scholarly journals Effects of curcumin on lipid peroxidation and antioxidant enzymes in kidney, liver, brain and testis of mice bearing Ehrlich Solid Tumor

2020 ◽  
Vol 74 ◽  
pp. 1-10
Author(s):  
Mustafa Nisari ◽  
Seher Yılmaz ◽  
Tolga Tolga Ertekin ◽  
Arzu Hanım Yay ◽  
Dilek Ceylan ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Natural Products ◽  
Antioxidant Enzymes ◽  
Solid Tumor ◽  
Tumor Development ◽  
Sod Activity ◽  
Ehrlich Ascites ◽  
Liver And Kidney ◽  
Healthy Control ◽  
Eat Cells

Introduction: Cancer is the second most common cause of death in the world. Several natural products have been studied for anticancer activity and for prevention or repair of oxidative injury. Curcumin is one of the natural products of high medicinal interest. This study was performed to investigate effects of curcumin on lipid peroxidation and antioxidant enzymes in tissues of mice bearing Ehrlich solid tumor. Materials and Methods: Forty mice were distributed to four groups as healthy control and treatments that received 1x106 Ehrlich ascites tumor (EAT) cells and EAT cells plus 25 mg/kg/day or 50 mg/kg/day curcumin with a single subcutaneous injection. The liver, kidney, brain and testis tissues were collected for the MDA, SOD and CAT analyses. Results: Tumor development increased MDA levels in liver (p=0.001), kidney (p<0.001) and testis (p<0.01) and curcumin reduced liver MDA. Liver and kidney SOD activities were increased by both levels of curcumin (p=0.001) but 50 mg/kg/day curcumin increased brain SOD activity (p<0.001). The kidney CAT activity was increased by 50 mg/kg/day curcumin (p<0.001). Discussion: This study showed that curcumin suppresses tumor progression, and alleviates the lipid peroxidation and improves antioxidant status in the tissues of solid tumor-bearing mice.

scholarly journals Rhamnetin improves antioxidant status in the liver of Ehrlich solid tumor bearing mice

2020 ◽  
Vol 7 (5) ◽  
pp. 494-500
Author(s):  
Mustafa Nisari ◽  
Özlem Bozkurt ◽  
Tolga Ertekin ◽  
Dilek Ceylan ◽  
Neriman İnanç ◽  
...  
Keyword(s):  
Solid Tumor ◽  
Antioxidant Status ◽  
Antioxidant Properties ◽  
Tumor Control ◽  
Subcutaneous Route ◽  
Ascites Tumor ◽  
Tumor Bearing ◽  
Ehrlich Ascites ◽  
Healthy Control ◽  
Eat Cells

Objective: Rhamnetin, a flavanol, is in the subclasses of the flavonoids existing in plants. The antioxidant properties of several plants containing flavonoids have been extensively studied in several diseases including cancer. This study investigated the effects of rhamnetin on tumor masses, oxidant and antioxidant status in the livers of mice bearing Ehrlich solid tumor. Material and Methods: Fifty male Balb/C mice weighing 25-30 g were used in the study. Ten mice were kept for Ehrlich ascites tumor (EAT) cells production and the remaining mice were randomly assigned to four groups containing 10 mice in each as healthy control and treatments receiving 1x106 EAT cells and EAT cells plus 100 µg/kg/day or 200 µg/kg/day rhamnetin via subcutaneous route. The tumor inhibition rates of rhamnetin treatments were calculated. The livers were analyzed for malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) levels. Results: Compare to tumor control, both levels of rhamnetin suppressed tumor masses throughout the experiment. The MDA levels were increased whereas SOD and CAT activities were reduced by EAT cells injection in the liver of mice. The 100 µg/kg/day rhamnetin treatment decreased MDA level but 200 µg/kg/day rhamnetin had no significant effect on increased MDA level. The reduced liver SOD (p<0.001) and CAT (p<0.01) activities were elevated by both levels of rhamnetin injection. Conclusions: The results of this study have revealed that rhamnetin suppresses tumor progression and improves antioxidant status in the livers of solid tumor-bearing mice.

Antioxidant Responses and Lipid Peroxidation of Penaeus Indicus Postlarvae Subjected to Sublethal Copper Exposure

Crustaceana ◽  
2011 ◽  
Vol 84 (10) ◽  
pp. 1197-1210 ◽  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Antioxidant Enzymes ◽  
Copper Toxicity ◽  
Sod Activity ◽  
Lipid Peroxidation Products ◽  
Coastal Marine ◽  
Potential Biomarker ◽  
Penaeus Indicus

AbstractThe objective of this study was to determine the effect of sublethal copper concentrations on certain antioxidant enzymes and lipid peroxidation products in the postlarvae (PL) of Penaeus indicus when subjected to short- and long-term exposure in the laboratory. The PL of P. indicus were exposed to 0.1641 ppm (sublethal) copper for a period of 30 days along with a parallel control. Sampling was carried out at six different time intervals, i.e., 24, 48, and 96 hrs (shortterm), and 10, 20, and 30 days (long-term). Variations in the activity of the antioxidant enzymes, namely, catalase (CAT) and superoxide dismutase (SOD), as well as lipid peroxidation products (LPP) were measured as biomarkers of metal toxicity. Our results showed a significant (P < 0.05) increase in LPP (indicating oxidative stress) and CAT activity (indicating an adaptive response of the PL for protection against oxidative stress) in the exposed PL for all periods of exposure. However, SOD activity significantly (P < 0.05) decreased on 20 and 30 days exposure, indicating susceptibility of the PL to oxidative stress upon long-term exposure. Therefore, CAT can serve as a better biomarker of oxidative stress than SOD to long-term copper toxicity. Our results indicate that copper contamination causes oxidative stress even at sublethal doses in Penaeus indicus PL, which can thus be used as a potential biomarker of copper toxicity for long-term monitoring of coastal marine ecosystems.

Effects of rosmarinic acid on liver and kidney antioxidant enzymes, lipid peroxidation and tissue ultrastructure in aging mice

2015 ◽  
Vol 6 (3) ◽  
pp. 927-931 ◽  
Author(s):  
Ying Zhang ◽  
Xiaoqiang Chen ◽  
Lei Yang ◽  
Yuangang Zu ◽  
Qi Lu
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Enzymes ◽  
Rosmarinic Acid ◽  
Rosmarinus Officinalis ◽  
Natural Polyphenol ◽  
Liver And Kidney ◽  
Tissue Ultrastructure

Rosmarinic acid (RA), which is a natural polyphenol, was isolated from Rosmarinus. officinalis L.

scholarly journals Biomarkers in Community-Acquired Pneumonia Assessment

2017 ◽  
Vol 71 (1-2) ◽  
pp. 8-13
Author(s):  
Natalja Voskresenska ◽  
Sergejs Babikovs ◽  
Jūlija Voicehovska ◽  
Andrejs Šķesters ◽  
Alise Silova ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Enzymes ◽  
Community Acquired Pneumonia ◽  
Treatment Efficiency ◽  
Control Groups ◽  
Plasma Selenium ◽  
Healthy Control ◽  
Males And Females ◽  
And Control ◽  
Reduced Activity

AbstractThe paper presents information on pneumonia (P) patients with features of oxidative stress (OS). Identifying features of OS in patients with P is of interest not only for diagnosis, but also for monitoring of treatment efficiency. We recruited 73 patients with community-acquired P (CAP), previously healthy adults, both males and females with mean age of 68.0 ± 15.2, hospitalised, and 61 healthy control patients matched for age. For quantitative evaluation of lipid peroxidation in CAP patients, the levels of aldehydic lipid peroxidation products like malondialdehyde (MDA) and 4- hydroxynon-2-enal (HNE) were quantified. Furthermore, concentrations of reduced glutathione (GSH) and several antioxidant enzymes and selenium in plasma were determined. In CAP patients, decreased levels of GSH and plasma selenium were observed. Plasma levels of MDA, and HNE did significantly differ between patient and control groups. We also noted reduced activity of antioxidant enzymes, namely, glutation peroxidase and superoxide dismutase. Low antioxidant enzymes activity was associated with a more severe CAP pattern. Both GSH and antioxidant enzymes may serve as markers for inflammation-related OS in CAP patients, and measurement of these biomarkers may be a valid indentifier for its management.

Effect of hexavalent chromium [Cr(VI)] stress in roots of Cr-tolerant and Cr-sensitive barley cultivars

2012 ◽  
Vol 60 (1) ◽  
pp. 29-36 ◽  
Author(s):  
M. Yildiz ◽  
H. Terzi
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Antioxidant Enzymes ◽  
Protein Content ◽  
Dehydrogenase Activity ◽  
Total Soluble Protein ◽  
Guaiacol Peroxidase ◽  
Sod Activity ◽  
Barley Cultivars ◽  
Significant Difference

The effect of different chromium [Cr(VI)] concentrations (0, 75, 150 and 225 μM) on dehydrogenase activity, total soluble protein, proline, malondialdehyde (MDA) and antioxidant enzymes was investigated in the roots of two barley cultivars (Cr-tolerant Zeynelağa and Cr-sensitive Orza-96) in hydroponic experiments. The root dehydrogenase activity and protein content decreased with an increase in the Cr(VI) concentration, but no significant difference was found between the two barley cultivars. Cr(VI) stress increased the contents of proline and MDA in both cultivars, but this effect was more pronounced in Orza-96 than in Zeynelağa. The activities of antioxidant enzymes, including superoxide dismutase (SOD), ascorbate peroxidase (APX) and guaiacol peroxidase (POD), exhibited changes. The SOD activity increased in Zeynelağa and decreased in Orza-96 at 225 μM Cr(VI) compared to their controls. Cr(VI) stress decreased the APX and POD activities. Zeynelağa had greater APX activity than Orza-96 at 150 and 225 μM Cr(VI). However, there was no marked difference in POD activities between the two cultivars. The decrease in root dehydrogenase activity and protein content, the increase in proline and lipid peroxidation, and the alterations in the activities of antioxidant enzymes may be indicative of oxidative stress induced by Cr(VI).

scholarly journals Effects of Curcumin on Lipid Peroxidation and Antioxidant Enzymes in Kidney, Liver, Brain and Testis of Mice Bearing Ehrlich Solid Tumor

Proceedings ◽  
2017 ◽  
Vol 1 (10) ◽  
pp. 994 ◽  
Author(s):  
Mustafa Nisari ◽  
Seher Yılmaz ◽  
Tolga Ertekin ◽  
Dilek Ceylan ◽  
Neriman İnanç ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Enzymes ◽  
Solid Tumor ◽  
Kidney Liver

Antioxidant enzymes activity and lipid peroxidation in liver and kidney of rats exposed to cadmium and ethanol

2004 ◽  
Vol 42 (3) ◽  
pp. 429-438 ◽  
Author(s):  
M Jurczuk ◽  
M M. Brzóska ◽  
J Moniuszko-Jakoniuk ◽  
M Gałażyn-Sidorczuk ◽  
E Kulikowska-Karpińska
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Enzymes ◽  
Enzymes Activity ◽  
Liver And Kidney

scholarly journals Effect of CO2 exposure on the antioxidant enzymes activity and gill histology of adult zebrafish (Danio rerio)

2021 ◽  
Vol 23 (09) ◽  
pp. 303-319
Author(s):  
Anto Thomas ◽  
◽  
Shanmugam Achiraman ◽  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Enzymes ◽  
Aquatic Organisms ◽  
Enzyme Analysis ◽  
Slight Variation ◽  
Fresh Water Fish ◽  
Sod Activity ◽  
Mda Content ◽  
Living Organisms ◽  
Gpx Activity

Increase in carbon dioxide level is considered as a threat to all living organisms and in particular aquatic organisms are vulnerable. Although a number of studies were carried out to predict the effect of increased CO2 with marine organisms, fresh water fish were the least concerned ones. Therefore, the aim of this study was to study the effect of antioxidant enzymes in zebrafish exposed to acute concentration of CO2 (based on prediction for 2300). Three ranges of pH were selected below the range where no fatality was observed, 6.0 – 6.5, 5.5 – 6.0 and 5.0 – 5.5. Antioxidant enzyme analysis of superoxide dismutase (SOD), catalase (CAT), lipid peroxidation (LP), glutathione reductase (GR) and glutathione peroxidase (GPx) was performed for the tissues, liver, gills and muscles. Although a significant decrease in SOD activity was observed in all three tissues, only a slight variation in CAT activity was found in all the tissues. MDA content which is an indicator of lipid peroxidation showed an increasing pattern in all the tissues. A slight increase in GR activity was found in all the tissues; however, a significant decrease in GPx activity was noted. Further, the histology of gills exposed to CO2 showed marked damage and injury including lamellar fusion and necrosis. Our study concludes that exposure to CO2 has led to oxidative stress which has resulted in cellular injury and damage

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