scholarly journals HER2 Positive Gastric and Gastroesophageal Adenocarcinoma: A Tertiary Center Experience in (NICRH) Bangladesh

2022 ◽  
Vol 8 (1) ◽  
pp. 368-378
Author(s):  
Nabir Hossain
Keyword(s):  
Gastric Cancer ◽  
Surgical Oncology ◽  
Cross Sectional Study ◽  
Tnm Staging ◽  
Global Perspective ◽  
Her2 Overexpression ◽  
Her2 Positive ◽  
Cross Sectional ◽  
Tertiary Center ◽  
The World

Background: Gastric cancer is the fourth commonest cancer worldwide. It is also recognized as the second commonest cause of cancer related death in the global perspective. Although the incidence of gastric cancer has gradually decreased over the last half of the century, it varies among the different part of the world and different ethnic group. Mortality from gastric cancer extremely high, and it is second only to lung cancer. Gastric cancer occurs more frequently in men than in women. Aim of the study: Aim of the study was to find the clinic-profile outcome HER2 Positive Gastric and Gastroesophageal Adenocarcinoma.Methods:This cross sectional study was conducted in the Department of Surgical Oncology of National Institute of Cancer, Research and Hospital, Mohakhali, Dhaka. The study period was from March, 2014 to April, 2015. A total of 80 patients were included for the study. After receiving the gastrectomy specimen, it was fixed in 10% formaldehyde. Data were compiled and necessary statistical analysis were carried out using computer based software package for social science (SPSS 16.1). Ethical clearance was taken from the ethical committee of NICRH.Results:The highest patients were from 61-70 years’ age group and the lowest were from 71-80 years. The mean age of the patients was 59.71 (±10.19) years. The female to male ratio in this study was 1: 2.48. 66 (82.5%) patients were presented with anemia which was followed by 39 (48.75%) cases with dehydration. Most of the tumors were located in the distal part of the stomach (11.67%). Regarding staging 79(12.65%) patients were in the advanced stage of the disease. The correlation between HER2 overexpression and TNM staging has been tabulated below where it is shown that only Nodal (N) staging has the significant correlation with the HER2 overexpression.Conclusion:It is already mentioned that, in early history of immunohistochemistry, HER2 overexpression in case of carcinoma stomach was highly varied in different studies (from 9-92%). But recently, it was found around 9-32%, in several studies all over the world. It is necessary to conduct further studies with larger samples and long term follow-up in order to draw definite conclusions regarding the role of HER2/neu overexpression.

scholarly journals The impact of COVID-19 pandemic on training and mental health of residents: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Eman Alshdaifat ◽  
Amer Sindiani ◽  
Wasim Khasawneh ◽  
Omar Abu-Azzam ◽  
Aref Qarqash ◽  
...  
Keyword(s):  
Mental Health ◽  
Residency Training ◽  
Training Programs ◽  
Cross Sectional Study ◽  
Protective Equipment ◽  
Sectional Study ◽  
Cross Sectional ◽  
Surgical Residents ◽  
Tertiary Center ◽  
The Impact

Abstract Background Residency programs have been impacted by the Coronavirus disease 2019 (COVID-19) pandemic. In this study we aim to investigate and evaluate the impact of the pandemic on residents as well as residency training programs. Methods This was a cross-sectional study including a survey of 43 questions prepared on Google forms and electronically distributed among a convenience sample of residents training at a tertiary center in North Jordan during the COVID-19 pandemic. Data were collected in the period between October 30th and November 8th of 2020. The survey included questions that addressed the impact of the pandemic on residents’ health as well as training programs. The study participants included residents in training at KAUH in 2020 and were stratified according to the type of residency program (surgical residents (SRs) and non-surgical residents (NSRs)). Statistical methods included descriptive analysis, Chi-square or Fisher’s exact test, Mann Whitney U test, and Cramer’s V and r statistics as measures of effect sizes. Results Of all 430 residents, 255 (59%) responded to the survey. A total of 17 (7%) of residents reported being infected with COVID-19 and a significant difference was reported between SRs and NSRs (10% vs 4%, V = .124 “small effect” (95% CI; .017–.229), p = 0.048). Approximately, 106 (42%) reported a decrease in the number of staff working at the clinic and 164 (64%) reported limited access to personal protective equipment during the pandemic. On a 4-point Likert scale for the feeling of anxiety, the median was 2 (2–3 IQR) in the NSRs group, vs 2 (1–2 IQR) in the SRs groups, with the NSRs being more likely to feel anxious (r = 0.13 “small effect” (95% CI; 0.007–0.249), p = .044). Similarly, the proportion of residents who reported feeling anxious about an inadequacy of protective equipment in the work area was significantly greater in the NSRs group (90.3% vs 75.2%; V = .201 “small effect” (95% CI; .078–.313), p = .001), as well as the proportion of residents who reported feeling increased stress and anxiety between colleagues being also significantly higher in the NSRs group (88.1% vs 76%; V = .158 “small effect” (95% CI; .032–.279), p = .012). Conclusion The burden of the ongoing pandemic on the mental health status of residents is very alarming and so providing residents with psychological counseling and support is needed. Also, critical implications on the flow of residency training programs have been noticed. This necessitates adapting and adopting smart educational techniques to compensate for such limitations.

scholarly journals Association between obesity and depression in patients with diabetes mellitus type 2; a study protocol

F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 7 ◽  
Author(s):  
Eduardo De la Cruz-Cano ◽  
Carlos Alfonso Tovilla-Zarate ◽  
Emilio Reyes-Ramos ◽  
Thelma Beatriz Gonzalez-Castro ◽  
Isela Juarez-Castro ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Diabetes Mellitus Type 2 ◽  
Cross Sectional Study ◽  
Diabetes Mellitus Type ◽  
Sectional Study ◽  
Cross Sectional ◽  
The World ◽  
Patients With Diabetes

Background: Diabetes mellitus and depression are highly prevalent conditions throughout the world and have significant impact on health outcomes. It has been estimated that diabetes mellitus type 2 affects about 246 million people in the world; nevertheless, incidence varies among countries. There is evidence that depression is associated with a poor metabolic control in patients with type 2 diabetes mellitus that present other health problems (such as hypertension and obesity). The aim of this study protocol is to determine if obesity increases the risk for depression in patient with diabetes type 2.Methods: The analysis will be reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).The studies suitable for inclusion will be assessed by the Newcastle-Ottawa Scale (NOS) to determine their methodological quality. To identify the studies of interest, we will search on PubMed and EBSCO databases. We will use the following keyword combinations: "Diabetes Mellitus type 2 AND obesity AND depression", "depression AND Diabetes Mellitus type 2", "Diabetes Mellitus type 2 AND body mass index cross sectional study", "depression AND obesity cross-sectional study". Causes for exclusion will be publications that studied patients diagnosed with diabetes mellitus type 1; articles that focused on the treatment and complications of diabetes mellitus type 2; publications that have studied other clinical or psychiatric conditions (for instance, seizure disorder or history of schizophrenia, bipolar disorder, psychotic symptoms or dementia).Conclusion: The results of this study will form the basis for a better understanding of the association between obesity and depression in patients with diabetes mellitus type 2, and will allow development of prediction tools and better interventions. It is evident that several modifiable and non-modifiable risk factors play an important role in the pathogenesis of diabetes among population. Currently, evidence for the deleterious effects of diabetes mellitus type 2 are based on cross-sectional or other observational designs. Therefore, this study will have important implications for future research and public health guidance.

scholarly journals An investigation on the frequency of thoughts, readiness and suicide attempt in individuals with thalassemia

2021 ◽  
Vol 15 (6) ◽  
pp. 1847-1853
Author(s):  
Sahar Attar ◽  
Nour Mohammad Bakhshani ◽  
Qasem Miri Aliabad
Keyword(s):  
Suicidal Ideation ◽  
Suicide Attempts ◽  
Statistical Tests ◽  
Genetic Diseases ◽  
Thalassemia Major ◽  
Cross Sectional Study ◽  
World Health ◽  
Cross Sectional ◽  
Significant Difference ◽  
The World

Background and Aim: Thalassemia major is one of the most common chronic genetic diseases in the world and in Iran that can impose many adverse effects on the self and society. Psychologically, patients with thalassemia are under stress. According to the World Health Organization (WHO), suicide is one of the leading causes of death worldwide. It is important to identify the people who have the highest risk factors for suicide. The present research investigates the frequency of thoughts, readiness and suicide attempts in people with thalassemia. Methods: This was a cross-sectional study. Its sample was 150 patients with thalassemia in the age range of 10 to 46 years whom we selected through census by sampling at convenience. We gave to patients a standardized Beck Suicide Thought Assessment Questionnaire. We analyzed the research data using descriptive and inferential statistical tests. Results: From among 150 patients with thalassemia in this study, 57.3% of the respondents were male and 42.7% were female. The results showed that there was a negative and significant relationship between suicide thoughts and attempts and age (-0.234) (P <0.05). The mean prevalence of suicide in men (1.89) was significantly higher compared to women (0.79) (P <0.05). We did not observe significant difference in prevalence of suicide thoughts and attempts between married and single groups with a mean difference (0.69) (P <0.05) and, in different educational groups, no significant difference was reported (P> 0.05). Conclusion: The findings of this research showed that among patients with thalassemia, the prevalence of suicidal ideation has a significant percentage. Since suicidal ideation provides a platform for preparation and attempt to commit suicide, so by providing mental health services and regular screening, we can take an effective step to prevent this problem among patients with thalassemia. Keywords: Thalassemia, Suicidal ideation, Suicide.

scholarly journals A retrospective study of colorectal carcinoma in central India

2017 ◽  
Vol 4 (3) ◽  
pp. 977
Author(s):  
Suresh Clement H. ◽  
S. Madhu Babu ◽  
Samir Ahmad ◽  
Harsha Omkar M.
Keyword(s):  
Breast Cancer ◽  
Central India ◽  
Cross Sectional Study ◽  
Reproductive Age ◽  
Age Group ◽  
Cross Sectional ◽  
Outer Quadrant ◽  
The World ◽  
Menstruating Women ◽  
Epidemiological Profile

Background: Inner lining of lobules or ducts of milk of breast tissue is the origin of the breast cancer. Among females, it constitutes 10.4% of cancer cases incidence all over the world. It thus is the fifth leading cause of mortality all over the world. As known, it is more common in females than males. The objective of this study was to study the clinical and epidemiological profile of breast cancer patients.Methods: A hospital based cross sectional study was carried out for a period of two and half years at M. G. M. Hospital, Warangal. Both males and females of 30 years and above were included in the study. Total number of carcinoma cases admitted during 2005 to 2007 for a period of two and half years were 1,428. Total number of carcinoma breast cases admitted during 2005 to 2007 for a period of two and half years were 242.Results: Maximum cases i.e. 44.6% belonged to stage III of breast cancer. Maximum cases were seen among Hindus i.e. 76.4%. As expected, only one case was reported by males which constituted only 0.42%. Highest number of cases i.e. 99 (40.9%) were reported during the age group of 40-50 years. Multi para women constituted more number of cases in 78.8%. Maximum number of cases of breast cancer i.e. 41.6% occurred among menstruating women. Most commonly affected quadrant was upper outer in 55.1% of cases. The most common type was Schirrous carcinoma in 39.6% of cases.Conclusions: Upper outer quadrant was most commonly affected. This indicates that the women in the reproductive age group should be directed to examine their breast daily with specific attention to upper outer quadrant.

scholarly journals Faktor-Faktor yang Mempengaruhi Prilaku Pemberian Asi Eksklusif di Kelurahan Tabona Kecamatan Kota Ternate Selatan

2018 ◽  
Vol 7 (2) ◽  
pp. 14
Author(s):  
Karima Soamole
Keyword(s):  
Exclusive Breastfeeding ◽  
Complementary Feeding ◽  
Cross Sectional Study ◽  
World Health ◽  
Survey Method ◽  
Additional Food ◽  
Cross Sectional ◽  
The World ◽  
Health Organization ◽  
The Relationship

Abstract : It is estimated that 80% of mothers who gave birth were able to produce milk in quantities sufficient for the purposes of the baby in full without any additional food and according to the World Health Organization recommends breastfeeding until the age of 4-6 months baby. Annually, more than 25,000 babies Indonesia and 1.3 million babies around the world can be saved by exclusive breastfeeding in 1999, while according to the 2000 report, the WHO approximately 1.5 million children die because they are not feeding properly, less than 15% infants worldwide are given for four months of exclusive breastfeeding and complementary feeding is often inappropriate and unsafe. This research is explanatory research because it explains the relationship between independent variables and dependent variable through hypothesis testing. The method used in this study is a survey method with cross sectional study design. The population in this study are all mothers who breastfeed in Puskesmas Kalumata 2012. Knowledge of the highest in the category of knowledge of both 81 (95.3%) and the behavior of the Exclusive breastfeeding is highest among respondents with a good knowledge of the 55 categories (67.9%). Respondents' attitudes toward breastfeeding Exclusive showed much respondeng that supports 54 (63.5%) and 31 (36.5%) that does not support exclusive breastfeeding her baby. Family Support tehadap respondents in the most exclusive breastfeeding: supporting respondents in exclusive breastfeeding her baby 64 (75.3%) and 21 (24.7%) who did not support the.

scholarly journals Occupational hazards and public health concerns of migrant construction workers: an epidemiological study in southern India

2019 ◽  
Vol 6 (2) ◽  
pp. 818
Author(s):  
C. J. Nirmala ◽  
S. Dharaneesh Prasad
Keyword(s):  
Respiratory Infections ◽  
Labour Force ◽  
Cross Sectional Study ◽  
Construction Workers ◽  
Gastrointestinal Infections ◽  
Chi Square ◽  
Cross Sectional ◽  
The World ◽  
Musculoskeletal Problems ◽  
Chi Square Test

Background: Construction industry is one of the stable growing industries of the world and construction labour form 7.5% of the world labour force. In India, it is the largest economic activity after agriculture. Migrant construction workers are at a greater risk of developing certain health disorders and sickness than workers in many other industries. The objective was to study the socio demographic profile, morbidity profile among construction workers.Methods: A cross sectional study conducted at two construction sites in southern Bangalore and all workers were enrolled as study subjects. Data was collected using a pretested semi structured questionnaire. Statistical analysis used: descriptive statistics like percentages and Chi square test for test of significance.Results: Majority of the study population belonged to 15-45 years age group (87.3%), class IV (40.3%) socioeconomic status, Hindu religion (85%). Around 40% of them were illiterates and 68% of them were unskilled workers, rest semiskilled workers. Around 50% were from Raichur district of North Karnataka. Prevalence of injury was 8%, musculo-skeletal problems were around 50% followed by respiratory infections and gastrointestinal infections.Conclusions: The prevalence of musculoskeletal problems, respiratory problems and gastrointestinal infections was reported to be high among unskilled and semiskilled construction workers. There is need for health education and other prevention strategies for control of the same. Measures are needed to improve the work environment of construction workers by ensuring availability of personal protective equipments, good living conditions and sanitation facilities at the sites. 

scholarly journals Measles Distribution Map according to Measles Immunization and Vitamin A Coverage

2019 ◽  
Vol 7 (1) ◽  
pp. 51
Author(s):  
Vika Gress Vio Dilita ◽  
Lucia Yovita Hendrati
Keyword(s):  
Vitamin A ◽  
Immunization Coverage ◽  
Cross Sectional Study ◽  
Study Data ◽  
World Health ◽  
Sample Population ◽  
Cross Sectional ◽  
The World ◽  
Health Organization ◽  
Measles Incidence

Background: According to the World Health Organization (WHO), Indonesia is one of the ten countries with the most significant number of measles cases in the world. Immunization coverage in Trenggalek Regency has reached the target of prevention of measles in the elimination stage, namely measles immunization coverage> 95%, the incidence of measles persists and increases in the last three years, from 2013 to 2015. Purpose: This study aimed to evaluate the trends between measles immunization status and the provision of vitamin A with the incidence of measles in Trenggalek Regency. Methods: This type of research is an observational study with a cross-sectional study design. The sample population is consist of 14 sub-districts in Trenggalek Regency. Data was taken from the health profile of Trenggalek Regency in 2013, 2014, and 2015. In this study, data processing were analysed by Health Mapper application version 4.3.0.0 with product version 4.03 to determine data descriptively. Results: Distribution of measles incidence with immunization coverage in Trenggalek Regency in 2013, 2014, and 2015 showed that measles incidence tended to increase followed with the decreasing number of measles immunization coverage each year. Ironically, the distribution of measles incidence with vitamin A administration in 2013, 2014, and 2015 showed the incidence of measles had increased because of the inconsistent amount of vitamin A administration. Conclusion: Measles incidence tends to occur in low immunization coverage areas and has decreased from the previous year. Giving vitamin A does not prevent the occurrence of measles, but serves to reduce compilation.

scholarly journals Perception of Newcomers Regarding Learning English and Culture in Canada

2019 ◽  
Vol 12 (10) ◽  
pp. 86
Author(s):  
Shahla Sattar Khan ◽  
Mehmet Takkac
Keyword(s):  
Second Language ◽  
Cross Sectional Study ◽  
Demographic Characteristics ◽  
Sectional Study ◽  
Cross Sectional ◽  
Language Play ◽  
New Immigrants ◽  
The World ◽  
Points Of View ◽  
Learning English

There are some factors, which are motivational, and on the other hand, there are many challenges that may cause hindrance for learning English as a second language. Therefore, the main objective is to assess perception regarding factors for learning English as a second language, especially among new immigrants. This was a cross-sectional study conducted at a Polycultural center, Canada during the period of June-2017 to July-2017. The results of the study reinforced that new immigrants face challenges while learning English. Almost more than half the participants said that they find difficulty in understanding majority words. Regarding learning culture, two-thirds mentioned that the learning about culture gives them different points of view about the world and develops their critical thoughts. However, the socio-demographic characteristics like age, native language, play an important role in learning English.

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