scholarly journals Common Diagnostic Challenges and Pitfalls in Genitourinary Organs, With Emphasis on Immunohistochemical and Molecular Updates

2021 ◽  
Vol 145 (11) ◽  
pp. 1387-1404
Author(s):  
Liwei Jia ◽  
Fang-ming Deng ◽  
Max X. Kong ◽  
Chin-Lee Wu ◽  
Ximing J. Yang

Context.— Lesions in the genitourinary (GU) organs, both benign and malignant, can demonstrate overlapping morphology, and practicing surgical pathologists should be aware of these potential pitfalls and consider a broad differential diagnosis for each specific type of lesion involving the GU organs. The following summary of the contents presented at the 6th Annual Chinese American Pathologists Association (CAPA) Diagnostic Course (October 10–11, 2020), supplemented with relevant literature review, exemplifies the common diagnostic challenges and pitfalls for mass lesions of the GU system of adults, including adrenal gland, with emphasis on immunohistochemical and molecular updates when relevant. Objective.— To describe the common mass lesions in the GU system of adults, including adrenal gland, with emphasis on the diagnostic challenges and pitfalls that may arise in the pathologic assessment, and to highlight immunohistochemical workups and emerging molecular findings when relevant. Data Sources.— The contents presented at the course and literature search comprise our data sources. Conclusions.— The diagnostic challenges and pitfalls that arise in the pathologic assessment of the mass lesions in the GU system of adults, including adrenal gland, are common. We summarize the contents presented at the course, supplemented with relevant literature review, and hope to provide a diagnostic framework to evaluate these lesions in routine clinical practice.

2017 ◽  
Vol 7 (12) ◽  
pp. 28 ◽  
Author(s):  
Marie-France Deschênes ◽  
Johanne Goudreau

Background: In clinical practice settings, where situations of uncertainty exist, clinical reasoning is situated or contextualized. It calls upon honed knowledge, wherein nurses rely on highly-developed and organized knowledge networks known as “mental scripts”.Methods: The aim of this integrative literature review was to address ways to develop knowledge and clinical reasoning in nursing through the use of mental scripts, and to tackle these pedagogical considerations. The literature search was performed using the following data sources: CINHAL, MEDLINE Google Scholar, PubMed, ProQuest, PsycINFO, Scopus and Web of Science.Results: Script concordance, which optimises situated clinical reasoning, ties in with the socio-cognitive perspective of cognitive apprenticeship, using role models to guide the development of knowledge and clinical reasoning in nursing. Moreover, this perspective proposes implementing new teaching strategies, which focus on situational awareness, reflective acuity, and cognitive dialogue.Conclusions: The perspective of script concordance allows a foreseeable innovative formulation of practices favourable to the development of clinical reasoning in nursing.


2017 ◽  
Vol 8 (1) ◽  
pp. 271-280
Author(s):  
Natalia Tomczewska-Popowycz

The purpose of the study is to explore the challenges of defining what is commonly known as “ethnic tourism”. Provided here a review, comparison, integration and systematization of the definitions of the phenomenon, its facets and characteristics. In particular, such variations as sentimental tourism, ethnic tourism, nostalgic tourism, diaspora tourism, genealogy tourism, are ancestral tourism subjected to a comparative analysis. The study is based on a systemic literature review and qualitative and frequency analysis of the definitions of the phenomenon. The literature search was not limited to publications by Ukrainian authors, but included Polish and Russian available relevant literature on the topic. Offered a new definition of ethnic tourism and other definition connected with ethnic aspects. The lack of clear definitions and differences in understanding significantly impeding the development of his area of tourism. This study gives rise to more function in operation of this type of tourism in theory and practice.


2020 ◽  
Vol 144 (3) ◽  
pp. 290-304
Author(s):  
Jenny Ross ◽  
Guangyuan Li ◽  
Ximing J. Yang

Context.— Immunohistochemistry (IHC) has become increasingly important in the evaluation of pathologic conditions in the genitourinary (GU) organs. In addition to careful evaluation of hematoxylin-eosin sections and generation of a differential diagnosis, choosing the optimal panel of IHC markers becomes even more important when the biopsy material is very limited. The following summary of our experience supplemented with relevant literature review exemplifies how to use IHC to facilitate pathologic diagnosis in the GU system. Objective.— To describe our experience with the most common immunohistochemical markers used in GU pathology. Data Sources.— Institutional experience and literature search comprise our data sources. Conclusions.— Application of IHC provides enormous benefits to the interpretation of GU pathologic conditions, including benign and malignant lesions. However, both insufficient and excessive types of use of IHC, as well as incorrect interpretations in common and rare GU conditions, could present pitfalls in diagnosis.


Author(s):  
Mohamed Tarik Mohamed, Ramy Samy Aly

    The aim of this work is to review the literature aiming at highlighting the thoughtful drawbacks of bariatric surgeries on the buttock region. Together with understanding the best method of contouring this region back to its youthful shape as stated in previous literature. Criteria of searching used a search string to literature dating 1968 till present. Search string used on PubMed to find relevant literature. Search string involved searching for keywords; buttock contouring, post bariatric contouring, buttock lift, post massive weight loss. The repeated literature had been omitted. Exclusion criteria was any literature before 1968; as a mere factor of abundance of literature after then. Literature included was dedicated for post bariatric ptosis correction. After removal of duplicates 74 papers were included in the literature review for 6 months. literature was reviewed in pursuit of the most appropriate technique for post massive weight loss buttock contouring. The prevalence of weight loss surgeries, which has recently occurred as a treatment for the prevalence of obesity, behind the need for treatment of sagging skin around the body, including the buttocks, has been clarified many ways to resolve, including surgical and non-surgical, there is no way like me to treat that problem, but it differs from Individual to another, heavily dependent on the surgeon.    


2022 ◽  
Vol 7 (1) ◽  
pp. 285-298
Author(s):  
Nurulainy Mohd Noor ◽  
Vivien W. C. Yew ◽  
Nur Hafizah Yusoff

Every generation is uniquely featured by naturally designed specific characteristics. A generation is influenced by different backgrounds and upbringing, a major factor that differentiates each generation. Specifically, the significance of new millennial women’s role varies from one country to another. The study aims to analyse the significant roles of millennial women in Malaysia by reviewing empirical studies and performing a relevant literature search through specific terms related to the topic. Resultantly, millennial women’s rising earning power provided significant empowerment and stability. High human capital investment also allowed millennial women to manage the changing family institution that indirectly impacts the stability of society. Finally, the study revealed that new millennial women are transforming and continually evolving to navigate a changing world.


2019 ◽  
Vol 19 (16) ◽  
pp. 1298-1368 ◽  
Author(s):  
Ankit Jain ◽  
Poonam Piplani

: Triazole is a valuable platform in medicinal chemistry, possessing assorted pharmacological properties, which could play a major role in the common mechanisms associated with various disorders like cancer, infections, inflammation, convulsions, oxidative stress and neurodegeneration. Structural modification of this scaffold could be helpful in the generation of new therapeutically useful agents. Although research endeavors are moving towards the growth of synthetic analogs of triazole, there is still a lot of scope to achieve drug discovery break-through in this area. Upcoming therapeutic prospective of this moiety has captured the attention of medicinal chemists to synthesize novel triazole derivatives. The authors amalgamated the chemistry, synthetic strategies and detailed pharmacological activities of the triazole nucleus in the present review. Information regarding the marketed triazole derivatives has also been incorporated. The objective of the review is to provide insights to designing and synthesizing novel triazole derivatives with advanced and unexplored pharmacological implications.


Author(s):  
Daisy Vyas Shirk ◽  
Sarah D. Williams

Background: Ehlers-Danlos Syndromes (EDS) comprise a group of heterogeneous hereditary connective tissue disorders [1, 2]. Psychiatric disorders such as depression, anxiety, panic disorder, agoraphobia, schizophrenia, neurodevelopmental disorders, personality disorder, eating disorders, substance misuse and interpersonal issues have been reported in the literature to be associated with EDS [1-3]. Objectives: The case of a 15-year -old male who was hospitalized after a suicide attempt by gunshot was discovered to have symptoms suggestive of EDS is presented in this paper along with the results of a literature search of psychiatric manifestations of EDS in children and adolescents. Methods: Literature review was conducted on the UpToDate website on March 11, 2020 to review symptoms of EhlersDanlos Syndrome for the purpose of preliminary diagnosis of this patient. Additional literature search was conducted on PubMed on 4/2/20 at 12:10 P.M. and on 4/9/20 at 10:51 P.M. and on the search engine Google on 4/2/20 at 12:25 P.M. On May 11, 2020 at 2 P.M., another web search was conducted with review of 6 different websites pertaining to EhlersDanlos Syndrome. Results: A systematic review of psychiatric manifestations of Ehlers-Danlos Syndromes revealed a strong incidence of psychiatric symptoms. Conclusion: Our patient’s psychiatric symptoms of depression, suicidal ideations, anxiety and social and educational struggles may have been at least partially due to chronic pain- abdominal, headache and musculoskeletal, and social ostracization associated with Ehlers-Danlos Syndrome. Education regarding this illness helped our patient’s recovery as he came to understand why he was so “odd” and the cause of his multisystemic chronic pain.


2021 ◽  
Vol 49 (2) ◽  
pp. 030006052199223
Author(s):  
Xiaolin Zhang ◽  
Hongmei Jiao ◽  
Xinmin Liu

Esophageal diverticulum with secondary bronchoesophageal fistula is a rare clinical entity that manifests as respiratory infections, coughing during eating or drinking, hemoptysis, and sometimes fatal complications. In the present study, we describe a case of bronchoesophageal fistula emanating from esophageal diverticulum in a 45-year-old man who presented with bronchiectasis. We summarize the characteristics of this rare condition based on a review of the relevant literature.


Author(s):  
Nan-Hua Nadja Yang ◽  
Ana Carolina Bertassini ◽  
Jéssica Alves Justo Mendes ◽  
Mateus Cecílio Gerolamo

AbstractFor the transition towards a circular economy (CE), organisations have to be prepared to adapt to major changes. Thus, the concept and implementation of change management (CM) will be essential to an organisation’s success during this transformative period. Studies have shown that organisational CE barriers were more significant than individual CE barriers. To overcome such obstacles, the most appropriate set of managerial practices should be carefully considered. These barriers also have the potential to influence the agricultural sector, which seeks to adopt more sustainable ways of production. The goal of this paper is to propose a solution framework based on CM strategies to overcome organisational challenges posed by a CE, especially for agribusinesses. To accomplish this objectively, a systematic literature review and a content analysis were conducted. The common errors in CM within the implementation process and the main CE barriers were identified and classified. An in-depth analysis of the issue’s roots led to a solid understanding of how to tackle such CM problems. This paper presents an overview of organisational CE barriers verified in the agricultural context, the common errors in CM, and the correlation between these findings. The two areas were then combined in a matrix that shows the connection between common errors in CM errors and CE barriers. Based on this result, a solution framework called 3CE2CE was developed that provides a step-by-step guide on how organisations can successfully undergo transformation processes towards a CE with the principles of CM.


2020 ◽  
Vol 37 (12) ◽  
pp. 841.1-841
Author(s):  
Lucy Hall ◽  
Sophie Dando ◽  
Anthony Hanks

Aims/Objectives/BackgroundIn the Emergency department (ED), noise is a frequent and often unavoidable consequence of work undertaken and levels can often be raised during the day and night. Raised ambient noise levels have potential implications for the workforce, patients and relatives.Investigation into the problem of noise levels in the ED follows feedback from a young patient who couldn’t sleep during a prolonged stay. His complaint focused on loud, irregular banging noises such as those from closing bins that kept him awake.The team felt work should be done to see if it was a wider spread problem or just isolated to his case. A simple sound recording experiment and literature search was conducted.Methods/DesignThe literature search was conducted using electronic/online databases (Medline; Cochrane library) with a fixed date range and specific inclusion criteria.The noise exposure experiment was conducted using a verified phone app to record the sound levels. They were measured at 3 times, during a night shift, in the paediatric emergency department of UHW. All measurements were at a fixed distance and were averaged and compared with WHO recommendations.Results/ConclusionsThere are many sources of noise pollution in the ED, some are unavoidable for safety and clinical reasons.The literature review produced a small number of papers all of which found that sound levels were raised above recommended levels. Similarly, all the sounds measured in the ED also exceeded the recommendations.The most consistent finding across the papers, matched by findings from recordings, was that human behavioural modification is an easy and effective way to reduce noise levels.There are simple steps that can be taken to reduce and eliminate soundsRaising awareness regarding this problem is of great importance and focussing future work on assessing the impact in younger patients within the Emergency Department is paramount.


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