On the hygienic rating of silicon compounds in drinking water (literature review)

Introduction. Silicon is a unique element in its physicochemical properties, almost ubiquitous in water supply sources but is not normalized in drinking water in the world practice of ensuring the harmlessness of water use of the population. In our country, the half-century history of the development of hygienic silicon standards in the water began with the justification of the MPC of silicon-containing reagents used in water treatment. However, over time, doubts have arisen about the suitability of manufactured silicon standards for controlling natural silicon in drinking water. Proponents of the harmlessness of natural soluble forms of silicon advocated the elimination of silicon standards in water. In contrast, researchers of the action of silicon in silicon biogeochemical provinces have constantly revealed its adverse effects on the health of the population living in these regions, confirming this with animal experiments. methods. Literature search methods on Scopus, CyberLeninka, PubMed databases: selective, analytical-synthetic, typological. the main part. The review provides information on soluble forms of silicon, their stability and bioavailability, examines the retrospective and current state of hygienic rationing of silicon in water, discusses the shortcomings of the currently existing MPC of silicon, sodium and potassium silicates in drinking water. A detailed review of studies carried out in the silicon biogeochemical provinces of Chuvashia is given, where the inhabitants of the ecological disaster zone, who consumed drinking water with a profound imbalance of macro-and microelements and a high silicon content relative to the optimum area, observed various metabolic disorders (mineral, lipid, carbohydrate, peroxide), changes in microbiocenosis of the large intestine and immune status, an increase in the incidence rate of the adult population with chronic non-infectious diseases by 2-3 times against the national average, the highest incidence rates in children of all age groups. Conclusions. The review draws attention to the need for expanded studies of the effect on the body of natural silicon in drinking water with the usual balance of trace elements to resolve issues about the standards for natural silicon at the federal and regional levels and to establish differentiated standards for silicon-containing reagents in drinking water.

The medaka fish Tol2 transposable element is in an early stage of decay: identification of a nonautonomous copy

The majority of DNA-based transposable elements comprise autonomous and nonautonomous copies, or only nonautonomous copies, where the autonomous copy contains an intact gene for a transposase protein and the nonautonomous copy does not. Even if autonomous copies coexist, they are generally less frequent. The <i>Tol2</i> element of medaka fish is one of the few elements for which a nonautonomous copy has not yet been found. Here we report the presence of a nonautonomous <i>Tol2</i> copy that was identified by surveying the medaka genome sequence database. This copy contained 3 local sequence alterations that affected the deduced amino acid sequence of the transposase: a deletion of 15 nucleotides resulting in a deletion of 5 amino acids, a base substitution causing a single amino acid change, and another base substitution giving rise to a stop codon. Transposition assays using cultured human cells revealed that the transposase activity was reduced by the 15-nucleotide deletion and abolished by the nonsense mutation. This is the first example of a nonautonomous <i>Tol2</i> copy. Thus, <i>Tol2</i> is in an early stage of decay in the medaka genome, and is therefore a unique element to observe an almost whole decay process that progresses in natural populations.

EMPLOYING HERITAGE ELEMENTS IN CONTEMPORARY ARCHITECTURE - BAZAAR MARKET AS A UNIQUE ELEMENT IN ISLAMIC ARCHITECTURE

This paper examines the definition of the market and its types in terms of size and location. It is the agent in which commodities are exchanged and the processes of sale and purchase at various levels. The market developed during different time periods while malls are recently appeared to invade cities. The research examines the bazaars in Islamic cities and their development and spread in the neighborhoods of cities. These bazaars were formed as part of the city's urban planning, its streets and buildings commensurate with the streets and buildings of the Islamic city. They developed in construction technology and architecture styles during various historical periods. They contain great architectural and construction elements and different sets of decorations and climate treatments, so that they have become unique architectural and construction museums. A special social relationship is formed in bazaars between the seller and the buyer while the wanderer in these traditional markets enjoys the local products and the spirit of the place with its distinctive architectural work. These bazaars have been established near the Friday mosques, where shoppers visit them, and their importance has been proven over the centuries and will remain the ideal place for shopping in Islamic cities.

Investigation of Correlation Between Fracture Toughness and Charpy Impact Energy of Cryogenic Steel Welds

The high manganese steel was developed to improve the fracture toughness and safety at cryogenic temperatures, the austenite structure was formed by increasing the manganese (Mn) content. The developed weld high manganese steel was alloyed with austenite stabilizing elements (e.g., C, Mn, and Ni) for cryogenic toughness and fluxes contained less than 10% of acidic slag formers such as rutile (TiO2) and silica (SiO2). This paper describes the work carried out to enhance the fracture toughness of Mn contents in an economical way by means of increase of manganese up to 23% instead of using nickel (Ni) which has unique element to improve fracture toughness especially at cryogenic steel. The new cryogenic steels should be carefully evaluated in terms of safety for application in real structures including LNG ships. In this study, the fracture toughness performance was evaluated for recently developed cryogenic steels (high-Mn steels), especially the crack tip opening displacement (CTOD) parameter was evaluated using the prediction formula proposed by conventional equation. The CTOD value was investigated the effect of microstructure and mechanical properties of Fe–C–Mn and Fe–C–Mn–Ni high manganese steel, it was revealed that the e-martesnsite phase formed in high manganese steel of 0.2C–20Mn and 0.4C–20Mn as a result of a low stability of austenite upon strain-induced phase transformation.

Automated Nanopackaging using Cellulose Fibers Composition with Feasibility in SEM Environment

By contributing to the system enhancement, the integration of Nano systems for nanosensors with biomaterials proves to be a unique element in the development of novel innovative systems. The techniques by which manipulation, handling, and preparation of the device are accomplished with respect to industrial use are a critical component that must be considered before the system is developed. The approach must be able to be used in a scanning electron microscope (SEM), resistant to environmental changes, and designed to be automated. Based on this deduction, the main objective of this research work is to develop a novel design of Nano electronic parts, which address the issue of packaging at a nanoscale. The proposed research work has used wood fibres and DNA as the bio material to develop nanoscale packaging. The use of a certain atomic force microscope (ATM) for handling DNA in dry circumstances is demonstrated with SCM wood fibrils/fibers manipulation in a scanning electron microscope (SEM).Keywords: Nano electronics, bioelectronics, scanning electron microscope (SEM), packaging, atomic force microscope (ATM)

Regulation of HPV18 Genome Replication, Establishment and Persistence by Sequences in the Viral Upstream Regulatory Region

During persistent human papillomavirus infection, the viral genome replicates as an extrachromosomal plasmid that is efficiently partitioned to daughter cells during cell division. We have previously shown that an element which overlaps the HPV18 transcriptional enhancer promotes stable DNA replication of replicons containing the viral replication origin. Here we perform comprehensive analyses to elucidate the function of this maintenance element. We conclude that no unique element or binding site in this region is absolutely required for persistent replication and partitioning, and instead propose that the overall chromatin architecture of this region is important to promote efficient use of the replication origin. These results have important implications on the genome partitioning mechanism of papillomaviruses. Importance Persistent infection with oncogenic HPVs is responsible for ∼5% human cancers. The viral DNA replicates as an extrachromosomal plasmid and is partitioned to daughter cells in dividing keratinocytes. Using a complementation assay that allows us to separate viral transcription and replication, we provide insight into viral sequences that are required for long term replication and persistence in keratinocytes. Understanding how viral genomes replicate persistently for such long periods of time will guide the development of anti-viral therapies.

Exploratory Analysis of Pedestrian Road Trauma in Finland

In Finland, all fatal on-road and off-road motor vehicle crashes are subject to an in-depth investigation coordinated by the Finnish Crash Data Institute (OTI). This study presents an exploratory and two-step cluster analysis of fatal pedestrian crashes between 2010 and 2019 that were subject to in-depth investigations. In total, 281 investigations occurred across Finland between 2010 and 2019. The highest number of cases were recorded in the Uusimaa region, including Helsinki, representing 26.4% of cases. Females (48.0%) were involved in fewer cases than males; however, older females represented the most commonly injured demographic. A unique element to the patterns of injury in this study is the seasonal effects, with the highest proportion of crashes investigated in winter and autumn. Cluster analysis identified four unique clusters. Clusters were characterised by crashes involving older pedestrians crossing in low-speed environments, crashes in higher speed environments away from pedestrian crossings, crashes on private roads or in parking facilities, and crashes involving intoxicated pedestrians. The most common recommendations from the investigation teams to improve safety were signalisation and infrastructure upgrades of pedestrian crossings, improvements to street lighting, advanced driver assistance (ADAS) technologies, and increased emphasis on driver behaviour and training. The findings highlight road safety issues that need to be addressed to reduce pedestrian trauma in Finland, including provision of safer crossing facilities for elderly pedestrians, improvements to parking and shared facilities, and addressing issues of intoxicated pedestrians. Efforts to remedy these key issues will further Finland’s progression towards meeting Vision Zero targets while creating a safer and sustainable urban environment in line with the United Nations sustainable development goals.

Can moral reasoning be modeled in an experiment?

A review of the literature on moral issues indicates that none of the empirical approaches to moral reasoning proposes an experimental approach which controls for such object-related experimental variables as: knowledge, motivation, acceptance of moral norms and consequences of human behavior in moral situations in a single research procedure. A unique element of the proposed experimental method is a multi-stage model determining morality indicators. In the two-phase design experiment, psychology students were asked to create model ethical stories and then conduct an overall assessment of each of these stories. As a result, a base of ethical stories was created with empirical moral indicators (positive, negative, neutral). The patterns in the moral evaluation of ethical stories were determined by identifying three processes (selection, differentiation and integration). The final result is a confirmed design of the experiment and a set of formulas that can be used in education and research on morality reasoning.

Kolakoski sequence: links between recurrence, symmetry and limit density

The Kolakoski sequence $S$ is the unique element of \(\left\lbrace 1,2 \right\rbrace^{\omega}\) starting with 1 and coinciding with its own run length encoding. We use the parity of the lengths of particular subclasses of initial words of \(S\) as a unifying tool to address the links between the main open questions - recurrence, mirror/reversal invariance and asymptotic density of digits. In particular we prove that recurrence implies reversal invariance, and give sufficient conditions which would imply that the density of 1s is \(\frac{1}{2}\).

Sequences in the Human papillomavirus Type 18 (HPV18) Upstream Regulatory Region regulate Viral Genome Replication, Establishment and Persistence

During persistent human papillomavirus infection, the viral genome replicates as an extrachromosomal plasmid that is efficiently partitioned to daughter cells during cell division. We have previously shown that an element which overlaps the HPV18 transcriptional enhancer promotes stable DNA replication of replicons containing the viral replication origin. Here we perform comprehensive analyses to elucidate the function of this maintenance element. We conclude that no unique element or binding site in this region is absolutely required for persistent replication and partitioning, and instead propose that the overall chromatin architecture of this region is important to promote efficient use of the replication origin. These results have important implications on the genome partitioning mechanism of papillomaviruses.