Developments in Metallic Biomaterials and Surface Coatings for Various Biomedical Applications

2020 ◽  
pp. 197-206
Author(s):  
Gurmohan Singh ◽  
Abhineet Saini
Keyword(s):  
Biomedical Applications ◽  
Surface Coatings ◽  
Metallic Biomaterials

scholarly journals Impact of anti-biofouling surface coatings on the properties of nanomaterials and their biomedical applications

2018 ◽  
Vol 6 (1) ◽  
pp. 9-24 ◽  
Author(s):  
Yuancheng Li ◽  
Yaolin Xu ◽  
Candace C. Fleischer ◽  
Jing Huang ◽  
Run Lin ◽  
...  
Keyword(s):  
Surface Coating ◽  
Biomedical Applications ◽  
Biological Systems ◽  
Surface Coatings ◽  
Specific Interactions ◽  
Coating Materials

Various anti-biofouling surface coating materials for nanoparticles have been reviewed for the reduction of their non-specific interactions with biological systems.

Cytocompatibility of Magnesium-Zinc-Calcium Alloys with Bone Marrow Derived Mesenchymal Stem Cells

2014 ◽  
Vol 922 ◽  
pp. 1-6
Author(s):  
Aaron F. Cipriano ◽  
Christopher Miller ◽  
Hui Nan Liu
Keyword(s):  
Biomedical Applications ◽  
Culture Media ◽  
Corrosion Properties ◽  
Cell Culture Media ◽  
Tissue Culture Polystyrene ◽  
Metallic Biomaterials ◽  
Zn Content ◽  
Before And After ◽  
Orthopedic Applications ◽  
Early Indication

Magnesium (Mg)-based alloys have attracted great interest as metallic biomaterials for orthopedic applications due to their biocompatibility, biodegradability, and mechanical properties that resemble those of cortical bone. However, the potential toxicity of alloying elements in commercially available Mg alloys makes it critical to engineer and screen new alloys specifically for biomedical applications. The objective of this study was to evaluate and compare the in vitrodegradation and cytocompatibility of two distinct Mg - Zinc (Zn) - Calcium (Ca) alloys (Mg-4%Zn-1%Ca and Mg-9%Zn-1%Ca, wt. %; abbreviated as ZCa41 and ZCa91, respectively) using a bonemarrow derived mesenchymal stem cell (BMSC) model. Both Zn and Ca play critical roles in boneformation and growth, and have been shown to increase mechanical and corrosion properties of Mgalloys. BMSCs provide vertebrates the continuous supply of osteoblasts needed for bone remodelingand repair, and thus were selected to determine the effect of increasing Zn content on cell behavior.Surface microstructure and composition of the alloys were characterized before and after BMSC culture using field emission scanning electron microscopy (FESEM) and energy dispersive X-rayspectroscopy (EDS). Thermanox® treated glass and plasma treated tissue culture polystyrene were used as a control and reference, respectively. Results indicated that the ZCa91 alloy improved BMSC adhesion as compared with ZCa41 alloy. The formation of high-aspect ratio needle-likefeatures on the surface of ZCa41 alloy after its degradation in cell culture media was speculated tocontribute to the lower cell adhesion. This study provided an early indication on cytocompatibility of Mg-Zn-Ca alloys for biomedical applications.

Formability of Hydroxyapatite on Beta-Type Ti-Nb-Ta-Zr Alloy for Biomedical Applications through Alkaline Treatment Process

2007 ◽  
Vol 352 ◽  
pp. 297-300
Author(s):  
Toshikazu Akahori ◽  
Mitsuo Niinomi ◽  
Masaaki Nakai
Keyword(s):  
Alkaline Solution ◽  
Biomedical Applications ◽  
Treatment Process ◽  
Solution Treatment ◽  
Sodium Titanate ◽  
Alkaline Treatment ◽  
Simple Method ◽  
Metallic Biomaterials ◽  
Naoh Solution ◽  
Bioactive Surface Modification

Titanium and its alloys have been widely used as biomaterials for hard tissue replacements because of their excellent mechanical properties and biocompatibility. However, the bonding between their surfaces and bone is not enough after implantation. The bioactive surface modification such as a hydroxyapatite (HAp) coating on their surfaces has been investigated. Recently, a simple method for forming HAp layer on the surfaces of titanium and its alloys has been developed. This method is called as alkaline treatment process. In this method, HAp deposits on the surfaces of titanium and its alloys by dipping into simulated body fluid (SBF) after an alkaline solution treatment that is followed by a baking treatment (alkaline treatment). This process is applicable to newly developed beta-type Ti-29Nb-13Ta-4.6Zr alloy (TNTZ) for biomedical applications achieving bioactive HAp modification. In this study, the morphology of the HAp layer formed on the surface of TNTZ was investigated after various alkaline treatments followed by dipping in SBF. The formability of HAp on the surface of TNTZ was then discussed. The formability of HAp on TNTZ is much lower than that of commercially pure Ti, Ti-6Al-4V ELI and Ti-15Mo-5Zr-3Al alloys, which are representative metallic biomaterials. The formability of HAp on TNTZ is improved by increasing the amount of Na in the sodium titanate gels formed during an alkaline solution treatment where the NaOH concentrations and the dipping time are over 5 M and 172.8 ks, respectively. The formability of HAp on TNTZ is considerably improved by dipping in a 5 M NaOH solution for 172.8 ks. This condition for alkaline solution treatment process is the most suitable for TNTZ.

scholarly journals Improved corrosion resistance of commercially pure magnesium after its modification by plasma electrolytic oxidation with organic additives

2018 ◽  
Vol 33 (5) ◽  
pp. 725-740 ◽  
Author(s):  
Monica Echeverry-Rendon ◽  
Valentina Duque ◽  
David Quintero ◽  
Sara M Robledo ◽  
Martin C Harmsen ◽  
...  
Keyword(s):  
Corrosion Resistance ◽  
Electrolyte Solution ◽  
Surface Coating ◽  
Plasma Electrolytic Oxidation ◽  
Biomedical Applications ◽  
The Body ◽  
Pure Magnesium ◽  
Surface Coatings ◽  
Electrolytic Oxidation ◽  
Plasma Electrolytic

The optimal mechanical properties render magnesium widely used in industrial and biomedical applications. However, magnesium is highly reactive and unstable in aqueous solutions, which can be modulated to increase stability of reactive metals that include the use of alloys or by altering the surface with coatings. Plasma electrolytic oxidation is an efficient and tuneable method to apply a surface coating. By varying the plasma electrolytic oxidation parameters voltage, current density, time and (additives in the) electrolytic solution, the morphology, composition and surface energy of surface coatings are set. In the present study, we evaluated the influence on surface coatings of two solute additives, i.e. hexamethylenetetramine and mannitol, to base solutes silicate and potassium hydroxide. Results from in vitro studies in NaCl demonstrated an improvement in the corrosion resistance. In addition, coatings were obtained by a two-step anodization procedure, firstly anodizing in an electrolyte solution containing sodium fluoride and secondly in an electrolyte solution with hexamethylenetetramine and mannitol, respectively. Results showed that the first layer acts as a protective layer which improves the corrosion resistance in comparison with the samples with a single anodizing step. In conclusion, these coatings are promising candidates to be used in biomedical applications in particular because the components are non-toxic for the body and the rate of degradation of the surface coating is lower than that of pure magnesium.

Ti-Mo Alloys Used in Medical Applications

2015 ◽  
Vol 1128 ◽  
pp. 105-111 ◽  
Author(s):  
Mădălina Simona Bălţatu ◽  
Petrică Vizureanu ◽  
Mircea Horia Tierean ◽  
Mirabela Georgiana Minciună ◽  
Dragoş Cristian Achiţei
Keyword(s):  
Mechanical Properties ◽  
Titanium Alloys ◽  
Biomedical Applications ◽  
Medical Field ◽  
Steel Alloys ◽  
Good Corrosion Resistance ◽  
Metallic Biomaterials ◽  
Good Biocompatibility ◽  
Implant Alloys ◽  
General Aspects

Metallic biomaterials are used in various applications of the most important medical fields (orthopedic, dental and cardiovascular). The main metallic biomaterials are stainless steels, Co-based alloys and Ti-based alloys. Recently, titanium alloys are getting much attention for biomaterials because these types of materials have very good mechanical properties, good corrosion resistance and an excellent biocompatibility. The paper contains important information about titanium alloys used for biomedical applications, which are considered the most widely. It is very important to understand the microstructural evolution and property-microstructure relationship in implant alloys. In the present paper, authors present a short literature review on general aspects of promising biocompatible binary Ti-Mo alloys compared with CoCr and stainless steel alloys, as an alternative of the known metallic biomaterials. This alloys show superior mechanical compatibility and very good biocompatibility. The aim of this review is to highlight the mechanical properties for several types of biomaterials, their application in medical field, especially the Ti-Mo group.

scholarly journals Core-shell Semiconductor Nanocrystals: Effect of Composition, Size, Surface Coatings on their Optical Properties, Toxicity and Pharmacokinetics

2017 ◽  
Vol 23 (3) ◽  
pp. 340-349 ◽  
Author(s):  
Wafa' T. Al-Jamal
Keyword(s):  
Quantum Dots ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Biomedical Applications ◽  
Semiconductor Nanocrystals ◽  
Organic Dye ◽  
Surface Coatings ◽  
Core Shell ◽  
Biomedical Field

Quantum dots are semiconducting nanocrystals that exhibit extraordinary optical properties. QD have shown higher photostability compared to standard organic dye type probes. Therefore, they have been heavily explored in the biomedical field. This review will discuss the different approaches to synthesis, solubilise and functionalise QD. Their main biomedical applications in imaging and photodynamic therapy will be highlighted. Finally, QD biodistribution profile and in vivo toxicity will be discussed.

scholarly journals A Comparative Study of Friction and Wear Processes of Model Metallic Biomaterials Including Registration of Friction-Induced Temperature Response of a Tribological Pair

Materials ◽  
2019 ◽  
Vol 12 (24) ◽  
pp. 4163 ◽  
Author(s):  
Magdalena Łępicka ◽  
Artur Ciszewski ◽  
Karol Golak ◽  
Małgorzata Grądzka-Dahlke
Keyword(s):  
Comparative Study ◽  
Mass Loss ◽  
Temperature Increase ◽  
Biomedical Applications ◽  
Friction And Wear ◽  
Temperature Response ◽  
Metallic Alloys ◽  
Cocrmo Alloy ◽  
Metallic Biomaterials ◽  
316L Steel

Nowadays, metallic alloys are extensively used in wear-related biomedical applications. However, it was shown that one of the factors which may contribute to the premature implant failure is the temperature effect caused by the sliding action between the bearing surfaces. Nevertheless, there are not many papers where the wear-related temperature phenomena of biomedical alloys are discussed. Thus, in our paper, we present findings from the tribological tests of the model metallic biomaterials—316L steel, CoCrMo alloy and Ti gr. 2. In our study, the temperature alterations induced by the wear action of the examined materials were analyzed. According to the findings, the temperature response of the biomedical alloys is tribological pair dependent. While the mass loss of the tribological pair 316L–316L steel was the slightest, at the same time the temperature increase was the greatest. Based on the presented findings, further analyses in friction-induced temperature response of biomedical alloys is recommended.

Osteoconductivity of Hydrothermal-Treated Valve Metals

2014 ◽  
Vol 783-786 ◽  
pp. 1298-1302 ◽  
Author(s):  
Kensuke Kuroda ◽  
Mansjur Zuldesmi ◽  
Masazumi Okido
Keyword(s):  
Contact Angle ◽  
Water Contact Angle ◽  
Surface Coatings ◽  
Tissue Formation ◽  
Hydrophilic Surface ◽  
Bioactive Substances ◽  
Water Contact ◽  
Metallic Biomaterials ◽  
Valve Metals

Anti-corroded valve metals, such as Ti, Nb, Ta, and Zr have been used as metallic biomaterials. However, as untreated surfaces, they do not have high osteoconductivity, and surface coatings with bioactive substances are needed for the implantation into the bone. Surface property, especially hydrophilicity, is considered to have a strong influence on the biological reactions. However, the influence of a hydrophilic surface on osteoconductivity is not completely clear. In this study, we produced super-hydrophilic surface on valve metals (Ti, Nb, Ta and Zr) using a hydrothermal treatment at 180 °C for 180 min. in the distilled water, and then the treated samples were stored in 5PBS(-). This maintained water contact angle less than 10 (deg.) in an apparent. The osteoconducivity of super-hydrophilic treated metals was evaluated with in vivo tests. The hard tissue formation on the samples increased with decreasing the water contact angle. That is to say that super-hydrophilic valve metals without coating of bioactive substances had high osteoconductivity, and the surface properties strongly affected on the osteoconductivity.

scholarly journals Biocompatible Titanium Alloys used in Medical Applications

2019 ◽  
Vol 70 (4) ◽  
pp. 1302-1306 ◽  
Author(s):  
Madalina Simona Baltatu ◽  
Catalin Andrei Tugui ◽  
Manuela Cristina Perju ◽  
Marcelin Benchea ◽  
Mihaela Claudia Spataru ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Corrosion Resistance ◽  
Biomedical Applications ◽  
Elasticity Modulus ◽  
Medical Applications ◽  
Global Level ◽  
Medical Field ◽  
High Corrosion Resistance ◽  
Metallic Biomaterials ◽  
Ti Alloys

At global level, there is a continuing concern for the research and development of alloys for medical and biomedical applications. Metallic biomaterials are used in various applications of the most important medical fields like orthopedic, dental and cardiovascular. The main metallic biomaterials used in human body are stainless steels, Co-based alloys and Ti-based alloys. Titanium and its alloys are of greater interest in medical applications because they exhibit characteristics required for implant materials, namely, good mechanical properties (less elasticity modulus than stainless steel or CoCr alloys, fatigue strength, high corrosion resistance), high biocompatibility. The aim of this review is to describe and compare the main characteristics (mechanical properties, corrosion resistance and biocompatibility) for latest research of nontoxic Ti alloys biomaterials used for medical field.

scholarly journals Nature-Based Biomaterials and Their Application in Biomedicine

Polymers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 3321
Author(s):  
Eoin Troy ◽  
Maura A. Tilbury ◽  
Anne Marie Power ◽  
J. Gerard Wall
Keyword(s):  
Biomedical Applications ◽  
Controlled Drug Release ◽  
Implantable Devices ◽  
Surface Coatings ◽  
Natural Polymers ◽  
Innovative Biomaterials ◽  
Novel Applications ◽  
Plant Sources ◽  
Structural Versatility

Natural polymers, based on proteins or polysaccharides, have attracted increasing interest in recent years due to their broad potential uses in biomedicine. The chemical stability, structural versatility, biocompatibility and high availability of these materials lend them to diverse applications in areas such as tissue engineering, drug delivery and wound healing. Biomaterials purified from animal or plant sources have also been engineered to improve their structural properties or promote interactions with surrounding cells and tissues for improved in vivo performance, leading to novel applications as implantable devices, in controlled drug release and as surface coatings. This review describes biomaterials derived from and inspired by natural proteins and polysaccharides and highlights their promise across diverse biomedical fields. We outline current therapeutic applications of these nature-based materials and consider expected future developments in identifying and utilising innovative biomaterials in new biomedical applications.

Sign in / Sign up

Export Citation Format

Share Document