MP73-17 AN EVALUATION OF THE IMPACT OF CREATININE TO WEIGHT RATIO IN 24–HOUR URINE STUDIES FOR RENAL STONE PREVENTION

2014 ◽  
Vol 191 (4S) ◽  
Author(s):  
Jack Lambert ◽  
Justin Watson ◽  
Nicole Miller ◽  
Shaun Wason ◽  
Michael Fabrizio ◽  
...  
2013 ◽  
Vol 27 (3) ◽  
pp. 366-369 ◽  
Author(s):  
Mark D. Sawyer ◽  
Mary S. Dietrich ◽  
Ryan B. Pickens ◽  
S. Duke Herrell ◽  
Nicole L. Miller

Crystals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 206
Author(s):  
Qing Peng ◽  
Sheng Peng ◽  
Qiang Cao

Graphene is a good candidate for protective material owing to its extremely high stiffness and high strength-to-weight ratio. However, the impact performance of twisted bilayer graphene is still obscure. Herein we have investigated the ballistic resistance capacity of twisted bilayer graphene compared to that of AA-stacked bilayer graphene using molecular dynamic simulations. The energy propagation processes are identical, while the ballistic resistance capacity of the twisted bilayer graphene is almost two times larger than the AA-bilayer graphene. The enhanced capacity of the twisted bilayer graphene is assumed to be caused by the mismatch between the two sheets of graphene, which results in earlier fracture of the first graphene layer and reduces the possibility of penetration.


Marine Drugs ◽  
2020 ◽  
Vol 18 (12) ◽  
pp. 591
Author(s):  
Bożena Grimling ◽  
Bożena Karolewicz ◽  
Urszula Nawrot ◽  
Katarzyna Włodarczyk ◽  
Agata Górniak

Chitosans represent a group of multifunctional drug excipients. Here, we aimed to estimate the impact of high-molecular weight chitosan on the physicochemical properties of clotrimazole–chitosan solid mixtures (CL–CH), prepared by grinding and kneading methods. We characterised these formulas by infrared spectroscopy, differential scanning calorimetry, and powder X-ray diffractometry, and performed in vitro clotrimazole dissolution tests. Additionally, we examined the antifungal activity of clotrimazole–chitosan mixtures against clinical Candida isolates under neutral and acid conditions. The synergistic effect of clotrimazole and chitosan S combinations was observed in tests carried out at pH 4 on Candida glabrata strains. The inhibition of C. glabrata growth reached at least 90%, regardless of the drug/excipient weight ratio, and even at half of the minimal inhibitory concentrations of clotrimazole. Our results demonstrate that clotrimazole and high-molecular weight chitosan could be an effective combination in a topical antifungal formulation, as chitosan acts synergistically with clotrimazole against non-albicans candida strains.


Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Sally K Hammad ◽  
Min Zi ◽  
Sukhpal Prehar ◽  
Robert Little ◽  
Ludwig Neyses ◽  
...  

Introduction: Hypertension is a major risk factor for cardiac hypertrophy and heart failure. Genome wide association studies have recently identified single nucleotide polymorphisms in ATP2B1 , the gene encoding the calcium extrusion pump, plasma membrane calcium ATPase (PMCA1), as having a strong association with hypertension risk. Hypothesis: PMCA1 plays an important role in regulation of blood pressure and protection against hypertension and cardiac hypertrophy. Aims: We aim to examine whether there is a functional link between PMCA1 and blood pressure regulation, and the development of hypertension. And to determine the impact this link may have on cardiac structure and function. Methods and Results: To study the role of PMCA1 we generated a global PMCA1 heterozygous knockout mouse (PMCA1 Ht ). PMCA1 Ht mice had 46% to 52% reduction in PMCA1 protein expression compared to the WT, in aorta, heart, kidney and brain. To study the mice under hypertensive stress conditions, 3 month old PMCA1 Ht and wild type (WT) mice were infused via minipump with angiotensin II (1mg/Kg/daily) or water as a control. Upon angiotensin treatment, PMCA1 Ht mice showed a significantly greater increase in systolic (62.24±3.05 mmHg) and diastolic pressure (52.68±4.67 mmHg), in comparison to the WT (33.37±2.91 mmHg and 23.94±4.56 mmHg, respectively), P<0.001, n=12. Moreover, PMCA1 Ht mice showed a significantly greater hypertrophic response as indicated by a greater heart weight to tibia length ratio, cardiomyocyte cell size (410±18.7 μm 2 ), compared to WT mice (340.4±9.8 μm 2 ), and increased expression of B-type natriuretic peptide (BNP), 2.36 ± 0.25 fold change, n =5-6, P< 0.01. Echocardiography showed no significant changes between PMCA1 Ht and WT mice, in heart rate, and in cardiac function, as indicated by fractional shortening and ejection fraction. In addition, PMCA1 Ht mice showed no sign of lung congestion as indicated by lung weight to body weight ratio. Conclusion: ATP2B1 deletion leads to increased blood pressure and cardiac hypertrophy. This provides functional evidence that PMCA1 is involved in blood pressure regulation and protects against the development of hypertension and cardiac hypertrophy.


HortScience ◽  
2016 ◽  
Vol 51 (9) ◽  
pp. 1153-1158 ◽  
Author(s):  
Matthew D. Taylor ◽  
Rachel Kreis ◽  
Lidia Rejtö

The pH of peatmoss generally ranges from 3.0 to 4.0 and limestone is typically added to raise pH to a suitable range. Compost is also used as a substrate component and typically has a high pH of 6.0 to 8.0. When using compost, lime rates must be reduced or eliminated. The two objectives of this study were to determine the resulting pH of substrates created with varying amounts of limestone and compost and assess the impact of the various amounts of limestone and compost on pH buffering capacity. Compost was created from a 1:1:1 weight ratio of a mixture of green plant material and restaurant food waste:horse manure:wood chips. The first experiment was a factorial design with five compost rates (0%, 10%, 20%, 30%, and 40% by volume), four limestone rates (0, 1.2, 2.4, and 3.6 g·L−1 substrate) with five replications. The experiment was conducted three times, each with a different batch of compost. With 0 lime, initial substrate pH increased from 4.5 to 6.7 as compost rate increased. This trend occurred at all other lime rates, which had pH ranges of 5.2–6.9, 5.6–7.0, and 6.1–7.1 for rates of 1.2, 2.4, and 3.6 g·L−1 substrate, respectively. Substrate pH increased significantly as either compost or lime rates increased. The second experiment was a factorial design with four compost rates by volume (0%, 10%, 20%, and 30%), the same four limestone rates as Expt. 1, and five replications. Each substrate treatment was titrated through incubations with six sulfuric acid rates (0, 0.1, 0.2, 0.4, or 0.7 mol of H+ per gram of dry substrate). Substrates with a similar initial pH had very similar buffering capacities regardless of the compost or limestone rate. These results indicate compost can be used to establish growing substrate pH similar to limestone, and this change will have little to no effect on pH buffering capacity.


2020 ◽  
Vol 10 (2) ◽  
pp. 684 ◽  
Author(s):  
Mohamad Zaki Hassan ◽  
S. M. Sapuan ◽  
Zainudin A. Rasid ◽  
Ariff Farhan Mohd Nor ◽  
Rozzeta Dolah ◽  
...  

Banana fiber has a high potential for use in fiber composite structures due to its promise as a polymer reinforcement. However, it has poor bonding characteristics with the matrixes due to hydrophobic–hydrophilic incompatibility, inconsistency in blending weight ratio, and fiber length instability. In this study, the optimal conditions for a banana/epoxy composite as determined previously were used to fabricate a sandwich structure where carbon/Kevlar twill plies acted as the skins. The structure was evaluated based on two experimental tests: low-velocity impact and compression after impact (CAI) tests. Here, the synthetic fiber including Kevlar, carbon, and glass sandwich structures were also tested for comparison purposes. In general, the results showed a low peak load and larger damage area in the optimal banana/epoxy structures. The impact damage area, as characterized by the dye penetration, increased with increasing impact energy. The optimal banana composite and synthetic fiber systems were proven to offer a similar residual strength and normalized strength when higher impact energies were applied. Delamination and fracture behavior were dominant in the optimal banana structures subjected to CAI testing. Finally, optimization of the compounding parameters of the optimal banana fibers improved the impact and CAI properties of the structure, making them comparable to those of synthetic sandwich composites.


2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Quanchao Sun ◽  
You Wu ◽  
Feng Zhao ◽  
Jianjun Wang

Lung ischemia/reperfusion (I/R) injury occurs in various clinical conditions and heavily damaged lung function. Oxidative stress reaction and antioxidant enzymes play a pivotal role in the etiopathogenesis of lung I/R injury. In the current study, we investigated the impact of Maresin 1 on lung I/R injury and explored the possible mechanism involved in this process. MaR 1 ameliorated I/R-induced lung injury score, wet/dry weight ratio, myeloperoxidase, tumor necrosis factor, bronchoalveolar lavage fluid (BALF) leukocyte count, BALF neutrophil ratio, and pulmonary permeability index levels in lung tissue. MaR 1 significantly reduced ROS, methane dicarboxylic aldehyde, and 15-F2t-isoprostane generation and restored antioxidative enzyme (superoxide dismutase, glutathione peroxidase, and catalase) activities. Administration of MaR 1 improved the expression of nuclear Nrf-2 and cytosolic HO-1 in I/R-treated lung tissue. Furthermore, we also found that the protective effects of MaR 1 on lung tissue injury and oxidative stress were reversed by HO-1 activity inhibitor, Znpp-IX. Nrf-2 transcription factor inhibitor, brusatol, significantly decreased MaR 1-induced nuclear Nrf-2 and cytosolic HO-1 expression. In conclusion, these results indicate that MaR 1 protects against lung I/R injury through suppressing oxidative stress. The mechanism is partially explained by activation of the Nrf-2-mediated HO-1 signaling pathway.


2014 ◽  
Vol 353 ◽  
pp. 126-130 ◽  
Author(s):  
Maya Radune ◽  
A. Radune ◽  
Svetlana Lugovskoy ◽  
M. Zinigrad ◽  
David Fuks ◽  
...  

In the present study the modeling of the HEBM process is presented. The impact velocity, impact angle, rotation speed, mass of balls, ball-to-powder weight ratio and time of milling have been taken into account in order to calculate the energy transferred from the balls to the powder. Two different systems, namely, TiN-AlN and polysalicylic acid were experimentally investigated in order to confirm the validity of the model. The calculation results are in a reasonable agreement with the results of experimental research.


2017 ◽  
Vol 52 (4) ◽  
pp. 531-542 ◽  
Author(s):  
Siva Sankar Panda ◽  
Sushanta K Samal ◽  
Smita Mohanty ◽  
Sanjay K Nayak

The present study represents the synthesis of flexible polyurethane nanocomposite foam using Cloisite 30B nanoclays varying at 1, 2, and 3 wt%. The polyurethane nanocomposite foam formulated with 50:50 weight ratio of synthetic polyether polyol and renewable resource-based castor oil. The progress of isocyanate reaction and formation of bidentate urea through H-bonding in the polymeric matrix phase were confirmed from Fourier transform infrared analysis. The surface morphology of the nanocomposite foams was examined by scanning electron microscopy and X-ray diffraction analysis. Polyurethane nanocomposite foam displayed exfoliated structures at 3 wt% Cloisite 30B. The thermal and mechanical properties were also studied to report the impact of Cloisite 30B in biobased flexible polyurethane foam. Enhanced thermogravimetric outcome signified higher thermal stability of polyurethane nanocomposite foam as compared to polyurethane foam. Further, improvement of the soft segment glass transition temperature (Tg) confirmed the role of Cloisite 30B in the phase separation behavior between the hard segment and soft segment in nanocomposite foams. A significant enhancement in the mechanical strength with incorporation of a small amount of Cloisite 30B nanoclay to the flexible polyurethane foam allows it for various low cost applications.


2015 ◽  
Vol 787 ◽  
pp. 480-484
Author(s):  
M. Vimalesh ◽  
Srikanth Prabhu ◽  
K.S. Vijay Sekar

Inconel 718, a Nickel based superalloy is widely used for aerospace applications mainly due to its high temperature resistance and high strength to weight ratio. Its poor machinability is a limiting factor in commercial, cost intensive applications. This paper investigates the machinability of Inconel 718 in high speed drilling. The impact of the material on thrust forces, torque and chip microstructure have been measured at four different cutting speeds – 19, 27,43 and 67 m/min. The high tensile strength coupled with low thermal conductivity compounds the machining process. The thrust forces decrease with cutting speed, but the torque fluctuates at intermediate cutting speeds. Chip formation is continuous across cutting speeds, with thin cross sections and evidence of saw tooth edges. Inconel work hardens more than titanium alloys and shows good ductile to brittle transition at low temperatures creating chips of lesser length as observed using scanning electron microscopy.


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