aspirin as well as from an economic standpoint. Until evidence based data from controlled studies will be available the term “aspirin resistance” should not be further used. A more robust monitoring of factors resulting in cardiovascular events such as inflammation is recommended.

Middle School Students with Exceptional Learning Needs Investigate the Use of Visuals for Learning Science

2012 ◽  
Vol 7 (1) ◽  
Author(s):  
Robin Ward McCartney ◽  
Donna Dugger Wadsworth
Keyword(s):  
Students With Disabilities ◽  
Learning Needs ◽  
Evidence Based ◽  
School Students ◽  
Construction Of Knowledge ◽  
Personal Perceptions ◽  
Is Theory ◽  
Visual Graphic ◽  
Enhanced Learning ◽  
Positive Results

A visual instructional tool that is theory-driven and supported by evidence-based research is used to support student learning and information-processing. The graphic organizer has enhanced learning in Science Education as well as Special Education, emphasizing the construction of knowledge with meaningful sequential relationships rather than memorizing isolated fragments of information. Students construct a visual schema that represents a system of interrelated concepts and icons created by the learner. This article provides a description of a qualitative application of how students with disabilities are able to represent their ideas by assimilating subject matter and their personal perceptions of content by drawing pictures connected to concepts within the visual graphic. Positive results were documented in this study.

Appointment of Antimicrobial Medications in a Hospital Depending on the Results of Microbiological Monitoring of HAI

2020 ◽  
Vol 65 (9-10) ◽  
pp. 21-27
Author(s):  
S. D. Mitrokhin ◽  
O. E. Orlova ◽  
I. V. Gosteva ◽  
A. S. Shkoda
Keyword(s):  
Therapy Monitoring ◽  
Hospital Environment ◽  
Antimicrobial Drugs ◽  
Microbiological Monitoring ◽  
Medical Institutions ◽  
Extreme Drug Resistance ◽  
Microbiological Laboratory ◽  
The Russian Federation ◽  
Medical Programs ◽  
Epidemiological Situation

One of the tasks of the hospital-s clinical pharmacologists service is to continuously monitor the consumption of antimicrobial drugs (DDD analysis) depending on the microbiological and epidemiological situation in the hospital. This is necessary for the implementation of various medical programs and technologies aimed at reducing the selection pressure of antimicrobial drugs and reducing the risk of the emergence, accumulation, and spread of bacteria strains with multiple and/or extreme drug resistance to these drugs in the hospital environment. To date, some medical institutions, especially in the various regions of the Russian Federation, do not have a proper team of clinical pharmacologists and a modern, well-equipped and computerized microbiological laboratory. This does not allow full implementation of the above-mentioned programs in such hospitals, e. g. Antimicrobial therapy monitoring system — SСAT and technologies, e. g. «carbapenem-preserving technologies» and «microbiological monitoring».

scholarly journals Using Benford’s law to assess the quality of COVID-19 register data in Brazil

2020 ◽  
Author(s):  
Lucas Silva ◽  
Dalson Figueiredo Filho
Keyword(s):  
Goodness Of Fit ◽  
Epidemiological Surveillance ◽  
Evidence Based ◽  
Mean Absolute Deviation ◽  
Chi Square ◽  
Absolute Deviation ◽  
Distortion Factor ◽  
Benford Law ◽  
Official Data

Abstract We employ Newcomb–Benford law (NBL) to evaluate the reliability of COVID-19 figures in Brazil. Using official data from February 25 to September 15, we apply a first digit test for a national aggregate dataset of total cases and cumulative deaths. We find strong evidence that Brazilian reports do not conform to the NBL theoretical expectations. These results are robust to different goodness of fit (chi-square, mean absolute deviation and distortion factor) and data sources (John Hopkins University and Our World in Data). Despite the growing appreciation for evidence-based-policymaking, which requires valid and reliable data, we show that the Brazilian epidemiological surveillance system fails to provide trustful data under the NBL assumption on the COVID-19 epidemic.

scholarly journals What Did Angola Learn from the World and What Did the World Learn from COVID-19? Reflection on Epidemiological Surveillance in Health

2020 ◽  
Vol 22 (4) ◽  
pp. 528-540
Author(s):  
Euclides Nenga Manuel Sacomboio
Keyword(s):  
Critical Thinking ◽  
Critical Analysis ◽  
Epidemiological Surveillance ◽  
Professional Experience ◽  
State Of Emergency ◽  
The World ◽  
History Of ◽  
The Government ◽  
Scientific Reflection ◽  
Epidemiological Situation

The global community is racing to slow down and eventually stop the spread of COVID-19, which is a pandemic that has killed thousands of lives and made tens of thousands sick. The new coronavirus has already reached Angola, with 25 confirmed cases, among them 2 died and 6 were cured. The government has decreed a state of emergency on 24 March 2020 for 15 days, which was extended twice for the same number of days that will make it possible to reduce clusters of people and keep them at home. This study reflected on the diverse ways of leadership. It is an article of theoretical, technical and scientific reflection, based on the experience of a new epidemiological situation, with a critical analysis based on technical, scientific and professional experience, with bibliographic input of data obtained from information published in scientific articles, newspapers, magazines and other official documents published in Angola and worldwide related to COVID-19. This article emerged from critical thinking based on the current situation of COVID-19 in Angola in the world and is reflected in this article, what Angola should learn and learned from the experience of other countries that also imported the disease, their history of investment in health, characteristics of their populations, their economies and other aspects.

scholarly journals EPIDEMIC ENCEPHALITIS AND SIMPLE HERPES

1927 ◽  
Vol 8 (6) ◽  
pp. 713-726 ◽  
Author(s):  
Simon Flexner
Keyword(s):  
Guinea Pig ◽  
Past Experience ◽  
The State ◽  
Encephalitis Virus ◽  
Point Of View ◽  
Epidemic Encephalitis ◽  
Direct Corollary ◽  
The Subject ◽  
Positive Results ◽  
Epidemic Diseases

The purpose of this paper is to explain the state of our knowledge of the etiology of epidemic encephalitis, and especially to draw a line of demarcation between the established virus of simple herpes and the hypothetical virus of epidemic encephalitis. It had already been shown that the experimental observations on rabbits do no suffice to prove the identity of the herpes with the encephalitis virus. The discussion of the subject in this paper shows that identity cannot be postulated on the basis of the performed guinea pig experiments. Attention has been drawn to the significant fact that there is lack of harmony in the positive results of those investigators who believe that the incitants of epidemic encephalitis have been discovered. An attempt has been made to attribute some of the discrepancies reported by these investigators either to accidental and contaminating microbic agents, or to the uncovering of virulent agents preexisting in a latent state in the animals employed for inoculation, the existence of which was not previously known or suspected. Since past experience leads us to believe in a single incitant for widespread epidemic diseases, it is probable that, when certainly discovered, the microbe of epidemic encephalitis will prove to be simple and not multiple. The direct corollary to this point of view is that up to the present, the etiology of epidemic encephalitis has not been determined.

scholarly journals Assessment of Urban Agriculture for Evidence-Based Food Planning: A Case Study in Chengdu, China

2021 ◽  
Vol 13 (6) ◽  
pp. 3234
Author(s):  
Nan Wang ◽  
Li Zhu ◽  
Yuanhao Bing ◽  
Liwei Chen ◽  
Shulang Fei
Keyword(s):  
Urban Agriculture ◽  
Food System ◽  
Point Of View ◽  
Assessment Tools ◽  
Local Context ◽  
Evidence Based ◽  
Sustainable Food ◽  
Local Food System ◽  
Food Planning ◽  
Indicator Framework

Along the rapid pace of urbanization, urban agriculture is increasingly recognized as an important tool of sustainable food and nutrition supply, while contributing to the resilience and sustainability of cities from various dimensions. From a governance point of view, it is fundamental to systemically assess the urban agriculture based on local context for evidence-based food planning. In China, values of urban agriculture are being noticed in recent years, with attempts emerging to involve urban agriculture in urban planning and agriculture strategies. However, clear definition to identify the scope and holistic approaches to assess and monitor local urban agriculture are still lacking. The paper took Chengdu as the study area, to conduct a thorough assessment of the foundation, capacity, practices, functions, opportunities, and challenges of the urban agriculture locally. Building on these results, the study further developed an indicator framework tailored to Chengdu’s conditions and city objectives, for in-depth evaluation and monitoring of local urban agriculture by themes, following which a pilot in-depth assessment was conducted in Chengdu using the indicator framework. The outcome of this research for the first time provided an overall characterization of the urban agriculture in Chengdu and assessment tools tailored to urban agriculture in Chinese cities, establishing a good basis for strategic local food system planning and contributing to the formation of the Chinese paradigm in urban agriculture research.

The phenomenon of migration of nociogenic structures in the human sensor-algic system (results of clinical and neurophysiological studies and morphological experiments)

2020 ◽  
pp. 16-24
Author(s):  
Maksim Vladimirovich Shpagin ◽  
Mikhail Valerievich Kolesnikov ◽  
Olga Yurievna Khutorskaya ◽  
Dmitriy Evgenievich Timoshkin ◽  
Artem Andreevich Belikin ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Nervous System ◽  
Pain Syndrome ◽  
Point Of View ◽  
Chronic Pain Syndrome ◽  
Integrative Therapy ◽  
Neurophysiological Studies ◽  
Positive Results ◽  
Structural Point ◽  
Chronicity Of Pain

From the informational and structural point of view, the chronicity of pain is associated with the migration of nociogenic zones. The phenomenon of migration is based on the mechanisms of neuroplasticity, compensatory-restorative processes in the nervous system. On the basis of the phenomenon of migration of the nociogenic zone, a system of regional integrative therapy of chronic pain syndrome has been developed. Recommendations on the advisability of invasive shutdown of the nociogenic zone using invasive pharmacotherapy or surgical denervation have been proposed. In the course of studying the characteristics of chronic pain, depending on the duration of the disease, a direct proportional correlation was revealed between the increase in the components of pain and the duration of the pain syndrome, which can be explained by the increase in the number of nociogenic structures that form the complexity and stability of the pain syndrome. Thus, the necessity of neurodestructive interventions increases for attaining positive results. An important area of therapy is the inclusion of psychotherapy, pharmacotherapy and neuromodulation into the system of regional-integrative influence.

scholarly journals Screening of mucoadhesive vaginal gel formulations

2014 ◽  
Vol 50 (4) ◽  
pp. 931-941 ◽  
Author(s):  
Ana Ochoa Andrade ◽  
María Emma Parente ◽  
Gastón Ares
Keyword(s):  
Xanthan Gum ◽  
Rational Design ◽  
Point Of View ◽  
Vaginal Fluid ◽  
Multiple Factor Analysis ◽  
Vaginal Drug Delivery ◽  
Rheological Measurements ◽  
Gel Formulations ◽  
Positive Results

Rational design of vaginal drug delivery formulations requires special attention to vehicle properties that optimize vaginal coating and retention. The aim of the present work was to perform a screening of mucoadhesive vaginal gels formulated with carbomer or carrageenan in binary combination with a second polymer (carbomer, guar or xanthan gum). The gels were characterised using in vitroadhesion, spreadability and leakage potential studies, as well as rheological measurements (stress and frequency sweep tests) and the effect of dilution with simulated vaginal fluid (SVF) on spreadability. Results were analysed using analysis of variance and multiple factor analysis. The combination of polymers enhanced adhesion of both primary gelling agents, carbomer and carrageenan. From the rheological point of view all formulations presented a similar behaviour, prevalently elastic and characterised by loss tangent values well below 1. No correlation between rheological and adhesion behaviour was found. Carbomer and carrageenan gels containing the highest percentage of xanthan gum displayed good in vitro mucoadhesion and spreadability, minimal leakage potential and high resistance to dilution. The positive results obtained with carrageenan-xanthan gum-based gels can encourage the use of natural biocompatible adjuvants in the composition of vaginal products, a formulation field that is currently under the synthetic domain.

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