scholarly journals The circRNA and Role in Alzheimer’s Disease: From Regulation to Therapeutic and Diagnostic Targets

2022 ◽  
Author(s):  
Wen Li ◽  
Guohua Jin
Keyword(s):  
Neurodegenerative Disorder ◽  
Neuronal Loss ◽  
Vital Role ◽  
Tau Proteins ◽  
Circular Rnas ◽  
Full Spectrum ◽  
The Family ◽  
Important Player ◽  
Post Transcriptional Regulation

Alzheimer\'s disease (AD) is a devastating neurodegenerative disorder and the most common form of dementia worldwide. Although the great progress on the prevention and treatment of AD, no effective therapies are available as yet. With the increasing incidence of AD, it has brought a growing burden to the family and society. Histopathologically, AD is characterized by the presence of myloid β (Aβ) plaques composed of Aβ and neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau proteins, which lead to neuronal loss. However, the full spectrum of precise molecular mechanism that contribute to AD pathogenesis remains largely unknown. circular RNAs (circRNAs) are a novel class of endogenous non-coding RNAs that play a vital role in post-transcriptional regulation. Recent reports showed circRNAs to be an important player in the development of neurodegenerative diseases like AD. In this chapter, we review recent progress on understanding the role of circRNAs in AD, and many studies implicating specific circRNAs in the development of the disease. Moreover, we explore the potential promise of these findings for future diagnosis and treatment.

A Review on the Anti-Viral Activity of Houttuynia cordata: A Possible Herb for the Management and Treatment of COVID-19

2021 ◽  
Vol 4 (2) ◽  
pp. 3-10
Author(s):  
Emdormi Rymbai ◽  
Keyword(s):  
Vital Role ◽  
Viral Agent ◽  
Houttuynia Cordata ◽  
Traditional Medicines ◽  
Virulent Newcastle Disease Virus ◽  
Wide Range ◽  
Anti Cancer ◽  
The Family ◽  
Anti Oxidant

Plants are an important source of natural products and they play a vital role in the field of medicinal chemistry and pharmaceutical science. Traditional medicines have been practiced and used for thousands of years, mostly in Asian countries, where plants are the main sources of medicine. Houttuynia cordata, a herb that belongs to the family Saururaceae, has a wide range of pharmacological activities and is used traditionally in conditions like anisolobis sores, heatstroke, lung carbuncles, malaria, scrotal abscess, tonsillitis, salammoniac poison and has also been widely accepted to possess anti-cancer, anti-oxidant, anti-hypertension, anti-inflammatory, anti-mutagenic, antibacterial, anti-viral and anti-purulent activity. Moreover, it is one of the herbs that was recognized during pandemic outbreaks, such as Severe Acute Respiratory Syndrome Coronavirus (SARS CoV) in China, virulent Newcastle Disease Virus (VNDV) in Java (Indonesia) and Newcastle (England). In this review, we briefly discuss the role of H. cordata as an anti-viral agent and the possibility of developing a dosage form against Coronavirus disease-19 (COVID-19).

scholarly journals Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Bruno Alexandre Quadros Gomes ◽  
João Paulo Bastos Silva ◽  
Camila Fernanda Rodrigues Romeiro ◽  
Sávio Monteiro dos Santos ◽  
Caroline Azulay Rodrigues ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorder ◽  
Vital Role ◽  
Hippocampal Damage ◽  
Neuroprotective Effects ◽  
Amyloid A ◽  
Silent Information Regulator 1 ◽  
Anti Inflammatory

Alzheimer’s disease (AD) is a progressive and neurodegenerative disorder of the cortex and hippocampus, which eventually leads to cognitive impairment. Although the etiology of AD remains unclear, the presence ofβ-amyloid (Aβ) peptides in these learning and memory regions is a hallmark of AD. Therefore, the inhibition of Aβpeptide aggregation has been considered the primary therapeutic strategy for AD treatment. Many studies have shown that resveratrol has antioxidant, anti-inflammatory, and neuroprotective properties and can decrease the toxicity and aggregation of Aβpeptides in the hippocampus of AD patients, promote neurogenesis, and prevent hippocampal damage. In addition, the antioxidant activity of resveratrol plays an important role in neuronal differentiation through the activation of silent information regulator-1 (SIRT1). SIRT1 plays a vital role in the growth and differentiation of neurons and prevents the apoptotic death of these neurons by deacetylating and repressing p53 activity; however, the exact mechanisms remain unclear. Resveratrol also has anti-inflammatory effects as it suppresses M1 microglia activation, which is involved in the initiation of neurodegeneration, and promotes Th2 responses by increasing anti-inflammatory cytokines and SIRT1 expression. This review will focus on the antioxidant and anti-inflammatory neuroprotective effects of resveratrol, specifically on its role in SIRT1 and the association with AD pathophysiology.

scholarly journals The Emerging Picture of the Roles of CircRNA-CDR1as in Cancer

2020 ◽  
Vol 8 ◽  
Author(s):  
Chaohua Jiang ◽  
Xiaohong Zeng ◽  
Renfeng Shan ◽  
Wu Wen ◽  
Jianfeng Li ◽  
...  
Keyword(s):  
Binding Sites ◽  
Antisense Rna ◽  
Bioinformatic Analysis ◽  
Vital Role ◽  
Cerebellar Degeneration ◽  
Circular Rnas ◽  
Related Protein ◽  
Future Prospects ◽  
Biological Features

Circular RNAs (circRNAs) are covalently closed circular structures without 5′ caps and 3′ tails, which are mainly formed from precursor mRNAs (pre-mRNAs) via back-splicing of exons. With the development of RNA sequencing and bioinformatic analysis, circRNAs were recently rediscovered and found to be widely expressed in the tree of life. Cerebellar degeneration-related protein 1 antisense RNA (CDR1as) is recognized as one of the most well-identified circRNAs. It contains over 70 miR-7 binding sites and can regulate gene activity by sponging miR-7. Increasing numbers of studies have recently demonstrated that CDR1as is abnormally expressed in many types of tumors, such as colorectal cancer, cholangiocarcinoma and osteosarcoma, and plays a vital role in the development of cancer. However, there are few reviews focusing on CDR1as and cancer. Hence, it is important to review and discuss the role of CDR1as in cancer. Here, we first review the main biological features of CDR1as. We then focus on the expression and roles of CDR1as in cancer. Finally, we summarize what is known on the role of CDR1as in cancer and discuss future prospects in this area of research.

scholarly journals Role of The Family in Entrepreneurship Develoment in Nepali Society

2016 ◽  
Vol 9 (1) ◽  
pp. 37-47 ◽  
Author(s):  
Sushil Kumar Pant
Keyword(s):  
Economic Growth ◽  
Statistical Tests ◽  
Job Creation ◽  
Vital Role ◽  
Ethnic Communities ◽  
Entrepreneurship Research ◽  
Entrepreneurship Development ◽  
The Family ◽  
The Impact

Entrepreneurship is the engine for social and economic growth of any society. It drives people toward wealth and job creation, which leads to better lives for people in the society. There has been growing interest in entrepreneurship research recently. This paper attempted to assess the impact of family in Nepalese society. This was viewed as essential in a country in which more than 125 ethnic communities are found. The findings show that family has some impact in people to become entrepreneurship but it was not strongly substantiated by statistical tests. It was found that entrepreneur’s parental profession plays some role in entrepreneurship development in Nepal which was similar to some findings that parental profession plays vital role in the choice of profession in children.Journal of Nepalese Bussiness Studies Vol. 9, No. 1, 2015 pp. 37-47

scholarly journals The Role of Non-Coding RNAs in the Sorafenib Resistance of Hepatocellular Carcinoma

2021 ◽  
Vol 11 ◽  
Author(s):  
Xinyao Hu ◽  
Hua Zhu ◽  
Yang Shen ◽  
Xiaoyu Zhang ◽  
Xiaoqin He ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Molecular Mechanisms ◽  
Vital Role ◽  
Circular Rnas ◽  
First Line ◽  
Advanced Hcc ◽  
Chemotherapy Agent ◽  
Development Of Resistance ◽  
Non Coding Rnas

Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death. Sorafenib is approved by the U.S. Food and Drug Administration to be a first-line chemotherapy agent for patients with advanced HCC. A portion of advanced HCC patients can benefit from the treatment with sorafenib, but many patients ultimately develop sorafenib resistance, leading to a poor prognosis. The molecular mechanisms of sorafenib resistance are sophisticated and indefinite. Notably, non-coding RNAs (ncRNAs), which include long ncRNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs (circRNAs), are critically participated in the occurrence and progression of tumors. Moreover, growing evidence has suggested that ncRNAs are crucial regulators in the development of resistance to sorafenib. Herein, we integrally and systematically summarized the molecular mechanisms and vital role of ncRNAs impact sorafenib resistance of HCC, and ultimately explored the potential clinical administrations of ncRNAs as new prognostic biomarkers and therapeutic targets for HCC.

scholarly journals Perempuan dan Narasi Kekerasan: Studi Kritis Peran Gender dalam Deradikalisasi

2016 ◽  
Vol 5 (2) ◽  
pp. 431 ◽  
Author(s):  
Abdul Ghofur ◽  
Sulistiyono Susilo
Keyword(s):  
Early Detection ◽  
Political Violence ◽  
Gender Inequality ◽  
Family Environment ◽  
Well Being ◽  
Vital Role ◽  
The Family ◽  
Social Realm ◽  
Role Of Women

Radicalism is a process initiated from the ideas and teachings that stem from individual stages. Hence, the early detection effort in deradicalization by involving women can run effectively, regarding the fact that women play a vital role in the family, particularly in shaping the character of children. Unfortunately, the role of women in preventing, or actually in promoting and participating, terrorism and political violence seems to be neglected. This qualitative study attempts to examine the role of women in preventing radicalization and at the same time promoting and participat-ing to alleviate terrorism and political violence. The findings of the study reveal that the role of women in the deradicali-zation can be done in a number of strategies, although not restricted, such as reduction of gender inequality and disparity, giving women a greater role to participate in a multi-field of social realm, strengthening the well-being to prevent radicalization, making women as leaders who hold moderate and tolerant values in education, especially within, though not limited, the family environment, and initiating peace through women’s reproductive functions.

scholarly journals A study to assess the awareness and knowledge about the maternal nutrition and complications encountered by the antenatal mothers in the rural population

2017 ◽  
Vol 6 (6) ◽  
pp. 2532 ◽  
Author(s):  
Sindhu S. ◽  
Vidhya D. ◽  
Sivankumar K. ◽  
Karthiga M. A.
Keyword(s):  
Tamil Nadu ◽  
Maternal Nutrition ◽  
Healthy Lifestyle ◽  
Vital Role ◽  
Danger Signs ◽  
Balanced Diet ◽  
Healthy Pregnancy ◽  
The Family ◽  
Good Nutrition

Background: Nutrition plays a vital role in life. Good nutrition is an important part of leading a healthy lifestyle. A healthy pregnancy diet will promote your baby's growth and development. The purpose of this study was to highlight the knowledge, attitude and practices of pregnant women regarding the healthy diet, psychological support, regular visits, danger signs and complications during pregnancy among mothers who visit our hospital along with different socio demographic factors.Methods: This study was conducted on 350 antenatal women from January 2016 to February 2017 at Tamil Nadu, India. A 24 point- 15 minutes’ questionnaire was designed about the knowledge, attitude and practice about the nutrition, danger signs and complications in pregnancy.Results: Around 98% of women were very clear that nutrition is necessary in pregnancy and 53% of them told that the quantity of food intake should be increased. Major source of knowledge about the nutrition was obtained from the family members (81%). The common danger sign was abdominal pain (61%) followed by bleeding per vaginum (22%). About 77% of mothers had an idea that minimum of 6-10 visit should be there in their antenatal period.Conclusions: This study emphasizes that health professionals should concentrate more in the nutritional values and the antenatal classes should be taken regarding the role of adequate nutrition, constituents and sources of balanced diet and the consequences of over and under nutrition.

scholarly journals Comparison of Anxiety Levels in Patients with Coronavirus Disease (COVID-19) and their Families

Bionatura ◽  
2021 ◽  
Vol 3 (3) ◽  
pp. 1935-1938
Author(s):  
Azin Chakeri ◽  
Maryam Rostami Qadi ◽  
Shima Haghani
Keyword(s):  
Vital Role ◽  
Definitive Diagnosis ◽  
Anxiety Level ◽  
Her Family ◽  
Psychological Therapies ◽  
The Family ◽  
The Mean ◽  
Anxiety Levels ◽  
Anxiety Questionnaire

Very little research has been done on the anxiety of the families of patients with covid-19. Considering the vital role of the family in the continuation of supportive-psychological therapies and the direct impact on the patient's anxiety level, in this study, we examined the anxiety level of the family of patients with Covid-19 and compared their with their patient's anxiety level. In this comparative study, the samples were 60 people who were given a definitive diagnosis of covid-19 in selected hospitals (Masih Daneshvari Hospital and Besat Hospital). From the family members, the person who, according to the patient, is most affected and has an emotional relationship with him (spouse-father-mother-child) was selected. The standard Spielberger Anxiety Questionnaire has been used to measure apparent (state) and hidden (trait) anxiety. The questionnaire was completed by both groups (patient-family) and compared with each other. The mean of evident anxiety in patients and caregivers was 70.82 and 74.2, respectively, which this difference was statistically significant (P = 0.023). It is also observed that the mean of hidden anxiety in patients and caregivers was 68.83 and 74.71, respectively, which the mean of hidden anxiety in patients was significantly less than caregivers (P = 0.006). After identifying anxiety, nurses can better and more effectively deal with these unwanted conditions in the patient and her family by providing appropriate and correct education.

scholarly journals Long Non-coding RNA: Insight Into Mechanisms of Alzheimer's Disease

2022 ◽  
Vol 14 ◽  
Author(s):  
Zhen Lan ◽  
Yanting Chen ◽  
Jiali Jin ◽  
Yun Xu ◽  
Xiaolei Zhu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurodegenerative Disorder ◽  
Vital Role ◽  
Biological Functions ◽  
Non Coding Rna ◽  
Non Coding Rnas ◽  
Long Non Coding Rna ◽  
Insight Into

Alzheimer's disease (AD), a heterogeneous neurodegenerative disorder, is the most common cause of dementia accounting for an estimated 60–80% of cases. The pathogenesis of AD remains unclear, and no curative treatment is available so far. Increasing evidence has revealed a vital role of non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs), in AD. LncRNAs contribute to the pathogenesis of AD via modulating amyloid production, Tau hyperphosphorylation, mitochondrial dysfunction, oxidative stress, synaptic impairment and neuroinflammation. This review describes the biological functions and mechanisms of lncRNAs in AD, indicating that lncRNAs may provide potential therapeutic targets for the diagnosis and treatment of AD.

scholarly journals Micro RNAS as New Players in Control of Hypothalamic Functions

2019 ◽  
Vol 9 (2) ◽  
pp. 138-143
Author(s):  
O. A. Beylerli ◽  
I. F. Gareev ◽  
A. T. Beylerli
Keyword(s):  
Regulation Of Gene Expression ◽  
Vital Role ◽  
Key Factors ◽  
Eukaryotic Genes ◽  
Micro Rnas ◽  
A Cell ◽  
The Central Nervous System ◽  
And Function ◽  
Post Transcriptional Regulation

Micro RNAs (miRNAs) are short non-coding RNAs (ncRNAs) of ~22 nucleotides in length involved in the post-transcriptional regulation of gene expression. They were discovered over 15 years ago and their functions are becoming clearer. They play an important role in all biological processes. MiRNAs are important modulators of the expression of eukaryotic genes. Focusing on transcripts encoding proteins they impact on the cellular transcriptome thus helping to determine the destiny of a cell. More and more data emerge to indicate an important functional role of miRNAs in the brain development. Since their discovery many miRNAs have been described as key factors in the development and function of the central nervous system. Some play a significant role in the genesis and differentiation of nerve cells (neurons and glial cells). Notably, it has recently been established that miRNAs play a vital role in the mechanisms underpinning the infantile increase of the gonadotropin-releasing hormone (GnRH) production by neurons in the hypothalamus. This phenomenon is necessary for the onset of puberty in mammals. In this review offers our attempt to describe miRNAs as new players in the control of hypothalamic functions, namely the onset of puberty.

Sign in / Sign up

Export Citation Format

Share Document