Lipoprotein(A) and BMI: Significant correlation with positive family history of cardiovascular diseases in obese, hypertensive and diabetic children

2002 ◽  
Vol 3 (2) ◽  
pp. 114
Keyword(s):  
Family History ◽  
Cardiovascular Diseases ◽  
Positive Family History ◽  
Lipoprotein A ◽  
Diabetic Children ◽  
History Of

scholarly journals Evaluation of Cardiovascular Diseases Risk in the Iranian Population

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Meisam Akhlaghdoust ◽  
Davoud Pirani ◽  
Mohamad Nasiri ◽  
Sahar Lashkari Ahangarani ◽  
Nazgol Haghsetan ◽  
...  
Keyword(s):  
Family History ◽  
Cardiovascular Diseases ◽  
Risk Score ◽  
Smoking Status ◽  
Positive Family History ◽  
Iranian Population ◽  
Risk Scores ◽  
Cvd Risk ◽  
Assessment Scores ◽  
History Of

Background: Cardiovascular diseases (CVDs) are among the leading causes of death and morbidity around the world. Risk score assessment can assist in anticipating a person's CVD risk over the next five years. Objectives: This study aimed to investigate the risk of CVDs in the general Iranian population. Methods: This study was conducted in September 2020, and 5324 participants aged 35 to 74 years were registered from 95 metro stations throughout Tehran. Participants' demographics (ie, age, gender, current smoking and exercise habits, and family history of hypertension, CVDs, and diabetes) were collected by in-person interviews, and their body mass index (BMI) and systolic blood pressure (SBP) were measured. The five-year risk of CVDs was estimated and categorized into low (< 10%), some risk (10 - 20%), moderate (21 - 30%), increased (31 - 40%), and high (> 40%) groups, and its association with the participants’ demographics was evaluated by SPSS version 21. Results: The mean age of 5324 participants was 45.3 ± 14.8 years, and 64% were male. The frequency of CVD risk scores was as follows: low (54%), some risk (17.5%), moderate (15.4%), increased (5.7%), and high (3.5%), which were significantly associated with gender (P < 0.001), smoking status (P = 0.048), exercise (P = 0.014), and family history of diseases (all P < 0.001). Age (β = 0.774, P < 0.001) increased the odds of CVD, while other variables had small or no effects on CVD. Conclusions: This study found a high prevalence of high-risk CVD in the Iranian population, emphasizing the importance of risk score assessment, which should include not only basic non-laboratory risk assessment scores, but also exercise and a positive family history of associated diseases.

scholarly journals Similar Myocardial Perfusion and Vascular Stiffness in Children and Adolescents with High Lipoprotein (a) Levels, in Comparison with Healthy Controls

Pulse ◽  
2021 ◽  
pp. 1-8
Author(s):  
Kyriaki Papadopoulou-Legbelou ◽  
Areti Triantafyllou ◽  
Olga Vampertzi ◽  
Nikolaos Koletsos ◽  
Stella Douma ◽  
...  
Keyword(s):  
Family History ◽  
Children And Adolescents ◽  
Vascular Function ◽  
Augmentation Index ◽  
Positive Family History ◽  
Premature Coronary Artery Disease ◽  
Healthy Children ◽  
Vascular Aging ◽  
Lipoprotein A ◽  
History Of

<b><i>Background and Aims:</i></b> This study investigated the possible correlation between elevated lipoprotein (a) (Lp(a)) levels and early vascular aging biomarkers in healthy children and adolescents. <b><i>Methods:</i></b> Twenty-seven healthy children/adolescents, mean age 9.9 ± 3.7 years, with high Lp(a) levels without other lipid abnormalities and 27 age- and sex-matched controls with normal Lp(a) levels, were included in the study. The investigation of possible early vascular aging was assessed by measuring vascular function indices: carotid intima-media thickness (c-IMT), pulse wave velocity (PWV), augmentation index (AIx), and subendocardial viability ratio (SEVR). <b><i>Results:</i></b> Although serum lipid values were within normal levels, mean values of total cholesterol and apolipoprotein B were higher in the group of children with high Lp(a) levels than controls (<i>p</i> = 0.006 and <i>p</i> &#x3c; 0.001, respectively). Vascular function indices did not show significant differences, neither between the 2 groups nor in the subgroups of children with increased Lp(a) levels. These subgroups were defined by the presence or absence of family history of premature coronary artery disease. Lp(a) levels did not show a significant correlation with the other parameters studied, both regarding the whole sample (patients and controls), as well as in the subgroups of elevated Lp(a) levels. However, in the group of children with high Lp(a) levels, c-IMT and PWV were positively correlated with diastolic blood pressure (<i>r</i> = 0.427, <i>p</i> = 0.026 and <i>r</i> = 0.425, <i>p</i> = 0.030, respectively), while SEVR was negatively correlated with AIx (<i>r</i> = −0.455, <i>p</i> = 0.017). <b><i>Conclusions:</i></b> Healthy children and adolescents with high Lp(a) levels do not yet have impaired vascular indices, compared to controls. However, in order to prevent early atherosclerosis, it is crucial to early identify and follow up children with high Lp(a) levels and positive family history of premature coronary disease or other cardiovascular risk factors.

Abstract P534: Is a Positive Family History of Cardiovascular Diseases Associated With Ideal Cardiovascular Health in the Community? The Polish Norwegian Study

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Georgeta Vaidean ◽  
Marta Manczuk ◽  
Sandeep Vansal
Keyword(s):  
Family History ◽  
Cardiovascular Diseases ◽  
Sex Education ◽  
Health Care Services ◽  
Cardiovascular Health ◽  
Positive Family History ◽  
Ideal Cardiovascular Health ◽  
Care Services ◽  
Ideal Metrics ◽  
History Of

Introduction: Self-reported family history of cardiovascular diseases (FHxCVD) is associated with an increased cardiovascular risk. In contrast to genetic profiling, FHxCVD has the advantage that it reflects not only genetic susceptibility, but also factors related to a shared environment and behaviors. Ideal cardiovascular health (ICVH) is a summary indicator of behavioral and major subsequent biological factors. FHxCVD is presumed to motivate the adoption of a healthy lifestyle, yet little evidence exists to support this hypothesis in a community setting. Hypothesis: We assessed the hypothesis that self-reported family history of cardiovascular diseases is associated with ICVH in a community based study. Methods: We used cross-sectional, baseline data of 10934 participants, age 45 to 64 years free of cardiovascular diseases in an ongoing cohort study (PONS). Data were collected through structured questionnaires and fasting blood samples. Ideal cardiovascular health was defined according to the American Heart Association criteria (7 metrics assessed at 3 levels: ideal, intermediate, and poor). FHxCVD was self-reported, based on three questions inquiring about coronary heart disease, stroke, hypertension in parents and siblings. We considered a positive FHxCVD if an affirmative answer to any of these three questions was reported. We used multivariable logistic models and adjusted for age, sex, education, place of residence, health care services. Results: The prevalence of poor CVH (0-2 ideal metrics) was 63% and of ideal CVH (6, 7 ideal metrics) was 0.07%. The prevalence of a positive FHxCVD was 77%. Mean (SD) for ICVH score was 2.20 (1.06), with no difference between those with positive and negative FHxCVD. A positive FHxCVD was associated with increased odds of a poor cardiovascular health (0-2 health components), OR (95%CI) 1.12 (1.01-1.23), after adjusting for age, sex, education, rural residence and health care services. Among participants with known history of hypertension, having a positive family history of HTN (but not of CHD or stroke) was associated with lower odds of having their blood pressure controlled (OR 0.83 , 95%CI 0.71-0.96), after multivariable adjustment. Conclusion: In this community-based study we found that self-reported FHxCVD is not accompanied by healthy behaviors. In spite of its personal value, simple knowledge of one’s FHxCVD may not suffice as motivator for lifestyle changes.

Clinical and paraclinical characteristics of young patients with myocardial infarction from Northeast of Romania

2021 ◽  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Family History ◽  
Cardiovascular Diseases ◽  
Older Patients ◽  
Positive Family History ◽  
Young Patients ◽  
Study Results ◽  
History Of ◽  
Case Outcome

The aim of this study was to evaluate the clinical and paraclinical features in young patients (18–40 years) with acute myocardial infarction (AMI) in the Northeast of Romania. We have considered all patients admitted between the 1st of January 2017 through the 31st of December 2019 at a tertiary care Cardiology Institute with the primary discharge diagnosis of AMI. These patients have been split into 2 groups depending on their age: the first group consisting of patients with an age equal to or lower than 40 years old and the second group consisting of patients with an age greater than 40 years old. After this, we have randomly selected a representative sample from each of the two groups. A total of 99 patients were ultimately enrolled in the study: 42 in the first group and 57 in the second group. Data collected included age, gender, medical history, laboratory tests, echocardiography parameters, coronarography study results, and case outcome. Most young patients with myocardial infarction were male, more likely to smoke (69% vs 35.1%, p = 0.001), and with a positive family history of cardiovascular diseases (35.7% vs 1.8%, p < 0.001) in comparison to their older counterparts. Also, they had fewer comorbidities, such as diabetes mellitus, hypertension, or a positive history of stroke or atrial fibrillation. Mean ejection fraction was significantly higher in young patients (43.4 ± 10.65 vs 37.16 ± 10.77, p = 0.005) and both tricuspid and mitral valve regurgitations were less severe. Coronary lesions were more severe in the older patients (p = 0.009), usually with more coronary arteries involved. No significant difference was recorded in the number of hospitalization days or in the case outcome. Acute myocardial infarction in young patients typically occurs more in men who smoke, those who are more than 30 years old, and those who have a positive family history of cardiovascular diseases. Echocardiographic parameters seem to be better than in the case of older patients and the coronary involvement is usually less severe.

scholarly journals The association between diabetes and thyroid cancer risk: a hospital-based case-control study in China

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Meng Wang ◽  
Wei-Wei Gong ◽  
Feng Lu ◽  
Ru-Ying Hu ◽  
Qing-Fang He ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Family History ◽  
Case Control Study ◽  
Positive Family History ◽  
Case Control ◽  
Diabetes Duration ◽  
Family History Of Diabetes ◽  
Thyroid Cancer Risk ◽  
History Of ◽  
Control Study

Abstract Background Previous studies have indicated inconsistent relationships of diabetes with thyroid cancer risk, yet little is known in China. In this study, we aimed to investigate the associations between diabetes, diabetes duration and the risk of thyroid cancer in Chinese population. Methods A 1:1 matched case-control study was performed between 2015 and 2017 in Zhejiang Province including 2,937 thyroid cancer cases and 2,937 healthy controls. Odds ratios (ORs) with 95 % confidence intervals (CIs) for thyroid cancer were estimated in logistic regression models. Specific effects stratified by age, as well as sex, body mass index (BMI) and family history of diabetes were also examined. Results Overall, neither diabetes (OR = 0.75, 95 % CI: 0.21–2.73) nor diabetes duration (OR = 0.14, 95 % CI: 0.02–1.22 for diabetes duration ≦ 5 years; OR = 2.10, 95 % CI: 0.32–13.94 for diabetes duration > 5 years) was significantly associated with thyroid cancer. In stratified analyses, significant lower risk of thyroid cancer was observed among subjects with diabetes and shorter diabetes duration ( ≦ 5 years), but limited to those who were aged more than 40 years, female, overweight/obese and had positive family history of diabetes. Conclusions Diabetes and shorter diabetes duration were significantly associated with decreased risk of thyroid cancer in individuals characterized by older age, female sex, higher BMI and positive family history of diabetes.

scholarly journals Differential expression of micro RNA-29 family in non-diabetic adults of diabetic and non-diabetic parents

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Uzair Abbas ◽  
Bushra Imdad ◽  
Sikander Adil Mughal ◽  
Israr Ahmed Baloch ◽  
Afshan Mehboob Khan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Family History ◽  
Positive Family History ◽  
Cross Sectional Study ◽  
Vital Role ◽  
Micro Rna ◽  
Cross Sectional ◽  
Family History Of Diabetes ◽  
History Of

Abstract Objective MicroRNAs are known to regulate 60% of genes at post translational level. MicroRNAs including Micro RNA-29 family play a vital role in cellular activities and have validate role in numerous metabolic disorders inclusive of diabetes mellitus and its complications. While micro RNA profile changes years before the occurrence of disease. This cross-sectional study was conducted in non-diabetic adults of diabetic and non-diabetic parents to explore the early changes in expression of micro RNA-29 family as it can be served as early biomarker of type 2 diabetes in non-diabetic adults. This study was conducted from January 2019 to January 2021. Micro RNA was extracted from plasma of 50 participants and expression was compared through qPCR. While data was analyzed through SPSS version 21.0. Results 29a and 29b had lower expression in participants with family history of DM compared to those having no family history of DM (P < 0.0001). While micro RNA 29c was found to be significantly higher in participants with positive family history of type 2 diabetes as compared to those without family history of diabetes (P = 0.001).

A Group Therapy Approach to Facilitate Integration of Risk Information for Women at Risk for Breast Cancer

1998 ◽  
Vol 43 (4) ◽  
pp. 375-380 ◽  
Author(s):  
Mary Jane Esplen ◽  
Brenda Toner ◽  
Jonathan Hunter ◽  
Gordon Glendon ◽  
Kate Butler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
At Risk ◽  
Family History ◽  
Group Therapy ◽  
Perceived Risk ◽  
Positive Family History ◽  
Risk Information ◽  
Degree Relative ◽  
Therapy Approach ◽  
History Of

Objective: To describe and illustrate elements of a group counselling approach designed to enhance the communication of risk information on breast cancer (BC) to women with a family history of this disease. Breast cancer is a leading cause of female cancer death. The most important risk factor for BC is a positive family history in at least 1 first-degree relative, and approximately one-third of women with BC have a family history of the disease. Recent evidence suggests that there is a significant psychological impact associated with having a family history of BC, and this may influence the psychological adjustment and response to being counselled for personal risk. New counselling approaches are required. Method: This paper describes a group therapy approach that incorporates principles of supportive-expressive therapy designed to address the emotional impact of being at risk for BC and to promote accuracy of perceived risk. The key elements of the intervention are described along with clinical illustrations from groups that are part of an ongoing study to develop and standardize the group therapy. Conclusion: Qualitative data from the groups suggest that this model of therapy is both feasible and effective.

Levels of anxiety, depression and denial in patients with myocardial infarction

1997 ◽  
Vol 12 (3) ◽  
pp. 149-151 ◽  
Author(s):  
D Sarantidis ◽  
A Thomas ◽  
K Iphantis ◽  
N Katsaros ◽  
J Tripodianakis ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Intensive Care Unit ◽  
Family History ◽  
Positive Family History ◽  
Anxiety And Depression ◽  
Previous Myocardial Infarction ◽  
History Of ◽  
Seeking Help ◽  
Anxiety Depression

SummaryIn this study we investigated 1) the changes in anxiety, depression and denial from admission to discharge in patients admitted to the intensive care unit following an acute myocardial infarction and 2) the effect of smoking habits, time lapsed from the appearance of symptoms to seeking help behavior, presence of a person that motivated the patient to seek help, previous myocardial infarction (MI) and family history of MI, on these changes. The results indicated that 1) the levels of both anxiety and depression increased from admission to discharge, while denial decreased; 2) positive family history of MI was associated with lower difference of denial between admission and discharge.

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