Frequency and histological-cytological correlation of premalignant and malignant changes in the cervix in women of different ages

Introduction: Cervical cancer is the fourth most common and accounts for about 6.6% of all cancers in women. Aim: The aim was to determine the frequency of premalignant and malignant changes in the cervix, to examine the histological-cytological correlation of premalignant and malignant changes in the cervix and the correlation of the women's age with the stage of cervical disease. Material and Methods: A retrospective study analyzed 186 cervical biopsy specimens and cervical smears (Papanicolau test) at the Institute of Pathology of the Faculty of Medicine in Pristina, based in Kosovska Mitrovica, over a three-year period from 2016 to 2018. Results: Of the 186 subjects, 62 had mild premalignant changes of type LSIL, 22 HSIL, and as many as 20 (10.75%) cervical cancer. There was a statistically significant positive association between histological and cytological findings (r = 0.854; p <0.001). There was a statistically significant difference in the age of the subjects with regard to histological findings (F = 11,327; p <0.001). Subjects with HSIL were significantly older than those diagnosed with cervicitis chronica (p = 0.029). Subjects diagnosed with planocellular carcinoma were significantly older than women with cervicitis chronica (p <0.001) and LSIL (p <0.001). Conclusion: There is an increasing trend of cervical cancer in Northern Kosovo and in the Serbian enclaves in central Kosovo and Metohija. Subjects with cervical cancer were significantly older than subjects with mild premalignant cervical changes. There is a significant histologic-cytological correlation of cervical findings, so we believe that more massive cervical screening, especially in younger women, could reduce the incidence of premalignant and malignant diseases of the cervix.

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Neurological improvement is associated with neck pain attenuation after surgery for cervical ossification of the posterior longitudinal ligament

Scientific Reports ◽

10.1038/s41598-021-91268-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Masao Koda ◽

Toshitaka Yoshii ◽

Satoru Egawa ◽

Kenichiro Sakai ◽

Kazuo Kusano ◽

...

Keyword(s):

Neck Pain ◽

Positive Association ◽

Posterior Longitudinal Ligament ◽

Neurological Recovery ◽

Stepwise Logistic Regression ◽

Significant Positive Association ◽

Cervical Spine Surgery ◽

Neurological Improvement ◽

Significant Difference ◽

Univariate Analyses

AbstractAlthough favourable surgical outcomes for myelopathy caused by cervical ossification of the posterior longitudinal ligament (OPLL) have been reported, factors significantly associated with post-operative neck pain attenuation still remain unclear. The primary aim of the present study was to determine factors significantly associated with post-operative neck pain attenuation in patients with cervical OPLL using a prospective multi-centre registry of surgically treated cervical OPLL. Significant postoperative neck pain reduction (50% reduction of neck pain) was achieved in 31.3% of patients. There was no significant difference in neck pain attenuation between surgical procedures. Statistical analyses with univariate analyses followed by stepwise logistic regression revealed neurological recovery as a factor having a significant positive association with post-operative neck pain attenuation (p = 0.04, odds ratio 5.68 (95% confidence interval: 1.27–22.2)). In conclusion, neurological recovery was an independent factor having a significant positive association with post-operative neck pain attenuation in patients with cervical myelopathy caused by OPLL who underwent cervical spine surgery.

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Entering the Mental Backstage: Mindfulness and Mind-Wandering among Performing Artists

10.53350/pjmhs211572068 ◽

2021 ◽

Vol 15 (7) ◽

pp. 2068-2071

Author(s):

Avneet Kaur ◽

Shwetha T.S

Keyword(s):

Negative Relationship ◽

Positive Association ◽

Mind Wandering ◽

Self Report ◽

Years Of Experience ◽

Significant Positive Association ◽

Performing Artists ◽

Creative Processes ◽

Significant Negative Relationship ◽

Significant Difference

Existing literature has explored the role of mindfulness and mind-wandering on creative processes. However, it has overlooked the diversity in the creative domains as well as the experience of the artist while accounting for their relationship. In the present study, mindfulness and mind wandering- deliberate and spontaneous were explored among performing artists, i.e. musicians, theatre artists, and dancers. The study also looked at the artists’ experience in their field. After an initial screening using a creativity tool, 66 performing artists were recruited, following which two self-report indices that assessed mind wandering and mindfulness were administered. The data collected was subjected to quantitative data analysis in SPSS. A Oneway ANOVA showed significant effect of the creative domain on mindfulness for the three groups, with a significant difference between musicians and dancers. Among the musicians, a significant negative relationship between mind wandering spontaneous and years of experience was seen. Among the dancers, there was a significant positive association between mind wandering spontaneous, mind wandering deliberate and years of experience. The current study highlighted the need to approach the study of creativity using a contextual perspective. Keywords: Creativity, Dance, Music, Theatre.

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Prevalence of cervical disease at age 20 after immunisation with bivalent HPV vaccine at age 12-13 in Scotland: retrospective population study

BMJ ◽

10.1136/bmj.l1161 ◽

2019 ◽

pp. l1161 ◽

Cited By ~ 44

Author(s):

Tim Palmer ◽

Lynn Wallace ◽

Kevin G Pollock ◽

Kate Cuschieri ◽

Chris Robertson ◽

...

Keyword(s):

Cervical Cancer ◽

Population Study ◽

Hpv Vaccine ◽

Cervical Screening ◽

Intraepithelial Neoplasia ◽

Cervical Cancer Prevention ◽

Effective Vaccine ◽

Herd Protection ◽

Cervical Disease ◽

Grade 3

Abstract Objective To quantify the effect on cervical disease at age 20 years of immunisation with bivalent human papillomavirus (HPV) vaccine at age 12-13 years. Design Retrospective population study, 1988-96. Setting National vaccination and cervical screening programmes in Scotland. Participants 138 692 women born between 1 January 1988 and 5 June 1996 and who had a smear test result recorded at age 20. Main outcome measures Effect of vaccination on cytology results and associated histological diagnoses from first year of screening (while aged 20), calculated using logistic regression. Results 138 692 records were retrieved. Compared with unvaccinated women born in 1988, vaccinated women born in 1995 and 1996 showed an 89% reduction (95% confidence interval 81% to 94%) in prevalent cervical intraepithelial neoplasia (CIN) grade 3 or worse (from 0.59% (0.48% to 0.71%) to 0.06% (0.04% to 0.11%)), an 88% reduction (83% to 92%) in CIN grade 2 or worse (from 1.44% (1.28% to 1.63%) to 0.17% (0.12% to 0.24%)), and a 79% reduction (69% to 86%) in CIN grade 1 (from 0.69% (0.58% to 0.63%) to 0.15% (0.10% to 0.21%)). Younger age at immunisation was associated with increasing vaccine effectiveness: 86% (75% to 92%) for CIN grade 3 or worse for women vaccinated at age 12-13 compared with 51% (28% to 66%) for women vaccinated at age 17. Evidence of herd protection against high grade cervical disease was found in unvaccinated girls in the 1995 and 1996 cohorts. Conclusions Routine vaccination of girls aged 12-13 years with the bivalent HPV vaccine in Scotland has led to a dramatic reduction in preinvasive cervical disease. Evidence of clinically relevant herd protection is apparent in unvaccinated women. These data are consistent with the reduced prevalence of high risk HPV in Scotland. The bivalent vaccine is confirmed as being highly effective vaccine and should greatly reduce the incidence of cervical cancer. The findings will need to be considered by cervical cancer prevention programmes worldwide.

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The Increasing Problem in Tayside of Cervical Cancer in Younger Women

Scottish Medical Journal ◽

10.1177/003693308903400108 ◽

1989 ◽

Vol 34 (1) ◽

pp. 403-405 ◽

Cited By ~ 4

Author(s):

J. Dodgson ◽

E.M. Walker ◽

K.A. Hussein ◽

A.J. Robertson ◽

I.D. Duncan

Keyword(s):

Cervical Cancer ◽

Retrospective Analysis ◽

Cervical Carcinoma ◽

Cervical Screening ◽

False Negative ◽

Younger Patients ◽

Younger Women ◽

Careful Inspection ◽

Number Of Patients

The incidence of cervical carcinoma in younger women is increasing in Tayside despite a decrease in the overall incidence. However, stage for stage, we did not encounter a poorer survival in younger patients. A number of patients had been sterilised or had a pregnancy when cytological screening was available and not made use of. There were also some false negative smears which were reclassified for retrospective analysis. We would recommend cervical screening every three years and careful inspection of the cervix and a smear taken in cases of abnormal gynaecological symptoms such as post coital bleeding.

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EFFECT OF NICOTINE ABUSE ON OXIDATIVE STRESS AND PERCEIVED STRESS AND ITS RELATIONSHIP WITH COPING SELF EFFICACY AMONG UNIVERSITY GRADUATES

Journal of Experimental Biology and Agricultural Sciences ◽

10.18006/2020.8(6).849.858 ◽

2020 ◽

Vol 8 (6) ◽

pp. 849-858

Author(s):

Sandeep Kumar ◽

◽

Astha Dwivedi ◽

Anuja Mishra ◽

Sharmistha Singh ◽

...

Keyword(s):

Oxidative Stress ◽

Perceived Stress ◽

Self Efficacy ◽

Coping Styles ◽

Linear Regression Analysis ◽

Positive Association ◽

University Graduates ◽

Significant Positive Association ◽

Nicotine Abuse ◽

Significant Difference

An interdisciplinary review of the literature portrayed stress as an important cause for nicotine abuse among university students. Independent studies have shown nicotine to contribute perceived stress (PS) and oxidative stress (OS) but its mediation relation with PS and OS remains unclear and inspires active exploration. A prominent study on the relationship of smoking with perceived stress and coping styles in adolescents motivates to study the effect of nicotine abuse (NA) on PS, CSE, and OS indices among young adult university graduates. The study sample included 45 university graduates with 1-3 years of tobacco abuse history and 50 age-matched controls. The respondents were compared for perceived stress scale (PSS) score, coping self-efficacy (CSE) score, erythrocyte malondialdehyde (E_MDA), plasma MDA (P_MDA), erythrocyte superoxide dismutase (E_SOD), and plasma catalase (P_CAT). The study found NA increased the PS but not the CSE. Linear regression analysis showed a strong inverse relation between the PSS Score and CSE Score in the controls. Among the biochemical indices of OS, only P_MDA showed a significant difference between the groups. Multiple regressions showed a significant positive association of E_MDA with PSS Score and a significant negative association of E_SOD with PSS Score across the groups. Further, the mediation model is used to show a significant relationship between NA and PSS Score by Combined MDA (C_MDA). The result of study suggested that nicotine increases PS and reduces CSE. P_MDA is an important biochemical marker of nicotine abuse. E_MDA and E_SOD are important predictors of PS. These findings are important for psychobiochemical interventions in the management of NA. Therefore, this study encourages an interdisciplinary discourse on nicotine abuse with psychological and biochemical measures.

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Tophi reduction: ultrasound imaging and correlation with plasma levels of uric acid in patients undergoing treatment for tophaceous gout

Reumatismo ◽

10.4081/reumatismo.2019.1058 ◽

2019 ◽

Vol 71 (2) ◽

pp. 75-80

Author(s):

A.J.L. Ferrari ◽

A.R. Corrêa Fernandes ◽

R. De Almeida Agustinelli ◽

H. Seike ◽

E. De Ávila Fernandes

Keyword(s):

Uric Acid ◽

Drug Therapy ◽

Plasma Levels ◽

Ultrasound Examination ◽

Positive Association ◽

Serum Levels ◽

Tophaceous Gout ◽

Significant Positive Association ◽

Significant Difference ◽

Male Patients

The objective was to determine the reduction of tophi in patients undergoing drug therapy in correlation with urate serum levels through ultrasound examination. A total of 31 male patients, between the ages of 33 to 77 years, with tophaceous gout were evaluated between 2005 and 2009, 11 of which were selected. Ultrasound examinations of visible tophi and evaluations of serum uric acids levels were performed annually on each patient. There was a statistically significant difference between measurements 1, 2, 3 and measurement 4 and between measurements 4 and 5. A strong significant positive association was seen between variation of tophus size and the reduction of serum uric acid levels.

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Post-operative neurological improvement is associated with significant neck pain attenuation after surgery for cervical ossification of the posterior longitudinal ligament: a prospective multicenter registry study

10.21203/rs.3.rs-139889/v1 ◽

2021 ◽

Author(s):

Masao Koda ◽

Toshitaka Yoshii ◽

Satoru Egawa ◽

Kenichiro Sakai ◽

Kazuo Kusano ◽

...

Keyword(s):

Neck Pain ◽

Positive Association ◽

Posterior Longitudinal Ligament ◽

Neurological Recovery ◽

Registry Study ◽

Significant Positive Association ◽

Cervical Spine Surgery ◽

Neurological Improvement ◽

Significant Difference ◽

Multicenter Registry

Abstract Although favourable surgical outcomes for myelopathy caused by cervical ossification of the posterior longitudinal ligament (OPLL) have been reported, factors significantly associated with post-operative neck pain attenuation still remain unclear. The primary aim of the present study was to determine factors significantly associated with post-operative neck pain attenuation in patients with cervical OPLL using a prospective multi-centre registry of surgically treated cervical OPLL. Significant postoperative neck pain reduction (50% reduction of neck pain) was achieved in 84 patients (30.9%). There was no significant difference in neck pain attenuation between surgical procedures. Statistical analyses revealed neurological recovery as a factor having a significant positive association with post-operative neck pain attenuation (p = 0.04). Neurological recovery was an independent factor having a significant positive association with post-operative neck pain attenuation in patients with cervical myelopathy caused by OPLL who underwent cervical spine surgery.

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Beliefs on Learning and Teaching Language Components: The Case of Iranian EAP and EFL Learners

Advances in Language and Literary Studies ◽

10.7575/aiac.alls.v.8n.3p.5 ◽

2017 ◽

Vol 8 (3) ◽

pp. 5

Author(s):

Gholamreza Parsi

Keyword(s):

Pearson Correlation ◽

Correlation Coefficients ◽

Positive Association ◽

Significant Positive Association ◽

Efl Learners ◽

Learning And Teaching ◽

Teaching Language ◽

Significant Difference ◽

The Face ◽

Basic English

The present study intended to investigate the possible difference between EAP and EFL learners’ beliefs concerning learning and teaching of language components, namely, vocabulary, pronunciation and grammar. Furthermore, this study examined the association between EAP and EFL learners’ beliefs and their language components’ development. To this end, 231 undergraduate EAP (117) and EFL (114) learners at Ferdowsi University took part in the study by completing a five-point Likert scale questionnaire adapted from Simon and Taverniers (2011). The face and content validity of the questionnaire was confirmed by the experts’ judgment and factor analysis. Moreover using Cronbach alpha coefficient the questionnaire was found acceptably reliable (α=0.88). Furthermore, for language components’ development, the EAP learners’ scores in English course and EFL learners’ average scores in their Basic English courses were taken into account. The results of an Independent Samples t-test revealed that there existed a statistically significant difference between EAP and EFL learners’ beliefs on learning and teaching language components. Furthermore, the results of Pearson correlation coefficients indicated a statistically significant positive association between EFL learners’ beliefs and their language components’ development, however no statistically significant correlation was found between EAP learners’ beliefs and their language components’ development.

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Association of P1635 and P1655 polymorphisms in dysbindin (DTNBP1) gene with schizophrenia

Acta Neuropsychiatrica ◽

10.1111/j.1601-5215.2011.00598.x ◽

2012 ◽

Vol 24 (3) ◽

pp. 155-159 ◽

Cited By ~ 3

Author(s):

Fatemeh Alizadeh ◽

Mohammad Amin Tabatabaiefar ◽

Mohammad Ghadiri ◽

Mir Saeed Yekaninejad ◽

Nazanin Jalilian ◽

...

Keyword(s):

Genetic Variants ◽

Population Studies ◽

Positive Association ◽

Multiple Comparisons ◽

Control Groups ◽

Significant Positive Association ◽

Significant Difference ◽

Pcr Rflp ◽

And Control ◽

Epigenetic Processes

Objectives: Schizophrenia (SCZ) is a severe psychiatric disorder with a lifetime prevalence of approximately 1% in most of the populations studied. SCZ is multifactorial with the contribution of multiple susceptibility genes that could act in conjunction with epigenetic processes and environmental factors. There is some evidence supporting the association between genetic variants in dysbindin (DTNBP1) gene and SCZ in populations. In this study, we investigated the association between polymorphisms P1635 and P1655 in dysbindin gene with SCZ.Methods: Totally, 115 unrelated patients with SCZ and 117 unrelated healthy volunteers were studied. Genomic DNA was extracted from blood. Genotyping was done with the PCR-RFLP method. The allele and genotype associations were analysed with X2 test. The Benjamini-Hochberg procedure was used to correct p values for multiple comparisons.Results: The results showed no significant difference between patients and controls in allelic frequencies or genotypic distributions of SNP P1635 (p = 0.809), but a significant difference between the case and control groups for SNP P1655 (p = 0.009) was found. We could also find a significant positive association between A-C haplotype and SCZ (OR = 1.7, 95% CI 1.18–2.42; p = 0.004, pc = 0.02) and a protective effect for A-G haplotype (p = 0.003, OR = 0.57, 95% CI 1.18–2.42; p = 0.003, pc = 0.02).Conclusion: This study may provide further support for the association between SNP polymorphisms in DTNBP1 and SCZ in the Iranian population. Studies with more markers and subjects for various populations will be necessary to understand the genetic contribution of the gene to the development of SCZ.

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The pandemic of COVID-19 decreased adherence to treatment among hypertension patients at Dr. Zainoel Abidin Hospital

Trends in Infection and Global Health ◽

10.24815/tigh.v1i2.22418 ◽

2021 ◽

Vol 1 (2) ◽

pp. 58-65

Author(s):

Ghina Salsabila Rahman ◽

Muhammad Ridwan ◽

Hilwah Nora ◽

Maimun Syukri ◽

Fitri Dewi Ismida

Keyword(s):

Treatment Adherence ◽

Patient Adherence ◽

Positive Association ◽

Bivariate Analysis ◽

Significant Positive Association ◽

Cross Sectional ◽

Hypertensive Patients ◽

Mortality And Morbidity ◽

Number Of Patients ◽

Significant Difference

Hypertension is one of the leading causes of mortality and morbidity worldwide. Treatment adherence is an essential factor in controlling blood pressure among hypertensive patients. This study aimed to evaluate the effect of the Coronavirus disease 2019 (COVID-19) pandemic on treatment adherence among hypertensive patients at Dr. Zainoel Abidin Hospital, Aceh, Indonesia, as well as to determine its associated factors. A cross-sectional study was conducted at the Cardiac Center by utilizing medical records of hypertensive patients visiting during the period of April-July 2019 and December 2020-March 2021. Bivariate analysis using the Kruskal-Wallis test was employed to examine the effect of the COVID-19 pandemic on patients’ adherence. The results showed that the number of patients adhering to treatment significantly decreased (p=0.000) by 22.7%, from 179 patients in 2019 to 64 patients in 2020. The data also suggested a significant positive association between residential and patient adherence before the pandemic (p=0.006); however, no significant difference was observed between residential and patients’ adherence after the pandemic (p=0.282). Furthermore, our study found no association between age and adherence before and after the pandemic (p=0.690 in 2019 and p=0.125 in 2020). In conclusion, the pandemic of COVID-19 significantly affected treatment adherence among patients with hypertension at Aceh provincial hospital, with a decreased number in patient visits up to 22.7%.

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