Diagnostic Accuracy of Ultrasound in Differentiation Uterine Leiomyosarcoma from Uterine Leiomyoma: A Systematic Review

2021 ◽  
Vol 15 (11) ◽  
pp. 2836-2839
Author(s):  
Muhammad Naeem ◽  
Syeda Khadija-Tul-Sughra Murrium ◽  
Saad Qayyum ◽  
Muhammad Zain Ul Abidin ◽  
Wajiha Sohail Khan
Keyword(s):  
Smooth Muscle ◽  
Uterine Leiomyoma ◽  
English Language ◽  
Late Onset ◽  
Systemic Review ◽  
Uterine Leiomyosarcoma ◽  
Wide Range ◽  
Sonographic Patterns ◽  
Electronic Database Search ◽  
Post Menopausal

Background: Uterine leiomyosarcoma is a rare malignant pathology of smooth muscle of uterus which is mostly asymptomatic with a wide range of late onset of symptoms such as post-menopausal bleeding and severe abdominal pelvic pain and abnormal vaginal discharge. Uterine leiomyosarcoma characteristically has structural and clinical similarities with giant uterine leiomyoma because both originate from the smooth muscle cells of the uterus. The diagnosis of uterine leiomyosarcoma through ultrasound is very different difficult due to indistinguishable sonographic features of uterine leiomyoma and leiomyosarcoma but there are certain sonological features which can prove the reliability of ultrasound as the diagnostic tool for differentiating uterine leiomyosarcoma from uterine leiomyoma. Aim: To access the accuracy of ultrasound in differentiating uterine leiomyosarcoma from uterine leiomyoma. Methods: An electronic database search was performed (PubMed, Science direct, Google Scholar) with the data range from 2000 to 2021. All studies included in the research was in English language. Articles which had descriptive studies related to sonographic features of uterine leiomyosarcoma and uterine leiomyoma. Results: Total 15 articles were found regarding the prevalence, clinical manifestation and sonographic findings of uterine leiomyosarcoma and uterine leiomyoma ,10 articles were included in the introduction and technique where as 6 articles were selected for systemic review with the sample size ranging from 20-200 in all different articles and age criteria of the participant in the selected articles was above 40 years with most candidates were investigated in the post menopause period. Conclusion: We identified certain sonographic patterns that can accurately differentiate uterine leiomyoma sarcoma from uterine leiomyoma with moderate sensitivity and specificity. Keywords: Transvaginal ultrasonography, leiomyoma, leiomyosarcoma

scholarly journals Adherence to Food-Based Dietary Guidelines: A Systemic Review of High-Income and Low- and Middle-Income Countries

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 1038
Author(s):  
Ana Carolina B. Leme ◽  
Sophia Hou ◽  
Regina Mara Fisberg ◽  
Mauro Fisberg ◽  
Jess Haines
Keyword(s):  
English Language ◽  
Economic Status ◽  
High Income ◽  
Dietary Guidelines ◽  
Systemic Review ◽  
Healthy Children ◽  
Future Health ◽  
Middle Income ◽  
Middle Income Countries ◽  
Low And Middle Income

Research comparing the adherence to food-based dietary guidelines (FBDGs) across countries with different socio-economic status is lacking, which may be a concern for developing nutrition policies. The aim was to report on the adherence to FBDGs in high-income (HIC) and low-and-middle-income countries (LMIC). A systematic review with searches in six databases was performed up to June 2020. English language articles were included if they investigated a population of healthy children and adults (7–65 years), using an observational or experimental design evaluating adherence to national FBDGs. Findings indicate that almost 40% of populations in both HIC and LMIC do not adhere to their national FBDGs. Fruit and vegetables (FV) were most adhered to and the prevalence of adhering FV guidelines was between 7% to 67.3%. HIC have higher consumption of discretionary foods, while results were mixed for LMIC. Grains and dairy were consumed below recommendations in both HIC and LMIC. Consumption of animal proteins (>30%), particularly red meat, exceeded the recommendations. Individuals from HIC and LMIC may be falling short of at least one dietary recommendation from their country’s guidelines. Future health policies, behavioral-change strategies, and dietary guidelines may consider these results in their development.

scholarly journals Tamoxifen and oxidative stress: an overlooked connection

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Nermin S. Ahmed ◽  
Marek Samec ◽  
Alena Liskova ◽  
Peter Kubatka ◽  
Luciano Saso
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Gold Standard ◽  
Pharmacological Activities ◽  
Standard Drug ◽  
Menopausal Women ◽  
Wide Range ◽  
Post Menopausal ◽  
Apoptotic Effects ◽  
And Oxidative Stress

AbstractTamoxifen is the gold standard drug for the treatment of breast cancer in pre and post-menopausal women. Its journey from a failing contraceptive to a blockbuster is an example of pharmaceutical innovation challenges. Tamoxifen has a wide range of pharmacological activities; a drug that was initially thought to work via a simple Estrogen receptor (ER) mechanism was proven to mediate its activity through several non-ER mechanisms. Here in we review the previous literature describing ER and non-ER targets of tamoxifen, we highlighted the overlooked connection between tamoxifen, tamoxifen apoptotic effects and oxidative stress.

scholarly journals Effects of electrical stimulation on isolated rodent gastric smooth muscle cells evaluated via a joint computational simulation and experimental approach

2009 ◽  
Vol 297 (4) ◽  
pp. G672-G680 ◽  
Author(s):  
P. Du ◽  
S. Li ◽  
G. O'Grady ◽  
L. K. Cheng ◽  
A. J. Pullan ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Electrical Stimulation ◽  
Pulse Train ◽  
Pulse Width ◽  
Computational Simulation ◽  
Minimum Energy ◽  
Experimental Studies ◽  
Single Pulse ◽  
Plateau Phase ◽  
Wide Range

Gastric electrical stimulation (GES) involves the delivery of electrical impulses to the stomach for therapeutic purposes. New GES protocols are needed that are optimized for improved motility outcomes and energy efficiency. In this study, a biophysically based smooth muscle cell (SMC) model was modified on the basis of experimental data and employed in conjunction with experimental studies to define the effects of a large range of GES protocols on individual SMCs. For the validation studies, rat gastric SMCs were isolated and subjected to patch-clamp analysis during stimulation. Experimental results were in satisfactory agreement with simulation results. The results define the effects of a wide range of GES parameters (pulse width, amplitude, and pulse-train frequency) on isolated SMCs. The minimum pulse width required to invoke a supramechanical threshold response from SMCs (defined at −30 mV) was 65 ms (at 250-pA amplitude). The minimum amplitude required to invoke this threshold was 75 pA (at 1,000-ms pulse width). The amplitude of the invoked response beyond this threshold was proportional to the stimulation amplitude. A high-frequency train of stimuli (40 Hz; 10 ms, 150 pA) could invoke and maintain the SMC plateau phase while requiring 60% less power and accruing ∼30% less intracellular Ca2+ concentration during the plateau phase than a comparable single-pulse protocol could in a demonstrated example. Validated computational simulations are an effective strategy for efficiently identifying effective minimum-energy GES protocols, and pulse-train protocols may also help to reduce the power consumption of future GES devices.

Practitioners respond to Freda Mishan's ‘The Global ELT coursebook: A case of Cinderella's slipper?’

2021 ◽  
pp. 1-4
Author(s):  
David Connolly
Keyword(s):  
English Language ◽  
Language Teaching ◽  
English Language Teaching ◽  
Wide Range

First of all, I would like to thank Freda Mishan (2021) for a fascinating and insightful article into English language teaching (ELT) coursebooks. She covers a wide range of perspectives and raises many important issues. Although I may have different views on some of these, I think she has done a great service in helping me look with fresh eyes at what many teachers take for granted: the humble yet ubiquitous ELT coursebook.

Human acanthocephaliasis: A thorn in the side of parasite diagnostics

2021 ◽  
Author(s):  
Blaine A. Mathison ◽  
Ninad Mehta ◽  
Marc Roger Couturier
Keyword(s):  
Life Cycle ◽  
English Language ◽  
Clinical Presentation ◽  
Zoonotic Infections ◽  
The Past ◽  
Wide Range ◽  
Treatment And Diagnosis

Acanthacephala is a phylum of parasitic pseudocoelamates that infect a wide range of vertebrate and invertebrate hosts and can cause zoonotic infections in humans. The zoologic literature is quite rich and diverse, however the human-centric literature is sparse and sporadically reported over the past 70 years. Causal agents of acanthacephaliasis in humans are reviewed as well as their biology and life cycle. This review provides the first consolidated and summarized report of human cases of acanthacephaliasis based on English language publications, including epidemiology, clinical presentation, treatment, and diagnosis and identification.

Method for automatic key concepts extraction

2019 ◽  
Vol 37 (1) ◽  
pp. 2-15 ◽  
Author(s):  
Sudarsana Desul ◽  
Madurai Meenachi N. ◽  
Thejas Venkatesh ◽  
Vijitha Gunta ◽  
Gowtham R. ◽  
...  
Keyword(s):  
Coming Out ◽  
English Language ◽  
Hybrid Approach ◽  
Ontology Learning ◽  
Specific Domain ◽  
Content Type ◽  
Concept Extraction ◽  
Nuclear Domain ◽  
Wide Range ◽  
Key Concepts

PurposeOntology of a domain mainly consists of a set of concepts and their semantic relations. It is typically constructed and maintained by using ontology editors with substantial human intervention. It is desirable to perform the task automatically, which has led to the development of ontology learning techniques. One of the main challenges of ontology learning from the text is to identify key concepts from the documents. A wide range of techniques for key concept extraction have been proposed but are having the limitations of low accuracy, poor performance, not so flexible and applicability to a specific domain. The propose of this study is to explore a new method to extract key concepts and to apply them to literature in the nuclear domain.Design/methodology/approachIn this article, a novel method for key concept extraction is proposed and applied to the documents from the nuclear domain. A hybrid approach was used, which includes a combination of domain, syntactic name entity knowledge and statistical based methods. The performance of the developed method has been evaluated from the data obtained using two out of three voting logic from three domain experts by using 120 documents retrieved from SCOPUS database.FindingsThe work reported pertains to extracting concepts from the set of selected documents and aids the search for documents relating to given concepts. The results of a case study indicated that the method developed has demonstrated better metrics than Text2Onto and CFinder. The method described has the capability of extracting valid key concepts from a set of candidates with long phrases.Research limitations/implicationsThe present study is restricted to literature coming out in the English language and applied to the documents from nuclear domain. It has the potential to extend to other domains also.Practical implicationsThe work carried out in the current study has the potential of leading to updating International Nuclear Information System thesaurus for ontology in the nuclear domain. This can lead to efficient search methods.Originality/valueThis work is the first attempt to automatically extract key concepts from the nuclear documents. The proposed approach will address and fix the most of the problems that are existed in the current methods and thereby increase the performance.

scholarly journals Occurrence of linezolid induced thrombocytopenia and its association with the risk factors: a review article

2018 ◽  
Vol 7 (12) ◽  
pp. 2483 ◽  
Author(s):  
Radha A. ◽  
Anuradha H. V. ◽  
Radhika K.
Keyword(s):  
Risk Factors ◽  
English Language ◽  
Cross Sectional Study ◽  
Albumin Concentration ◽  
Cross Sectional ◽  
Baseline Platelet Count ◽  
Gram Positive Bacteria ◽  
Search Terms ◽  
Wide Range ◽  
Linezolid Therapy

Linezolid is the oxazolidinone group of antibiotic with wide range of activity against the gram positive bacteria including methicillin resistant staphylococcus aureus and penicillin resistant pneumococci and vancomycin resistant enterococci. Patients who are on linezolid were reported to have reversible myelosuppression especially thrombocytopenia and anaemia. Since there are less number of studies regarding the occurrence of thrombocytopenia and the risk factors associated with it, this study was undertaken to evaluate the occurrence of linezolid induced thrombocytopenia and its association with risk factors. It was a systematic review with synthesis of available literature in English language. Articles were retrieved using search terms included “linezolid”, “and”, “or”, “thrombocytopenia” from Clinical key and PubMed, published during 2000 - 2017. Out of 16 studies retrieved, only 7 studies were analysed based on inclusion and exclusion criteria; of them, 3 were found to be prospective and retrospective cohort each and only one was retrospective cross-sectional study. The occurrence of linezolid induced thrombocytopenia range from 18-50% with normal renal function and 57% of incidence associated with renal insufficiency patients. The risk factors were found to be dose of linezolid >18-27mg/kg, body weight of subjects <55kg, creatinine clearance <88.39 to 60ml/min/1.73m2 and baseline platelet count <200*103/mm3, serum albumin concentration, serum creatinine, concomitant caspofungin therapy and duration of linezolid therapy.

scholarly journals Urtica dioica (Stinging Nettle) – Properties, Uses and Applications

2021 ◽  
pp. 154-159
Author(s):  
Anjali, Sushma ◽  
Reena Sharma
Keyword(s):  
Fungal Infections ◽  
Database Search ◽  
Urtica Dioica ◽  
Pharmacological Properties ◽  
Electronic Database ◽  
Stinging Nettle ◽  
Wide Range ◽  
The World ◽  
Electronic Database Search ◽  
Pharmacological Potential

Utricaceae is a family of herbs and shrubs that can be found in a variety of habitats around the world. A lot of research has been carried out till date targeted for close understanding of this medicinal plant. The botanical distribution, Ethnomedicinal applications, Traditional uses as well as Pharmacological properties of the Urtica genus, are discussed in this study. The composition such as flavonoids and array of phenolic compounds which includes alcohols, Diocanol, Diol glucosides, Terpenes diols, and sugars as well are an inclusion in the genus Urtica. A wide range of research reports have been published representing its biological and pharmacological potential against cancer, tumors, bacterial, viral or fungal infections significantly. The information about the Urtica genus has been extracted using electronic database search such as Google Scholar and Pubmed as well as a library search for peer-reviewed journal publications.

scholarly journals The problem of human tragedy in the genre of science fiction (on the example of R. Bradbury’s works "Tomorrow's Child" and "The Veldt")

2021 ◽  
pp. 78-87
Author(s):  
O. M. Byndas ◽  
Keyword(s):  
Science Fiction ◽  
English Language ◽  
Human Society ◽  
Wide Range ◽  
Fantastic Fiction ◽  
The Future ◽  
Absolute Dependence ◽  
Inner World ◽  
The Difference ◽  
Definition Of

This article deals with the problem of relationships among people in the future, which are based not on respect and understanding of each other's value, but on absolute dependence on technical progress. The purpose of this work is to highlight the problem of humanity’s tragedy in the genre of science fiction, using the example of Ray Bradbury’s works „Tomorrow's Child” and „The Veldt”. Firstly, it is noted that the difference and, accordingly, the problem begins immediately with terminology, because there is no single stable definition of the term „fantasy” (as a generic phenomenon) in English-language science. The options offered by scientists are speculative fiction, fantastic fiction, fantasy literature. The author notes that science fiction (Sci-Fi) describes many different super important problems of the human society: technological progress, information wars, the desire of people to be immortal, powerful, rich, possessing the Universe. In fact, the tragedy of humanity begins from these desires. However, R. Bradbury’s works „Tomorrow's Child” and „The Veldt” have a wide range of topics, affecting aesthetic, intellectual, moral and scientific problems. In addition, the science fiction writer reveals his special interest in the inner world of the child. In the mentioned-above stories, the idea of the coexistence of people and the techno world is traced, which leads to a tragic situation. Covering the problem of humanity’s tragedy in the future, described back in the distant 1950s, R. Bradbury aims to present another idea of the future, he describes, at the same time, possible threats to us, and shows what significant consequences this can lead to.

scholarly journals Topic Modelling in Bangla Language: An LDA Approach to Optimize Topics and News Classification

2018 ◽  
Vol 11 (4) ◽  
pp. 77 ◽  
Author(s):  
Malek Mouhoub ◽  
Mustakim Al Helal
Keyword(s):  
Topic Modeling ◽  
Text Categorization ◽  
English Language ◽  
Latent Dirichlet Allocation ◽  
Similarity Measures ◽  
Document Collections ◽  
Statistical Language Modeling ◽  
Document Models ◽  
Wide Range ◽  
News Corpus

Topic modeling is a powerful technique for unsupervised analysis of large document collections. Topic models have a wide range of applications including tag recommendation, text categorization, keyword extraction and similarity search in the text mining, information retrieval and statistical language modeling. The research on topic modeling is gaining popularity day by day. There are various efficient topic modeling techniques available for the English language as it is one of the most spoken languages in the whole world but not for the other spoken languages. Bangla being the seventh most spoken native language in the world by population, it needs automation in different aspects. This paper deals with finding the core topics of Bangla news corpus and classifying news with similarity measures. The document models are built using LDA (Latent Dirichlet Allocation) with bigram.

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