Precision Medicine and Childhood Asthma: A Guide for the Unwary

Many thousands of articles relating to asthma appear in medical and scientific journals each year, yet there is still no consensus as to how the condition should be defined. Some argue that the condition does not exist as an entity and that the term should be discarded. The key feature that distinguishes it from other respiratory diseases is that airway smooth muscles, which normally vary little in length, have lost their stable configuration and shorten excessively in response to a wide range of stimuli. The lungs’ and airways’ limited repertoire of responses results in patients with very different pathologies experiencing very similar symptoms and signs. In the absence of objective verification of airway smooth muscle (ASM) lability, over and underdiagnosis are all too common. Allergic inflammation can exacerbate symptoms but given that worldwide most asthmatics are not atopic, these are two discrete conditions. Comorbidities are common and are often responsible for symptoms attributed to asthma. Common amongst these are a chronic bacterial dysbiosis and dysfunctional breathing. For progress to be made in areas of therapy, diagnosis, monitoring and prevention, it is essential that a diagnosis of asthma is confirmed by objective tests and that all co-morbidities are accurately detailed.

Filament Eruption Driving EUV Loop Contraction and Then Expansion above a Stable Filament

We analyze the observations of EUV loop evolution associated with the filament eruption located at the border of an active region (AR). The event SOL2013-03-16T14:00 was observed with a large difference in view point by the Solar Dynamics Observatory and Solar Terrestrial Relations Observatory. The filament height is fitted with the sum of a linear and exponential function. These two phases point to different physical mechanisms such as tether-cutting reconnection and a magnetic instability. While no X-ray emission is reported, this event presents classical eruption features like separation of double ribbons and the growth of flare loops. We report the migration of the southern foot of the erupting filament flux rope due to the interchange reconnection with encountered magnetic loops of a neighboring AR. Parallel to the erupting filament, a stable filament remains in the core of the AR. The specificity of this eruption is that coronal loops, located above the nearly joining ends of the two filaments, first contract in phase, then expand and reach a new stable configuration close to the one present at the eruption onset. Both contraction and expansion phases last around 20 minutes. The main difference with previous cases is that the PIL bent about 180° around the end of the erupting filament because the magnetic configuration is at least tripolar. These observations are challenging for models that interpreted previous cases of loop contraction within a bipolar configuration. New simulations are required to broaden the complexity of the configurations studied.

Survivability of Suddenly Loaded Arrays of Micropillars

When a multicomponent system is suddenly loaded, its capability of bearing the load depends not only on the strength of components but also on how a load released by a failed component is distributed among the remaining intact ones. Specifically, we consider an array of pillars which are located on a flat substrate and subjected to an impulsive and compressive load. Immediately after the loading, the pillars whose strengths are below the load magnitude crash. Then, loads released by these crashed pillars are transferred to and assimilated by the intact ones according to a load-sharing rule which reflects the mechanical properties of the pillars and the substrate. A sequence of bursts involving crashes and load transfers either destroys all the pillars or drives the array to a stable configuration when a smaller number of pillars sustain the applied load. By employing a fibre bundle model framework, we numerically study how the array integrity depends on sudden loading amplitudes, randomly distributed pillar strength thresholds and varying ranges of load transfer. Based on the simulation, we estimate the survivability of arrays of pillars defined as the probability of sustaining the applied load despite numerous damaged pillars. It is found that the resulting survival functions are accurately fitted by the family of complementary cumulative skew-normal distributions.

Flow interaction of three-dimensional self-propelled flexible plates in tandem

Tandem configurations of two self-propelled flexible flappers of finite span are explored by means of numerical simulations. The same sinusoidal vertical motion is imposed on the leading edge of both flappers, but with a phase shift ( $\phi$ ). In addition, a vertical offset, $H$ , is prescribed between the flappers. The configurations that emerge are characterized in terms of their hydrodynamic performance and topology. The flappers reach a stable configuration with a constant mean propulsive speed and a mean equilibrium horizontal distance. Depending on $H$ and $\phi$ , two different tandem configurations are observed, namely compact and regular configurations. The performance of the upstream flapper (i.e. the leader) is virtually equal to the performance of an isolated flapper, except in the compact configuration, where the close interaction with the downstream flapper (i.e. the follower) results in higher power requirements and propulsive speed than an isolated flapper. Conversely, the follower's performance is significantly affected by the wake of the leader in both regular and compact configurations. The analysis of the flow shows that the follower's performance is influenced by the interaction with the vertical jet induced by the vortex rings shed by the leader. This interaction can be beneficial or detrimental for the follower's performance, depending on the alignment of the jet velocity with the follower's vertical motion. Finally, a qualitative prediction of the performance of a hypothetical follower is presented. The model is semi-empirical, and it uses the flow field of an isolated flapper.

Aerodynamic Performance of a Nanostructure-Induced Multistable Shell

Multistable shells that have the ability to hold more than one stable configuration are promising for adaptive structures, especially for airfoil. In contrast to existing studies on bistable shells, which are well demonstrated by the Venus flytrap plant with the ability to feed itself, this work experimentally studies the aerodynamic response of various stable configurations of a nanostructure-induced multistable shell. This multistable shell is manufactured by using nanotechnology and surface mechanical attrition treatment (SMAT) to locally process nine circular zones in an original flat plate. The aerodynamic responses of eight stable configurations of the developed multistable shell, including four twisted configurations and four untwisted configurations with different cambers, are visually captured and quantitively measured in a wind tunnel. The results clearly demonstrate the feasibility of utilizing different controllable configurations to adjust the aerodynamic performance of the multistable shell.

Color-flavor locked compact stars: An exact solution approach

We present an exact solution that could describe compact star composed of color-flavor locked (CFL) phase. Einstein’s field equations were solved through CFL equation of state (EoS) along with a specific form of [Formula: see text] metric potential. Further, to explore a generalized solution we have also included pressure anisotropy. The solution is then analyzed by varying the color superconducting gap [Formula: see text] and its effects on the physical parameters. The stability of the solution through various criteria is also analyzed. To show the physical validity of the obtained solution we have generated the [Formula: see text] curve and fitted three well-known compact stars. This work shows that the anisotropy of the pressure at the interior increases with the color superconducting gap leading to decrease in adiabatic index closer to the critical limit. Further, the fluctuating range of mass due to the density perturbation is larger for lower color superconducting gap leading to more stable configuration.

Hydromagnetic Instability of Two Viscoelastic Dusty-Fluids in Porous Medium

An attempt has been made to investigate the instability of the plane interface between two viscoelastic superposed conducting fluids in the presence of suspended particles and variable horizontal magnetic field through porous medium is studied. The cases of two fluids of uniform densities, viscosities, magnetic fields, and suspended particles number densities separated by a horizontal boundary; and of exponentially varying density, viscosity, suspended particles number density, and magnetic field are considered. It is found that the stability criterion is independent of the effects of viscoelasticity, medium porosity, and suspended particles but is dependent on the orientation and magnitude of the magnetic field. The magnetic field succeeds in stabilizing a certain range of wavenumbers which were unstable in the absence of the magnetic field. The system is found to be stable for potentially stable configuration/stratification. The growth rates are found to increase (for certain wavenumbers) and decrease (for other wavenumbers) with the increase in kinematic viscosity, suspended particles number density, magnetic field, medium permeability and stress relaxation time.

Elastic Guided Waves in Bistable Composite Structures – Experimental and Numerical Investigation

Background: Bistable composite laminates are emerging as smart structures in automotive and aerospace applications. However, the behavior of the wave propagation within such laminates has not been investigated, which hinders their implementation in structural health monitoring (SHM) and non-destructive evaluation (NDE). Objective: As a result, this manuscript examines the propagation behavior of guided waves in bistable composite structures. By understanding the effect of pre-stressing in bistable composite laminates on the characteristics of propagating waves, such as velocity and amplitude, a more knowledgeable decision about their applications in flaw detection and assessment can be made. Methods: The fundamental symmetric (S0) and anti-symmetric (A0) Lamb wave modes were investigated during propagation in two bistable composite laminates, [0/90]T and [02/902]T, and were assessed experimentally and numerically using ABAQUS. For the tested frequencies, which ranged from 60 kHz to 250 kHz, the behavior of the propagating wave was evaluated for both stable configurations and across two different actuators that were lined up with the fiber directions. Signal processing techniques were thus extensively used to enhance the measured signals and identify both the group velocities and the amplitudes’ trend of the S0 and A0 wave modes. Results: Our results showed that there is a minimal variation (typically below 1%) in the amplitude and velocity of the A0 and S0 modes when the composite plates switch between the first stable configuration and the second stable configuration in both composite plates. These results were numerically validated by replicating the bi-stability of the composites. The numerical data were in relatively close agreement (10% average error) with the experimental values and trends. Furthermore, the bistable effect was examined in detail relative to a reference numerical flat (monostable) plate. Although the bistable effect induced a notable amount of internal residual stress, this did not significantly impact the propagating wave modes, with a maximum difference of about 2% when comparing wave velocities. Conclusions: The effect on the wave propagation behavior along different directions of both stable configurations was shown to be minimal. These results, which were validated numerically, clear the ambiguity on the usage of these laminates in experimental health monitoring.

Detection of the YORP Effect on the contact-binary (68346) 2001 KZ66 from combined radar and optical observations

The YORP effect is a small thermal-radiation torque experienced by small asteroids, and is considered to be crucial in their physical and dynamical evolution. It is important to understand this effect by providing measurements of YORP for a range of asteroid types to facilitate the development of a theoretical framework. We are conducting a long-term observational study on a selection of near-Earth asteroids to support this. We focus here on (68346) 2001 KZ66, for which we obtained both optical and radar observations spanning a decade. This allowed us to perform a comprehensive analysis of the asteroid’s rotational evolution. Furthermore, radar observations from the Arecibo Observatory enabled us to generate a detailed shape model. We determined that (68346) is a retrograde rotator with its pole near the southern ecliptic pole, within a 15○ radius of longitude 170○ and latitude −85○. By combining our radar-derived shape model with the optical light curves we developed a refined solution to fit all available data, which required a YORP strength of $(8.43\pm 0.69)\times 10^{-8} \rm ~rad ~day^{-2}$. (68346) has a distinct bifurcated shape comprising a large ellipsoidal component joined by a sharp neckline to a smaller non-ellipsoidal component. This object likely formed from either the gentle merging of a binary system, or from the deformation of a rubble pile due to YORP spin-up. The shape exists in a stable configuration close to its minimum in topographic variation, where regolith is unlikely to migrate from areas of higher potential.