Protocol for #iBeatCRC: a community-based intervention to increase early-onset colorectal cancer awareness using a sequential explanatory mixed-methods approach

IntroductionTh last two decades have seen a twofold increase in colorectal cancer (CRC) incidence among individuals under the recommended screening age of 50 years. Although the origin of this early-onset CRC (EOCRC) spike remains unknown, prior studies have reported that EOCRC harbours a distinct molecular and clinical phenotype in younger individuals. The sharp increase in EOCRC incidence rates may be attributable to a complex interplay of factors, including race; lifestyle; and ecological, sociodemographic and geographical factors. However, more research that address psychosocial experiences and accounts for lifestyle-related behaviours before, during and after an EOCRC diagnosis are warranted. This study aims to develop and pilot test a theory-driven, community-based intervention to increase awareness of EOCRC, reduce its associated risk factors and improve early detection among adults aged 18–49 years.Methods and analysisGuided by the Behaviour Change Wheel, we will use a multistage mixed-methods study design. We will pilot a sequential mixed-methods intervention study as follows: (1) First, we will analyse linked quantitative data from the Utah Cancer Registry and National Cancer Institute Surveillance, Epidemiology and End Results registry, linked to state-wide demographic and vital records in the Utah Population Database to identify EOCRC hotspots in Utah by examining the EOCRC incidence and survival variance explained by personal and county-level factors. (2) Next, we will conduct one-on-one interviews with 20 EOCRC survivors residing in EOCRC hotspots to ascertain psychosocial and lifestyle challenges that accompany an EOCRC diagnosis. (3) Finally, we will consider existing evidence-based approaches, our integrated results (quantitative +qualitative) and community action board input to design a community-based intervention to increase EOCRC awareness that can feasibly be delivered by means of outdoor mass media, and via social media. We will pilot the multicomponent media campaign with a quasiexperimental design among 17 EOCRC hotspot residents and 17 EOCRC ‘coldspot’ residents.Ethics and disseminationEthics approval was obtained from the University of Utah Institutional Review Board (IRB_00138357). Signed informed consent will be obtained from all participants prior to any data collection. Study results will be disseminated through CRC community blogs, targeted infographics, conference presentations at national and international professional conferences and publications in peer-reviewed journals. Final intervention-specific data will be available on reasonable request from the corresponding author.Trial registration numberNCT04715074.

Determination of the concentration of CO2 and H2O vapor under conditions of overlapping spectral lines

The efficiency of determining the concentration of CO2 and H2O vapors in the atmosphere has been investigated taking into account the overlap of their spectral lines. It is proposed to use regression relationships established between the determined and measured parameters of the investigated medium. These ratios can be set both for fixed values of temperature and pressure, and for a set range of their values. When calculating the absorption value, all overlaps of spectral lines are taken into account, taking into account their broadening at different temperatures and pressures. This allows the method to be used in multicomponent media with strongly overlapping spectral lines. The established regression relations are resistant to errors in the measurement information, which also improves the accuracy of determining the concentrations of the component composition of the gas medium. In addition, they are determined promptly (in real time), since the calculation of concentrations using established relationships (analytical expressions) between the determined and measured values does not present computational difficulties.

Discrete-Impulse Energy Supply in Milk and Dairy Products Processing

The basis of the discrete-impulse energy supply (DIES) concept is the efficient use of supplied energy. The references describe in detail the general principles of DIES, examine the energy and thermodynamic aspects and the main mechanisms of intensification that can be initiated on the basis of this principle. DIES mechanisms conveniently can be divided into hard and soft ones. The former should be used to stimulate hydromechanical processes, and the latter to accelerate the processes of phase heat and mass transfer, or for the purpose of intensive mixing of multicomponent media. The authors have studied the possibility of using DIES to intensify the hydromechanical processes, in particular emulsification of milk fat (homogenization of milk, preparation of spreads), processing of cream cheese masses. Objects of research were whole non-homogenized milk, fat emulsions, cream cheese mass. In order to evaluate the efficiency of milk homogenization the homogenization coefficient change was studied, which was determined by centrifugation method as the most affordable and accurate one. Emulsions were evaluated according to the degree of destabilization, resistance and dispersion of the fat phase. The rheological characteristics of cheese masses were evaluated by the effective viscosity change.

A study of the influence produced by the dynamics of the working bodies of cotton-processing machines on the cotton fibre quality

Cotton mass is considered as a compressible porous two-component medium, consisting of a mixture of cotton fibres and air included in the porous medium, which is essential in dynamic treatment processes and requires consideration when planning technological modes. It was found that the speed of sound in multicomponent media significantly decreases with an increase in the content of the gaseous component. With a certain content of components, it can become less than in each of the components separately. This is due to the fact that with an increase in the content of the gaseous component, the density of the medium increases insignificantly, and the compressibility of air sharply decreases in the pores. As a result of the research, it was found that the value of the dynamic change in the density of cotton raw materials can significantly exceed its density during static compression. This kind of influence can have both adverse and desirable effects on the primary stage of cotton processing. The dynamic characteristics of raw cotton as an object of mechanical technology were studied. The values of the speed of sound as a function of the density of cotton raw materials were determined on the basis of the theory of a two-component porous medium. The types of the dynamic compression curve of raw cotton have been established. Experimental studies on the compressibility of raw cotton are generalized. From the analysis of the cleaning processing of fibres and seeds on cleaning machines, it follows that when assigning a technological processing mode, it is necessary to comply it with the value of the sound speed for a given density of raw materials. It is necessary to avoid such rates of penetration of the working bodies into raw materials that are commensurate with the speed of sound at a given raw material density. This local dramatic increase in cotton media characteristics is a significant cause of fibre damage

Euler-Bernoulli cantilever beam bending considering the inner diffusion flows finite propagation speed

Исследуются нестационарные колебания балки Эйлера-Бернулли с учетом массопереноса. Используется модель упругой диффузии для многокомпонентных сред. Для получения решения задачи используются вариационный принцип Даламбера и метод эквивалентный граничных условий. Unsteady vibrations of the Euler-Bernoulli beam are studied taking into account mass transfer. The model of elastic diffusion for multicomponent media is used. To obtain a solution to the problem, the d’Alembert variational principle and the equivalent boundary conditions method are used.

Optical Diagnostics of Temperature and Structural Parameters of an Axisymmetric Flame

In this paper a method for restoring the parameters of multicomponent media for optical diagnostics of jet using the example of a hydrogen-air flame study is considered. Hilbert visualization and numerical modeling of phase perturbations induced by the studied medium in the probing light field are used. The study of the burning jet was carried out using the methods of Hilbert op-tics and Abel transformation in the model of axial symmetry of the torch. A software package has been developed that implements a direct solution to the problem: calculation of the spatial optical phase structure of the flame and its corresponding hilbertograms based on the temperature and molar concentrations of the combustion products of the mixture. The reliability of the obtained results is confirmed by comparing the Hilbert structures obtained in the experiment and the reconstructed optical density field of the phase using the Abel transform. The results of the comparison are used as a quality criterion for modeling the phase structure and temperature field in the study of the combustion process. The developed method can be used to solve the in-verse problem of restoring the temperature field from the Hilbert image of the phase structure of a hydrogen-air flame in the approximation of axial symmetry. The research is motivated by the scientific and practical significance of the problem, which consists in finding methods for controlling the structural and thermodynamic parameters of reacting jets and flames.

MODELATION OF THE RADIATION CHARACTERISTICS OF THE GAS PHASE COMBUSTION PRODUCTS BASED ON HIGH THEMPERATURE ATLASES OF SPECTRAL LINE PARAMETERS

High temperature atlass of spectral lines parameters of the combustion production of energy fuels and their use for modeling the radiation characteristics of the optically active ingredients and radiation heat transfer in high structurally inhomogeneous multicomponent media are considering. The model of the absorption bands to determine the functions of spectral transmission and parameterization according to the results of numerical modelation performed by direct calculation of the fine structure of the emission (absorption) spectra, followed by their numerical integration. The results of the calculations are compared with the data of experimental studies.

Fine structural spectrometry and spectroradiometry of combustion products of energy fuels

The results of experimental studies of the fine structure of the spectra of molecular absorption and emission of combustion products of energetic fuels and their application in solving problems of radiative heat transfer in structurally inhomogeneous multicomponent media are considered. The methods of determining the parameters of the spectral absorption lines from the experimental emission spectra of the flame in the combustion products of gas fuel the identification of optically active ingredients in the combustion products and anthropogenic emissions into the atmosphere are analyzed. Attention is drawn to the fact that the emission of gas components is selective and the methods for calculating the radiative heat exchange in the combustion chambers of power units must take into account the acute selection of the molecular absorption spectra of radiation.