The strength of the Science, Technology, Engineering, and Math (STEM) talent pool is a key factor for boosting innovation. This pipeline has been weakened substantially as emerging groups of STEMs, particularly White and minority women, have failed to enter STEM professions at the same rates as White males. Moreover, once women from diverse backgrounds overcome significant hurdles during the educational process, they depart the STEM workplace at alarmingly high rates. Some of the reasons for this phenomenon are discussed in this chapter, along with some solutions about how to decrease these departures. Additionally, ways to focus on the future needs of the changing demographics of the STEM workforce are reviewed. Ultimately, the goal is to offset STEM shortages in intellectual capital and mitigate brain drain and brain migration circumstances so that the U.S. can fully leverage the contributions of high-ability women from diverse groups, eventually benefitting innovation strategies.