Staging and quantification of florbetaben PET images using machine learning: impact of predicted regional cortical tracer uptake and amyloid stage on clinical outcomes

Abstract Purpose We developed a machine learning–based classifier for in vivo amyloid positron emission tomography (PET) staging, quantified cortical uptake of the PET tracer by using a machine learning method, and investigated the impact of these amyloid PET parameters on clinical and structural outcomes. Methods A total of 337 18F-florbetaben PET scans obtained at Samsung Medical Center were assessed. We defined a feature vector representing the change in PET tracer uptake from grey to white matter. Using support vector machine (SVM) regression and SVM classification, we quantified the cortical uptake as predicted regional cortical tracer uptake (pRCTU) and categorised the scans as positive and negative. Positive scans were further classified into two stages according to the striatal uptake. We compared outcome parameters among stages and further assessed the association between the pRCTU and outcome variables. Finally, we performed path analysis to determine mediation effects between PET variables. Results The classification accuracy was 97.3% for cortical amyloid positivity and 91.1% for striatal positivity. The left frontal and precuneus/posterior cingulate regions, as well as the anterior portion of the striatum, were important in determination of stages. The clinical scores and magnetic resonance imaging parameters showed negative associations with PET stage. However, except for the hippocampal volume, most outcomes were associated with the stage through the complete mediation effect of pRCTU. Conclusion Using a machine learning algorithm, we achieved high accuracy for in vivo amyloid PET staging. The in vivo amyloid stage was associated with cognitive function and cerebral atrophy mostly through the mediation effect of cortical amyloid.

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Hoax News Classification using Machine Learning Algorithms

International Journal of Engineering and Advanced Technology - Regular Issue ◽

10.35940/ijeat.b3753.129219 ◽

2019 ◽

Vol 9 (2) ◽

pp. 3938-3944

Keyword(s):

Machine Learning ◽

Social Media ◽

Learning Algorithm ◽

Detection System ◽

Machine Learning Algorithms ◽

Training Data ◽

Stochastic Gradient Descent ◽

Support Vector ◽

The Impact ◽

F Measure

Hoax news on social media has had a dramatic effect on our society in recent years. The impact of hoax news felt by many people, anxiety, financial loss, and loss of the right name. Therefore we need a detection system that can help reduce hoax news on social media. Hoax news classification is one of the stages in the construction of a hoax news detection system, and this unsupervised learning algorithm becomes a method for creating hoax news datasets, machine learning tools for data processing, and text processing for detecting data. The next will produce a classification of a hoax or not a Hoax based on the text inputted. Hoax news classification in this study uses five algorithms, namely Support Vector Machine, Naïve Bayes, Decision Tree, Logistic Regression, Stochastic Gradient Descent, and Neural Network (MLP). These five algorithms to produce the best algorithm that can use to detect hoax news, with the highest parameters, accuracy, F-measure, Precision, and recall. From the results of testing conducted on five classification algorithms produced shows that the NN-MPL algorithm has an average of 93% for the value of accuracy, F-Measure, and Precision, the highest compared to five other algorithms, but for the highest Recall value generated from the algorithm SVM which is 94%. the results of this experiment show that different effects for different classifiers, and that means that the more hoax data used as training data, the more accurate the system calculates accuracy in more detail.

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The effect of gamma value on support vector machine performance with different kernels

International Journal of Electrical and Computer Engineering (IJECE) ◽

10.11591/ijece.v10i5.pp5497-5506 ◽

2020 ◽

Vol 10 (5) ◽

pp. 5497

Author(s):

Intisar Shadeed Al-Mejibli ◽

Jwan K. Alwan ◽

Dhafar Hamed Abd

Keyword(s):

Machine Learning ◽

Support Vector Machine ◽

Learning Algorithm ◽

Kernel Functions ◽

Supervised Machine Learning ◽

Support Vector ◽

Svm Classifier ◽

Machine Performance ◽

Rbf Kernel ◽

The Impact

Currently, the support vector machine (SVM) regarded as one of supervised machine learning algorithm that provides analysis of data for classification and regression. This technique is implemented in many fields such as bioinformatics, face recognition, text and hypertext categorization, generalized predictive control and many other different areas. The performance of SVM is affected by some parameters, which are used in the training phase, and the settings of parameters can have a profound impact on the resulting engine’s implementation. This paper investigated the SVM performance based on value of gamma parameter with used kernels. It studied the impact of gamma value on (SVM) efficiency classifier using different kernels on various datasets descriptions. SVM classifier has been implemented by using Python. The kernel functions that have been investigated are polynomials, radial based function (RBF) and sigmoid. UC irvine machine learning repository is the source of all the used datasets. Generally, the results show uneven effect on the classification accuracy of three kernels on used datasets. The changing of the gamma value taking on consideration the used dataset influences polynomial and sigmoid kernels. While the performance of RBF kernel function is more stable with different values of gamma as its accuracy is slightly changed.

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Predictive Modelling of Employee Turnover in Indian IT Industry Using Machine Learning Techniques

Vision The Journal of Business Perspective ◽

10.1177/0972262918821221 ◽

2019 ◽

Vol 23 (1) ◽

pp. 12-21 ◽

Cited By ~ 2

Author(s):

Shikha N. Khera ◽

Divya

Keyword(s):

Machine Learning ◽

Learning Algorithm ◽

Confusion Matrix ◽

Predictive Modelling ◽

Supervised Machine Learning ◽

Machine Learning Techniques ◽

Support Vector ◽

It Industry ◽

Knowledge Based ◽

Employee Attrition

Information technology (IT) industry in India has been facing a systemic issue of high attrition in the past few years, resulting in monetary and knowledge-based loses to the companies. The aim of this research is to develop a model to predict employee attrition and provide the organizations opportunities to address any issue and improve retention. Predictive model was developed based on supervised machine learning algorithm, support vector machine (SVM). Archival employee data (consisting of 22 input features) were collected from Human Resource databases of three IT companies in India, including their employment status (response variable) at the time of collection. Accuracy results from the confusion matrix for the SVM model showed that the model has an accuracy of 85 per cent. Also, results show that the model performs better in predicting who will leave the firm as compared to predicting who will not leave the company.

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Early Prediction of Seven-Day Mortality in Intensive Care Unit Using a Machine Learning Model: Results from the SPIN-UTI Project

Journal of Clinical Medicine ◽

10.3390/jcm10050992 ◽

2021 ◽

Vol 10 (5) ◽

pp. 992

Author(s):

Martina Barchitta ◽

Andrea Maugeri ◽

Giuliana Favara ◽

Paolo Marco Riela ◽

Giovanni Gallo ◽

...

Keyword(s):

Machine Learning ◽

Intensive Care ◽

Intensive Care Units ◽

Learning Algorithm ◽

Area Under The Curve ◽

Support Vector ◽

Icu Admission ◽

Risk Of Death ◽

Saps Ii ◽

Svm Algorithm

Patients in intensive care units (ICUs) were at higher risk of worsen prognosis and mortality. Here, we aimed to evaluate the ability of the Simplified Acute Physiology Score (SAPS II) to predict the risk of 7-day mortality, and to test a machine learning algorithm which combines the SAPS II with additional patients’ characteristics at ICU admission. We used data from the “Italian Nosocomial Infections Surveillance in Intensive Care Units” network. Support Vector Machines (SVM) algorithm was used to classify 3782 patients according to sex, patient’s origin, type of ICU admission, non-surgical treatment for acute coronary disease, surgical intervention, SAPS II, presence of invasive devices, trauma, impaired immunity, antibiotic therapy and onset of HAI. The accuracy of SAPS II for predicting patients who died from those who did not was 69.3%, with an Area Under the Curve (AUC) of 0.678. Using the SVM algorithm, instead, we achieved an accuracy of 83.5% and AUC of 0.896. Notably, SAPS II was the variable that weighted more on the model and its removal resulted in an AUC of 0.653 and an accuracy of 68.4%. Overall, these findings suggest the present SVM model as a useful tool to early predict patients at higher risk of death at ICU admission.

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Machine learning-based ability to classify psychosis and early stages of disease through parenting and attachment-related variables is associated with social cognition

BMC Psychology ◽

10.1186/s40359-021-00552-3 ◽

2021 ◽

Vol 9 (1) ◽

Author(s):

Linda A. Antonucci ◽

Alessandra Raio ◽

Giulio Pergola ◽

Barbara Gelao ◽

Marco Papalino ◽

...

Keyword(s):

Machine Learning ◽

Social Cognition ◽

Attachment Style ◽

Learning Algorithm ◽

Early Recognition ◽

Emotion Perception ◽

First Episode ◽

Support Vector ◽

Significant Group ◽

Early Stages

Abstract Background Recent views posited that negative parenting and attachment insecurity can be considered as general environmental factors of vulnerability for psychosis, specifically for individuals diagnosed with psychosis (PSY). Furthermore, evidence highlighted a tight relationship between attachment style and social cognition abilities, a key PSY behavioral phenotype. The aim of this study is to generate a machine learning algorithm based on the perceived quality of parenting and attachment style-related features to discriminate between PSY and healthy controls (HC) and to investigate its ability to track PSY early stages and risk conditions, as well as its association with social cognition performance. Methods Perceived maternal and paternal parenting, as well as attachment anxiety and avoidance scores, were trained to separate 71 HC from 34 PSY (20 individuals diagnosed with schizophrenia + 14 diagnosed with bipolar disorder with psychotic manifestations) using support vector classification and repeated nested cross-validation. We then validated this model on independent datasets including individuals at the early stages of disease (ESD, i.e. first episode of psychosis or depression, or at-risk mental state for psychosis) and with familial high risk for PSY (FHR, i.e. having a first-degree relative suffering from psychosis). Then, we performed factorial analyses to test the group x classification rate interaction on emotion perception, social inference and managing of emotions abilities. Results The perceived parenting and attachment-based machine learning model discriminated PSY from HC with a Balanced Accuracy (BAC) of 72.2%. Slightly lower classification performance was measured in the ESD sample (HC-ESD BAC = 63.5%), while the model could not discriminate between FHR and HC (BAC = 44.2%). We observed a significant group x classification interaction in PSY and HC from the discovery sample on emotion perception and on the ability to manage emotions (both p = 0.02). The interaction on managing of emotion abilities was replicated in the ESD and HC validation sample (p = 0.03). Conclusion Our results suggest that parenting and attachment-related variables bear significant classification power when applied to both PSY and its early stages and are associated with variability in emotion processing. These variables could therefore be useful in psychosis early recognition programs aimed at softening the psychosis-associated disability.

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Efficient detection of hacker community based on twitter data using complex networks and machine learning algorithm

Journal of Intelligent & Fuzzy Systems ◽

10.3233/jifs-210458 ◽

2021 ◽

pp. 1-17

Author(s):

Ahmed Al-Tarawneh ◽

Ja’afer Al-Saraireh

Keyword(s):

Machine Learning ◽

Complex Networks ◽

Nearest Neighbor ◽

Learning Algorithm ◽

Machine Learning Algorithms ◽

Machine Learning Techniques ◽

Support Vector ◽

K Nearest Neighbor ◽

Efficient Detection ◽

Suggested Keywords

Twitter is one of the most popular platforms used to share and post ideas. Hackers and anonymous attackers use these platforms maliciously, and their behavior can be used to predict the risk of future attacks, by gathering and classifying hackers’ tweets using machine-learning techniques. Previous approaches for detecting infected tweets are based on human efforts or text analysis, thus they are limited to capturing the hidden text between tweet lines. The main aim of this research paper is to enhance the efficiency of hacker detection for the Twitter platform using the complex networks technique with adapted machine learning algorithms. This work presents a methodology that collects a list of users with their followers who are sharing their posts that have similar interests from a hackers’ community on Twitter. The list is built based on a set of suggested keywords that are the commonly used terms by hackers in their tweets. After that, a complex network is generated for all users to find relations among them in terms of network centrality, closeness, and betweenness. After extracting these values, a dataset of the most influential users in the hacker community is assembled. Subsequently, tweets belonging to users in the extracted dataset are gathered and classified into positive and negative classes. The output of this process is utilized with a machine learning process by applying different algorithms. This research build and investigate an accurate dataset containing real users who belong to a hackers’ community. Correctly, classified instances were measured for accuracy using the average values of K-nearest neighbor, Naive Bayes, Random Tree, and the support vector machine techniques, demonstrating about 90% and 88% accuracy for cross-validation and percentage split respectively. Consequently, the proposed network cyber Twitter model is able to detect hackers, and determine if tweets pose a risk to future institutions and individuals to provide early warning of possible attacks.

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Supervised Machine Learning Methods and Hyperspectral Imaging Techniques Jointly Applied for Brain Cancer Classification

Sensors ◽

10.3390/s21113827 ◽

2021 ◽

Vol 21 (11) ◽

pp. 3827

Author(s):

Gemma Urbanos ◽

Alberto Martín ◽

Guillermo Vázquez ◽

Marta Villanueva ◽

Manuel Villa ◽

...

Keyword(s):

Machine Learning ◽

Blood Vessel ◽

Hyperspectral Imaging ◽

Imaging Techniques ◽

Venous Blood ◽

Healthy Tissue ◽

Supervised Machine Learning ◽

Support Vector ◽

Arterial Blood

Hyperspectral imaging techniques (HSI) do not require contact with patients and are non-ionizing as well as non-invasive. As a consequence, they have been extensively applied in the medical field. HSI is being combined with machine learning (ML) processes to obtain models to assist in diagnosis. In particular, the combination of these techniques has proven to be a reliable aid in the differentiation of healthy and tumor tissue during brain tumor surgery. ML algorithms such as support vector machine (SVM), random forest (RF) and convolutional neural networks (CNN) are used to make predictions and provide in-vivo visualizations that may assist neurosurgeons in being more precise, hence reducing damages to healthy tissue. In this work, thirteen in-vivo hyperspectral images from twelve different patients with high-grade gliomas (grade III and IV) have been selected to train SVM, RF and CNN classifiers. Five different classes have been defined during the experiments: healthy tissue, tumor, venous blood vessel, arterial blood vessel and dura mater. Overall accuracy (OACC) results vary from 60% to 95% depending on the training conditions. Finally, as far as the contribution of each band to the OACC is concerned, the results obtained in this work are 3.81 times greater than those reported in the literature.

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CAFD: Context-Aware Fault Diagnostic Scheme towards Sensor Faults Utilizing Machine Learning

Sensors ◽

10.3390/s21020617 ◽

2021 ◽

Vol 21 (2) ◽

pp. 617

Author(s):

Umer Saeed ◽

Young-Doo Lee ◽

Sana Ullah Jan ◽

Insoo Koo

Keyword(s):

Machine Learning ◽

Learning Algorithm ◽

Diagnostic System ◽

Machine Learning Algorithms ◽

Support Vector ◽

Context Aware ◽

Sensor Faults ◽

Training Time ◽

Low Intensity ◽

Fault Diagnostic

Sensors’ existence as a key component of Cyber-Physical Systems makes it susceptible to failures due to complex environments, low-quality production, and aging. When defective, sensors either stop communicating or convey incorrect information. These unsteady situations threaten the safety, economy, and reliability of a system. The objective of this study is to construct a lightweight machine learning-based fault detection and diagnostic system within the limited energy resources, memory, and computation of a Wireless Sensor Network (WSN). In this paper, a Context-Aware Fault Diagnostic (CAFD) scheme is proposed based on an ensemble learning algorithm called Extra-Trees. To evaluate the performance of the proposed scheme, a realistic WSN scenario composed of humidity and temperature sensor observations is replicated with extreme low-intensity faults. Six commonly occurring types of sensor fault are considered: drift, hard-over/bias, spike, erratic/precision degradation, stuck, and data-loss. The proposed CAFD scheme reveals the ability to accurately detect and diagnose low-intensity sensor faults in a timely manner. Moreover, the efficiency of the Extra-Trees algorithm in terms of diagnostic accuracy, F1-score, ROC-AUC, and training time is demonstrated by comparison with cutting-edge machine learning algorithms: a Support Vector Machine and a Neural Network.

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Multivariate Analysis as a Tool for Quantification of Conformational Transitions in DNA Thin Films

Applied Sciences ◽

10.3390/app11135895 ◽

2021 ◽

Vol 11 (13) ◽

pp. 5895

Author(s):

Kristina Serec ◽

Sanja Dolanski Babić

Keyword(s):

Thin Films ◽

Learning Algorithm ◽

Principal Component Regression ◽

Principal Component ◽

Conformational Transitions ◽

Cancer Diagnostics ◽

Dna Conformation ◽

Support Vector ◽

Multivariate Statistical ◽

The Impact

The double-stranded B-form and A-form have long been considered the two most important native forms of DNA, each with its own distinct biological roles and hence the focus of many areas of study, from cellular functions to cancer diagnostics and drug treatment. Due to the heterogeneity and sensitivity of the secondary structure of DNA, there is a need for tools capable of a rapid and reliable quantification of DNA conformation in diverse environments. In this work, the second paper in the series that addresses conformational transitions in DNA thin films utilizing FTIR spectroscopy, we exploit popular chemometric methods: the principal component analysis (PCA), support vector machine (SVM) learning algorithm, and principal component regression (PCR), in order to quantify and categorize DNA conformation in thin films of different hydrated states. By complementing FTIR technique with multivariate statistical methods, we demonstrate the ability of our sample preparation and automated spectral analysis protocol to rapidly and efficiently determine conformation in DNA thin films based on the vibrational signatures in the 1800–935 cm−1 range. Furthermore, we assess the impact of small hydration-related changes in FTIR spectra on automated DNA conformation detection and how to avoid discrepancies by careful sampling.

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Exploring Impact of Age and Gender on Sentiment Analysis Using Machine Learning

Electronics ◽

10.3390/electronics9020374 ◽

2020 ◽

Vol 9 (2) ◽

pp. 374 ◽

Cited By ~ 2

Author(s):

Sudhanshu Kumar ◽

Monika Gahalawat ◽

Partha Pratim Roy ◽

Debi Prosad Dogra ◽

Byung-Gyu Kim

Keyword(s):

Machine Learning ◽

Sentiment Analysis ◽

Short Term Memory ◽

Age Groups ◽

Modern World ◽

Support Vector ◽

Digital Information ◽

Age And Gender ◽

And Gender ◽

The Impact

Sentiment analysis is a rapidly growing field of research due to the explosive growth in digital information. In the modern world of artificial intelligence, sentiment analysis is one of the essential tools to extract emotion information from massive data. Sentiment analysis is applied to a variety of user data from customer reviews to social network posts. To the best of our knowledge, there is less work on sentiment analysis based on the categorization of users by demographics. Demographics play an important role in deciding the marketing strategies for different products. In this study, we explore the impact of age and gender in sentiment analysis, as this can help e-commerce retailers to market their products based on specific demographics. The dataset is created by collecting reviews on books from Facebook users by asking them to answer a questionnaire containing questions about their preferences in books, along with their age groups and gender information. Next, the paper analyzes the segmented data for sentiments based on each age group and gender. Finally, sentiment analysis is done using different Machine Learning (ML) approaches including maximum entropy, support vector machine, convolutional neural network, and long short term memory to study the impact of age and gender on user reviews. Experiments have been conducted to identify new insights into the effect of age and gender for sentiment analysis.

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